web contact: pietsch@indiana.edu
Persons with injuries to the brain including, of course, the corpus callosum, sometimes report that one of their limbs, typically an arm, acts as though it belongs to somebody else. Here are the abstracts of 16 recent articles on the subject from the 1996-1998 literature.
TITLE: Partial status epilepticus associated with asomatognosia and private alien hand-like behaviors.
AUTHOR(S): Feinberg-TE; Roane-DM; Cohen-J
ADDRESS OF AUTHOR: Yarmon Neurobehavior and Alzheimer's Disease Center, Beth Israel Medical Center, New York, NY, USA.
SOURCE (BIBLIOGRAPHIC CITATION): Arch-Neurol. 1998 Dec; 55(12): 1574-6
INTERNATIONAL STANDARD SERIAL NUMBER: 0003-9942
PUBLICATION YEAR: 1998
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: BACKGROUND: Paroxysmal alien hand syndrome (AHS) has been reported in association with ictal phenomena, but simultaneous electroencephalographic verification has not been made. OBSERVATION: A 61-year-old woman with a right hemisphere glioblastoma multiforme developed movements of the left hand that she claimed were not under her control, and she denied ownership of the affected limb. Simultaneous electroencephalograms documented continuous spikes in the right frontotemporal region. Intravenous diazepam therapy (2.5 mg) reversed both the abnormal movements and the spike activity on the electroencephalograms. CONCLUSIONS: Our case demonstrates that partial seizures can produce AHS along with asomatognosia. This variety of AHS appears to be different, both etiologically and phenomenologically, from other forms of AHS.
MINOR MESH HEADINGS: Aged-; Brain-Neoplasms-complications; Electroencephalography-; Glioblastoma-complications; Laterality-; Motor-Activity; Status-Epilepticus-pathology
MAJOR MeSH HEADINGS: *Awareness-physiology; *Hand-physiopathology; *Movement-Disorders-etiology; *Parietal-Lobe-pathology; *Status-Epilepticus-complications
CHECKTAGS: Case-Report; Female; Human
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 1999081401
UPDATE CODE: 199903
SUBSET: AIM
Record 2 of 16 in MEDLINE EXPRESS (R) 1999/01-1999/04
TITLE: The alien hand sign--case report and review of the literature.
AUTHOR(S): Tow-AM; Chua-HC
ADDRESS OF AUTHOR: Department of Rehabilitation Medicine, Tan Tock Seng Hospital, Singapore.
SOURCE (BIBLIOGRAPHIC CITATION): Ann-Acad-Med-Singapore. 1998 Jul; 27(4): 582-5
INTERNATIONAL STANDARD SERIAL NUMBER: 0304-4602
PUBLICATION YEAR: 1998
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: SINGAPORE
ABSTRACT: The alien hand sign refers to a group of signs which include a feeling that the hand is foreign together with autonomous activity, as if the hand is driven by an external agent. These features are commonly associated with frontal and callosal lesions. We report the alien hand sign in a man with left medial cortical infarct, presenting with autonomous grasping and groping with his right upper limb, denial of ownership of his limb, and dissociative phenomena including self restriction and intermanual conflict.
MINOR MESH HEADINGS: Cerebral-Infarction-complications; Cerebral-Infarction-physiopathology; Dissociative-Disorders-etiology; Dissociative-Disorders-physiopathology; Hemiplegia-complications; Hemiplegia-diagnosis; Hemiplegia-physiopathology; Laterality-; Middle-Age; Movement-Disorders-etiology; Movement-Disorders-physiopathology
MAJOR MeSH HEADINGS: *Cerebral-Infarction-diagnosis; *Dissociative-Disorders-diagnosis; *Hand-physiopathology; *Movement-Disorders-diagnosis
CHECKTAGS: Case-Report; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE; REVIEW; REVIEW-OF-REPORTED-CASES
MEDLINE ACCESSION NUMBER: 1999007884
UPDATE CODE: 199903
Record 3 of 16 in MEDLINE EXPRESS (R) 1996-1998
TITLE: Sensory alien hand syndrome: case report and review of the literature.
