Indiana University Bloomington

Neuroscience
Neuroscience
Joseph Farley

Joseph Farley

B.S., Bloomfield College, 1974
Ph.D., University of California at San Diego, 1978
Faculty Fellow, National Institutes of Health Faculty Fellow, National Institute for Neurological and Communicative Disorders and Stroke

Email address: farleyj(at)indiana.edu

Research Interests

Dr. Farley studies the cellular and molecular bases of behavioral and neural plasticity, particularly those which involve changes in the biophysical properties of excitable membranes. Using voltage- and patch-clamp recording techniques with native neuronal membranes and artificial bilayers, as well as site-directed mutagenesis studies of cloned ion channel subunits in heterologous expression systems (e.g., Xenopus oocytes), he studies the cellular and molecular bases of associative learning in invertebrates and cellular models of memory (e.g., LTP) in the mammalian brain. Changes in potassium and calcium ion channels, their contributions to cellular mechanisms of coincidence- and non-coincidence detection, and the molecular mechanisms underlying those changes, such as protein kinase C-, PKA, tyrosine kinase, and phosphatase-dependent (PP1, PP2B) changes in channel activities are of current interest.

Dr. Farley also studies the mechanisms of nicotine addiction: desensitization and upregulation of neuronal nicotinic acetylcholine receptors (nAChR), and Alzheimer's disease: mechanisms of beta-amyloid peptide modulation of voltage- (e.g., Kv1.1) and ligand-dependent (alpha-7 nAChR) ion channel activities.

Representative Publications

Jin, I., Huang, H., Smith, B., and Farley, J. (in press). Protein tyrosine kinase involvement in learning-produced changes in Hermissenda Type B photoreceptors.

Farley,J. and Smith, B. (in press). Non-coincidence learning in Hermissenda: Explicitly-unpaired conditioning produced changes in excitability of Type B photoreceptors.

Farley, J. (in press). Modulation of rat brain synaptosomal calcium-activated otassium channels by protein kinases A and C.

Hallahan, B. and Farley, J. (in press). Calcineurin involvement in the Ca2+ -mediated suppression of murine KV1.1 channels.

Farley, J., Jin, I., and Huang, H. (in press). Neural organization of locomotion in Hermissenda.

Jin, I., Huang, H., Kim., J., and Farley, J. (2004). Chemosensory conditioning in molluscsa I: Failure of chemosensory contextual conditioning with Hermissenda. Learning and Behavior, 32(3): 257-276.

Farley, J., Huang, H., Jin, I., and Kim, J. (2004). Chemosensory conditioning in molluscs II: A critical review. Learning and Behavior, 32(3): 277-288.

Huang, H. and Farley, J. (2001). PP1 inhibitors depolarize Hermissenda photoreceptors and reduce K+ currents. Journal of Neurophysiology, 86: 1297-1311.

Britton, G. and Farley, J. (1999). Behavioral and neural bases of non-coincidence learning in Hermissenda. Journal of Neuroscience 19: 9126-9132.

Farley, J. and Han, Y. (1997). Learning-correlated changes in a delayed K+ current in Hermissenda Type A photoreceptors. Journal of Neurophysiology, 77: 1861-1888.

Farley, J., Reasoner, H., and Janssen, M. (1997). Potentiation of phototactic suppression in Hermissenda by a chemosensory stimulus during compound conditioning. Behavioral Neuroscience, 111: 326-341.

Farley, J. and Jin, I. (1997). Potentiation of phototactic suppression in Hermissenda by compound conditioning results in potentiated excitability changes in type B and A photoreceptors. Behavioral Neuroscience, 111: 309-319.

Farley, J., and Schuman, E. (1991). Protein kinase C inhibitors prevent induction and continued expression of cellular memory in Hermissenda Type B photoreceptors. Proceedings of the National Academy of Sciences, USA, 88: 2016-2020.

Farley, J., and Rudy, B. (1988). Multiple types of voltage-dependent Ca2+- activated K+ channels of large conductance in rat brain synaptosomal membranes. Biophysical Journal, 53: 919-934.

Farley, J. (1987). Contingency-learning and causal detection in Hermissenda: II. Cellular Mechanisms. Behavioral Neuroscience, 101: 28-56.

Farley, J. (1987). In vitro associative conditioning of Hermissenda: cumulative depolarization of Type B photoreceptors and short-term associative behavioral changes. Journal of Neurophysiology, 57: 1639-1668.

Richards, W. and Farley, J. (1987). Motor correlates of phototaxis and associative learning in Hermissenda crassicornis. Brain Research Bulletin, 19: 1-15.

Farley, J. and Auerbach, S. (1986). Protein kinase C activation induces conductance changes in Hermissenda photoreceptors like those seen in associative learning. Nature, 319: 220-223.

Farley, J. and Alkon, D. L. (1985). Cellular mechanisms of learning, memory, and information storage. Annual Review of Psychology, 36: 419-494.

Alkon, D. L., Farley, J., Sakakibara, M., and Hay, B. (1984). Voltage-dependent calcium and calcium-activated potassium conductances of a molluscan photoreceptor. Biophysical Journal, 46: 605-614.

Farley, J., Richards, W., Ling, L., Liman, E., and Alkon, D. L (1983). Membrane changes in a single photoreceptor during acquisition cause associative learning in Hermissenda. Science, 221: 1201-1203.

Farley, J. and Alkon, D. (1982). Associative and behavioral change in Hermissenda: Consequences of nervous system orientation for light- and pairing-specificity. Journal of Neurophysiology, 48: 785-807.

Farley, J. and Alkon, D. (1980). Neural organization predicts specificity of a retained associative behavioral change. Science, 210: 1373-1375.