Kenneth Mackie

Associate Professor

Education

rown University, ScB, Engineering, 1980
Yale University, MD, 1984

Research

Regulation of cannabinoid receptor signaling; regulation of endocannabinoid production; role of endocannabinoids in synaptic plasticity; novel cannabinoid receptors.

Representative Publications

Catterall, W.A. and Mackie, K. (2005). Local Anesthetics. In: Goodman and Gilman's The Pharmacological Basis of Therapeutics. (Ed. J.G. Hardman, L.E. Limbard, P.B. Molinoff, T.W. Rall, and R.W. Ruddon) McGraw Hill.

Mackie, K. (2005). Cannabinoid receptors as therapeutic targets. Ann. Review Pharmacol. 46:101-122.

Schuchmann, S.D., Schmitz, D. Rivera, C., Vanhatalo, S., Salmen, B., Mackie, K., Sipilä, S.T., Voipio, J., and Kaila, K. (2006). Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis. Nature Med. 12:817-823.

Katona I., Urbán, M.G., Wallace, M., Ledent, C., Jung, K.M, Piomelli, D., Mackie, K., and Freund, T.F. (2006). Molecular composition of the endocannabinoid system at glutamatergic synapses. J. Neurosci. 26:5628-5637.

Straiker, A. and Mackie, K. (2007). Metabotropic suppression of excitation in autaptic hippocampal neurons. J. Physiol., 578:773-785.

Berghuis, P., Rajnicek, A.M., Morozov, Y.M., Ross, R.A., Mulder, J., Monory, K., Marsicano, G., Lutz, B., Matteoli, M., Canty, A., Yanagawa, Y., Rakic, P., Mackie, K., and Harkany, T. (2007). Hardwiring the brain: Endocannabinoids control axon guidance. Science, 316:1212-1216.

Chen, K., Neu, A., Howard, A.L., Foldy, C., Echegoyen, J., Hilgenberg, L., Smoth, M., Mackie, K., and Soltesz, I. (2007). Prevention of plasticity of endocannabinoid signaling inhibits persistent limbic hyperexcitability caused by developmental seizures. J. Neurosci., 27:46-58.

Jung, K.-M., Astarita, G., Zhu, C., Wallace, M., Mackie, K., and Piomelli, D. (2007). A key role for diacylglycerol lipase-? in metabotropic glutamate receptor-dependent endocannabinoid metabolism. Mol. Pharmacol., 72:612-621.

Cachope, R., Mackie, K., Triller, A., O’Brien, J., and Perada, A.E. (2007). Potentiation of electrical and chemical synaptic transmission mediated by endocannabinoids. Neuron, 56:1034-1047.

Harkany, T., Guzmán, M., Galve-Roperh, I., Berghuis, P., Devi, L.A., and Mackie, K. (2007). The emerging functions of endocannabinoid signaling during development of the nervous system. Trends in Pharmacol. Sci., 28:83-92.

Mackie, K. (2007). From active ingredients to the discovery of the targets: The cannabinoid receptors. Chem. & Biodiversity, 4:1693-1706.

Daigle T.L., Kearn, C.S., and Mackie, K. (2008). Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling. Neuropharmacology, 54:36-44.

Mulder, J., Aguado, T., Keimpema, E., Barabas, K., Rosado-Ballester, C.J., Nguyen, L., Monory, K., Marciscano, G., Di Marzo, V., Hurd, Y.L., Guillemmot, F., Mackie, K., Lutz, B., Guzman, M., Lu,, H.C., Galve-Roperh, I., Harkany, T. (2008). Endocannabinoid signaling controls pyramidal cell specification and long range axon patterning. Proc. Natl. Acad. Sci. USA, 105: 8760-8765.

Daigle, T.L, Kwok, M.L., and Mackie, K. (2008). Regulation of CB1 receptor internalization by a promiscuous phosphorylation-dependent mechanism. J. Neurochem., 106: 70-82.

Lauckner, J.E., Jensen, J.B., Chen, H.-Y., Lui, H.-C., Hille, B., and Mackie, K. (2008). GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current. Proc. Natl. Acad. Sci. USA, 105: 2699-2704.

Harkany, T., Mackie, K., and Doherty, P. (in press). Wiring and firing neuronal networks: endocannabinoids take center stage. Curr. Opin. Neurobiol.