AUTHOR(S): Ay-H; Buonanno-FS; Price-BH; Le-DA; Koroshetz-WJ
ADDRESS OF AUTHOR: Department of Neurology, Stroke Service, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
SOURCE (BIBLIOGRAPHIC CITATION): J-Neurol-Neurosurg-Psychiatry. 1998 Sep; 65(3): 366-9
INTERNATIONAL STANDARD SERIAL NUMBER: 0022-3050
PUBLICATION YEAR: 1998
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: ENGLAND
ABSTRACT: An 81 year old right handed woman developed a left alien hand syndrome characterised by involuntary movements of choking and hitting the face, neck, and shoulder. The patient showed multiple disorders of primary sensation, sensory processing, hemispatial attention, and visual association, as well as a combination of sensory, optic, and cerebellar ataxia (triple ataxia) of the left arm in the absence of motor neglect or hemiparesis. Imaging studies disclosed subacute infarction in the right thalamus, hippocampus, inferior temporal lobes, splenium of corpus callosum, and occipital lobe due to right posterior cerebral artery occlusion. This rare syndrome should be considered as a "sensory" or "posterior" form of the alien hand syndrome, to be distinguished from the "motor" or "anterior" form described more commonly.
MINOR MESH HEADINGS: Aged-; Aged,-80-and-over; Brain-Mapping; Cerebral-Infarction-physiopathology; Dominance,-Cerebral-physiology; Hemiplegia-physiopathology; Magnetic-Resonance-Imaging; Neurologic-Examination; Sensation-Disorders-diagnosis; Sensation-Disorders-physiopathology; Tomography,-Emission-Computed
MAJOR MeSH HEADINGS: *Attention-physiology; *Awareness-physiology; *Cerebral-Infarction-diagnosis; *Hand-innervation; *Hemiplegia-diagnosis; *Laterality-physiology; *Motor-Activity-physiology
CHECKTAGS: Case-Report; Female; Human
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 1998397169
UPDATE CODE: 199811
Record 4 of 16 in MEDLINE EXPRESS (R) 1996-1998
TITLE: [An 81-year-old woman with progressive motor disturbance, extrapyramidal features, dementia, and oculomotor palsy (clinical conference)]
AUTHOR(S): Urabe-T; Mori-H; Sumino-S; Miwa-H; Wakiya-M; Shirai-T; Takubo-H; Mizuno-Y
ADDRESS OF AUTHOR: Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
SOURCE (BIBLIOGRAPHIC CITATION): No-To-Shinkei. 1998 Mar; 50(3): 291-301
INTERNATIONAL STANDARD SERIAL NUMBER: 0006-8969
PUBLICATION YEAR: 1998
LANGUAGE OF ARTICLE: JAPANESE; NON-ENGLISH
COUNTRY OF PUBLICATION: JAPAN
ABSTRACT: We report an 81-year-old woman who presented with motor disturbance in her right hand which was followed by parkinsonism, dementia, and supranuclear gaze palsy. She was well until her age of 73 (1989) when she had an onset of difficulty in using her right hand; she did not have weakness. She also developed small step gait. These symptoms had progressively become worse. She was admitted to our hospital in July of 1992 when she was 75 years old. On admission, she was alert and oriented, but she showed some difficulty in recent memory. She did not have aphasia or ideomotor apraxia, but she showed limb-kinetic apraxia in her right hand, ideational apraxia, dressing apraxia, constructional apraxia, tactile agnosia, and left-right disorientation. Alien-hand syndrome was observed in her right hand. Ocular movement was within normal limit for her age. She had oro-lingual dyskinesia. Otherwise, cranial nerves were intact. She walked in small-steps. She had rigidity and fine myoclonic movements in her right upper extremity. Deep reflexes were within normal limits and symmetric. Superficial and deep sensations were intact. Laboratory findings were unremarkable. She was discharged on August 15, 1992 for outpatient follow-up. Her motor and mental symptoms were progressive. By October of 1992, she developed supranuclear vertical gaze palsy, marked rigidity in the neck, and astereognosis. By June 1993, she became unable to walk without support. MRI taken in May of 1994 revealed atrophy of insular cortices, temporal lobe tips and parietal lobes more on the left side; the third ventricle was slightly dilated. She was admitted to another hospital on June 30, 1994. She had become a bed-ridden state with marked dementia and