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Indiana University Bloomington

Ken MackieKenneth Mackie

Associate Professor, Psychology

Office: Psychology 363

Phone: 812/ 855-2042

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Education

Brown University, ScB, Engineering, 1980
Yale University, MD, 1984

Research

Regulation of cannabinoid receptor signaling; regulation of endocannabinoid production; role of endocannabinoids in synaptic plasticity; novel cannabinoid receptors.

Representative Publications

Straiker, A., A. Gibson, J. Mitjavila, J. Blankman, S. Hu, B. Cravatt, and K. Mackie, ABHD12 deletion alters cannabinoid signaling and induces desensitization in autaptic hippocampal neurons.  Neuropharmacology, in press.

Wu, C.S., D.Morgan, C.P. Jew, C. Haskins, M.-J. Andrews, C.M. Spencer, T. Czyzyk, H. Bradshaw, K. Mackie, and H.C. Lu, Long-term consequences of perinatal fatty acid amino hydrolase inhibition.  Br. J. Pharmacol.  in press.

Straiker, A., K.T. Min, and K. Mackie, Fmr1 deletion enhances and ultimately desensitizes CB1 signaling in autaptic hippocampal neurons. Neurobiol Dis, 2013. 56: p. 1-5

Atwood, B.K., J. Wager-Miller, C. Haskins, A. Straiker, and K. Mackie, Functional selectivity in CB(2) cannabinoid receptor signaling and regulation: implications for the therapeutic potential of CB(2) ligands. Mol Pharmacol, 2012. 81(2): p. 250-63

Atwood, B.K., J. Wager-Miller, C. Haskins, A. Straiker, and K. Mackie, Functional selectivity in CB(2) cannabinoid receptor signaling and regulation: implications for the therapeutic potential of CB(2) ligands. Mol Pharmacol, 2012. 81(2): p. 250-63

Straiker, A., J. Wager-Miller, J. Hutchens, and K. Mackie, Differential signalling in human cannabinoid CB1 receptors and their splice variants in autaptic hippocampal neurones. Br J Pharmacol, 2012. 165(8): p. 2660-71

Pickel, V.M., E.T. Shobin, D.A. Lane, and K. Mackie, Cannabinoid-1 receptors in the mouse ventral pallidum are targeted to axonal profiles expressing functionally opposed opioid peptides and contacting N-acylphosphatidylethanolamine-hydrolyzing phospholipase D terminals. Neuroscience, 2012. 227: p. 10-21

Morgan, D.J., C.H. Muller, N.A. Murataeva, B.J. Davis, and K. Mackie, Delta9-Tetrahydrocannabinol (Delta9-THC) attenuates mouse sperm motility and male fecundity. Br J Pharmacol, 2012. 165(8): p. 2575-83

Ho, Y.C., H.J. Lee, L.W. Tung, Y.Y. Liao, S.Y. Fu, S.F. Teng, H.T. Liao, K. Mackie, and L.C. Chiou, Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition. J Neurosci, 2011. 31(41): p. 14600-10

Straiker, A., J. Wager-Miller, S.S. Hu, J.L. Blankman, B.F. Cravatt, and K. Mackie, COX-2 and fatty acid amide hydrolase can regulate the time course of depolarization-induced suppression of excitation. Br J Pharmacol, 2011. 164(6): p. 1672-83

Atwood, B.K., J. Huffman, A. Straiker, and K. Mackie, JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB1 receptor agonist. Br J Pharmacol, 2010. 160(3): p. 585-93

Wu, C.S., J. Zhu, J. Wager-Miller, S. Wang, D. O'Leary, K. Monory, B. Lutz, K. Mackie, and H.C. Lu, Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections. Eur J Neurosci, 2010. 32(5): p. 693-706

Straiker, A., S.S. Hu, J.Z. Long, A. Arnold, J. Wager-Miller, B.F. Cravatt, and K. Mackie, Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons. Mol Pharmacol, 2009. 76(6): p. 1220-7

Straiker, A. and K. Mackie, Cannabinoid signaling in inhibitory autaptic hippocampal neurons. Neuroscience, 2009. 163(1): p. 190-201

Daigle, T.L., C.S. Kearn, and K. Mackie, Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling. Neuropharmacology, 2008. 54(1): p. 36-44

Daigle, T.L., M.L. Kwok, and K. Mackie, Regulation of CB1 cannabinoid receptor internalization by a promiscuous phosphorylation-dependent mechanism. J Neurochem, 2008. 106(1): p. 70-82

Lauckner, J.E., J.B. Jensen, H.Y. Chen, H.C. Lu, B. Hille, and K. Mackie, GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current. Proc Natl Acad Sci U S A, 2008. 105(7): p. 2699-704

Berghuis, P., A.M. Rajnicek, Y.M. Morozov, R.A. Ross, J. Mulder, G.M. Urban, K. Monory, G. Marsicano, M. Matteoli, A. Canty, A.J. Irving, I. Katona, Y. Yanagawa, P. Rakic, B. Lutz, K. Mackie, and T. Harkany, Hardwiring the brain: endocannabinoids shape neuronal connectivity. Science, 2007. 316(5828): p. 1212-6

Pickel, V.M., J. Chan, C.S. Kearn, and K. Mackie, Targeting dopamine D2 and cannabinoid-1 (CB1) receptors in rat nucleus accumbens. J Comp Neurol, 2006. 495(3): p. 299-313