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Indiana University Bloomington

David GiedrocDavid P. Giedroc

Professor, Chemistry

Office:Simon Hall 320A

Phone: 812/856-5449

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Lab Website

Education

Ph.D. Biochemistry Vanderbilt University 1984
NIH postdoctoral fellow 1984-1988 Yale University 

Research

Metal sensor proteins in pathogenic bacteria; NMR structural studies of regulatory RNAs in mammalian RNA viruses

Representative Publications

iu, P., Li, L., Millership, J. J., Leibowitz, J. L., & GIEDROC, D. P. (2007) A U-turn motif-containing stem-loop in the coronavirus 5' untranslated region (UTR) plays a functional role in replication. RNA 13, 763-780.

Liu, T., Ramesh, A., Ma, Z, Ward, S. K., Zhang, L., George, G. N., Talaat, A. M., Sacchettini, J. C., & GIEDROC, D. P. (2007) CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator. Nature Chem. Biol. 3, 60-68.

Cornish, P. V., Stammler, S. N. & GIEDROC, D. P. (2006) The global structures of a wild-type and poorly functional plant luteoviral mRNA pseudoknot are essentially identical. RNA 12, 1959-1969.

Cornish, P. V. & GIEDROC, D. P. (2006) Pairwise coupling analysis of helical junction hydrogen bonding interactions in luteoviral RNA pseudoknots. Biochemistry 45, 11162-11171.

Cornish, P. V. GIEDROC, D. P. & Hennig, M. (2006) Dissecting non-canonical interactions in frameshift-stimulating mRNA pseudoknots. J. Biomol. NMR 35, 209-223.

Lee, S., Arunkumar, A.I., Chen, X., & GIEDROC, D. P. (2006) Structural Insights into Homo- and Heterotropic Allosteric Coupling in the Zinc Sensor S. aureus CzrA from Covalently Fused Dimers. J. Am. Chem. Soc. 128, 1937-1947.

Pennella, M.A., Arunkumar, A.I., & GIEDROC, D. P. (2006) Individual Metal Ligands Play Distinct Functional Roles in the Zinc Sensor Staphylococcus aureus CzrA. J. Mol. Biol. 356, 1124-1136.

Cornish, P.V., Hennig, M., & GIEDROC, D. P. (2005) A Loop 2 Cytidine-Stem 1 Minor Groove Interaction as a Positive Determinant for Pseudoknot-Stimulated -1 Ribosomal Frameshifting. Proc. Natl. Acad. Sci. USA 102, 12694-12699.

Pennella, M. A., & GIEDROC, D. P. (2005) Structural Determinants of Metal Selectivity in Prokaryotic Metal-Responsive Transcriptional Regulators. Biometals 18, 413-428 (invited review).

Apuy, J. A., Busenlehner, L. S., Russell, D. H., & GIEDROC, D. P. (2004) Ratiometric Pulsed Alkylation-Mass Spectrometry as a Probe of Thiolate Reactivity in Different Metalloderivatives of S. aureus pI258 CadC Biochemistry 43, 3824-3834.

Chen, X., Zhang, B., Harmon, P. M., Schaffner, W., Peterson, D. O., & GIEDROC, D. P. (2004) A Novel Cysteine Cluster in Human MTF-1 is Required for Heavy Metal-induced Transcriptional Activation in vivo. J. Biol. Chem. 279, 4515-4522.

Eicken, C., Pennella, M. A., Chen, X., Koshlap, K., VanZile, M. L., Sacchettini, J. C., & GIEDROC, D. P. (2003) A Metal-Ligand mediated Intersubunit Allosteric Switch in Related SmtB/ArsR Zinc Sensor Proteins. J. Mol. Biol. 333, 683-695.

GIEDROC, D. P., Cornish, P. V., & Hennig, M. A. (2003) Detection of Scalar Couplings Involving 2'-Hydroxyl Protons Across Hydrogen Bonds in a Frameshifting RNA Pseudoknot. J. Am. Chem. Soc 125, 4676-4677.

Pennella, M. A., Shokes, J. E., Cosper, N. J., Scott, R. A., & GIEDROC, D. P. (2003) Structural Elements of Metal Selectivity in Metal Sensor Proteins. Proc. Natl. Acad. Sci. USA 100, 3713-3718.