Professor, Molecular and Cellular Biochemistry Department
Office: Simon Hall 201A
BS, Microbiology and Biology, University of Michigan
PhD, Microbiology, Michigan State University
We are interested in both basic and applied studies of how RNA viruses interact with the host cell. The lab has three interrelated areas of focus, and these have the potential to enrich each other.
Wang Z., C. Hryc, B. Bammes, P.V. Afonine, J. Jokana, D-H. Chen, X. Liu, M. L. Baker, C. Kao, S. J. Ludtke, M. F. Schmid, P.D. Adams, and W. Chiu. 2014. An atomic model of Brome mosaic virus using direct electron detection and real-space optimization. Nature Commun. 5:5805. DOI:10.1037
Singh D., R. Vaughan, and C. C. Kao. 2014. LL-37 Enhancement of signal transduction by Toll-like Receptor 3 is regulated by pH; identification of a peptide antagonist of LL-37. J. Biol. Chem. 289: 27614-27624.
Yunus M. A., Lin X., Bailey D, Karakasiliotis I, Chaudhry Y, Zhang G., Thorne L., Kao C., and Goodfellow I. 2014. Characterization of the murine norovirus subgenomic RNA promoter. J. Virol. 89: 1218-1229.
Lin X. L. Thorne, Z. Jin, S. Li, I. Goodfellow, and C. C. Kao. 2014. Norovirus RdRps specifically recognize their core subgenomic promoter. NAR. Doi: 10.1093/narl/gku292.
Wen Y., and C. C. Kao. 2014. The hepatitis C virus core protein can modulate RNA-dependent RNA synthesis by the 2a polymerase. Virus Res. 30: 165-176.
Yamane D., McGivern D. R., Wauthier E., Ping L., Yi M., Madden V. J., Wen Y., Chugh P. E., McGee C. E., Widman D. G., Kim S., Shimakami T., Welsch C., Oikawa T., Heise M. T., Dittmer D. P., Kao C. C., Pitson S. M., Merrill Jr A. H., Reid, L. M., and. Lemon S. M. 2014. Regulation of hepatitis C virus replication by sphingosine kinase 2-mediated endogenous lipid peroxidation. Nature Medicine 20: 927-935.
Perez-Vargas J., C. Houser, K. M. Hastie, R. C. Vaughan, C. C. Kao, and G. R. Nemerow. 2014. Isolation and characterization of the DNA and protein-binding activities of adenovirus Core protein V. J. Virol. 88: 9287-9296. PMID: 24899200.
Vaughan R., B. Tragesser, P. Ni, X. Ma, B. Dragnea, and C. C. Kao. 2014. The tripartite virions of the brome mosaic virus have distinct physical properties that affect the timing of the infection process. J. Virol. 88, 6483-6491. PMID: 24672042.
Fan B., K.Y. Lu, F. X. Reymond Sutandy, Y.-W. Chen, K. Konan, H. Zhu, C. C. Kao and C. H. Chen. 2014. A human proteome microarray identified that the heterogeneous Ribonucleoprotein K (hnRNP K) recognizes the 5’ terminal sequence of the hepatitis C virus. Molec. Cell. Proteomics 13(1):84-92.
Ni P., R. Vaughan, B. Tragesser, and C. C. Kao. 2013. The plant host can affect the encapsidation of Brome Mosaic Virus (BMV) RNA; BMV virions are surprisingly heterogeneous. J. Mol. Biol. 426:1061-1076. PMID: 24036424.
Li, X., C. Shu, G. Yi, C. T. Chaton, C. K. Shelton, J. Diao, X. Zuo, C. Cheng Kao, A. B. Herr, and P. Li. 2013. Cyclic GMP-AMP synthase is activated by double-strand DNA-induced oligomerization. Immunity 39, 1019-1031.