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Indiana University Bloomington

Adam ZlotnickAdam Zlotnick

Professor, Molecular and Cellular Biochemistry Department

Office: Simon Hall 220A

Phone: 812/856-1925

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Lab Website

Education

BA, Biology, University of Virginia
PhD, Biology, Purdue University

Research

Our broad goal is to examine the structure and assembly of protein oligomers, determining structures of products, reactants and intermediates, and correlating them with solution studies. A major focus of the lab is to understand the biophysics of virus capsid assembly. The capsid of a spherical of virus is assembled from multiples of 60 protein subunits, arranged with icosahedral symmetry. All projects in the lab involve multimeric viral proteins and enzymes.

Representative Publications

Zlotnick, A. and Fane, B. A. (2011) Mechanisms of Icosahedral Virus Assembly in Structural Virology. (eds. Mavis Agbandje-McKenna and Robert McKenna) Ch 10, 180-202 (Royal Society of Chemistry, London, 2011).

Zhou, K., Li, L., Tan, Z., Zlotnick, A. and Jacobson, S.C. (2011) Characterization of Hepatitis B Virus Capsids by Resistive-Pulse Sensing. JACS, e-published.

Zlotnick, A. and Mukhopadhyay, S. (2011) Assembly, Allostery, and Antivirals. Trends in Micro. 19, 14-23.

Katen, S. P., Chirapu, S. R., Finn, M.G., and Zlotnick, A. (2010) Stabilization of Hepatitis B Virus assembly intermediates by phenylpropenamides. ACS Chemical Biology 5, 1125-36.

Porterfield, J. Z. and Zlotnick, A. (2010) A Simple and General Method for Determining the Protein and Nucleic Acid Content of Viruses by UV Absorbance. Virology 407, 281-8.

Moisant, P., Neeman, H, and Zlotnick, A. (2010) The Pathways of (Virus) Assembly. Biophysical J. 99, 1350-7.

Porterfield, J. Z. and Zlotnick, A. (2010) An Overview of Capsid Assembly Kinetics in Emerging Topics in Physical Virology. Peter G. Stockley and Reidun Twarock, eds. Imperial College Press, London.

Porterfield, JZ, Dhasan, MS, Loeb, DD, Nassal, M, Stray, SJ, and Zlotnick, A (2010) Full-length HBV Core Protein Packages Viral and Heterologous RNA With Similar High Cooperativity. J. Virol. 84, 7174-84.

Burns, K., Mukherjee, S., Johnson, J. M., Zlotnick, A. (2010) Re-Landscaping the virus assembly energy surface to generate 17nm nanoparticles. Biomacromolecules 11, 439-42.

Packianathan, C., Katen, S.P., Dann, C.E. III, Zlotnick, A. (2010) A conformational mechanism for regulating assembly of Hepatitis B virus capsids suggest a role for allostery in virus assembly. J Virol 84, 1607-1615.
Cover illustration.

Mukherjee, S., Kler, S., Oppenheim, A., Zlotnick, A. (2010) Association of SV40 Vp1 pentamers on linear dsDNA incorporates both low and high cooperativity elements. Virology 397, 199-204.

Katen, S. P. and Zlotnick, A. (2009) Thermodynamics of Virus Capsid Assembly in Biothermodynamics, Methods in Enz. 455, 395-417.

Bourne, C.R., Katen, S.P., Fultz, M.R., Packianathan, C., Zlotnick, A. (2009) Participation of assembly-deficient subunits in the self-assembly of an icosahedral virus capsid. Biochemistry 48, 1736–1742.

Bourne, C. R., Lee, S., Venkataiah, B., Lee, A., Korba, B., Finn, M.G., Zlotnick, A. (2008) Small-Molecule Effectors of Hepatitis B Virus Capsid Assembly Give Insight Into Virus Lifecycle. J. Virol., in press.