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Indiana University Bloomington

James ReillyJames P. Reilly

Professor and Chairman, Chemistry

Office: Chemistry C231A

Phone: 812/855-1980

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A.B., Chemistry, Princeton University, 1972
PhD Physical Chemistry, University of California, Berkeley, 1977
Postdoctoral Fellow, Max-Planck, 1978


Bacteria fingerprinting and proteomics by mass spectrometry; analysis of bacterial ribosomes; development of novel mass spectrometric techniques.

Representative Publications

  1. W. Running and J.P. Reilly, “Ribosomal proteins of Deinococcus radiodurans: their solvent accessibility and reactivity”, J. Proteome Res., 8, 1228–1246, (2009).
  2. J.P. Reilly, “Ultraviolet photofragmentation of biomolecular ions”, Mass Spectrometry Reviews. 28, 425-447 (2009).
  3. L. Zhang and J.P. Reilly, “Extracting both peptide sequence and glycan structural information by 157 nm photodissociation of N-linked glycopeptides”, J. Proteome Res. 8, 734-743 (2009).
  4. T-Y. Kim, J. Schwartz, and J.P. Reilly, “Development of a linear ion trap/orthogonal time-of-flight mass spectrometer for Time-Dependent Observation of Product Ions by Ultraviolet Photodissociation of Peptide Ions”, Analytical Chemistry, 81, 8809-8817, (2009).
  5. L. Zhang, and J.P. Reilly, “Peptide Photodissociation with 157nm Light in a Commercial Tandem time-of-Flight Mass Spectrometer”, Analytical Chemistry, 81, 7829-7838 (2009).
  6. T-Y. Kim and J.P. Reilly, “Time-Resolved Observation of Product Ions Generated by 157 nm Photodissociation of Singly Protonated Phosphopeptides”, J. Am. Soc. Mass Spectrom., 20, 2334-2341, (2009).
  7. T-Y. Kim and J.P. Reilly, “Gas-Phase Conformation-Specific Photofragmentation of Proline-Containing Peptides”, J. Am. Soc. Mass Spectrom., 21, 1455-1465, (2010).
  8. X. Liu and J.P. Reilly, “Correlating the chemical modification of Escherichia coli ribosomal proteins with crystal structure data”, Journal of Proteome Research, 8, 4466-4478 (2009). 
  9. L. Zhang, and J.P. Reilly, “Radical driven dissociation of odd-electron peptide radical ions produced in 157 nm photodissociation”, J. Am. Soc. Mass Spectrom. 20, 1378-1390 (2009).
  10. M.A. Lauber, W.E. Running and J.P. Reilly, “B. subtilis ribosomal proteins:  structural homology, post-translational modifications, and genome sequencing errors”, J. Proteome Res.8, 4193–4206 (2009).
  11. R. Parthasarathi, J.P. Reilly and K. Raghavachari, “New Insights into UV Photodissociation of Peptides”, Journal of the American Chemical Society, 132, 1606-1610 (2010).
  12. L. Zhang and J.P. Reilly, “Peptide De novo Sequencing using 157 nm Photodissociation in a Tandem Time-of-Flight Mass Spectrometer”, Analytical Chemistry, 82, 898-908 (2010).
  13. S. Ravipaty and J. Reilly, “Comprehensive Characterization of Methicillin-Resistant Staphylococcus aureus COL Secretome by Two-Dimensional Liquid Chromatography and Mass Spectrometry”, Molecular and Cellular Proteomics, 9, 1898-1919, (2010).
  14. L. Zhang and J.P. Reilly, “De Novo Sequencing of Tryptic Peptides Derived from Deinococcus radiodurans Ribosomal Proteins Using 157 nm Photodissociation MALDI TOF-TOF Mass Spectrometry”, Journal of Proteome Research, 9, 3025-3034, (2010).
  15. W. Running and J.P. Reilly, “Variation of the Chemical Reactivity of Thermus thermophilus HB8 Ribosomal Proteins as a function of pH”, Proteomics, 10, 3669-3687, (2010).
  16. M. A. Lauber and J.P. Reilly, “A Novel Amidinating Cross-linker for Facilitating Analyses of Protein Structures and Interactions”, Analytical Chemistry, 82, 7736-7743, (2010).
  17. B. C. Bohrer, Y. F. Li, J. P. Reilly, D. E. Clemmer, R. D. DiMarchi, P. Radivojac, H. Tang, and R. J. Arnold, “Combinatorial Libraries of Synthetic Peptides as a Model for Shotgun Proteomics”, Analytical Chemistry, 82, 6559-6568, (2010).
  18. X. Liu, Y.F. Li, B.C. Bohrer, R.J. Arnold, P. Radivojac, H. Tang, J.P. Reilly, “Investigation of VUV photodissociation propensities using peptide libraries”, International Journal of Mass Spectrometry, In Press, (2011).
  19. M. Lauber and J.P. Reilly, “Structural Analysis of a Prokaryotic Ribosome Using a Novel Amidinating Cross-Linker and Mass Spectrometry”, Journal of Proteome Research, Accepted, (2011).