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Indiana University Bloomington

Ken nephewKen Nephew

Professor, Medical Science

Office: Jordan Hall 302

Phone: 812/ 855-9445

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Education

Ph.D., Ohio State University, 1991

Research

DNA methylation in ovarian cancer; breast cancer chemoprevention; spinal cord regeneration; steroid hormone action.

Representative Publications

Chou JL, Lin HJ, Yang HW, Yan P, Deatherage D, Lai HC, Huang YW, Nephew KP, Huang TH, Chan M. 2011 Aberrant TGF-beta/SMAD4 signaling contributes to epigenetic silencing of a putative tumor suppressor, RunX1T1 in ovarian cancer. Epigenetics, In press

Teng IW , Hou PC, Lee KD , Chu PY , Yeh KT, Jin VX, Tseng MJ, Tsai SJ, Chang YS, Wu CS, Sun HS, Tsai KD, Jeng LB, Nephew KP, Huang TH, Leu YW, Hsiao SH. 2011. Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells. Cancer Res, in press

Shen C, Huang YW, Liu Y, Wang G, Zhao Y, Wang Z, Teng M, Flockhar DA, Skaar TC, Yan P, Nephew KP, Huang THM, Li L. A modulated empirical bayes model for identifying topological and temporal estrogen receptor a regulatory networks in breast cancer. Bioinformatics, in press

Rao X Di Leva G Li M, Fang F, Hartman-Frey C, Burow ME, Croce C, Nephew KP. 2011. MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways. Oncogene,30:1082-97

Bapat SA, Jin V, Berry N, Balch C, Sharma N, Kurrey N, Zhang S, Fang F, Lan X, Li M, Kennedy B, Bigsby RM, Huang TH, Nephew KP. 2010. Multivalent epigenetic marks confer microenvironment-responsive epigenetic plasticity to ovarian cancer cells. Epigenetics, 5:716-29

Fang F, Balch C, Schilder S, Breen T, Zhang S, Shen C, Li L, Kulesavage C, Snyder AJ, Nephew KP*, Matei DE*. 2010. A phase I and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer. Cancer, 116:4043-53 (*corresponding authors)

Hsu P-Y, Hsu H-K, Singer GAC, Yan PS, Rodriguez BAT, Liu JC, Weng YI, Deatherage DE, Chen Z, Pereira JS, Lopez R, Russo J, Wang Q, Lamartiniere CA, Nephew KP, Huang TH-M. 2010. Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping. Genome Res, 20:733-44

Matei DE*, Nephew KP*. 2010 Epigenetic therapies for chemosensitization of epithelial ovarian cancer. Gynecol Oncol 116:195-201 (*corresponding authors)

McCune K, Bhat-Nakshatri P, Thorat MA, Nephew KP, Badve S, Nakshatri H. 2010 Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet. Cancer Res 70:685-96

Di Leva G, Gasparini P, Piovan C, Ngankeu A, Garofalo M, Taccioli C, Iorio MV, Li M, Volinia S, Alder H,Nakamura T, Nuovo G, Liu Y, Nephew KP , Croce CM. 2010 A regulatory “miRcircuitry” involving miR-221&222 and ERa determines ERa status of breast cancer cells. J Nat. Cancer Inst 102:706-21

Liu Y, Balaraman Y, Wang G, Nephew KP, Zhou FC. 2009 Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation. Epigenetics 4:500-11

Nephew KP, Balch C, Zhang S, Huang TH. 2009 Epigenetics and ovarian cancer. Cancer Treat Res 149:131-46

Li M, Balch C, Montgomery S, Jeong M, Chung JH, Yan P, Huang T H-M, Kim S Nephew KP. 2009 Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer, BMC Medical Genomics 2:34-48.

Nam S, Li M, Choi K, Balch C, Kim S, Nephew KP. 2009 MicroRNA and mRNA integrated Analysis (MMIA): a web tool for examining biological functions of microRNA expression. Nucleic Acids Res 37 (Web Server issue):W356-62

Yang, Y, Balch C, Kulp S, Mand M, Tumati V, Edwards C, Nephew KP, Chen CS. 2009 A novel, rationally designed histone deacetylase inhibitor for therapy of platinum-resistant ovarian cancer. Neoplasia 11:552-63

Xin F, Li M, Balch C, Thomson M, Fan M, Liu Y, Hammond SM, Kim S, Nephew KP. 2009 Computational analysis of microRNA profiles and their target genes suggests significant involvement in breast cancer antiestrogen resistance. Bioinformatics 25:430-34