web contact: pietsch@indiana.edu
Persons with injuries to the brain including, of course, the corpus callosum, sometimes report that one of their limbs, typically an arm, acts as though it belongs to somebody else. Here are the abstracts of 15 recent articles on the subject from the 1994-1996 literature.
TI: Trois enseignements de la premiere allogreffe des deux mains.
[In Process Citation]
AU: Dubernard,-J-M; Burloux,-G; Giraux,-P; Bachman,-D; Petruzzo,-P; Kanitakis,-J
AD: Service d'Urologie et de Chirurgie de la Transplantation-Hopital Edouard Herriot-Pavillon V, Place d'Arsonval-69473 Lyon.
SO: Bull-Acad-Natl-Med. 2002; 186(6): 1051-62; discussion 1062-5
JN: Bulletin-de-l'Academie-nationale-de-medecine
IS: 0001-4079
PY: 2002
LA: French; Non-English
CP: France
AB: The first double hand transplantation was performed in Lyon in a 33 year-old recipient with bilateral amputation following an explosive handling accident. At 2 years, the global and the functional results were considered as very satisfactory. Three aspects are presented in this article: (1) immunosuppressive protocol was efficient and well tolerated. Only 2 skin rejection episodes on post operative days 53 and 82 were easily reversed with an increase in Prednisone doses and local applications of steroid cream; (2) successive functional magnetic resonance imaging demonstrated a global remodelling of the limb cortical map and a reversal of the functional reorganisation induced by amputation; (3) the psychological appropriation of "alien" hands improved with time. These grafts, permanently visible by the patient and others, induced a psychic defence mechanism: "denial", a lack of perception of some features of reality or a perception of reality that is immediately neglected or rejected. Denial tended to lessen as the new grafted hands gained in sensitivity and motricity.
PT: Journal-Article
SB: Index-Medicus
UD: 20030217
DA: 20030217
RO: National-Library-of-Medicine
AN: 12587343
XREC: IN-PROCESS (IP); ABSTRACT (AB)
Record 2 of 36 in PreMedline on SilverPlatter March Week 1 2003/03
TI: Bayesian analysis of population PK/PD models: general concepts and software.
AU: Lunn,-D-J; Best,-N; Thomas,-A; Wakefield,-J; Spiegelhalter,-D
AD: Department of Epidemiology and Public Health, Imperial College School of Medicine, Norfolk Place, London W2 1PG, UK.
SO: J-Pharmacokinet-Pharmacodyn. 2002 Jun; 29(3): 271-307
JN: Journal-of-pharmacokinetics-and-pharmacodynamics
IS: 1567-567X
PY: 2002
LA: English
CP: England
AB: Markov chain Monte Carlo (MCMC) techniques have revolutionized the field of Bayesian statistics by enabling posterior inference for arbitrarily complex models. The now widely used WinBUGS software has, over the years, made the methodology accessible to a great many applied scientists, in all fields of research. Despite this, serious application of MCMC methods within the field of population PK/PD has been comparatively limited. We appreciate that for many applied pharmacokineticists the prospect of conducting a Bayesian analysis will require numerous alien concepts to be taken on board and it may be difficult to justify investing the time and effort required in order to understand them (especially since the approach is so computer-intensive). For this reason we provide here a thorough (but often informal) discussion of all aspects of Bayesian inference as they apply specifically to population PK/PD. We also acknowledge that while the WinBUGS software is general purpose, model specification for some types of problem, population PK/PD being a prime example, can be very difficult, to the extent that a specialized interface for describing the problem at hand is often a practical necessity. In the latter part of this paper we describe such an interface, namely PKBugs. A principal aim of the paper is to offer sufficient technical background, in an easy to follow format, that the reader may develop both the confidence and know-how to make appropriate use of the PKBugs/WinBUGS framework (or similar software) for their own data analysis needs, should they choose to adopt a Bayesian approach.
PT: Journal-Article
SB: Index-Medicus
UD: 20021125
DA: 20021125
RO: National-Library-of-Medicine
AN: 12449499
XREC: IN-PROCESS (IP); ABSTRACT (AB)
FTXT: Kluwer Academic Publishers http://kapis.www.wkap.nl/oasis.htm/379552 , EBSCO Online http://ejournals.ebsco.com/direct.asp?ArticleID=R3J7H10X60BK1EEGDK9U , Kluwer Journals@Ovid http://gateway.ovid.com/ovidweb.cgi?T=JS&PAGE=fulltext&D=kap&NEWS=n∓DBC=n&AN=379552 , SwetsWise http://www.SwetsWise.com/link/access_db?issn=1567-567X&vol=29&iss=3&age=271&FT=1
Record 3 of 36 in PreMedline on SilverPlatter March Week 1 2003/03
TI: Posterior-variant alien hand syndrome: clinical features and response to rehabilitation.
AU: Pack,-B-C; Stewart,-K-J; Diamond,-P-T; Gale,-S-D
AD: Physical Medicine & Rehabilitation Department, University of Virginia, School of Medicine, Virginia, USA.
SO: Disabil-Rehabil. 2002 Oct 15; 24(15): 817-8
JN: Disability-and-rehabilitation
IS: 0963-8288
PY: 2002
LA: English
CP: England
AB: PURPOSE: This case highlights the clinical features and course of recovery of a patient presenting to the rehabilitation service with posterior-variant alien hand syndrome (AHS) following thalamic stroke. METHODS: Single case report. RESULTS: Clinical signs and symptoms included mild hemiparesis, dyspraxia, dysmetria, primary sensory loss and hemispatial neglect. Autonomous movements and personification of the affected extremity which were ego-syntonic in nature were characteristic of posterior-variant AHS. The associated neurological impairments resolved early during the course of rehabilitation and the patient made excellent functional gains. CONCLUSION: This case highlights the distinguishing features differentiating posterior-variant AHS from more classical AHS and underscores the excellent prognosis of this variant.
PT: Journal-Article
SB: Index-Medicus
UD: 20021119
DA: 20021119
RO: National-Library-of-Medicine
AN: 12437869
XREC: IN-PROCESS (IP); ABSTRACT (AB)
FTXT: Catchword http://www.catchword.com/cgi-bin/cgi?body=linker&ini=silver&reqidx=0963-288()24:15L.817 , InformationQuest http://www.eiq.com/usr_login.html?sici=0963-8288%28000000%2924%3A15%3C817%3AX%3E.0.CO%3B2-X , SwetsWise http://www.SwetsWise.com/link/access_db?issn=0963-8288&vol=24&iss=15&page=817&FT=1
Record 4 of 36 in PreMedline on SilverPlatter March Week 1 2003/03
TI: Posterior alien hand syndrome: case report.
AU: Rohde,-S; Weidauer,-S; Lanfermann,-H; Zanella,-F
AD: Institute of Neuroradiology, Johann Wolfgang Goethe University, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany, Stefan.Rohde@kgu.de
SO: Neuroradiology. 2002 Nov; 44(11): 921-3
JN: Neuroradiology-
IS: 0028-3940
PY: 2002
LA: English
CP: Germany
AB: The alien hand syndrome (AHS) is involuntary uncontrolled movement of an arm with a sense of estrangement from the limb itself. AHS was initially used to describe interhemispheric disconnection phenomena in patients with lesions in the anterior corpus callosum, but it has been found in patients with posterior cerebral lesions without involvement of the corpus callosum, for example parietal infarcts or corticobasal degeneration. The posterior alien hand syndrome is less frequent and presents with nonpurposive behaviour like lifting the arm or writhing fingers. We report an 80-year-old woman with a posterior AHS of the dominant right hand. MRI showed atrophy of the pre- and postcentral gyri without involvement of the corpus callosum. We discuss the aetiology of the posterior AHS and the differences from the anterior varieties.
PT: Journal-Article
SB: Index-Medicus
UD: 20021112
DA: 20021112
RO: National-Library-of-Medicine
AN: 12428127
XREC: IN-PROCESS (IP); ABSTRACT (AB)
FTXT: Springer-Verlag LINK (European Mirror) http://link.springer.de/cgi/linkref?issn=0028-3940&year=2002&volume=44≈page=921 , Springer-Verlag LINK (US Mirror) http://link.springer-ny.com/cgi/linkref?issn=0028-3940&year=2002&volume=4&page=921 , InformationQuest http://www.eiq.com/usr_login.html?sici=0028-3940%28000000%2944%3A11%3C921%3AX%3E.0.CO%3B2-X
Record 5 of 36 in PreMedline on SilverPlatter March Week 1 2003/03
TI: The alien hand and migraine with aura: a case report.
AU: Raieli,-V; Eliseo,-G-L; Monforte,-E-M; Puma,-D; Ragusa,-D; Eliseo,-M
AD: Child Headache Centre, Division of Child Neuropsychiatry, GF Ingrassia Hospital, Palermo, Italy. vinzi.raielk@inwind.it
SO: Cephalalgia. 2002 Oct; 22(8): 692-4
JN: Cephalalgia-an-international-journal-of-headache
IS: 0333-1024
PY: 2002
LA: English
CP: England
PT: Journal-Article
SB: Index-Medicus
UD: 20021017
DA: 20021017
RO: National-Library-of-Medicine
AN: 12383067
XREC: IN-PROCESS (IP)
FTXT: EBSCO Online http://ejournals.ebsco.com/direct.asp?ArticleID=KFCTJMW9BN9X8WE430F7 , Journals@OVID http://gateway.ovid.com/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&NEWS=namp;DBC=n&AN=00002881-200210000-00010 , Blackwell-Synergy http://www.blackwell-synergy.com/rd.asp?code=CHA&vol=22&page=692&got=abstract , SwetsWise http://www.SwetsWise.com/link/access_db?issn=0333-1024&vol=22&iss=8&age=692&FT=1
Record 6 of 36 in SilverPlatter MEDLINE(R) 2001-2003/01
TI: Isolated corpus callosal infarction secondary to pericallosal artery disease presenting as alien hand syndrome.
