A.B., Villanova University, 1971
M.A., University of Colorado, 1974
Ph.D., University of Colorado, 1975
Postdoctoral Fellow, University of California at San Diego
Research in my laboratory centers on the neurochemical correlates of behavior. We are especially interested in the neurochemistry of the basal ganglia and related limbic nuclei, which have been implicated in drug abuse as well as basic behavioral processes such as movement and motivation. To assess how these brain systems operate under naturally occurring conditions, we use electrophysiological (single-unit recording and iontophoresis) and neurochemical (microdialysis and voltammetry) techniques to measure neurotransmitter function at the neuronal level during behavior. Our primary focus is the role of dopamine in modulating afferent information, especially glutamate-mediated excitations arising from cerebrocortical neurons. Current projects are aimed at identifying: 1) the neuronal processing in pre-limbic and infra-limbic areas of prefrontal cortex during cocaine-seeking behavior and relapse; 2) the receptor mechanisms by which dopamine interacts with glutamate and other transmitters to modulate information flow through neuronal circuits; 3) the role of dopaminergic neurons in goal-directed behavior; 4) how modulation of glutamate transmission by ascorbate, a water-soluble vitamin, influences movement and neuronal activity; and 5) neuroadaptations and neurodysfunction in Huntington's and Parkinson's diseases.
Wood, D.A. and Rebec, G.V. (2004). Dissociation of core and shell single-unit activity in the nucleus accumbens in free-choice novelty. Behavioural Brain Research, 152: 59-66.
Sun, W.L. and Rebec, G.V. (2005). The role of prefrontal cortex D1-lik,e and D2-like receptors in cocaine-seeking behavior in rats. Psychopharmacology, 177: 315-323.
Rebec, G.V., Witowski, S.R., Sandstrom, M.I., Rostand, R.D., and Kennedy, R.T. (2005). Extracellular ascorbate modulates cortically evoked glutamate dynamics in rat striatum. Neuroscience Letters, 378: 166-170.
Wood, D.A., Buse, J.E., Wellman, C.L., and Rebec, G. V. (2005). Differential environmental exposure alters NMDA but not AMPA receptor subunit expression in nucleus accumbens core and shell. Brain Research, 1042: 176-183.
Sun, W.L., Akins, C.K., Mattingly, A.E., and Rebec, G.V. (2005). Ionotropic glutamate receptors in the ventral tegmental area regulate cocaine-seeking behavior in rats. Neuropsychopharmacology,30: 2073-2081.
Ball, K.T. and Rebec, G. V. (2005). Role of 5-HT2A AND 5-HT2C/B receptors in the acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on striatal single-unit activity and locomotion in freely moving rats. Psychopharmacology (Berl), 181:676-687.
Rebec, G.V. and Sun, W.L. (2005). Neuronal substrates of relapse to cocaine-seeking behavior: role of prefrontal cortex. Journal of the Experimental Analysis of Behavior, 84(3): 653-666.
Rebec, G.V., Conroy, S.K., Barton, S.J. (2006). Hyperactive striatal neurons in symptomatic Huntington R6/2 mice: Variations with behavioral state and repeated ascorbate treatment. Neuroscience, 137: 327-336.
Cortright, J.J. and Rebec, G.V. (2006). Ascorbate modulation of sensorimotor processing in striatum of freely moving rats. Brain Research, 1092(1): 108-116.
Wood, D.A., Siegel, A.K., and Rebec, G.V. (2006). Environmental enrichment reduces impulsivity during appetitive conditioning. Physiology and Behavior, 88(1-2): 132-137.
Kosobud, A.E.K., Kebabian, C.E., and Rebec, G.V. (2006). Nitrous oxide acutely suppresses ethanol consumption in HAD and P rats. International Journal of Neuroscience, 116: 835-845.
Ball, K.T., Budreau, D., and Rebec, G.V. (2006). Context-dependent behavioral and neuronal sensitization in striatum to MDMA (ecstasy) administration in rats. European Journal of Neuroscience, 24: 217-228.
Sun, W.L. and Rebec, G.V. (2006). Repeated cocaine self-administration alters processing of cocaine-related information in rat prefrontal cortex. Journal of Neuroscience, 26: 8004-8008.
Rebec, G.V. (2006). Behavioral electrophysiology of psychostimulants. Neuropsychopharmacology, July 19 [Epub ahead of print].
Rebec, G.V. (in press). From interferant anion to neuromodulator: ascorbate oxidizes its way to respectability. In: Electrochemical Methods in Neuroscience, Taylor & Francis Group, CRC Press, Boca Raton, FL.
Garris, P.A., Greco, P.G., Sandberg, S.G., Howes, G., Pongmaytegul, S., Heidenreich, B.A., Casto, J.M., Ensman, R., Poehlman, J., Alexander, A., and Rebec, G.V. (in press). In vivo voltammetry with telemetry. In: Electrochemical Methods in Neuroscience, Taylor & Francis Group, CRC Press, Boca Raton, FL.
Last updated:
October 3, 2006
URL:
http://www.indiana.edu/~neurosci/rebec.html
Comments:
iuneuron@indiana.edu
Copyright
1995, The Trustees of
Indiana University