dysphagia. She developed fever on November 5, 1996 and expired on December 16 of the same year. She was discussed in a neurological CPC and the chief discussant arrived at the conclusion that the patient had corticobasal degeneration. Other diagnoses entertained included progressive supranuclear palsy, pallidonigroluysian atrophy, diffuse Lewy body disease, and Pick's disease. But the most of the participants agreed with the chief discussant's diagnosis. Post-mortem examination revealed aspiration pneumonia in the lungs and liver fibrosis apparently due to viral hepatitis. In the central nervous system, frontal and parietal lobes were atrophic more on the left side. Atrophy was accentuated in the superior frontal gyri, precentral and postcentral gyri, and superior and inferior parietal lobuli. Neuronal loss and astrocytosis were seen in these regions with scattered ballooned neurons. The substantia nigra showed marked neuronal loss and gliosis; neuronal loss was also seen in the pars reticulata. The outer and inner segments of globus pallidus and the periacqueductal gray matter showed gliosis, however, no apparent neuronal loss was seen. Putamen, subthalamic nucleus, and the dentate nucleus were preserved. Pathologic changes were consistent with the diagnosis of corticobasal degeneration. It was interesting to note that anti-tau immunostaining and Gallyas staining revealed neuropil threads and astrocytic plaques in the cortical areas, and intracytoplasmic inclusion bodies in the cortical neurons; these inclusions were not stained by Bodian stain. Tuft-shaped astrocytes which may be seen in progressive supranuclear palsy were not observed in this patient. Although corticobasal degeneration and progressive supranuclear palsy share some neurological features in common, this patient showed typical pathologic changes of corticobasal degeneration.
MINOR MESH HEADINGS: Aged-; Aged,-80-and-over; Agnosia-complications; Apraxia-complications; Basal-Ganglia-Diseases-physiopathology; English-Abstract; Evoked-Potentials,-Somatosensory; Movement-Disorders-physiopathology; Nerve-Degeneration
MAJOR MeSH HEADINGS: *Basal-Ganglia-Diseases-complications; *Movement-Disorders-complications; *Ophthalmoplegia-complications; *Supranuclear-Palsy,-Progressive-complications
CHECKTAGS: Case-Report; English-Abstract; Female; Human
PUBLICATION TYPE: CLINICAL-CONFERENCE; JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 1998227130
UPDATE CODE: 199807
Record 5 of 16 in MEDLINE EXPRESS (R) 1996-1998
TITLE: "Naturalization" of the alien hand: case report.
AUTHOR(S): Nicholas-JJ; Wichner-MH; Gorelick-PB; Ramsey-MM
ADDRESS OF AUTHOR: Department of Physical Medicine and Rehabilitation, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA.
SOURCE (BIBLIOGRAPHIC CITATION): Arch-Phys-Med-Rehabil. 1998 Jan; 79(1): 113-4
INTERNATIONAL STANDARD SERIAL NUMBER: 0003-9993
PUBLICATION YEAR: 1998
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: The alien hand syndrome is an involuntary motor phenomenon that occurs infrequently and mostly in stroke patients. A case is reported of a 67-year-old man with left hemiparesis whose hand crept and crawled, especially at night, which caused him to awaken by grasping his collar. The disturbing nocturnal activity of the hand was stilled by placing it in a common oven mitt.
MINOR MESH HEADINGS: Aged-; Circadian-Rhythm; Corpus-Callosum-pathology; Laterality-; Movement-Disorders-pathology; Movement-Disorders-physiopathology; Orthotic-Devices; Syndrome-
MAJOR MeSH HEADINGS: *Cerebrovascular-Disorders-complications; *Hand-physiopathology; *Hemiplegia-complications; *Motor-Activity; *Movement-Disorders-etiology; *Movement-Disorders-rehabilitation
CHECKTAGS: Case-Report; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 1998103611
UPDATE CODE: 199804
SUBSET: AIM
Record 6 of 16 in MEDLINE EXPRESS (R) 1996-1998
TITLE: Looking for the agent: an investigation into consciousness of action and self-consciousness in schizophrenic patients.
AUTHOR(S): Daprati-E; Franck-N; Georgieff-N; Proust-J; Pacherie-E; Dalery-J; Jeannerod-M
ADDRESS OF AUTHOR: Institut des Sciences Cognitives, CNRS UPR 9075, Lyon, France.