AU: Suwanwela,-N-C; Leelacheavasit,-N
AD: Neurological Unit, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. fmednsu@md2.chula.ac.th
SO: J-Neurol-Neurosurg-Psychiatry. 2002 Apr; 72(4): 533-6
JN: Journal-of-neurology,-neurosurgery,-and-psychiatry
IS: 0022-3050
PY: 2002
LA: English
CP: England
AB: Two patients are described with the callosal type of alien hand syndrome. Both presented with abnormal feelings in the left upper limb and intermanual conflict without clinical evidence of callosal apraxia or frontal lobe dysfunction such as motor deficit or reflexive grasping. Imaging studies disclosed subacute infarction in the body and splenium of the corpus callosum due to pericallosal artery disease. These patients were unique in their presentation as a callosal type of alien hand syndrome secondary to ischaemic stroke.
MJME: *Brain-Ischemia-complications; *Cerebral-Arterial-Diseases-complications; *Cerebral-Infarction-etiology; *Corpus-Callosum-blood-supply; *Dyskinesias-etiology; *Hand-
MIME: Brain-Ischemia-psychology; Cerebral-Angiography; Cerebral-Infarction-complications; Cerebral-Infarction-psychology; Corpus-Callosum-pathology; Dyskinesias-physiopathology; Magnetic-Resonance-Imaging; Middle-Age; Perception-; Syndrome-
AGE: Middle-Age
TG: Case-Report; Female; Human; Male
PT: Journal-Article
SH: complications; psychology; etiology; blood-supply; pathology; physiopathology
JC: Neurology; Psychiatry; Neurosurgery
SB: Index-Medicus
UD: 20020501
DA: 20020322
CD: 20020501
RO: National-Library-of-Medicine
AN: 11909919
XREC: ABSTRACT (AB)
FTXT: EBSCO Online http://ejournals.ebsco.com/direct.asp?ArticleID=4A8VPV4WA19WAX7LWGAV , Journals@OVID http://gateway.ovid.com/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&NEWS=namp;DBC=n&AN=00005069-200204000-00027 , HighWire http://jnnp.bmjjournals.com/cgi/content/full/72/4/533 , SwetsWise http://www.SwetsWise.com/link/access_db?issn=0022-3050&vol=72&iss=4&age=533&FT=1
Record 7 of 36 in SilverPlatter MEDLINE(R) 2001-2003/01
TI: Abnormal diffusion-weighted magnetic resonance imaging in Creutzfeldt-Jakob disease following corneal transplantations.
AU: Rabinstein,-A-A; Whiteman,-M-L; Shebert,-R-T
AD: University of Miami School of Medicine D4-5, PO Box 016960, Miami, FL 33101, USA. alerabas@yahoo.com
SO: Arch-Neurol. 2002 Apr; 59(4): 637-9
JN: Archives-of-neurology
IS: 0003-9942
PY: 2002
LA: English
CP: United-States
AB: BACKGROUND: The value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic cases of Creutzfeldt-Jakob disease has been questioned. OBJECTIVE: To illustrate the value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic Creutzfeldt-Jakob disease. METHODS: Case report. RESULTS: A patient with a history of 3 corneal transplantations exhibited the alien hand sign on initial examination. Diffusion-weighted magnetic resonance imaging of the brain revealed prominent cortical diffusion abnormalities. During the following months, the patient developed rapidly progressive dementia. The diagnosis of Creutzfeldt-Jakob disease was proven by brain biopsy. CONCLUSION: Brain magnetic resonance imaging, particularly diffusion-weighted magnetic resonance imaging, can be very helpful in the diagnosis of Creutzfeldt-Jakob disease, even in suspected iatrogenic cases.
MJME: *Brain-pathology; *Corneal-Transplantation; *Creutzfeldt-Jakob-Syndrome-diagnosis; *Magnetic-Resonance-Imaging-methods
MIME: Creutzfeldt-Jakob-Syndrome-pathology; Middle-Age; Predictive-Value-of-Tests
AGE: Middle-Age
TG: Case-Report; Human; Male
PT: Journal-Article
SH: pathology; diagnosis; methods
SB: Abridged-Index-Medicus; Index-Medicus
UD: 20020419
DA: 20020409
CD: 20020419
RO: National-Library-of-Medicine
AN: 11939901
XREC: ABSTRACT (AB)
FTXT: Journals@OVID http://gateway.ovid.com/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&NEWS=namp;DBC=n&AN=00000816-200204000-00019
Record 8 of 36 in SilverPlatter MEDLINE(R) 2001-2003/01
TI: Der Begriff der Person in der Psychiatrie.
[Concept of the person in psychiatry]
AU: Fuchs,-T
AD: Psychiatrische Klinik, Universitat Heidelberg.
SO: Nervenarzt. 2002 Mar; 73(3): 239-46
JN: Nervenarzt,-Der
IS: 0028-2804
PY: 2002
LA: German; Non-English
CP: Germany
AB: At first sight, the concept of "person" appears in psychiatric terminology only in the negative sense, i.e., as in depersonalization. However, self-alienation may be regarded as the hallmark of mental illness in general and is based on the ambiguous structure of human personality itself. Thorough analysis of the concept of the person is therefore indispensable to understanding psychopathology. This paper focuses on the contrast of "persona" ("mask" or "role") on the one hand to "person" as an individual self on the other. Their dialectical relation derives from basic anthropological structures such as sociality, self-reference, self-transcendence, and fictionality. As can be shown, the historical and cultural ontogeny of the personality includes experiences of self-alienation which may become relevant for psychiatry as depersonalization syndromes. The example of depression is used to illustrate vital and emotional depersonalization, whereas schizophrenia may be described as "intentional depersonalization." Following this line of reasoning, the classic schizophrenic experiences of alien control or thought insertion are interpreted as a disturbance in the fundamental personality structures.
CM: Comment In: Nervenarzt. 2002 Mar;73(3):203-4
MJME: *Defense-Mechanisms; *Depersonalization-diagnosis; *Individuality-; *Personality-Development
MIME: Depersonalization-psychology; Schizophrenia-diagnosis; Schizophrenic-Psychology
TG: English-Abstract; Human
PT: Journal-Article; Review; Review,-Tutorial
SH: diagnosis; psychology
RF: 45 refs.
SB: Index-Medicus
UD: 20020625
DA: 20020419
CD: 20020625
RO: National-Library-of-Medicine
AN: 11963259
XREC: ABSTRACT (AB); COMMENTS (CM)
FTXT: EBSCO Online http://ejournals.ebsco.com/direct.asp?ArticleID=JKRNL3FA179VDKUXAQR4 , Springer-Verlag LINK (European Mirror) http://link.springer.de/cgi/linkref?issn=0028-2804&year=2002&volume=73≈page=239 , Springer-Verlag LINK (US Mirror) http://link.springer-ny.com/cgi/linkref?issn=0028-2804&year=2002&volume=3&page=239 , InformationQuest http://www.eiq.com/usr_login.html?sici=0028-2804%28000000%2973%3A3%3C239%3AX%3E20.CO%3B2-X
Record 9 of 36 in SilverPlatter MEDLINE(R) 2001-2003/01
TI: Familial Creutzfeldt-Jakob disease initially presenting with alien hand syndrome.
AU: Oberndorfer,-S; Urbanits,-S; Lahrmann,-H; Jarius,-C; Albrecht,-G; Grisold,-W
SO: J-Neurol. 2002 May; 249(5): 631-2
JN: Journal-of-neurology
IS: 0340-5354
PY: 2002
LA: English
CP: Germany
MJME: *Brain-physiopathology; *Creutzfeldt-Jakob-Syndrome-complications; *Creutzfeldt-Jakob-Syndrome-physiopathology; *Hand-innervation; *Hand-physiopathology; *Laterality-physiology; *Movement-Disorders-etiology; *Movement-Disorders-physiopathology
MIME: Aged-; Brain-metabolism; Brain-pathology; Creutzfeldt-Jakob-Syndrome-pathology; Magnetic-Resonance-Imaging; Movement-Disorders-pathology; Point-Mutation-genetics; Prions-genetics; Prions-metabolism; Tyrosine-3-Monooxygenase-cerebrospinal-fluid; tau-Proteins-cerebrospinal-fluid
AGE: Aged
TG: Case-Report; Female; Human
PT: Letter
SH: metabolism; pathology; physiopathology; complications; innervation; physiology; etiology; genetics; cerebrospinal-fluid
CAS: 0; 0; 0
EC: EC 1.14.16.2
PN: 14-3-3-protein; Prions; tau-Proteins
EN: Tyrosine-3-Monooxygenase
SB: Index-Medicus
UD: 20020809
DA: 20020521
CD: 20020809
RO: National-Library-of-Medicine
AN: 12021958
FTXT: Springer-Verlag LINK (European Mirror) http://link.springer.de/cgi/linkref?issn=0340-5354&year=2002&volume=249∓page=631 , Springer-Verlag LINK (US Mirror) http://link.springer-ny.com/cgi/linkref?issn=0340-5354&year=2002&volume=49&page=631 , EBSCO Online http://ejournals.ebsco.com/direct.asp?ArticleID=PDQXYCKYDTKEPA4Y6RN5 , InformationQuest http://www.eiq.com/usr_login.html?sici=0340-5354%28000000%29249%3A5%3C631%3AX%3E.0.CO%3B2-X
Record 10 of 36 in SilverPlatter MEDLINE(R) 2001-2003/01
TI: Posterior alien hand syndrome after a right thalamic infarct.
