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Indiana University Bloomington

Michael VannieuwenhzeMichael VanNieuwenhze

Associate Professor, Chemistry Department

Office: Simon Hall 200A

Phone: 812/ 856-7545

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Lab Website

Education

B.A. Kalamazoo College 1984
M.S. Yale University 1988
Ph.D. from Indiana University 1992
NIH Postdoctoral Fellow The Scripps Research Institute La Jolla1994

Research

Synthesis, study, and design of antibiotics that inhibit bacterial cell wall biosynthesis; peptidoglycan biosynthesis and bacterial cell morphology; development of HBV capsid-binding probes and assembly-directed antivirals; oxidized phospholipids in disease and diagnostics.

Representative Publications

Tocheva, E. I.; López-Garrido, Hughes, V.; Fredlund, J.; Kuru, E.; VanNieuwenhze, M. S.; Brun, Y.; Pogliano, K.; Jensen, G. J., “Peptidoglycan transformations during Bacillus subtilis sporulation,” Mol. Microbiol.  2013, DOI:  10.1111/mmi.12201.

Kim, S. J.; Singh, M.; Wohlrab, A.; Yu, T.-Y.; O’Connor, R. D.; VanNieuwenhze, M. S.*; Schaefer, J.*, “Isotridecanyl Side Chain of Plusbacin A3 is Essential for the Transglycosylase Inhibition of Peptidoglycan Biosynthesis,” Biochemistry  2013, 52, 1973-1979.

Kuru, E.; Hughes, H. V.; Brown, P. J. B.; Hall, E.; Tekkam, S.; Cava, F.; de Pedro, M. A.; Brun, Y. V.*; VanNieuwenhze, M. S.*, “In Situ Probing of Newly Synthesized Peptidoglycan in Live Bacteria with Fluorescent D-Amino Acids,” Angew. Chem. Int. Ed.  2012, 51, 12519-12523.

Kuru, E.; Hughes, H. V.; Brown, P. J. B.; Hall, E.; Tekkam, S.; Cava, F.; de Pedro, M. A.; Brun, Y. V.*; VanNieuwenhze, M. S.*, “In Situ Probing of Newly Synthesized Peptidoglycan in Live Bacteria with Fluorescent D-Amino Acids,” Angew. Chem. 2012, 124, 12687-12691.

Garcia-Reynaga, P.; VanNieuwenhze, M. S.*,  “Biomimetic Synthesis of Cbz-(S)-Dolaphenine,” Tetrahedron Lett.  2012, 53, 4889-4893.

Turner, W. W.; Hartvigsen, K.; Boullier, A.; Montano, E. N.; Witztum, J.; VanNieuwenhze, M. S.* “Design and Synthesis of a Stable Oxidized Phospholipid Mimic with Specific Binding Recognition for Macrophage Scavenger Receptors,” J. Med. Chem.  2012, 55, 8178-8182.

Hall, E. A.; Kuru, E.; VanNieuwenhze, M. S.* “Solid-Phase Synthesis of Lysobactin (Katanosin B):  Insights into Structure and Function,” Org. Lett.  2012, 14, 2730-2733.

Peng, R.; VanNieuwenhze, M. S.* “A Model Study for Construction of the DEF-Benzoxocin Ring System of Nogalamycin via Reductive Heck Cyclization,” Org. Lett.  2012, 14, 1962-1965.

Carrillo, A. K.; VanNieuwenhze, M. S.* “Synthesis of the AviMeCys-Containing D-Ring of Mersacidin,” Org. Lett.  2012, 14, 1034-1037.

Garcia-Reynaga, P.; Carrillo, A. K.; VanNieuwenhze, M. S.* “Decarbonylative Approach to the Synthesis of Enamides from Amino Acids:  Stereoselective Synthesis of the (S)-(Z)-Aminovinyl–D-Cysteine Unit of Mersacidin,” Org. Lett.  2012, 14, 1030-1033.