SOURCE (BIBLIOGRAPHIC CITATION): Cognition. 1997 Dec; 65(1): 71-86
INTERNATIONAL STANDARD SERIAL NUMBER: 0010-0277
PUBLICATION YEAR: 1997
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: NETHERLANDS
ABSTRACT: The abilities to attribute an action to its proper agent and to understand its meaning when it is produced by someone else are basic aspects of human social communication. Several psychiatric syndromes, such as schizophrenia, seem to lead to a dysfunction of the awareness of one's own action as well as of recognition of actions performed by others. Such syndromes offer a framework for studying the determinants of agency, the ability to correctly attribute actions to their veridical source. Thirty normal subjects and 30 schizophrenic patients with and without hallucinations and/or delusional experiences were required to execute simple finger and wrist movements, without direct visual control of their hand. The image of either their own hand or an alien hand executing the same or a different movement was presented on a TV-screen in real time. The task for the subjects was to discriminate whether the hand presented on the screen was their own or not. Hallucinating and deluded schizophrenic patients were more impaired in discriminating their own hand from the alien one than the non-hallucinating ones, and tended to misattribute the alien hand to themselves. Results are discussed according to a model of action control. A tentative description of the mechanisms leading to action consciousness is proposed.
MINOR MESH HEADINGS: Adult-; Delusions-etiology; Hallucinations-etiology; Middle-Age; Schizophrenic-Psychology
MAJOR MeSH HEADINGS: *Consciousness-physiology; *Psychomotor-Performance-physiology; *Schizophrenia-; *Self-Concept
CHECKTAGS: Comparative-Study; Female; Human; Male; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 1998116185
UPDATE CODE: 199807
Record 7 of 16 in MEDLINE EXPRESS (R) 1996-1998
TITLE: Isolated myoclonic alien hand as the sole presentation of pathologically established Creutzfeldt-Jakob disease: a report of two patients.
AUTHOR(S): MacGowan-DJ; Delanty-N; Petito-F; Edgar-M; Mastrianni-J; DeArmond-SJ
ADDRESS OF AUTHOR: Department of Neurology, New York Hospital, Cornell Medical Center, USA.
SOURCE (BIBLIOGRAPHIC CITATION): J-Neurol-Neurosurg-Psychiatry. 1997 Sep; 63(3): 404-7
INTERNATIONAL STANDARD SERIAL NUMBER: 0022-3050
PUBLICATION YEAR: 1997
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: ENGLAND
ABSTRACT: Creutzfeldt-Jakob disease may have many atypical presentations before the development of classic progressive dementia and startle myoclonus. In two patients with pathologically established disease association with a progressive alien hand syndrome was the sole initial manifestation of the disease.
MINOR MESH HEADINGS: Aged-; Fatal-Outcome; Perceptual-Disorders
MAJOR MeSH HEADINGS: *Creutzfeldt-Jakob-Syndrome-physiopathology; *Hand-physiopathology; *Myoclonus-physiopathology
CHECKTAGS: Case-Report; Female; Human
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 1997466926
UPDATE CODE: 199801
Record 8 of 16 in MEDLINE EXPRESS (R) 1996-1998
TITLE: Isolation of a right hemisphere cognitive system in a patient with anarchic (alien) hand sign.
AUTHOR(S): Baynes-K; Tramo-MJ; Reeves-AG; Gazzaniga-MS
ADDRESS OF AUTHOR: Center for Neuroscience, University of California, Davis 95616, USA. kbaynes@ucdavis.edu
SOURCE (BIBLIOGRAPHIC CITATION): Neuropsychologia. 1997 Aug; 35(8): 1159-73
INTERNATIONAL STANDARD SERIAL NUMBER: 0028-3932
PUBLICATION YEAR: 1997
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: ENGLAND
ABSTRACT: We report evidence of isolated conceptual knowledge in the right hemisphere of a woman with chronic anarchic hand sign after ischemic infarction of the central four-fifths of the corpus callosum. Limited visual information was available to the right hemisphere, access to medial temporal structures subserving memory was disrupted and disconnection from left hemisphere language structures was complete. Still, the right hemisphere could build mental representations of objects via tactile input and use them in cross-modal matching. These representations were not accessed consistently in auditory comprehension or naming tasks. This functional specificity and its pathoanatomical correlates demonstrate that the study of anarchic hand sign can illuminate not just motor control issues but may inform our understanding of the representation and lateralization of conceptual knowledge as well.