AU: Marey-Lopez,-J; Rubio-Nazabal,-E; Alonso-Magdalena,-L; Lopez-Facal,-S
AD: Department of Neurology, Hospital Juan Canalejo, La Coruna, Spain. jmareyl@telefonica.net
SO: J-Neurol-Neurosurg-Psychiatry. 2002 Oct; 73(4): 447-9
JN: Journal-of-neurology,-neurosurgery,-and-psychiatry
IS: 0022-3050
PY: 2002
LA: English
CP: England
AB: The alien hand syndrome, as originally defined, should be reserved for cases in which the hand feels foreign "together with" observable involuntary motor activity. These involuntary movements are unusual during or after acute stroke. Three varieties of alien hand syndrome have been reported, involving lesions of the corpus callosum alone, the corpus callosum plus dominant medial frontal cortex, and posterior cortical and subcortical areas. A patient with posterior alien hand syndrome of vascular aetiology is reported. Imaging studies disclosed an isolated infarction of the right thalamus sparing other cerebral regions.
MJME: *Agnosia-diagnosis; *Agnosia-etiology; *Cerebral-Infarction-complications; *Cerebral-Infarction-pathology; *Hand-physiopathology; *Laterality-; *Thalamus-blood-supply; *Thalamus-pathology
MIME: Agnosia-physiopathology; Magnetic-Resonance-Imaging; Middle-Age; Severity-of-Illness-Index; Syndrome-
AGE: Middle-Age
TG: Case-Report; Female; Human
PT: Journal-Article
SH: diagnosis; etiology; physiopathology; complications; pathology; blood-supply
JC: Neurology; Psychiatry; Neurosurgery
SB: Index-Medicus
UD: 20021023
DA: 20020917
CD: 20021023
RO: National-Library-of-Medicine
AN: 12235318
XREC: ABSTRACT (AB)
FTXT: EBSCO Online http://ejournals.ebsco.com/direct.asp?ArticleID=1LJHRVWL3MQG4UUR8L47 , Journals@OVID http://gateway.ovid.com/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&NEWS=namp;DBC=n&AN=00005069-200210000-00023 , HighWire http://jnnp.bmjjournals.com/cgi/content/full/73/4/447 , SwetsWise http://www.SwetsWise.com/link/access_db?issn=0022-3050&vol=73&iss=4&age=447&FT=1
Record 11 of 36 in SilverPlatter MEDLINE(R) 2001-2003/01
TI: Examination of motor output pathways in patients with corticobasal ganglionic degeneration using transcranial magnetic stimulation.
AU: Valls-Sole,-J; Tolosa,-E; Marti,-M-J; Valldeoriola,-F; Revilla,-M; Pastor,-P; Blesa,-R
AD: Unitat d'EMG, Neurology Service, Hospital Clinic, Universitat de Barcelona, Villarroel, 170 Barcelona 08036, Spain. jvalls@clinic.ub.es
SO: Brain. 2001 Jun; 124(Pt 6): 1131-7
JN: Brain-a-journal-of-neurology
IS: 0006-8950
PY: 2001
LA: English
CP: England
AB: The alien hand sign (AHS) is often encountered in patients with corticobasal ganglionic degeneration (CBGD), revealing a unilateral dysfunction of the motor system of unknown pathophysiology. We examined the possibility of an abnormal cortical representation of hand muscles in 10 patients with probable CBGD and a prominent AHS. Cortical maps were obtained from the responses to magnetic stimuli applied with a figure of eight coil at an intensity of 110% above motor threshold. For comparison, the same study was carried out in 10 normal volunteers, eight patients with Parkinson's disease and eight patients with Alzheimer's disease. AHS patients had a larger extension of the cortical map to stimulation of the hemisphere contralateral to the AHS in comparison with the ipsilateral hemisphere. Furthermore, in six patients, focal stimulation of the hemisphere ipsilateral to the AHS gave rise to ipsilateral responses, delayed by a mean of 7.7 +/- 2.2 ms with respect to those recorded in the same muscle to contralateral stimulation. None of the other patients or control subjects had ipsilateral responses. Our results indicate an enhanced excitability, or reduced inhibition, of the motor area of the hemisphere contralateral to the AHS. The delay of the ipsilateral responses is compatible with a disinhibited transcallosal input.
MJME: *Efferent-Pathways-physiopathology; *Hand-physiopathology; *Motor-Cortex-physiopathology; *Neurodegenerative-Diseases-physiopathology
MIME: Aged-; Brain-Mapping; Dyskinesias-; Efferent-Pathways-pathology; Electric-Stimulation; Evoked-Potentials,-Motor-physiology; Hand-innervation; Laterality-physiology; Magnetics-; Middle-Age; Motor-Cortex-pathology; Neural-Inhibition-physiology; Neurodegenerative-Diseases-pathology
AGE: Aged; Middle-Age
TG: Human
PT: Journal-Article
SH: pathology; physiopathology; physiology; innervation
SB: Abridged-Index-Medicus; Index-Medicus
UD: 20010705
DA: 20010516
CD: 20010705
RO: National-Library-of-Medicine
AN: 11353729
XREC: ABSTRACT (AB)
FTXT: HighWire http://brain.oupjournals.org/cgi/content/full/124/P6/1131 , SwetsWise http://www.SwetsWise.com/link/access_db?issn=0006-8950&vol=124&iss=P6&am;page=1131&FT=1
Record 12 of 36 in SilverPlatter MEDLINE(R) 2001-2003/01
TI: Sindrome de la mano alienigena en la enfermedad de Creutzfeldt-Jakob.
[Alien hand syndrome in Creutzfeldt-Jakob disease]
AU: Colomer-Rubio,-E; Sanchez-Roy,-R; Pareja-Martinez,-A; Perla,-C; Villarroya,-T; Cerda-Nicolas,-M; Carbonell,-C
AD: Servicio de Medicina Interna. Hospital Arnau de Vilanova. Valencia.
SO: Neurologia. 2001 May; 16(5): 223-6
JN: Neurologia-Barcelona,-Spain
IS: 0213-4853
PY: 2001
LA: Spanish; Non-English
CP: Spain
AB: Alien hand syndrome is defined by uncontrolable actions of the arm and hand that seem to have a purpose. It is usually associated with acute focal lesions after a stroke or surgery of the corpus callosum. It has been described in chronic dementiating diseases such as cortico-basal degeneration, Alzheimer's disease, orthochromatic leukodystrophy and Marchiafava-Bignami disease.We now report a patient with Creutzfeldt-Jakob disease and alien hand syndrome, which appeared after the cognitive alterations and had characteristics of the frontal type of alien hand affecting the dominant upper limb. In the three cases described previously in the literature the alien hand affected the non-dominant hand and the abnormal movement appeared before dementia was clinically obvious. The non specific nature and poorly localising sign of alien hand is remarked. Alien hand should be added the list of features of Creutzfeldt-Jakob disease.
MJME: *Creutzfeldt-Jakob-Syndrome-physiopathology; *Laterality-physiology
MIME: Aged-; Atrophy-pathology; Cerebellum-pathology; Cerebellum-physiopathology; Creutzfeldt-Jakob-Syndrome-pathology; Electroencephalography-; Frontal-Lobe-physiopathology; Magnetic-Resonance-Imaging
AGE: Aged
TG: Case-Report; English-Abstract; Human; Male
PT: Journal-Article
SH: pathology; physiopathology; physiology
SB: Index-Medicus
UD: 20011004
DA: 20010619
CD: 20011004
RO: National-Library-of-Medicine
AN: 11412722
XREC: ABSTRACT (AB)
Record 13 of 36 in SilverPlatter MEDLINE(R) 2001-2003/01
TI: Involuntary hand levitation associated with parietal damage: another alien hand syndrome.
AU: Carrilho,-P-E; Caramelli,-P; Cardoso,-F; Barbosa,-E-R; Buchpiguel,-C-A; Nitrini,-R
AD: Department of Neurology, School of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil. carrilho@certto.com.br
SO: Arq-Neuropsiquiatr. 2001 Sep; 59(3-A): 521-5
JN: Arquivos-de-neuro-psiquiatria
IS: 0004-282X
PY: 2001
LA: English
CP: Brazil
AB: The alien hand syndrome (AHS) usually consists of an autonomous motor activity perceived as an involuntary and purposeful movement, with a feeling of foreignness of the involved limb, commonly associated with a failure to recognise ownership of the limb in the absence of visual clues. It has been described in association to lesions of the frontal lobes and corpus callosum. However, parietal damage can promote an involuntary, but purposeless, hand levitation, which, sometimes, resembles AHS. In the present study, four patients (cortico-basal ganglionic degeneration - n=2; Alzheimer's disease - n=1 and parietal stroke - n=1) who developed alien hand motor behaviour and whose CT, MRI and/or SPECT have disclosed a major contralateral parietal damage or dysfunction are described. These results reinforce the idea that parietal lobe lesions may also play a role in some patients with purposeless involuntary limb levitation, which is different from the classic forms of AHS.
MJME: *Brain-Diseases-complications; *Dyskinesias-etiology; *Hand-; *Parietal-Lobe-pathology
MIME: Aged-; Alzheimer-Disease-complications; Alzheimer-Disease-diagnosis; Atrophy-complications; Atrophy-diagnosis; Basal-Ganglia-Diseases-complications; Basal-Ganglia-Diseases-diagnosis; Brain-Diseases-diagnosis; Cerebral-Cortex-pathology; Cerebrovascular-Accident-complications; Cerebrovascular-Accident-diagnosis; Magnetic-Resonance-Imaging; Middle-Age; Neurodegenerative-Diseases-complications; Neurodegenerative-Diseases-diagnosis; Syndrome-; Tomography,-Emission-Computed,-Single-Photon
AGE: Aged; Middle-Age
TG: Case-Report; Female; Human; Male
PT: Journal-Article
SH: complications; diagnosis; pathology; etiology
SB: Index-Medicus
UD: 20011204
DA: 20011005
CD: 20011204
RO: National-Library-of-Medicine
AN: 11588628
XREC: ABSTRACT (AB)
Record 14 of 36 in SilverPlatter MEDLINE(R) 2001-2003/01
TI: Utilization behavior: clinical manifestations and neurological mechanisms.
