Indiana University Bloomington

Neuroscience
Neuroscience
Preston E. Garraghty

Preston E. Garraghty

B.A., University of North Carolina at Greensboro, 1974
M.Ed., University of North Carolina at Greensboro, 1976
M.A., University of North Carolina at Greensboro, 1978
Ph.D., University of North Carolina at Greensboro, 1983
Postdoctoral Fellow, Yale University School of Medicine
Postdoctoral Fellow/Associate, Massachusetts Institute of Technology

Email address: pgarragh(at)indiana.edu

Research Interests

Dr. Garraghty studies the capacity of the mature mammalian brain to undergo modifications in its functional organization when inputs are altered. The basic experimental paradigm involves manipulating the pattern of peripheral inputs in adult primate somatosensory system. The effects of such manipulations are then studied using anatomical, electrophysiological, neurochemical, and molecular biological techniques. Current projects include assessment of several neurotransmitter subunits and other molecules known to play roles in synaptic development and plasticity. We also study the involvement of gonadal hormones in the mature brain’s response to sensory loss.

Representative Publications

Myers, W.A., Churchill, J.D., Muja, N., and Garraghty, P.E. (2000). The role of NMDA receptors in adult primate cortical somatosensory plasticity. Journal of Comparative Neurology, 418: 373-382.

Churchill, J.D., Green, J.T., Voss, S.E., Manley, E., Steinmetz, J.E., and Garraghty, P.E. (2001). Discrimination reversal conditioning of an eyeblink response is impaired by NMDA receptor blockade. Integrative Physiological and Behavioral Science, 36: 62-74.

Churchill, J.D., Arnold, L.L., and Garraghty, P.E. (2001). Somatotopic reorganization in the brainstem and thalamus following peripheral nerve injury in adult primates. Brain Research, 910: 142-152.

Butt, A.E., Schultz, J.A., Arnold, L.L., Garman, E.E., George, C.L., and Garraghty, P.E. (2003). Lesions of the rat nucleus basalis magnocellularis disrupt appetitive-to-aversive transfer learning. Integrative Physiological and Behavioral Science, 38:253-271.

Garraghty, P.E. (2003). Discovery of long-term potentiation. In: Nadel, L. (ed.), Encyclopedia of Cognitive Science, 2: Nature Publishing Group, London, 961-965.

Garraghty, P.E. (2003). Mechanisms of synaptic plasticity. In: Nadel, L. (ed.), Encyclopedia of Cognitive Science, 1: Nature Publishing Group, London, 307-311.

Churchill, J.D., Tharp, J.A., Wellman, C.L., Sengelaub, D.R., and Garraghty, P.E. (2004). Morphological correlates of injury-induced reorganization in primate somatosensory cortex. BMC Neuroscience, 5:43.(http://www.biomedcentral.com/1471-2202/5/43).

Goodman, M.R., Garman, E.E., Arnold, L.L., Sengelaub, D.R., and Garraghty, P.E. (2004). The effects of estradiol on avoidance learning in ovariectomized adult rats. Integrative Physiological and Behavioral Science, 39:192-206.

McDowell, A.L., Samuelson, D.L., Dina, B.S., and Garraghty, P. E. (2005). Discrete and contextual cue alterations eliminate the instrumental appetitive-to-aversive transfer impairment in phenytoin-treated rats. Integrative Physiological and Behavioral Science, 39:307-317.

Samuelson, D.L., Arnold, L.L., Mowery, T.M., Mesnard, N.A., and Garraghty, P.E. (2005). The effects of phenytoin on the performance of rats in a delayed match-to-place task. Integrative Physiological and Behavioral Science, 40:17-27.

Garraghty, P.E., Arnold, L.L., Wellman, C.L., and Mowery, T.M. (2006). Receptor autoradiographic correlates of deafferentation-induced reorganization in adult primate somatosensory cortex. Journal of Comparative Neurology, 497:636-645.

Churchill, J.D., and Garraghty, P.E. (2006). The influence of post-nerve injury survival duration on receptive field size: location, location, location. Neuroscience Letters, 405:10-13.

Mowery, T.M., McDowell, A.L., and Garraghty, P.E. (2008). Chronic developmental exposure to phenytoin has long-term behavioral consequences. International Journal of Developmental Neuroscience, 26: 401-407.

Mowery, T.M., Elliott, K., and Garraghty, P.E. (2009). The cortical response to sensory deprivation in adult rats is affected by gonadectomy. Experimental Brain Research, 195: 27-33.

Mowery, T.M., and Garraghty, P.E. (2009). Nerve-injury induced changes to GluR1 and GluR2/3 sub-unit expression in the area 3b of adult squirrel monkeys. Frontiers in Systems Neuroscience, 3: 1-7.

Mowery, T.M., Sarin, R.M., and Garraghty, P.E. (2011). Nerve injury-induced changes in GABA A and GABA B sub-unit expression in area 3b and cuneate nucleus of adult squirrel monkeys: further evidence of developmental recapiulation. Brain Research, in press.