MINOR MESH HEADINGS: Brain-Diseases-etiology; Cerebrovascular-Disorders-pathology; Cerebrovascular-Disorders-physiopathology; Corpus-Callosum-pathology; Knowledge-; Laterality-; Magnetic-Resonance-Imaging; Middle-Age
MAJOR MeSH HEADINGS: *Brain-Diseases-physiopathology; *Cerebrovascular-Disorders-complications; *Cognition-physiology; *Corpus-Callosum-physiopathology
CHECKTAGS: Case-Report; Female; Human; Support,-U.S.-Gov't,-P.H.S.
PUBLICATION TYPE: JOURNAL-ARTICLE
CONTRACT OR GRANT NUMBERS: R29DC00811DCNIDCD; MH18012MHNIMH; NS22626NSNINDS
MEDLINE ACCESSION NUMBER: 1997398483
UPDATE CODE: 199712
Record 9 of 16 in MEDLINE EXPRESS (R) 1996-1998
TITLE: [Involuntary motor activity or alien hand syndrome following ischemic lesion sparing medial frontal cortex]
ORIGINAL TITLE: Activite motrice involontaire ou "alien hand syndrome" a l'issue d'une lesion ischemique respectant le cortex frontal median.
AUTHOR(S): Pageot-N; Nighoghossian-N; Derex-L; Bascoulergue-Y; Trouilias-P
ADDRESS OF AUTHOR: Service de Neurologie B, Centre d'Urgences Cerebrovasculaires et de Recherches sur l'Ataxie, Lyon.
SOURCE (BIBLIOGRAPHIC CITATION): Rev-Neurol-Paris. 1997 Jun; 153(5): 339-43
INTERNATIONAL STANDARD SERIAL NUMBER: 0035-3787
PUBLICATION YEAR: 1997
LANGUAGE OF ARTICLE: FRENCH; NON-ENGLISH
COUNTRY OF PUBLICATION: FRANCE
ABSTRACT: We report a case of a left alien hand syndrome without grasp reflex, inter-manual conflict or sensory impairement after an infarction involving the striatum, premotor lateral cortex and colossal fibers but sparing medical premotor cortex. According to the location of the lesion, the mechanism underlying this clinical feature might mainly involve cortico-putamino-thalamo-cortical loop which links extrapyramidal system to medial premotor cortex.
MINOR MESH HEADINGS: Brain-physiopathology; Cerebral-Infarction-diagnosis; Cerebral-Infarction-physiopathology; English-Abstract; Hand-physiopathology; Magnetic-Resonance-Imaging; Middle-Age; Movement-Disorders-diagnosis; Movement-Disorders-physiopathology; Syndrome-
MAJOR MeSH HEADINGS: *Cerebral-Infarction-complications; *Hand-; *Movement-Disorders-etiology
CHECKTAGS: Case-Report; English-Abstract; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 1997441950
UPDATE CODE: 199712
Record 10 of 16 in MEDLINE EXPRESS (R) 1996-1998
TITLE: Alien hand syndrome: influence of neglect on the clinical presentation of frontal and callosal variants.
AUTHOR(S): Chan-JL; Ross-ED
ADDRESS OF AUTHOR: Department of Neurology, Chang Gung Memorial Hospital, Taipei, Taiwan.
SOURCE (BIBLIOGRAPHIC CITATION): Cortex. 1997 Jun; 33(2): 287-99
INTERNATIONAL STANDARD SERIAL NUMBER: 0010-9452
PUBLICATION YEAR: 1997
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: ITALY
ABSTRACT: Three patients with mesial frontal and extensive callosal lesions due to anterior cerebral artery infarction manifested an alien hand syndrome (AHS) with varied features. Patient 1 with left hemispheric lesion showed right hand's impulsive reaching and grasping and left hand's antagonistic movements to the right (intermanual conflict; IMC). Patients 2 and 3 with right hemispheric lesion manifested a left hemihypokinesia which was thought to have suppressed the frequency and amplitude or even the occurrence of left hand's reaching and grasping. IMC and other left hand's non-antagonistic, irrelevant movements to the right remained. Because the term "IMC" is often misused and not strictly defined, its association with right hand's reaching and grasping is quite uncommon, its significance as a sign of callosal disconnection is not well validated, and because left hand's reaching and grasping tend to be suppressed by motor neglect, a trend may then develop for the right hand to be the sole focus of pathological behaviour in patients with the so-called frontal AHS (Feinberg, Schindler, Flanagan et al., 1992).