AU: Archibald,-S-J; Mateer,-C-A; Kerns,-K-A
AD: Psychology Department, University of Victoria, British Columbia, Canada.
SO: Neuropsychol-Rev. 2001 Sep; 11(3): 117-30
JN: Neuropsychology-review
IS: 1040-7308
PY: 2001
LA: English
CP: United-States
AB: This paper describes a variety of motor release phenomena, including manual grasping and groping, imitation behavior, utilization behavior, and alien hand sign, their clinical manifestations. and proposed neural mechanisms. One of these specific neurobehavioral disorders, initially described by Lhermitte (Brain [1983] 106: 237-255), and termed utilization behavior, is addressed in more detail. Patients with this disorder are described as reaching out and using objects in the environment in an automatic manner. The current paper provides a comprehensive review of studies that have documented utilization behavior in individuals with a variety of pathologies, all having a specific predilection for the frontal lobes and frontal-striatal systems. Goldberg's (Behavioral and Brain Sciences [1985] 8: 567-616) theoretical framework for understanding motor release phenomena, which conceptualizes these behaviors as resulting from an imbalance between proposed medial (voluntary, goal directed, and future directed) and lateral (automatic, stimulus bound, and visually based) motor systems, is also discussed. Utilization behavior may prove to be a common underlying cause of high levels of excessive and intrusive motor behaviors within various clinical populations. A more comprehensive understanding of the neural systems underlying utilization behavior may prove highly useful for the differential diagnosis of conditions involving the mesial frontal cortex and fronto-striatal connections. Recent studies have started to investigate utilization behavior in clinical populations with known or suspected frontal system dysfunction, including adult patients with a variety of psychiatric conditions and children with ADHD.
MJME: *Brain-Diseases-psychology; *Frontal-Lobe-physiopathology; *Imitative-Behavior-physiology; *Motor-Activity-physiology
MIME: Brain-Diseases-physiopathology; Environment-; Models,-Neurological
TG: Human
PT: Journal-Article; Review; Review,-Tutorial
SH: physiopathology; psychology; physiology
RF: 98 refs.
SB: Index-Medicus
UD: 20020425
DA: 20020117
CD: 20020425
RO: National-Library-of-Medicine
AN: 11795839
XREC: ABSTRACT (AB)
FTXT: EBSCO Online http://ejournals.ebsco.com/direct.asp?ArticleID=CAM67T3P3U4GB1TD94BJ , Kluwer Journals@Ovid http://gateway.ovid.com/ovidweb.cgi?T=JS&PAGE=fulltext&D=kap&NEWS=n∓DBC=n&AN=343992 , SwetsWise http://www.SwetsWise.com/link/access_db?issn=1040-7308&vol=11&iss=3&age=117&FT=1
Record 15 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Subjective experience, involuntary movement, and posterior alien hand syndrome.
AU: Bundick,-T Jr; Spinella,-M
AD: Kessler Institute for Rehabilitation, 300 Market Street, Saddle Brook, NJ 07663, USA.
SO: J-Neurol-Neurosurg-Psychiatry. 2000 Jan; 68(1): 83-5
JN: Journal-of-neurology,-neurosurgery,-and-psychiatry
IS: 0022-3050
PY: 2000
LA: English
CP: ENGLAND
AB: The alien hand syndrome, as originally defined, was used to describe cases involving anterior corpus callosal lesions producing involuntary movement and a concomitant inability to distinguish the affected hand from an examiner's hand when these were placed in the patient's unaffected hand. In recent years, acceptable usage of the term has broadened considerably, and has been defined as involuntary movement occurring in the context of feelings of estrangement from or personification of the affected limb or its movements. Three varieties of alien hand syndrome have been reported, involving lesions of the corpus callosum alone, the corpus callosum plus dominant medial frontal cortex, and posterior cortical/subcortical areas. A patient with posterior alien hand syndrome of vascular aetiology is reported and the findings are discussed in the light of a conceptualization of posterior alien hand syndrome as a disorder which may be less associated with specific focal neuropathology than are its callosal and callosal-frontal counterparts.
CM: Comment In: J Neurol Neurosurg Psychiatry. 2000 Jan;68(1):7
Comment In: J Neurol Neurosurg Psychiatry. 2000 Nov;69(5):702
MJME: *Attention-physiology; *Brain-physiopathology; *Brain-Diseases-physiopathology; *Dominance,-Cerebral-physiology; *Laterality-physiology
MIME: Aged-; Brain-pathology; Brain-Diseases-pathology; Magnetic-Resonance-Imaging; Syndrome-
AGE: Aged
TG: Case-Report; Female; Human
PT: Journal-Article
SH: physiology; pathology; physiopathology
JC: Neurology; Psychiatry; Neurosurgery
SB: Index-Medicus
UD: 20011126
DA: 20000210
DR: 20011126
CD: 20000210
RO: National-Library-of-Medicine
AN: 10601408
XREC: ABSTRACT (AB); COMMENTS (CM)
FTXT: EBSCO Online http://ejournals.ebsco.com/direct.asp?ArticleID=GC8X1LV0JY4F7URECXU5 , Journals@OVID http://gateway.ovid.com/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&NEWS=namp;DBC=n&AN=00005069-200001000-00021 , HighWire http://jnnp.bmjjournals.com/cgi/content/full/68/1/83 , SwetsWise http://www.SwetsWise.com/link/access_db?issn=0022-3050&vol=68&iss=1&age=83&FT=1
Record 16 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Dystonia in corticobasal degeneration.
AU: Vanek,-Z-F; Jankovic,-J
AD: Department of Neurology, University of California, Los Angeles 90095-1769, USA.
SO: Adv-Neurol. 2000; 82: 61-7
JN: Advances-in-neurology
IS: 0091-3952
PY: 2000
LA: English
CP: UNITED-STATES
AB: Although a referral bias may have resulted in a higher proportion of atypical cases and consequently an overestimation of dystonia, asymmetric limb dystonia particularly affecting one arm initially was observed in 92% of all our CBD cases. Predominant leg dystonia is uncommon, and head, neck, or axial dystonia is rare. Dystonia is often associated with myoclonus, rigidity, apraxia, alien hand phenomenon, and sensory cortical signs in the affected limb, and there are no significant differences between the occurrence of these or other features, between patients with or without dystonia. There is no effective treatment for this relentless disorder except for temporary relief of dystonia and pain with local botulinum toxin injections. Further clinicopathologic studies are needed to elucidate the anatomical and physiologic substrates of dystonia in this disorder.
MJME: *Basal-Ganglia-Diseases-complications; *Cerebral-Cortex; *Dystonia-etiology; *Neurodegenerative-Diseases-complications
TG: Human
PT: Journal-Article; Review; Review,-Tutorial
SH: complications; etiology
RF: 29 refs.
SB: Index-Medicus
UD: 20001218
DA: 20000124
DR: 20001218
CD: 20000124
RO: National-Library-of-Medicine
AN: 10624471
XREC: ABSTRACT (AB)
Record 17 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Alien hand sign after a right parietal infarction.
AU: Marti-Fabregas,-J; Kulisevsky,-J; Baro,-E; Mendoza,-G; Valencia,-C; Marti-Vilalta,-J-L
AD: Neurology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain. jmartif@meditex.es
SO: Cerebrovasc-Dis. 2000 Jan-Feb; 10(1): 70-2
JN: Cerebrovascular-diseases-Basel,-Switzerland
IS: 1015-9770
PY: 2000
LA: English
CP: SWITZERLAND
AB: Involuntary movements are unusual during or after acute stroke, and alien hand sign has not been reported after single parietal infarction. We report on a woman who presented with involuntary movements and a sense of alienness of her left upper limb following a right parietal infarction. This combination, that can meet the criteria for the 'alien hand syndrome', is rarely seen after acute lesions sparing the corpus callosum and the mesial frontal areas. Copyright 2000 S. Karger AG, Basel
MJME: *Cerebral-Infarction-psychology; *Hand-physiology; *Movement-Disorders-etiology; *Parietal-Lobe-pathology
MIME: Aged-; Aged,-80-and-over; Cerebral-Infarction-pathology; Magnetic-Resonance-Imaging
AGE: Aged; Aged,-80-and-over
TG: Case-Report; Female; Human
PT: Journal-Article
SH: pathology; psychology; physiology; etiology
JC: Vascular-Diseases; Brain
SB: Index-Medicus
UD: 20001218
DA: 20000510
DR: 20001218
CD: 20000510
RO: National-Library-of-Medicine
AN: 10629350
XREC: ABSTRACT (AB)
FTXT: EBSCO Online http://ejournals.ebsco.com/direct.asp?ArticleID=QM8YJHA6NVDAE5DAUK6C , InformationQuest http://www.eiq.com/usr_login.html?sici=1015-9770%28000000%2910%3A1%3C70%3AX%3E2..CO%3B2-X , SwetsWise http://www.SwetsWise.com/link/access_db?issn=1015-9770&vol=10&iss=1&age=70&FT=1
Record 18 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Alien hand sign in Creutzfeldt-Jakob disease.
