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Indiana University Bloomington

Theodore WidlanskiTheodore S. Widlanski

Professor, Chemistry

Office: Chemistry C329B

Phone: 812/855-6863

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Education

PhD Harvard 1989

Research

Bioorganic methodology; enzyme reaction mechanisms; anti-breast tumor agents; DNA polymerization; new strategies for HIV inhibition; phosphotyrosine phosphatases; biomimetic catalysis.

Representative Publications

Asim K. Bera, Lena S. Polovnikova, Juliatek Roestamadji, Theodore S. Widlanski, George L. Kenyon, Michael J. McLeish and Miriam S. Hasson "Mechanism-based inactivation of benzoylformate decarboxylase, a thiamin diphosphate-dependent enzyme" J. Am.Chem.Soc. 129(14) 4120-4121 (2007)

Cheri L. Stowell, Kevin K. Barvian, Peter C.M.Young, Robert M. Bigsby, Dawn E. Verdugo, Carolyn R. Bertozzi and Theodore S. Widlanski "A Role for Sulfation- Desulfation in the Uptake of Bisphenol A into Breast Tumor Cells" Chemistry and Biology 13 , 891-897 (2006)

Levi S. Simpson and Theodore S. Widlanski "A Comprehensive Approach to the Synthesis of Sulfate Esters" J. Am.Chem.Soc. 128 (5), 1605-1610 (2006)

David C. Johnson II and Theodore S. Widlanski "Facile Deprotection of O-Cbz-Protected Nucleosides by Hydrogenolysis: An Alternative to O-Benzyl Ether-Protected Nucleosides" Org. Lett. 6 (25) 4643-4646 (2004)

David C. Johnson II and Theodore S. Widlanski "A Reversible Safety-Catch Method for the Hydrogenolysis of N-Benzyl Moieties" Tetrahedron Lett ., 45 , 8483-8487 (2004)

David C. Johnson II and Theodore S. Widlanski "The Synthesis of Nucleoside Phosphates and Polyphosphates" Curr. Protocols Nuc. Acid Res. Unit 13.1, 1-27 (2003)

David C. Johnson II and Theodore S. Widlanski "Cerium (III) Chloride-Mediated Reactions of Sulfonamide Dianions" J. Org. Chem. 68, 5300-5309 (2003)

Benjamin T. Burlingham, Lisa M. Pratt, Ernest R. Davidson, Vernon J. Shiner, Jon Fong and Theodore S. Widlanski " 34 S Isotope Effect on Sulfate Ester Hydrolysis; Mechanistic Implications" J. Am. Chem. Soc. 125, 13036-13037 (2003)

Benjamin T. Burlingham and Theodore S. Widlanski "An Intuitive Look at the Relationship of K 1 and IC 50 : A More General Use for the Dixon Plot" J. Chem. Ed 80 (2) 214-218 (2003)

David C. Johnson II and Theodore S. Widlanski "Multiple Routes for the Synthesis of N - Acylsulfonamide-bridged Nucleosides" Synthesis 6, 809-815 (2002)

Benjamin T. Burlingham and Theodore S. Widlanski "Synthesis and Biological Activity of N-Sulfonylphosphoramidates: Probing the Electrostatic Preferences of Alkaline Phosphatase" J. Org. Chem. 66 (23) 7561-7567 (2001) Cover Article