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Indiana University Bloomington

David KehoeDavid Kehoe

Professor, Biology

Office: Jordan Hall A413A

Phone: 812/856-4715

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Ph.D., University of California, Los Angeles, 1992
NSF Postdoctoral Fellow, Carnegie Institution, Stanford University, 1993


Environmental regulation of gene expression in bacteria


Fellow of the American Academy of Microbiology

Howard Hughes Medical Institute/United States National Academies Education Fellow in the Life Sciences

Representative Publications

Kehoe, D. M. 2010. Chromatic adaptation and the evolution of light color sensing in cyanobacteria. Proceedings of the National Academy of Sciences U.S.A., 107: 9029-9030.

Kolowrat, C., Partensky, F., Mella-Flores, D., Le Corguillé, G., Boutte, C., Blot, N., Ratin, M., Ferréol, M., Lecomte, X., Gourvil, P., Lennon, J.-F., Kehoe, D.M., and L. Garczarek. 2010. Ultraviolet stress delays chromosome replication in light/dark synchronized cells of the marine cyanobacterium Prochlorococcus marinus PCC9511. BMC Genomics, 10: 204.

Bezy, R. P. and D. M. Kehoe. 2010. Functional characterization of a cyanobacterial OmpR-class transcription factor binding site controlling responses to light color. Journal of Bacteriology, 192: 5923-5933.

Gutu, A., Alvey, R. M., Bashour, S., Zingg, D., and D. M. Kehoe. 2011. Sulfate-driven elemental sparing is regulated at the transcriptional and post-transcriptional levels in a filamentous cyanobacterium. Journal of Bacteriology, 193: 1449-1460.

Bezy, R. P., Wiltbank, L., and D. M. Kehoe. 2011. Light-dependent attenuation of phycoerythrin gene expression reveals convergent evolution of green light sensing in cyanobacteria. Proceedings of the National Academy of Sciences USA, 108: 18542-18547.

Gutu, A. and D. M. Kehoe. 2012. Emerging Perspectives on the Mechanisms, Regulation, and Distribution of Light Color Acclimation in Cyanobacteria. Molecular Plant, 5:1-13.

Shukla, A., Blot, N., Biswas, A., Partensky, F., Garczarek, L., Le Corguillé, G., Gutu, A., Schluchter, W., and D. M.  Kehoe. 2012. A phycoerythrin-specific bilin lyase-isomerase controls blue-green chromatic acclimation in marine Synechococcus. Proceedings of the National Academy of Sciences USA, 109: 20136-20141.

Bussell, A. N. and D. M. Kehoe. 2013. Hierarchical regulation between four-color and two-color cyanobacteriochromes. Proceedings of the National Academy of Sciences USA., 110: 12834-12839.

Gutu, A., Nesbit, A. D., Alverson, A., Palmer, J. D., and D. M. Kehoe. 2013. Light color regulation of photosynthetic genes by translation initiation factor IF3. Proceedings of the National Academy of Sciences USA., 110:16253–16258.

Bussell, A. N. and D. M. Kehoe. 2014. Chromatic acclimation: A many-colored mechanism for maximizing photosynthetic light harvesting efficiency. In The Cell Biology of Cyanobacteria. (Ed. E. Flores and A. Herrero) (Caister Academic Press, Norfolk, UK). In press.

Hasan, S. S., Jones, L. M., Stofleth, J. T., Ryan, C. M., Whitelegge, J. P., Kehoe, D. M., and W. A. Cramer. 2015. Role of domain-swapping in the hetero-oligomeric cytochrome b6f lipo-protein complex. Biochemistry, 54: 3151-3163.

Yerrapragada, S., Shukla, A., Hallsworth-Pepin, K., Choi, K., Wollam, A., Clifton, S., Qin, X., Muzny, D., Raghuraman, S., Ashki, H.,  Uzman, A., Highlander, S., Fryszczyn, B., Bingwa, B., Horton-Schaffer, C., Fox, G., Tirumalai, M., Liu, Y., Kim, S., Kehoe, D. M. and G. Weinstock. 2015. Extreme sensory complexity encoded in the 10-Mb draft genome sequence of the chromatically acclimating cyanobacterium Tolypothrix sp. PCC 7601. Genome Announcements, 3 (3).

Shukla, A., Choi, K., Bussell, A. N., Yerrapragada, S., Kim, S., Weinstock, G. and D. M. Kehoe. 2015. Genomic analysis of the 9.97 Mb freshwater cyanobacterium Tolypothrixsp. PCC 7601/ Fremyella diplosiphon (UTEX B 481) reveals highly complex two component system regulatory networks and light sensing capabilities. BMC Genomics. Submitted.