AU: Inzelberg,-R; Nisipeanu,-P; Blumen,-S-C; Carasso,-R-L
SO: J-Neurol-Neurosurg-Psychiatry. 2000 Jan; 68(1): 103-4
JN: Journal-of-neurology,-neurosurgery,-and-psychiatry
IS: 0022-3050
PY: 2000
LA: English
CP: ENGLAND
MJME: *Attention-physiology; *Corpus-Callosum-physiopathology; *Creutzfeldt-Jakob-Syndrome-physiopathology; *Dominance,-Cerebral-physiology; *Laterality-physiology
MIME: Aged-; Electroencephalography-
AGE: Aged
TG: Case-Report; Human; Male
PT: Letter
SH: physiology; physiopathology
JC: Neurology; Psychiatry; Neurosurgery
SB: Index-Medicus
UD: 20001218
DA: 20000210
DR: 20001218
CD: 20000210
RO: National-Library-of-Medicine
AN: 10671116
FTXT: EBSCO Online http://ejournals.ebsco.com/direct.asp?ArticleID=RM4TP7QL76AA87XLU58Y , Journals@OVID http://gateway.ovid.com/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&NEWS=namp;DBC=n&AN=00005069-200001000-00030 , HighWire http://jnnp.bmjjournals.com/cgi/content/full/68/1/103 , SwetsWise http://www.SwetsWise.com/link/access_db?issn=0022-3050&vol=68&iss=1&age=103&FT=1
Record 19 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Corticobasal ganglionic degeneration with Balint's syndrome.
AU: Mendez,-M-F
AD: Department of Neurology, UCLA School of Medicine, USA. mmendez@UCLA.edu
SO: J-Neuropsychiatry-Clin-Neurosci. 2000 Spring; 12(2): 273-5
JN: Journal-of-neuropsychiatry-and-clinical-neurosciences,-The
IS: 0895-0172
PY: 2000
LA: English
CP: UNITED-STATES
AB: Corticobasal ganglionic degeneration (CBGD) is a neurodegenerative dementia characterized by asymmetric parkinsonism, ideomotor apraxia, myoclonus, dystonia, and the alien hand syndrome. This report describes a patient with CBGD who developed Balint's syndrome with simultanagnosia, oculomotor apraxia, and optic ataxia.
MJME: *Basal-Ganglia-Diseases-pathology; *Nerve-Degeneration-pathology; *Vision-Disorders-pathology
MIME: Aged-; Basal-Ganglia-Diseases-psychology; Magnetic-Resonance-Imaging; Movement-Disorders-psychology; Nerve-Degeneration-psychology; Perceptual-Disorders-psychology; Syndrome-; Vision-Disorders-etiology; Vision-Disorders-psychology; Visual-Perception-physiology
AGE: Aged
TG: Case-Report; Human; Male
PT: Journal-Article
SH: pathology; psychology; etiology; physiology
JC: Psychiatry; Neurosciences
SB: Index-Medicus
UD: 20001218
DA: 20000915
DR: 20001218
CD: 20000915
RO: National-Library-of-Medicine
AN: 11001609
XREC: ABSTRACT (AB)
FTXT: EBSCO Online http://ejournals.ebsco.com/direct.asp?ArticleID=245MWQBY4EPJW9YEUE6V , HighWire http://neuro.psychiatryonline.org/cgi/content/full/12/2/273 , InformationQuest http://www.eiq.com/usr_login.html?sici=0895-0172%28000000%2912%3A2%3C273%3AX%3E20.CO%3B2-X
Record 20 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Involuntary masturbation as a manifestation of stroke-related alien hand syndrome.
AU: Ong-Hai,-B-G; Odderson,-I-R
AD: Department of Rehabilitation Medicine, St. Charles Hospital and Rehabilitation Center (BGOH), Port Jefferson, New York, USA.
SO: Am-J-Phys-Med-Rehabil. 2000 Jul-Aug; 79(4): 395-8
JN: American-journal-of-physical-medicine-and-rehabilitation-Association-of-AcademicPhysiatrists
IS: 0894-9115
PY: 2000
LA: English
CP: UNITED-STATES
AB: Alien hand syndrome is a perplexing and uncommon clinical diagnosis. We report an unusual manifestation of alien hand syndrome in a 73-yr-old man with a right anterior cerebral artery infarct affecting the right medial frontal cortex and the anterior portion of the corpus callosum. We conclude that alien hand syndrome should be considered in patients who present with a feeling of alienation of one or both upper limbs accompanied by complex purposeful involuntary movement.
MJME: *Brain-Infarction-complications; *Corpus-Callosum-pathology; *Hand-; *Masturbation-; *Movement-Disorders-etiology
MIME: Aged-; Dominance,-Cerebral
AGE: Aged
TG: Case-Report; Human; Male
PT: Journal-Article
SH: complications; pathology; etiology
JC: Physical-Medicine
SB: Abridged-Index-Medicus; Index-Medicus
UD: 20001218
DA: 20000725
DR: 20001218
CD: 20000725
RO: National-Library-of-Medicine
AN: 10892626
XREC: ABSTRACT (AB)
FTXT: Journals@OVID http://gateway.ovid.com/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&NEWS=namp;DBC=n&AN=00002060-200007000-00012
Record 21 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: The Frontal Behavioral Inventory in the differential diagnosis of frontotemporal dementia.
AU: Kertesz,-A; Nadkarni,-N; Davidson,-W; Thomas,-A-W
AD: Department of Cognitive Neurology, St. Joseph's Health Centre, London, Ontario, Canada.
SO: J-Int-Neuropsychol-Soc. 2000 May; 6(4): 460-8
JN: Journal-of-the-International-Neuropsychological-Society-JINS
IS: 1355-6177
PY: 2000
LA: English
CP: ENGLAND
AB: A personality and behavioral disorder is an important and defining feature of frontal lobe dementia (FLD) or frontotemporal degeneration (FTD). The diagnosis usually depends on the progressive development of various behavioral symptoms rather than a set of neuropsychological measures. Quantification of the personality-behavior disorder is important for standardizing the diagnosis. An inventory was constructed to capture the major positive and negative behaviors and personality change, and it was administered prospectively to caregivers of 108 patients in a cognitive neurology clinic, at the time of first diagnostic assessment. The prevalence and extent of behavioral abnormality was quantitated in the clinic population of FLD, vascular dementia (VaD), Alzheimer's disease (AD), primary progressive aphasia (PPA), and depressive disorder (DD) patients. The mean scores of FLD patients were significantly above all other groups. Scores in VaD were also higher than in AD, PPA, and DD. Interrater reliability (Cohen's kappa of .90) and item consistency (a Cronbach alpha of .89) were both high. Perseveration, indifference, inattention, inappropriateness, and loss of insight rated highest in FLD, significantly different from all other groups. Apathy, aspontaneity, inflexibility, disorganization, impulsivity, personal neglect, and poor judgment were also significantly higher in FLD. Discriminant function correctly classified 92.7% versus all other patients (NON-FLD) in the study. A total of 18.8% of VaD patients were misclassified as FLD. Indifference, alien hand, and inappropriateness were the highest discriminant functions. Perseveration and verbal apraxia were important discriminatory items for FLD and PPA, respectively. The FBI is a standardized behavioral inventory useful to diagnose FLD, to differentiate it from other dementias, and to quantify the behavior disorder.
MJME: *Dementia-diagnosis; *Frontal-Lobe; *Neuropsychological-Tests; *Temporal-Lobe
MIME: Aged-; Behavior-; Dementia-psychology; Diagnosis,-Differential; Discriminant-Analysis; Middle-Age; Observer-Variation; Personality-; Reproducibility-of-Results
AGE: Aged; Middle-Age
TG: Female; Human; Male
PT: Clinical-Trial; Journal-Article
SH: diagnosis; psychology
SB: Index-Medicus
UD: 20001218
DA: 20000814
DR: 20001218
CD: 20000814
RO: National-Library-of-Medicine
AN: 10902415
XREC: ABSTRACT (AB)
FTXT: EBSCO Online http://ejournals.ebsco.com/direct.asp?ArticleID=YANBW1BMDDPWJTF5NWKK , SwetsWise http://www.SwetsWise.com/link/access_db?issn=1355-6177&vol=6&iss=4&pge=460&FT=1
Record 22 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: [An autopsy case of corticobasal degeneration without prominent cortical pathology--an imitator of progressive supranuclear palsy]
AU: Hattori,-M; Yoshida,-M; Ojika,-K; Yuasa,-H; Mitake,-S; Hashizume,-Y
AD: Department of Neurology, Tosei General Hospital.
SO: Rinsho-Shinkeigaku. 2000 Apr; 40(4): 372-7
JN: Rinsho-shinkeigaku; Clinical-neurology
IS: 0009-918X
PY: 2000
LA: Japanese; Non-English
CP: JAPAN
AB: We describe an autopsy case of parkinsonism with bradykinesia, muscle rigidity, and dementia as major symptoms. The patient had developed bradykinesia at the age of 62, and then muscle rigidity, a parkinsonian posture, bradylalia, and dementia gradually appeared. Neurological examination revealed rigidity in the neck and limbs, with motion and speech being generally slow. He lacked involuntary movements including alien hand, tremor, chorea, and dystonia. Vertical gaze palsy, both upward and downward was noted, but other cranial nerves were intact. He was diagnosed as suffering from PSP clinically based on vertical gaze palsy, bradykinesia, instability on standing and gait, and dementia. Levodopa was only transiently effective. Within three years he became bed-ridden and in a state of akinetic mutism. At age 65 he died from pneumonia. Neuropathology revealed severe neuronal degeneration and gliosis in the substantia nigra. Because atrophy of the tegmentum of brainstem, dentate nuclei, inferior olivary nuclei was very mild and Alzheimer neurofibrillary tangles in the brainstem were relatively few, PSP was ruled out. Cortical neuronal degeneration was not apparent, but in the deep layer of cingulate gyrus, frontal lobe, and insula, there were several ballooned neurons. Gallyas-Braak silver staining showed no tuft-shaped astrocytes, specific for PSP, but it disclosed astrocytic plaques in the basal ganglia and the cerebral cortex. At present, astrocytic plaques are recognized as a hallmark of corticobasal degeneration (CBD), along with ballooned neurons in the cerebral cortex. The present case thus illustrates that CBD has a wide spectrum and may include cases in which degeneration of cerebral cortex is very mild.
