Skip to main content
Indiana University Bloomington

Joel YbeJoel Ybe

Senior Research Scientist

Office: Simon Hall 405B

Phone: 812/856-4882

Send Email

Lab Website


Ph.D., Rutgers University & University of Medicine and Dentistry of New Jersey, 1991
Postdoctoral Fellow, Princeton University, 1991-1995
Assistant Research Biochemist, University of California San Francisco (UCSF), 1995-2000


Structure and function of Huntingtin-interacting protein 1(HIP1) in clathrin-mediated endocytosis and in the neurodegenerative disorder, Huntington's disease.  X-ray crystallography, biochemistry, and mammalian cell systems.  Work supported by National Institutes of Health (2R01GM064387-06) (see press releases 

Representative Publications

Wilbur, J.D., Hwang, P.K., Ybe, J.A., Lane, M., Sellers, B.D., Tran, T., Jacbson, M.P., Fletterick, R.J., Brodsky, F.M., 2010. Conformation switching of clathrin light chain regulates clathrin lattice assembly.  Developmental Cell (accepted).

Ybe, J.A., Clegg, M.E., Illingworth, M., Gonzalez, C., and Niu, Q. 2009.  Two distantly spaced basic patches in the flexible domain of Huntingtin-Interacting Protein 1 (HIP1) are essential for the binding of clathrin light chain.  Research Letters in Biochemistry, doi:10.1155/2009/256124.

Niu, Q., and Ybe, J.A., 2008. Crystal structure at 2.8 Å of Huntingtin-interacting protein 1 (HIP1) coiled-coil domain reveals a charged surface suitable for HIP-protein interactor (HIPPI). J. Mol. Biol., 375, 1197-1205.

Ybe, J.A., Perez-Miller, S., Niu, Q., Coates, D.A., Drazer, M., and Clegg, M.E., 2007. Light chain C-terminal region reinforces the stability of clathrin heavy chain trimers. Traffic 8, 1101-1110.

Ybe, J.A., Mishra, S., Helms, S., and Nix, J., 2007. Crystal structure at 2.8 Å of the DLLRKN containing Coiled-coil Domain of Huntingtin-Interacting Protein 1 (HIP1) Reveals a Surface Suitable for Clathrin Light Chain Binding. J. Mol. Biol. 367, 8-15.

Ybe, J.A., Ruppel, N., Mishra, S., VanHaaften, E., 2003. Contribution of cysteines to clathrin trimerization domain stability and mapping of light chain binding. Traffic 4, 850-856.

Ybe, J.A., Wakeham, D.E., Brodsky, F.M., and Hwang, P.K. 2000. Molecular structures of proteins involved in vesicle fusion.Traffic 1, 474.

Wakeham, D.E., Ybe, J.A., Brodsky, F.M., and Hwang, P.K. 2000. Molecular structures of proteins involved in vesicle coat formation.Traffic 1, 393-398.

Ybe, J.A., Brodsky, F.M., Hofmann, K., Lin, K., Liu, S.H., Chen, L., Earnest, T.N., Fletterick, R.J., and Hwang, P.K. 1999. Clathrin self-assembly is mediated by a tandemly repeated superhelix.Nature 399, 371-375.

Ybe, J.A., Greene, B., Liu, S.H., Pley, U., Parham, P., and Brodsky, F.M. 1998. Clathrin self assembly is regulated by three light-chain residues controlling the formation of critical salt bridges.EMBO J. 17, 1297-1303.

Ybe, J.A. and Hecht, M.H. 1996. Sequence replacements in the central b-turn of plastocyanin.Protein Science 5, 814-824.