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Indiana University Bloomington

Milos NovotnyMilos V. Novotny

Professor, Department of Chemistry

Office: Chemistry C105A

Phone: 812/ 855-4532

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Lab Website

Education

Ph.D. Biochemistry 1965 University of Brno
Postdoctoral Positions: Czechoslovak Academy of Sciences,
Royal Karolinska Institute (Sweden)
University of Houston

Research

Interaction of mammalian pheromones with olfactory proteins; bioanalytical chemistry/high-sensitivity structural determinations in glycobiology; ligand/polysaccharide interactions.

Representative Publications

Pheromones, Binding Proteins and Receptor Responses in Rodents. M.V. Novotny, Biochem.Soc. Transactions, 31, 117-122 (2003).

New Hyphenated Methodologies in High Sensitivity Glycoprotein Analysis. M. Novotny and Y. Mechref, J. Sep. Science, J. Sep. Sci., 28 1956-1968 (2005).

Combining lectin microcolumns with high-resolution separation techniques for enrichment of glycoproteins and glycopeptides. M. Madera, Y. Mechref and M. V. Novotny, Analytical Chemistry 77, 4081-4090 (2005).

Comprehensive Assessment of N-Glycans Derived from a Murine Monoclonal Antibody: a Case for Multimethodological Approach, Yehia Mechref, Jan Muzikar, and Milos V. Novotny, Electrophoresis 26, 2034-2046 (2005).

Stir Bar Sorptive Extraction: A New Quantitative and Comprehensive Sampling Technique for Determination of Chemical Signal Profiles from Biological Media, H.A. Soini, K.E. Bruce, D. Wiesler, F. David, P. Sandra, M.V. Novotny, J. Chem. Ecol. 31, 377-392 (2005)

A monolithic PNGase F enzyme microreactor enabling glycan mass mapping of glycoproteins by mass spectrometry, A. Palm and M.V. Novotny, Rapid Comm. Mass Spectrom. 19, 1730-1738 (2005).

Microdeposition Device Interfacing Capillary Electrochromatography and Microcolumn Liquid Chromatography with Matrix-assisted Laser Desorption/Ionization Mass Spectrometry. T. J. Tegeler, Y. Mechref, K. Boraas, J.P. Reilly and M.V. Novotny, Anal. Chem. 76, 6698-6706 (2004).

Temperature Dependent Backbone Dynamics of Major Urinary Protein-I Complexed with the Pheromone 2-sec-Butyl-4,5-dihydrothiazole, H. Krizova, L. Zidek, M.J. Stone, M.V. Novotny, V. Sklenar. Journal of Biomolecular NMR 28, 369-384 (2004).

Determination of Trace Isoflavonoid Phytoestrogens in Biological Materials by Capillary Electrochromatography. Jason A. Starkey, Yehia Mechref, C.K. Byun, Rosemary Steinmetz, Ora H. Pescovitz, Milos V. Novotny, Anal. Chem., 74 5998-6005 (2003).

Thermodynamic Analysis of Binding Between Mouse Major Urinary Protein-I and the Pheromone 2-sec-Butyl-4,5-dihydrothiazole. S.D. Sharrow, M.V. Novotny and M.J. Stone, Biochemistry 42. 6302-6309 (2003).

Structural Characterization of Oligosaccharides Using MALDI-TOF/TOF Tandem Mass Spectrometry. Yehia Mechref, Milos V. Novotny and Cheni Kirshnan, Anal. Chem.75, 4895-4903 (2003).

Microscale Nonreductive Release of O-Linked Glycans for Subsequent Analysis through MALDI/TOF Mass Spectrometry and Capillary Electrophoresis. Y. Huang, Y. Mechref and M.V. Novotny, Anal. Chem 73, 6063-6069, (2001).