MJME: *Basal-Ganglia-pathology; *Cerebral-Cortex-pathology; *Nerve-Degeneration-pathology; *Supranuclear-Palsy,-Progressive-pathology
MIME: Aged-; Diagnosis,-Differential
AGE: Aged
TG: Case-Report; English-Abstract; Human; Male
PT: Journal-Article
SH: pathology
SB: Index-Medicus
UD: 20001124
DA: 20001124
CD: 20001124
RO: National-Library-of-Medicine
AN: 10967656
XREC: ABSTRACT (AB)
Record 23 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Alien hand, free will and Arnold Pick.
AU: Kertesz,-A
SO: Can-J-Neurol-Sci. 2000 Aug; 27(3): 183
JN: Canadian-journal-of-neurological-sciences,-The; Journal-canadien-des-sciences-neurologiques,-Le
IS: 0317-1671
PY: 2000
LA: English
CP: CANADA
CM: Comment On: Can J Neurol Sci. 2000 Aug;27(3):192-203
MJME: *Basal-Ganglia; *Cerebral-Cortex; *Movement-Disorders-etiology; *Nerve-Degeneration-complications; *Pick-Disease-of-the-Brain-complications
MIME: Movement-Disorders-psychology; Volition-
TG: Human
PT: Comment; Editorial
SH: etiology; psychology; complications
SB: Index-Medicus
UD: 20001222
DA: 20001211
CD: 20001222
RO: National-Library-of-Medicine
AN: 10975529
XREC: COMMENTS (CM)
Record 24 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Alien hand phenomena: a review with the addition of six personal cases.
AU: Fisher,-C-M
AD: Neurology Service of the Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
SO: Can-J-Neurol-Sci. 2000 Aug; 27(3): 192-203
JN: Canadian-journal-of-neurological-sciences,-The; Journal-canadien-des-sciences-neurologiques,-Le
IS: 0317-1671
PY: 2000
LA: English
CP: CANADA
AB: This is a comprehensive literature review of the motor abnormalities that have come to be included under the designation of Alien Hand Phenomena (AHP). Some of the disorders are dyspractic in nature - intermanual conflict, mirror movements, interference etc., while others - groping, grasping with inability to release, utilization etc. are frontal lobe reflexes. AHP are mainly associated with two pathological processes: 1) Infarction or hemorrhage in the territory of the anterior cerebral arteries; and 2) Corticobasal degeneration. Included in the review is a description of AHP in six personal cases of corticobasal degeneration. The summary includes a short discussion of the possible anatomy of 'free will' based on AHP.
CM: Comment In: Can J Neurol Sci. 2000 Aug;27(3):183
MJME: *Basal-Ganglia; *Cerebral-Cortex; *Cerebrovascular-Disorders-complications; *Hand-; *Movement-Disorders-etiology; *Nerve-Degeneration-complications
MIME: Aged-; Child-; Middle-Age; Movement-Disorders-psychology; Volition-
AGE: Aged; Child; Middle-Age
TG: Case-Report; Female; Human
PT: Journal-Article; Review; Review-of-Reported-Cases
SH: complications; etiology; psychology
RF: 59 refs.
SB: Index-Medicus
UD: 20001222
DA: 20001211
CD: 20001222
RO: National-Library-of-Medicine
AN: 10975531
XREC: ABSTRACT (AB); COMMENTS (CM)
Record 25 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Touch feel illusion in schizophrenic patients.
AU: Peled,-A; Ritsner,-M; Hirschmann,-S; Geva,-A-B; Modai,-I
AD: Institute for Psychiatric Studies, Sha'ar Menashe Mental Health Center, Hadera, Israel.
SO: Biol-Psychiatry. 2000 Dec 1; 48(11): 1105-8
JN: Biological-psychiatry
IS: 0006-3223
PY: 2000
LA: English
CP: UNITED-STATES
AB: BACKGROUND: The rubber hand illusion is a tactile sensation referred to as an alien limb. The illusion has been explained by a spurious reconciliation of visual and tactile inputs reflecting functional connectivity in the brain and was used to explore alterations of functional connectivity in schizophrenia. METHODS: The rubber hand illusion was achieved when two paintbrushes simultaneously stroke the hand of the subject hidden from vision by a screen, as well as an artificial hand placed in view of the subject. The rubber hand illusion was assessed with a questionnaire affirming or denying the occurrence of the illusion. RESULTS: Schizophrenic subjects felt the illusion stronger and faster then did normal control subjects. Some rubber hand illusion effects correlated with positive symptoms of schizophrenia but not with negative symptoms. CONCLUSIONS: Altered functional integration of environmental inputs could constitute the basis for erroneous interpretations of reality, such as delusions and hallucinations.
MJME: *Illusions-; *Perceptual-Distortion; *Schizophrenia-physiopathology; *Schizophrenic-Psychology; *Touch-
MIME: Adult-; Case-Control-Studies; Middle-Age; Psychiatric-Status-Rating-Scales; Refractory-Period,-Psychological
AGE: Adult; Middle-Age
TG: Female; Human; Male
PT: Journal-Article
SH: physiopathology
JC: Psychiatry; Psychophysiology
SB: Index-Medicus
UD: 20001227
DA: 20001227
CD: 20001227
RO: National-Library-of-Medicine
AN: 11094144
XREC: ABSTRACT (AB)
FTXT: ScienceDirect (tm) http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=SilverLinker&_urlversion=4&_method=citationSearch&_volkey=0006%2d3223%2348%231105%2311&_version=1&md5=aeb6974b45591f651be0aba7947d3705 , SwetsWise http://www.SwetsWise.com/link/access_db?issn=0006-3223&vol=48&iss=11&page=1105&FT=1
Record 26 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Paroxysmal alien hand syndrome.
AU: Aleem,-M-A
SO: J-Assoc-Physicians-India. 2000 Oct; 48(10): 1035-6
JN: Journal-of-the-Association-of-Physicians-of-India,-The
IS: 0004-5772
PY: 2000
LA: English
CP: India
CM: Comment On: J Assoc Physicians India. 1999 Dec;47(12):1200
MJME: *Hand-innervation; *Neuralgia-diagnosis; *Somatosensory-Disorders-diagnosis
MIME: Syndrome-
TG: Human
PT: Comment; Letter
SH: innervation; diagnosis
SB: Index-Medicus
UD: 20010626
DA: 20010131
DR: 20010626
CD: 20010215
RO: National-Library-of-Medicine
AN: 11200914
XREC: COMMENTS (CM)
Record 27 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: 2-NAP, a peripheral CCK-A receptor antagonist, modulates the development of a preference for the mother by the newborn lamb.
AU: Goursaud,-A-P; Nowak,-R
AD: Equipe de Comportement Animal, CNRS/INRA URA 1291, Unite de Physiologie de la Reproduction et des Comportements, 37380 Nouzilly, France.
SO: Pharmacol-Biochem-Behav. 2000 Nov; 67(3): 603-11
JN: Pharmacology,-biochemistry,-and-behavior
IS: 0091-3057
PY: 2000
LA: English
CP: United-States
AB: The aim of this study was to investigate the effect of devazepide (DEV), a cholecystokinin (CCK)-A receptor antagonist, which crosses the blood-brain barrier (BBB) and prevents the development of a preferential relationship with the dam, and compare it to that of 2-NAP, which acts peripherally. At birth, lambs received either an intraperitoneal injection of saline (CTL), DEV (0.1 mg/kg), or 2-NAP (0.01, 0.1, or 1 mg/kg). No major side effects were observed after the injection, however, there was a trend for lambs receiving CCK-A antagonists to be more vocal in the first 2 h and to loose more weight between birth and 3 h. When tested in a two-choice test situations at 24 h of age, the latency to reach a ewe and the total time spent next to them were not affected by the treatments. On the other hand, unlike CTLs, lambs receiving DEV or 0.1 mg of 2-NAP did not spend significantly more time near their dam than near the alien ewe. 2-NAP had no effect at 0.01 mg/kg, but at 1 mg/kg, it improved the preference score. There was no relationship between preference scores and the variations in weight recorded during the neonatal period. The effects of DEV, but not those of 2-NAP, persisted at 48 h of age. Thus, these results support the hypothesis that peripheral CCK receptors are involved in the development of a preference for the mother, but the effects differ according to the amount of 2-NAP that the lambs receive.
MJME: *Aspartic-Acid-analogs-and-derivatives; *Aspartic-Acid-pharmacology; *Behavior,-Animal-drug-effects; *Devazepide-pharmacology; *Hormone-Antagonists-pharmacology; *Mothers-; *Naphthalenesulfonates-pharmacology; *Receptors,-Cholecystokinin-antagonists-and-inhibitors
MIME: Animals,-Newborn; Behavior,-Animal-physiology; Object-Attachment; Receptors,-Cholecystokinin-physiology; Sheep-; Vocalization,-Animal-drug-effects; Vocalization,-Animal-physiology
TG: Animal; Female; Pregnancy; Support,-Non-U.S.-Gov't
PT: Journal-Article
SH: analogs-and-derivatives; pharmacology; drug-effects; physiology; antagonists-and-inhibitors
CAS: 0; 0; 0; 0; 103420-77-5; 141577-40-4; 56-84-8
PN: CCK-A-receptor; Hormone-Antagonists; Naphthalenesulfonates; Receptors,-Cholecystokinin; Devazepide; N-(2-naphthalenesulfonyl)aspartyl-(2-phenethyl)amide; Aspartic-Acid
JC: Biochemistry; Pharmacology; Behavior; Psychopharmacology
SB: Index-Medicus
UD: 20010419
DA: 20010222
CD: 20010419
RO: National-Library-of-Medicine
AN: 11164092
XREC: ABSTRACT (AB)
FTXT: ScienceDirect (tm) http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=SilverLinker&_urlversion=4&_method=citationSearch&_volkey=0091%2d3057%2367%23603%233&_version=1&md5=36b48a0b389b88064587ecd155904d2b , SwetsWise http://www.SwetsWise.com/link/access_db?issn=0091-3057&vol=67&iss=3&age=603&FT=1
Record 28 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Alien hand syndrome.