MINOR MESH HEADINGS: Aged-; Agnosia-diagnosis; Agnosia-psychology; Apraxia-diagnosis; Apraxia-physiopathology; Apraxia-psychology; Brain-Damage,-Chronic-diagnosis; Brain-Damage,-Chronic-physiopathology; Brain-Damage,-Chronic-psychology; Brain-Mapping; Cerebral-Infarction-physiopathology; Cerebral-Infarction-psychology; Hand-innervation; Middle-Age; Neuropsychological-Tests; Psychomotor-Performance-physiology
MAJOR MeSH HEADINGS: *Agnosia-physiopathology; *Attention-physiology; *Awareness-physiology; *Cerebral-Infarction-diagnosis; *Corpus-Callosum-physiopathology; *Frontal-Lobe-physiopathology; *Laterality-physiology
CHECKTAGS: Case-Report; Female; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 1997363967
UPDATE CODE: 199710
Record 11 of 16 in MEDLINE EXPRESS (R) 1996-1998
TITLE: [Cortico-basal degeneration]
AUTHOR(S): Morimatsu-M
ADDRESS OF AUTHOR: Department of Neurology, Yamaguchi University School of Medicine.
SOURCE (BIBLIOGRAPHIC CITATION): Nippon-Rinsho. 1997 Jan; 55(1): 139-43
INTERNATIONAL STANDARD SERIAL NUMBER: 0047-1852
PUBLICATION YEAR: 1997
LANGUAGE OF ARTICLE: JAPANESE; NON-ENGLISH
COUNTRY OF PUBLICATION: JAPAN
ABSTRACT: Corticobasal degeneration (CBD) is not rare disease, because in our clinic 13 patients were observed for the past 8 years, with ratio to those with Parkinson's disease being 1:18. Our clinical criteria of this disease consist of the combination of 1) limb-kinetic apraxia as cortical sign, 2) akinetic-rigid sign as extrapyramidal sign, 3) their marked asymmetry, and as additional findings, 4) the presence of grasp reflex, alien hand sign, reflex myoclonus, limb dystonia, and others, and 5) neuroimagings (MRI, SPECT) suggestive of asymmetric cortical lesions. There are reports indicating that clinical CBD was diagnosed as Pick's disease, progressive supranuclear palsy and Alzheimer's disease, pathologically. Therefore, more basic investigations, especially from molecular biology are necessary to discriminate these corticobasal complex disorders.
MINOR MESH HEADINGS: Adult-; Aged-; Diagnosis,-Differential; English-Abstract; Middle-Age; Spinocerebellar-Degeneration-pathology; Spinocerebellar-Degeneration-physiopathology
MAJOR MeSH HEADINGS: *Basal-Ganglia-pathology; *Cerebral-Cortex-pathology; *Spinocerebellar-Degeneration-diagnosis
CHECKTAGS: English-Abstract; Female; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE; REVIEW; REVIEW,-TUTORIAL
MEDLINE ACCESSION NUMBER: 1997166740
UPDATE CODE: 199705
Record 12 of 16 in MEDLINE EXPRESS (R) 1996-1998
TITLE: Corticobasal degeneration: widespread argentophilic threads and glia in addition to neurofibrillary tangles. Similarities of cytoskeletal abnormalities in corticobasal degeneration and progressive supranuclear palsy.
