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Indiana University Bloomington

David KehoeNikki Pohl

Professor, Chemistry

Office: Simon Hall 120A

Phone: 812/855-0298

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Lab Website

Education

Ph.D., University of Wisconsin-Madison, 1997
NIH Postdoctoral Fellow, Stanford University

Research

Glycobiology and glycochemistry (synthetic and analytical), carbohydrate active enzymes, carbohydrate-binding proteins (especially those related to immune responses), proteins from archaea and hyperthermophiles

Representative Publications

Pohl Recent Publications

Vela Ramirez, J. E.; Goodman, J. T.; Boggiatto, P. M.; Roychoudhury, R.; Pohl, N. L. B.; Hostetter, J. M.; Wannemuehler, M. J.; Narasimhan, B.* Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles. The AAPS Journal, 2015, 17, 256-267.

Nagy, G.; Pohl, N. L. B.* Complete Hexose Isomer Identification with Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2015, 26, 677-685.

Nagy, G.; Pohl, N. L. B.* Monosaccharide identification as a first step toward de novo carbohydrate sequencing: Mass spectrometry strategy for the identification and differentiation of diastereomeric and enantiomeric pentose isomers. Anal. Chem. 2015, 87, 4566-4571.

Vela Ramirez, J. E.; Goodman, J. T.; Boggiatto, P. M.; Roychoudhury, R.; Pohl, N. L. B.; Hostetter, J. M.; Wannemuehler, M. J.; Narasimhan, B.* Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles. The AAPS Journal, 2015, 17, 256-267.

Tang, S.-L.; Pohl, N. L. B.* Automated Solution-Phase Synthesis of β-1,4-Mannuronate and β-1,4-Mannan. Org. Lett. 2015, 17, 2642-2645.

Roychoudhury, R.; Martinez, P.; Grinnage-Pulley, T.; Schaut, R. G.; Petersen, C. A.; Pohl, N. L. B.* Acid-triggered degradable reagents for differentiation of adaptive and innate immune responses to Leishmania-associated carbohydrate. Angew. Chem. Int. Ed. 2015, 54, 9610-9613.

Tang, S.-L.; Linz, L.; Bonning, B.; Pohl, N. L. B.* Automated Solution-Phase Synthesis of Insect Glycans to Probe the Binding Affinity of Pea Enation Mosaic Virus. J. Org. Chem. 2015, 80, 10482-10489.

Mizanur, R. M.; Pohl, N. L. B.* Phosphomannose isomerase/GDP-mannose pyrophosphorylase from Pyrococcus furiosus: a thermostable biocatalyst for the synthesis of guanidinediphosphate-activated and mannose-containing sugar nucleotides. Org. Biomol. Chem. 2009, 7, 2135-2139.

Edwards, H. E.; Nagappayya, S. K.; Pohl, N. L. B. Probing the Limitations of Fluorous Content for Tag-Mediated Microarray Formation. Chem. Commun. 2012, 48, 510-512.

Lin, L.; Abdel Motaal, B.; Schmidt-Supprian, M.; Pohl, N. L. B.* Multigram Synthesis of Isobutyl-beta-C-galactoside as a Substitute of Isopropylthiogalactoside for Exogenous Gene Induction in Mammalian Cells. J. Org. Chem.2012, 77, 1539-1546.

Chavez-Santoscoy, A.; Roychoudhury, R.; Pohl, N. L. B.; Wannemuehler, M. J.; Narasimhan, B.; Ramer-Tait, A. E. Tailoring the Immune Response by Targeting C-type Lectin Receptors on Alveolar Macrophages Using “Pathogen-like” Amphiphilic Polyanhydride Nanoparticles. Biomaterials, 2012, 33, 4762-4772.

Camci-Unal, G.; Mizanur, R. M.; Pohl, N. L. B. Synthesis of a 3-deoxy-D-manno-octulosonic acid (KDO) building block from D-glucose via fermentation. Org. Biomol. Chem. 2012, 10, 5856-5860.

Warner, C.; Camci-Unal, G.; Pohl, N. L. B.; Reilly, P. Substrate Binding by the Catalytic Domain and Carbohydrate Binding Module of Ruminococcus flavefaciens FD-1 Xyloglucanase/Endoglucanase. Ind. Eng. Chem. Res. 2013, 52, 30-36. (special issue)

Lin, L.; Pohl, N. L. B. Synthesis of a Series of Maltotriose Phosphates with an Evaluation of the Utility of a Fluorous Phosphate Protecting Group. Carbohydr. Res. 2013, 369, 14-24.