AU: Bhattacharyya,-K-B
SO: J-Assoc-Physicians-India. 2000 Dec; 48(12): 1226
JN: Journal-of-the-Association-of-Physicians-of-India,-The
IS: 0004-5772
PY: 2000
LA: English
CP: India
MJME: *Basal-Ganglia-Diseases-complications; *Hand-; *Movement-Disorders-etiology; *Somatosensory-Disorders-etiology
MIME: Syndrome-
TG: Human
PT: Letter
SH: complications; etiology
SB: Index-Medicus
UD: 20010517
DA: 20010330
CD: 20010517
RO: National-Library-of-Medicine
AN: 11280245
Record 29 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Clinical features differentiating patients with postmortem confirmed progressive supranuclear palsy and corticobasal degeneration.
AU: Litvan,-I; Grimes,-D-A; Lang,-A-E; Jankovic,-J; McKee,-A; Verny,-M; Jellinger,-K; Chaudhuri,-K-R; Pearce,-R-K
AD: Neuropharmacology Unit Defense & Veteran Head Injury Program, Henry M. Jackson Foundation, Federal Building, Room 714, Bethesda, Maryland 20892-9130, USA, email: litvanI@helix.nih.gov.
SO: J-Neurol. 1999 Sep; 246 Suppl 2: II1-5
JN: Journal-of-neurology
IS: 0340-5354
PY: 1999
LA: English
CP: GERMANY
AB: Progressive supranuclear palsy (PSP) and cortocobasal degeneration (CBD) are often clinically confused with each other because they share a rapid disease progression, parkinsonism that responds poorly or transiently to levodopa therapy, and associated signs (e.g., ocular abnormalities, pyramidal signs and cognitive involvement). To improve the accuracy in diagnosing these disorders, this study examined the clinical features of 51 patients pathologically diagnosed with PSP and CBD. Logistic regression analysis identified two sets of predictors (models) for CBD patients, one consisting of asymmetric parkinsonism, cognitive disturbances at onset and instability and falls at first clinic visit, and the other one of asymmetric parkinsonism, cognitive disturbances at symptom onset and speech disturbances. While PSP patients often had severe postural instability at onset, symmetric parkinsonism, vertical supranuclear gaze palsy, speech and frontal lobe-type features, CBD patients presented with lateralized motor (e.g., parkinsonism, dystonia or myoclonus) and cognitive signs (e.g., ideomotor apraxia, aphasia or alien limb). On the other hand, CBD patients presenting with an alternate phenotype characterized by early severe frontal dementia and bilateral parkinsonism were generally misdiagnosed. PSP patients without vertical supranuclear gaze palsy were misdiagnosed. Recognizing the features which differentiate these disorders and the less obvious disease presentations as well as developing an increased index of suspicion will improve the diagnostic accuracy of these disorders.
MJME: *Parkinsonian-Disorders-physiopathology; *Supranuclear-Palsy,-Progressive-physiopathology
MIME: Aged-; Brain-physiopathology; Cognition-Disorders-physiopathology; Parkinsonian-Disorders-diagnosis; Supranuclear-Palsy,-Progressive-diagnosis
AGE: Aged
TG: Comparative-Study; Female; Human; Male
PT: Journal-Article; Review; Review,-Tutorial
SH: physiopathology; diagnosis
RF: 22 refs.
SB: Index-Medicus
UD: 20001218
DA: 19991210
DR: 20001218
CD: 19991210
RO: National-Library-of-Medicine
AN: 10525996
XREC: ABSTRACT (AB)
Record 30 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Quatre mains "etranges" pour deux mains apres une lesion calleuse.
[Four "alien" hands for two hands after a lesion in corpus callosum]
AU: Bakchine,-S; Slachevsky,-A; Tourbah,-A; Serres,-I; Abdelmounni,-H
AD: Centre de Langage et de Neuropsychologie, Hopital de la Pitie-Salpetriere, Paris. serge.bakchine@psl.ap-hop-paris.fr
SO: Rev-Neurol-(Paris). 1999 Nov; 155(11): 929-34
JN: Revue-neurologique
IS: 0035-3787
PY: 1999
LA: French; Non-English
CP: FRANCE
AB: Callosal lesions, associated or not to internal frontal lesions, may produce different types of complex gestural behaviors. Four signs can be identified, each of which has been generally reported separately: the "alien hand" sign, the "diagnostic apraxia", the "wayward hand" and the "callosal apraxia". Some authors justify considering these signs as different entities, while others propose regrouping them either in an unique syndrome--the "alien hand"--or as two syndromes--the "frontal alien hand" and the "callosal alien hand". We present the observation of a patient who presented with the four mentioned syndromes in association. In this context, we review the clinical features of each of the four signs and the arguments supporting their individualization.
MJME: *Agnosia-diagnosis; *Apraxias-diagnosis; *Corpus-Callosum-pathology
MIME: Agnosia-etiology; Apraxias-etiology; Brain-Ischemia-complications; Gestures-; Hand-; Magnetic-Resonance-Imaging; Middle-Age
AGE: Middle-Age
TG: Case-Report; English-Abstract; Human; Male
PT: Journal-Article
SH: diagnosis; etiology; complications; pathology
SB: Index-Medicus
UD: 20001218
DA: 20000208
DR: 20001218
CD: 20000208
RO: National-Library-of-Medicine
AN: 10603637
XREC: ABSTRACT (AB)
Record 31 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Alien hand syndrome: report of two cases.
AU: Wu,-F-Y; Leong,-C-P; Su,-T-L
AD: Department of Rehabilitation, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, R.O.C.
SO: Changgeng-Yi-Xue-Za-Zhi. 1999 Dec; 22(4): 660-5
JN: Changgeng-yi-xue-za-zhi-Changgeng-ji-nian-yi-yuan; Chang-Gung-medical-journal-Chang-Gung-Memorial-Hospital
PY: 1999
LA: English
CP: CHINA-(REPUBLIC:-1949--)
AB: Alien hand syndrome (AHS) refers to the occurrence of apparently purposeful movements in the hand which are independent of volitional control. Two subtypes of AHS have been proposed: frontal AHS, with grasp reflex and compulsive manipulation of tools by the dominant hand, and callosal AHS, which occurs in the nondominant hand and is characterized mainly by intermanual conflict. Here, we report two cases of frontal-type alien hand syndrome with symptoms of reflexive grasping, impulsive groping, and apraxia (in case 1), and compulsive manipulation of tools (in case 2). Brain computed tomography revealed a left anterior cerebral artery (ACA) territory infarct and multiple small infarcts of both hemispheres in patient 1 and a left ACA infarct in patient 2. The involuntary movements were bothersome to these patients in their daily activities. Both patients attended conventional physical and occupational therapies, and patient 2 received additional biofeedback training. Follow-up studies showed the spontaneous grasping behavior was still present in patient 1 and AHS had subsided in patient 2. We also describe a potentially effective technique involving biofeedback for patients with alien hand syndrome.
MJME: *Cerebrovascular-Accident-complications; *Movement-Disorders-etiology
MIME: Aged-; Electromyography-; Movement-Disorders-therapy
AGE: Aged
TG: Case-Report; Female; Human
PT: Journal-Article
SH: complications; etiology; therapy
SB: Index-Medicus
UD: 20001218
DA: 20000316
DR: 20001218
CD: 20000316
RO: National-Library-of-Medicine
AN: 10695218
XREC: ABSTRACT (AB)
Record 32 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Alien hand syndrome.
AU: John,-P-A; Jose,-J; Girija,-A-S
AD: Dept. of Medicine, Medical College, Calicut, Kerala-673 008.
SO: J-Assoc-Physicians-India. 1999 Dec; 47(12): 1200
JN: Journal-of-the-Association-of-Physicians-of-India,-The
IS: 0004-5772
PY: 1999
LA: English
CP: India
CM: Comment In: J Assoc Physicians India. 2000 Oct;48(10):1035-6
Comment In: J Assoc Physicians India. 2000 Oct;48:1035-6
MJME: *Cerebral-Infarction-complications; *Corpus-Callosum-pathology; *Frontal-Lobe-pathology; *Hand-; *Somatosensory-Disorders-etiology
MIME: Laterality-; Middle-Age; Movement-Disorders-etiology
AGE: Middle-Age
TG: Case-Report; Human; Male
PT: Journal-Article
SH: complications; pathology; etiology
SB: Index-Medicus
UD: 20011115
DA: 20010227
DR: 20011115
CD: 20010329
RO: National-Library-of-Medicine
AN: 11225226
XREC: COMMENTS (CM)
Record 33 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Ego-syntonic alien hand syndrome after right posterior cerebral artery stroke.
AU: Groom,-K-N; Ng,-W-K; Kevorkian,-C-G; Levy,-J-K
AD: Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA.