AUTHOR(S): Takahashi-T; Amano-N; Hanihara-T; Nagatomo-H; Yagishita-S; Itoh-Y; Yamaoka-K; Toda-H; Tanabe-T
ADDRESS OF AUTHOR: Division of Neurology and Psychiatry, Kanagawa Rehabilitation Center, Atsugi, Japan. QZM00531@niftyserve.or.jp
SOURCE (BIBLIOGRAPHIC CITATION): J-Neurol-Sci. 1996 Jun; 138(1-2): 66-77
INTERNATIONAL STANDARD SERIAL NUMBER: 0022-510X
PUBLICATION YEAR: 1996
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: NETHERLANDS
ABSTRACT: A 57-year-old man had exhibited cortical sensory disturbance, rigidity, spasticity, dementia, alien hand, grasp reflex, supranuclear ophthalmoplegia, pseudobulbar palsy, and neck dystonia for 4 years. Histological examination of autopsied specimens revealed neuronal loss in the cerebral cortex, with ballooned neurons, subthalamic nucleus, substantia nigra, basal ganglia, midbrain tegmentum, and the thalamus. There were neurofibrillary tangles in the subthalamic nucleus and the substantia nigra. Gallyas-Braak silver impregnation demonstrated numerous argentophilic tangles, threads, and a few argentophilic glia in the cerebral cortex, subcortical white matter, particularly in the precentral gyrus, subcortical nuclei, and the brainstem. These argentophilic structures were largely positive for tau, and negative for ubiquitin, paired helical filaments, and phosphorylated neurofilament. Ultrastructurally, 15-nm-wide straight tubules were observed in the neurons of the substantia nigra, globus pallidus, and the precentral cortex, coexisting with a few twisted tubules periodically constricted at 160- to 230-nm intervals. It was conclusively shown that Gallyas- and tau-positive cytoskeletal abnormalities occurred widely in brain of corticobasal degeneration. Both distribution and morphology of abnormal phosphorylated tau protein in corticobasal degeneration appear to resemble these features in progressive supranuclear palsy. These findings suggest a common cytoskeletal etiopathological significance in corticobasal degeneration and progressive supranuclear palsy.
MINOR MESH HEADINGS: Basal-Ganglia-pathology; Cerebral-Cortex-pathology; Immunohistochemistry-; Laterality-physiology; Microscopy,-Electron; Middle-Age; Neuroglia-pathology; Silver-Staining
MAJOR MeSH HEADINGS: *Basal-Ganglia-physiopathology; *Cerebral-Cortex-physiopathology; *Cytoskeleton-ultrastructure; *Nerve-Degeneration-physiology; *Neurofibrillary-Tangles-pathology; *Supranuclear-Palsy,-Progressive-pathology
CHECKTAGS: Case-Report; Comparative-Study; Human; Male; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 1996383377
UPDATE CODE: 199702
Record 13 of 16 in MEDLINE EXPRESS (R) 1996-1998
TITLE: Leg manifestation in alien hand syndrome.
AUTHOR(S): Chan-JL; Chen-RS; Ng-KK
ADDRESS OF AUTHOR: Department of Neurology, Chang Gung Memorial Hospital and College of Medicine and Technology, Taipei, Taiwan, ROC.
SOURCE (BIBLIOGRAPHIC CITATION): J-Formos-Med-Assoc. 1996 Apr; 95(4): 342-6
INTERNATIONAL STANDARD SERIAL NUMBER: 0929-6646
PUBLICATION YEAR: 1996
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: TAIWAN
ABSTRACT: A patient with left alien hand syndrome (AHS) accompanied by leg symptoms due to right anterior cerebral artery territory infarction is reported. Magnetic resonance imaging demonstrated that the responsible lesion involved the right anterior cingulate gyrus, supplementary motor area, medical prefrontal cortex and corpus callosum extending from the genu to the isthmus. The leg symptoms included: 1) motor perseveration manifesting as compulsive straight walking with difficulty stopping on command; 2) dissociation between mind and action resulting in going to unintended places with subsequent complaints of poor memory not due to spatial disorientation; 3) discrepancy between verbal and actual leg motor responses to auditory verbal suggestions; and 4) movement dissociation between the legs resulting in transient standing still or brief sticking to the ground, a situation simulating akinesia. As the legs usually perform together to coordinate movements of standing and walking, unlike the hands performing well-learned, skilled unimanual or bimanual coordinating movements, the counterpart in the leg of the alien hand sign in AHS was not manifested. Nevertheless, in the presence of AHS, the associated leg symptoms bear similar neurobehavioral features and should be dealt with on equal terms.
