Indiana University Bloomington

Neuroscience
Neuroscience
William P. Hetrick

William P. Hetrick

B.A., Point Loma College, 1987
M.A., California State University, 1993
Ph.D., The Ohio State University 1999
Clinical Internship, Harvard Medical School/McLean Hospital, Belmont, MA

Email address: whetrick(at)indiana.edu

Research Interests

My research interests concern brain-behavior relationships in psychopathology. One pursuit is nested within the information processing model of schizophrenia and investigates the origins and correlates of perceptual and attentional anomalies in schizophrenia spectrum disorders. Most clinical descriptions of these anomalies emphasize the observation that schizophrenics have difficulty modulating sensory inputs and experience flooding, or inundation, by sensory stimuli. My laboratory, in collaboration with colleagues at the University of California, Irvine and Ohio State University, is examining the prevalence and course of perceptual and attentional deficits in clinical populations, relationships among a number of methods of assessing sensory gating (e.g., phenomenological, cognitive-behavioral, electroencephalographic, electromyographic), the reliability of these indices, and sex-differences in sensory gating. A second area of interest concerns with-in subject response variability. Substantial intra- and inter-individual heterogeneity not only of clinical symptoms but of a variety of physiological and psychological responses is consistently reported among people suffering from schizophrenia. A third domain of research interest is behavioral neuroendocrinology.

Representative Publications

Bunney Jr., W.E., Hetrick, W.P., Garland-Bunney, B., Patterson, J.V., Jin, Y., Potkin, S.G., and Sandman, C.A. (1999). A structured interview for assessing perceptual anomalies (SIAPA). Schizophrenia Bulletin, 25, 577-592.

Jin, Y., Bunney, Jr., W.E., Sandman, C.A., Patterson, J.V., Hetrick, W.P., and Potkin, S.G. (1998). Is P50 suppression a measure of sensory gating in schizophrenia? Biological Psychiatry, 43, 873-878.

Sandman, C.A., Thompson, T., Barrett, R.P., Verhoeven, W.M.A., McCubbin, J.A., and Hetrick, W.P. (1998). Opiate blockers. In: S. Reiss and M. G. Aman (Eds.), Psychotropic Medications and Developmental Disabilities: The International Consensus Handbook.Columbus, OH: Ohio State University Nisonger Center.

Sandman, C.A., Hetrick, W.P., Taylor, D.V., and Chicz-DeMet, A. (1998). Dissociation of POMC peptides after self-injury predicts responses to centrally acting opiate blockers. American Journal on Mental Retardation, 102, 182-199.

Jin, Y., Potkin, S.G., Patterson, J.V., Sandman, C.A., Hetrick, W.P., and Bunney Jr., W.E.. (1997). Effects of P50 temporal variability on sensory gating in schizophrenia. Psychiatry Research, 70, 71-81.