SO: Arch-Phys-Med-Rehabil. 1999 Feb; 80(2): 162-5
JN: Archives-of-physical-medicine-and-rehabilitation
IS: 0003-9993
PY: 1999
LA: English
CP: UNITED-STATES
AB: The alien hand syndrome classically consists of involuntary movements accompanied by a feeling of foreignness and personification of the affected limb. Autocriticism, in which patients criticize and express astonished frustration with the behavior of the autonomous limb, is a commonly noted feature. Most cases of alien hand are associated with lesions of the supplementary motor areas of the frontal lobes, the corpus callosum, or both. The authors report on a 79-year-old man who sustained a right posterior cerebral artery distribution infarction and developed alien hand syndrome in the absence of callosal involvement. Also unique is that the patient perceived the alien hand as acceptable and positive, not hostile and repugnant. This case suggests not only that the neuroanatomic regions responsible for alien hand syndrome may require re-examination, but also that its definition may need expansion.
MJME: *Apraxias-diagnosis; *Automatism-diagnosis; *Cerebral-Infarction-diagnosis; *Dominance,-Cerebral-physiology; *Ego-; *Hand-innervation
MIME: Aged-; Apraxias-physiopathology; Attention-physiology; Automatism-physiopathology; Awareness-physiology; Brain-Mapping; Cerebral-Arteries-pathology; Cerebral-Infarction-physiopathology; Corpus-Callosum-pathology; Corpus-Callosum-physiopathology; Magnetic-Resonance-Imaging; Neurologic-Examination; Neuropsychological-Tests
AGE: Aged
TG: Case-Report; Human; Male
PT: Journal-Article
SH: diagnosis; physiopathology; physiology; pathology; innervation
SB: Abridged-Index-Medicus; Index-Medicus
UD: 20001218
DA: 19990301
DR: 20001218
CD: 19990301
RO: National-Library-of-Medicine
AN: 10025490
XREC: ABSTRACT (AB)
Record 34 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Sensory alien hand syndrome.
AU: Persaud,-R-S
SO: J-Neurol-Neurosurg-Psychiatry. 1999 Jul; 67(1): 130-1
JN: Journal-of-neurology,-neurosurgery,-and-psychiatry
IS: 0022-3050
PY: 1999
LA: English
CP: ENGLAND
CM: Comment On: J Neurol Neurosurg Psychiatry. 1999 Jul;67(1):130-1
MJME: *Anxiety-physiopathology; *Awareness-physiology; *Cerebral-Infarction-physiopathology; *Hand-innervation; *Hemiplegia-physiopathology
MIME: Syndrome-
TG: Human
PT: Comment; Letter
SH: physiopathology; physiology; innervation
JC: Neurology; Psychiatry; Neurosurgery
SB: Index-Medicus
UD: 20001218
DA: 19990819
DR: 20001218
CD: 19990819
RO: National-Library-of-Medicine
AN: 10369840
XREC: COMMENTS (CM)
FTXT: EBSCO Online http://ejournals.ebsco.com/direct.asp?ArticleID=WGKRB4G51TDUTJDW2L9U , Journals@OVID http://gateway.ovid.com/ovidweb.cgi?T=JS&PAGE=titles&D=ovft&NEWS=n≈DBC=n&SEARCH=0022-3050.is+and+%2267%22.vo+and+%221%22.ip+and+%22130%22.pg , HighWire http://jnnp.bmjjournals.com/cgi/content/full/67/1/130 , SwetsWise http://www.SwetsWise.com/link/access_db?issn=0022-3050&vol=67&iss=1&age=130&FT=1
Record 35 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Anatomical correlates of alien hand syndromes.
AU: Chan,-J-L; Liu,-A-B
AD: Department of Neurology, Taipei Municipal Yang-Ming Hospital and Taipei Medical College, Taiwan.
SO: Neuropsychiatry-Neuropsychol-Behav-Neurol. 1999 Jul; 12(3): 149-55
JN: Neuropsychiatry,-neuropsychology,-and-behavioral-neurology
IS: 0894-878X
PY: 1999
LA: English
CP: UNITED-STATES
AB: OBJECTIVE: The objective of this study was to correlate various alien hand syndromes (AHS) with sites of lesion in 16 patients with anterior cerebral artery (ACA) territory infarction. BACKGROUND: All previous reports of AHS were case studies. Their clinico-anatomic correlations were still controversial. While the callosal lesion appears necessary for various types of AHS, which portion of the corpus callosum is associated with which syndrome is still not yet completely resolved. METHOD: Sixteen patients with ACA territory infarction were selected from a stroke registry containing 7355 individuals. They were divided into three lesion groups according to location identified by computed tomography or magnetic resonance imaging: mesial frontal, callosal and combined mesial frontal and callosal. Neurobehavioral examination focused on the presence or absence of grasp reflex, various alien hand signs, intermanual conflict, and callosal disconnection syndrome. By gross visual analysis of the obtained data, a trend for clinicoanatomic correlation emerged. RESULTS: Patients with restricted mesial frontal lesions (three subjects), restricted anterior callosal lesions (four subjects) or "restricted" mesial frontal and anterior callosal lesions (two subjects) did not have symptoms of AHS. The remaining seven patients with extensive callosal injury involving the midbody and isthmus all had symptoms of AHS. Four of the patients with relatively isolated callosal involvement showed intermanual conflict (IMC) associated with a callosal AHS, while the remaining three patients with additional lesions involving the mesial frontal cortex showed impulsive reaching and grasping behaviors of the contralesional hand (a component of frontal AHS) and IMC (a component of callosal AHS). CONCLUSIONS: A comparison of the lesions and symptoms of seven patients in two different groups shows that mesial frontal and anterior callosal (genu and rostral body) lesions are associated with a contralateral frontal AHS. Isolated involvement of the callosal midbody and isthmus is associated with a callosal AHS. When the mesial frontal cortex and corpus callosum (genu and whole body) are extensively involved, a mixed frontal and callosal AHS may occur in the same patient.
MJME: *Attention-physiology; *Cerebral-Infarction-physiopathology; *Corpus-Callosum-physiopathology; *Dominance,-Cerebral-physiology; *Laterality-physiology
MIME: Aged-; Apraxias-diagnosis; Apraxias-physiopathology; Brain-Mapping; Cerebral-Infarction-diagnosis; Frontal-Lobe-physiopathology; Magnetic-Resonance-Imaging; Middle-Age; Psychomotor-Performance-physiology; Tomography,-X-Ray-Computed
AGE: Aged; Middle-Age
TG: Female; Human; Male; Support,-Non-U.S.-Gov't
PT: Journal-Article
SH: diagnosis; physiopathology; physiology
SB: Index-Medicus
UD: 20001218
DA: 19991014
DR: 20001218
CD: 19991014
RO: National-Library-of-Medicine
AN: 10456797
XREC: ABSTRACT (AB)
Record 36 of 36 in SilverPlatter MEDLINE(R) 1999-2000
TI: Perception of self-generated movement following left parietal lesion.
AU: Sirigu,-A; Daprati,-E; Pradat-Diehl,-P; Franck,-N; Jeannerod,-M
AD: Institut des Sciences Cognitives, Lyon, France. sirigu@isc.cnrs.fr
SO: Brain. 1999 Oct; 122 ( Pt 10): 1867-74
JN: Brain-a-journal-of-neurology
IS: 0006-8950
PY: 1999
LA: English
CP: ENGLAND
AB: Three apraxic patients with lesions in the left parietal cortex were required to execute finger movements with either hand, while the visual feedback they received about the movement was manipulated systematically. We used a device which allowed us to present on a video monitor either the patient's hand or the examiner's hand simultaneously performing an identical or a different movement. In each trial, patients were required to decide whether the hand shown on the screen was their own or not. Hand movements produced in response to verbal command included simple (single-finger extension) and complex gestures (multi-finger extension). Ownership judgements were analysed and compared with those produced by six normal controls and two non-apraxic neurological patients. Apraxic patients and controls accurately recognized their own hand on the screen (own movement condition) and correctly identified the viewed hand as the examiner's when it performed a movement different from their own movement (incongruent movement condition). However, when the viewed hand was the examiner's hand executing their own movement (congruent movement condition), apraxic patients were significantly more impaired than controls. When the results were analysed as a function of gesture type, the number of correct responses was significantly lower for apraxic patients with respect to controls only for complex gestures. Interestingly, when patients executed the finger gestures inaccurately, they still failed to recognize the examiner's hand as alien, and claimed that the correct movement presented on the screen was their own. These results confirm that parietal lesions alter the representational aspects of gestures, and suggest a failure in evaluating and comparing internal and external feedback about movement. We conclude that the parietal cortex plays an important role in generating and maintaining a kinaesthetic model of ongoing movements.
MJME: *Apraxias-physiopathology; *Hand-physiology; *Movement-; *Parietal-Lobe-physiopathology; *Perception-physiology
MIME: Aged-; Feedback-; Fingers-physiology; Fingers-physiopathology; Gestures-; Hand-physiopathology; Hemiplegia-; Kinetics-; Matched-Pair-Analysis; Middle-Age; Models,-Neurological; Motion-Perception-physiology; Parietal-Lobe-injuries; Visual-Perception-physiology
AGE: Aged; Middle-Age
TG: Female; Human; Male; Support,-Non-U.S.-Gov't
PT: Journal-Article
SH: physiopathology; physiology; injuries
SB: Abridged-Index-Medicus; Index-Medicus
UD: 20001218
DA: 19991105
DR: 20001218
CD: 19991105
RO: National-Library-of-Medicine
AN: 10506089
XREC: ABSTRACT (AB)
FTXT: HighWire http://brain.oupjournals.org/cgi/content/full/122 /P10/1867 , SwetsWise http://www.SwetsWise.com/link/access_db?issn=0006-8950&vol=122 &iss=P10&page=1867&FT=1