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Indiana University Bloomington

Melanie MarketonMelanie Marketon

Assistant Professor, Biology

Office: Jordan Hall 455A

Phone: 812/856-3198

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Lab Website

Education

Ph.D., University of Texas at Dallas, 2002
Postdoctoral Fellow, University of Chicago, 2003-2006

Research

Molecular mechanisms of pathogenic microbe-host interactions

Representative Publications

RfaL is required for Yersinia pestis type III secretion and virulence.
Houppert AS, Bohman L, Merritt PM, Cole CB, Caulfield AJ, Lathem WW, Marketon MM.
Infect Immun. 2013 Apr;81(4):1186-97. doi: 10.1128/IAI.01417-12. Epub 2013 Jan 28.

YopK controls both rate and fidelity of Yop translocation.
Dewoody R, Merritt PM, Marketon MM.
Mol Microbiol. 2013 Jan;87(2):301-17. doi: 10.1111/mmi.12099. Epub 2012 Dec 4.

Identification of chromosomal genes in Yersinia pestis that influence type III secretion and delivery of Yops into target cells.
Houppert AS, Kwiatkowski E, Glass EM, DeBord KL, Merritt PM, Schneewind O, Marketon MM.
PLoS One. 2012;7(3):e34039. doi: 10.1371/journal.pone.0034039. Epub 2012 Mar 30.

Dewoody, R., and M.M. Marketon. 2012. Regulation of the type III secretion system injectisome: Hall monitors for translocation. Submitted to Frontiers in Cellular and Infection Microbiology.

Dewoody, R., P.M. Merritt, and M.M. Marketon. 2012. YopK control both rate and fidelity of Yop translocation. Submitted to Molecular Microbiology.

Houppert, A.S., L. Bohman, A.J. Caulfield, W.W. Lathem, and M.M.Marketon. 2012. RfaL is required for Yersinia pestis type III secretion and virulence. Submitted to Infection and Immunity.

Houppert, A. S., E. Kwiatkowski, E. M. Glass, K. L. DeBord, P. M. Merritt, O. Schneewind, and M. M. Marketon. 2012. Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells. PLoS ONE 7(3): e34039. doi:10.1371/journal.pone.0034039. PMCID: PMC3316589.

YopK regulates the Yersinia pestis type III secretion system from within host cells.
Dewoody R, Merritt PM, Houppert AS, Marketon MM.
Mol Microbiol. 2011 Mar;79(6):1445-61. doi: 10.1111/j.1365-2958.2011.07534.x. Epub 2011 Jan 19.

Dewoody, R., P.M. Merritt, A.S. Houppert, and M.M. Marketon.  2011. YopK Regulates the Yersinia pestis Type III Secretion System from Within Host Cells. Mol Microbiol. 79:1445-1461. PMCID: PMC3210821.

Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV.
DeBord KL, Anderson DM, Marketon MM, Overheim KA, DePaolo RW, Ciletti NA, Jabri B, Schneewind O.
Infect Immun. 2006 Aug;74(8):4910-4.

DeBord, K.L., D.M. Anderson, M.M. Marketon, K.A. Overheim, R.W. DePaolo, N. Ciletti, B. Jabri, and O. Schneewind. 2006. Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV. Infect Immun. 74: 4910-4914. PMCID: PMC1539636.

DeBord, K.L., D.M. Anderson, M.M. Marketon, K.A. Overheim, R.W. DePaolo, N. Ciletti, B. Jabri, and O. Schneewind. 2006. Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV. Infect Immun. 74: 4910-4914. PMCID: PMC1539636.

Rejection of impassable substrates by Yersinia type III secretion machines.
Sorg JA, Miller NC, Marketon MM, Schneewind O.
J Bacteriol. 2005 Oct;187(20):7090-102.

Plague bacteria target immune cells during infection.
Marketon MM, DePaolo RW, DeBord KL, Jabri B, Schneewind O.
Science. 2005 Sep 9;309(5741):1739-41. Epub 2005 Jul 28.

Sorg, J.A, N.C. Miller, M.M. Marketon, and O. Schneewind. 2005. Rejection of Impassable Substrates by Yersinia Type III Secretion Machines. J. Bacteriol. 187: 7090-7102. PMCID: PMC1251613.

Marketon, M.M., R.W. DePaolo, K.L. DeBord, B. Jabri, and O. Schneewind. 2005. Plague Bacteria Target Immune Cells during Infection. Science 309: 1739-1741. PMCID: PMC3210820.