MINOR MESH HEADINGS: Cerebral-Infarction-diagnosis; Magnetic-Resonance-Imaging; Middle-Age; Syndrome-
MAJOR MeSH HEADINGS: *Cerebral-Infarction-complications; *Hand-; *Leg-; *Movement-Disorders-etiology
CHECKTAGS: Case-Report; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 1997089399
UPDATE CODE: 199702
Record 14 of 16 in MEDLINE EXPRESS (R) 1996-1998
TITLE: Alien hand syndrome of the dominant hand and ideomotor apraxia of the nondominant hand.
AUTHOR(S): Kischka-U; Ettlin-TM; Lichtenstern-L; Riedo-C
ADDRESS OF AUTHOR: Department of Neurology, University of Magdeburg, Germany.
SOURCE (BIBLIOGRAPHIC CITATION): Eur-Neurol. 1996; 36(1): 39-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0014-3022
PUBLICATION YEAR: 1996
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: SWITZERLAND
ABSTRACT: Following an extended infarction in the territory of the left anterior cerebral artery including the anterior corpus callosum, a 66-year-old right-handed man exhibited an alien hand syndrome on the right side and an ideomotor apraxia of the left hand. In addition to other typical symptoms of frontal lobe lesions, he presented with an interesting difference in the manifestation of perseveration in either hand. In the right hand, the perseveration was part of the alien hand syndrome, whereas in the left hand perseveration showed in the inability to switch promptly from one movement to another on instruction during praxis testing.
MINOR MESH HEADINGS: Aged-; Apraxia-etiology; Brain-physiopathology; Cerebrovascular-Disorders-complications; Cerebrovascular-Disorders-diagnosis; Cerebrovascular-Disorders-physiopathology; Movement-Disorders-etiology; Syndrome-; Tomography,-X-Ray-Computed
MAJOR MeSH HEADINGS: *Apraxia-complications; *Hand-physiopathology; *Movement-Disorders-complications; *Movement-Disorders-physiopathology
CHECKTAGS: Case-Report; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 1996357625
UPDATE CODE: 199701
Record 15 of 16 in MEDLINE EXPRESS (R) 1996-1998
TITLE: [The alien hand sign]
AUTHOR(S): Tanaka-Y
ADDRESS OF AUTHOR: Department of Neurology, Jichi Medical School, Tochigi, Japan.
SOURCE (BIBLIOGRAPHIC CITATION): No-To-Shinkei. 1996 Mar; 48(3): 229-38
INTERNATIONAL STANDARD SERIAL NUMBER: 0006-8969
PUBLICATION YEAR: 1996
LANGUAGE OF ARTICLE: JAPANESE; NON-ENGLISH
COUNTRY OF PUBLICATION: JAPAN
MINOR MESH HEADINGS: Corpus-Callosum-physiopathology; Frontal-Lobe-pathology; Frontal-Lobe-physiopathology; Hand-physiopathology; Hand-Strength; Reflex-
MAJOR MeSH HEADINGS: *Hand-; *Movement-Disorders-physiopathology
CHECKTAGS: Human
PUBLICATION TYPE: JOURNAL-ARTICLE; REVIEW; REVIEW,-TUTORIAL
MEDLINE ACCESSION NUMBER: 1997021973
UPDATE CODE: 199701
Record 16 of 16 in MEDLINE EXPRESS (R) 1996-1998
TITLE: Transient alien hand syndrome: is this a seizure or a transient ischaemic attack? [letter]
AUTHOR(S): Andre-C; Dominques-RC
SOURCE (BIBLIOGRAPHIC CITATION): J-Neurol-Neurosurg-Psychiatry. 1996 Feb; 60(2): 232-3
INTERNATIONAL STANDARD SERIAL NUMBER: 0022-3050
PUBLICATION YEAR: 1996
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: ENGLAND
MINOR MESH HEADINGS: Middle-Age; Syndrome-
MAJOR MeSH HEADINGS: *Cerebral-Ischemia,-Transient-physiopathology; *Hand-physiopathology
CHECKTAGS: Case-Report; Human; Male
PUBLICATION TYPE: LETTER
MEDLINE ACCESSION NUMBER: 1996225751
UPDATE CODE: 199611