Indiana University Bloomington

Dale R. Sengelaub

Dale R. Sengelaub

B.A., State University of New York at Stony Brook, 1978
Ph.D., Cornell University, 1983
Postdoctoral Fellow, University of California at Los Angeles

Email address: sengelau(at)

Research Interests

(see also

Dr. Sengelaub studies the processes that regulate the structure and organization of both the developing and adult nervous system. Using a variety of species, neural systems, anatomical, and electrophysiological techniques, he addresses the factors which regulate neuron number, distribution, morphology, and connectivity in the brain and spinal cord. Processes such as dendritic growth and retraction, and the maintenance of adult neuron morphology after nerve injury or spinal damage are of primary interest. Current projects include ontogeny and hormonal control of sex differences in spinal nuclei, functional and morphological plasticity in hormonally sensitive neuromuscular systems, and examination of the neuroprotective/therapeutic effects of hormones.

Representative Publications

Huguenard, A.L., Fernando, S.M., Monks, D.A., Sengelaub, D.R. (2011). Overexpression of androgen receptors in target musculature confers androgen sensitivity to motoneuron dendrites. Endocrinology, 152(2), 639-650.

Verhovshek, T., Sengelaub, D.R. (2010). Trophic effects of BDNF blockade in an androgen-sensitive neuromuscular system. Endocrinology, 51 (11), 5337-5348.

Lenz, K.M., Sengelaub, D.R. (2010). Maternal care effects on the development of a sexually dimorphic neuromuscular system: The role of spinal oxytocin. Hormones and Behavior, 58, 575-581.

Verhovshek, T., Cai, Y., Osborne, M.C., Sengelaub, D.R. (2010). Androgen regulates brain-derived neurotrophic factor in spinal motoneurons and their target musculature. Endocrinology, 151, 253-261.

Verhovshek, T., Buckley, K.E., Sergent, M.A., Sengelaub, D.R. (2010). Testosterone metabolites differentially maintain adult morphology in a sexually dimorphic neuromuscular system. Developmental Neurobiology, 70, 206-221.

Little, C.M., Coons, K.D., Sengelaub, D.R. (2009). Neuroprotective effects of testosterone on the morphology and function of somatic motoneurons following the death of neighboring motoneurons. The Journal of Comparative Neurology, 512, 359-372.

Fargo, K.N., Foecking, E.M., Jones, K.J., Sengelaub, D.R. (2009). Neuroprotective actions of androgens on motoneurons. Frontiers in Neuroendocrinology, 30, 130-141.

Lenz, K.M., Sengelaub, D.R. (2009). Maternal care effects on SNB motoneuron development: The mediating role of sensory afferent distribution and activity. Developmental Neurobiology, 69, 603-615.

Fargo, K.N., Foster, A.M., Sengelaub, D.R. (2009). Neuroprotective effect of testosterone treatment on motoneuron recruitment following the death of nearby motoneurons. Developmental Neurobiology, 69, 825-835.

Wilson, R.E., Coons, K.D., Sengelaub, D.R. (2009). Neuroprotective effects of testosterone on dendritic morphology following partial motoneuron depletion: Efficacy in female rats. Neuroscience Letters, 465, 123-127.

Lenz, K.M., Graham, M.D., Parada, M., Fleming, A.S., Sengelaub, D.R., Monks, D.A. (2008). Tactile stimulation during artificial rearing influences adult function and morphology in a sexually dimorphic neuromuscular system. Developmental Neurobiology, 68, 542-557.

Sengelaub, D.R., Forger, N.G. (2008). The spinal nucleus of the bulbocavernosus: Firsts in androgen-dependent neural sex differences. Hormones and Behavior, 53, 596-612.

Martin-Alguacil, N., Schober, J., Sengelaub, D.R., Pfaff, D., Shelley, D.N. (2008). Clitoral sexual arousal: Neuronal tracing study from the clitoris through the spinal tracts. The Journal of Urology, 180, 1241-1248.

Fargo, K.N., Iwema, C.L., Clark-Phelps, M.C., Sengelaub, D.R. (2007). Exogenous testosterone reverses age-related atrophy in a spinal neuromuscular system. Hormones and Behavior, 51, 20-30.

Osborne, M.C., Verhovshek, T., Sengelaub, D.R. (2007). Androgen regulates trkB expression in spinal motoneurons. Journal of Neuroscience Research, 85, 303-309.

Fargo, K.N., Sengelaub, D.R. (2007). Androgenic, but not estrogenic, protection of motoneurons from somal and dendritic atrophy induced by the death of neighboring motoneurons. Developmental Neurobiology, 67, 1094-1106.

Nowacek, A.S., Sengelaub, D.R. (2006). Estrogenic support of motoneuron dendritic growth via the neuromuscular periphery in a sexually dimorphic motor system. Journal of Neurobiology, 66, 962-976.

Lenz, K.M., Sengelaub, D.R. (2006). Maternal licking influences dendritic development of motoneurons in a sexually dimorphic neuromuscular system. Brain Research, 1092, 87-99.