The following MEDLINE items were compiled by SilverPlatter and are presented with their generous cooperation and permission. (See SilverPlatter's Worldwide Library for bibliographic search information.)For a non-technical summary of Andermann's syndrome, try here!
Record 1 of 30 in MEDLINE (R) 1999 Part B
TITLE: Exceptionally long absence status: multifactorial etiology, drug interactions and complications.
AUTHOR: D'Agostino,-M-D; Andermann,-F; Dubeau,-F; Fedi,-M; Bastos,-A
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
SOURCE: Epileptic-Disord. 1999 Dec; 1(4): 229-32
INTERNATIONAL STANDARD SERIAL NUMBER: 1294-9361
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: FRANCE
ABSTRACT: To our knowledge, petit mal status lasting longer than 2-3 days has been documented only once [1]. We report a 66 year-old man with well-documented, idiopathic generalized epilepsy who developed petit mal status lasting 6 weeks. Valproate levels remained low because of interactions with phenytoin. When phenytoin was discontinued, valproate levels increased, and he progressively improved. Chronic ischemic changes in the white matter may have been an additional factor in the causation and, most likely, in the duration of his status. Exceptionally long status and stupor increase the risk of medical complications. Valproate remains the medication of choice for the treatment of petit mal status. Despite the extraordinary course in this patient, complete recovery took place, confirming the benign nature of even such a prolonged episode.
MAJOR MESH DESCRIPTORS: *Anticonvulsants-adverse-effects; *Brain-Ischemia-complications; *Epilepsy,-Generalized-drug-therapy; *Phenytoin-adverse-effects; *Status-Epilepticus-etiology; *Valproic-Acid-adverse-effects
MINOR MESH DESCRIPTORS: Aged-; Anticonvulsants-therapeutic-use; Brain-Ischemia-diagnosis; Dementia,-Vascular-complications; Dementia,-Vascular-diagnosis; Drug-Interactions; Hernia,-Inguinal-surgery; Phenytoin-therapeutic-use; Postoperative-Complications-diagnosis; Postoperative-Complications-drug-therapy; Postoperative-Complications-etiology; Status-Epilepticus-diagnosis; Status-Epilepticus-drug-therapy; Valproic-Acid-therapeutic-use
CHECKTAGS: Case-Report; Human; Male
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: adverse-effects; therapeutic-use; complications; diagnosis; drug-therapy; surgery; etiology
CAS REGISTRY NUMBER OR EC NUMBER: 0; 57-41-0; 99-66-1
NAME OF SUBSTANCE: Anticonvulsants; Phenytoin; Valproic-Acid
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20392849
RECORD FEATURES: ABSTRACT (AB)
Record 2 of 30 in MEDLINE (R) 1999 Part B
TITLE: Mapping of a gene determining familial partial epilepsy with variable foci to chromosome 22q11-q12.
AUTHOR: Xiong,-L; Labuda,-M; Li,-D-S; Hudson,-T-J; Desbiens,-R; Patry,-G; Verret,-S; Langevin,-P; Mercho,-S; Seni,-M-H; Scheffer,-I; Dubeau,-F; Berkovic,-S-F; Andermann,-F; Andermann,-E; Pandolfo,-M
ADDRESS OF AUTHOR: Centre Hospitalier de Universite de Montreal, Hopital Notre-Dame, Montreal, QC, H2L 4M1 Canada.
SOURCE: Am-J-Hum-Genet. 1999 Dec; 65(6): 1698-710
INTERNATIONAL STANDARD SERIAL NUMBER: 0002-9297
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: We identified two large French-Canadian families segregating a familial partial epilepsy syndrome with variable foci (FPEVF) characterized by mostly nocturnal seizures arising from frontal, temporal, and occasionally occipital epileptic foci. There is no evidence for structural brain damage or permanent neurological dysfunction. The syndrome is inherited as an autosomal dominant trait with incomplete penetrance. We mapped the disease locus to a 3. 8-cM interval on chromosome 22q11-q12, between markers D22S1144 and D22S685. Using the most conservative diagnostic scheme, the maximum cumulative LOD score was 6.53 at recombination fraction (straight theta) 0 with D22S689. The LOD score in the larger family was 5.34 at straight theta=0 with the same marker. The two families share an identical linked haplotype for >/=10 cM, including the candidate interval, indicating a recent founder effect. A severe phenotype in one of the probands may be caused by homozygosity for the causative mutation, as suggested by extensive homozygosity for the linked haplotype and a bilineal family history of epilepsy. An Australian family with a similar phenotype was not found to link to chromosome 22, indicating genetic heterogeneity of FPEVF.
MAJOR MESH DESCRIPTORS: *Chromosome-Mapping; *Chromosomes,-Human,-Pair-22-genetics; *Epilepsies,-Partial-genetics; *Linkage-Genetics-genetics
MINOR MESH DESCRIPTORS: Australia-; Canada-; Founder-Effect; Genes,-Dominant-genetics; Genetic-Heterogeneity; Genetic-Markers; Haplotypes-genetics; Homozygote-; Pedigree-; Penetrance-; Polymorphism-Genetics-genetics; Receptors,-Purinergic-P1-genetics; Recombination,-Genetic-genetics
CHECKTAGS: Female; Human; Male; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: genetics
CAS REGISTRY NUMBER OR EC NUMBER: 0; 0
NAME OF SUBSTANCE: Genetic-Markers; Receptors,-Purinergic-P1
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20046905
RECORD FEATURES: ABSTRACT (AB)
Record 3 of 30 in MEDLINE (R) 1999 Part B
TITLE: Epilepsy as a dynamic disorder: a clinical perspective.
AUTHOR: Andermann,-F
ADDRESS OF AUTHOR: Department of Neurology and Pediatrics, McGill University, Montreal Neurological Hospital and Institute, Quebec, Canada.
SOURCE: Adv-Neurol. 1999; 817-10
INTERNATIONAL STANDARD SERIAL NUMBER: 0091-3952
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
MAJOR MESH DESCRIPTORS: *Epilepsy-physiopathology
MINOR MESH DESCRIPTORS: Child-Development; Child,-Preschool; Disease-Progression; Epilepsy-etiology; Epilepsy-psychology
CHECKTAGS: Human
PUBLICATION TYPE: Journal-Article; Review; Review,-Tutorial
SUBHEADINGS: etiology; physiopathology; psychology
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20076997
Record 4 of 30 in MEDLINE (R) 1999 Part B
TITLE: The running down phenomenon in temporal lobe epilepsy.
AUTHOR: Salanova,-V; Rasmussen,-T; Andermann,-F
ADDRESS OF AUTHOR: Department of Neurosurgery, University Hospital, Indianapolis, Indiana, USA.
SOURCE: Adv-Neurol. 1999; 81165-9
INTERNATIONAL STANDARD SERIAL NUMBER: 0091-3952
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-surgery
MINOR MESH DESCRIPTORS: Cerebral-Cortex-physiopathology; Electroencephalography-; Epilepsy,-Temporal-Lobe-complications; Epilepsy,-Temporal-Lobe-physiopathology; Incidence-; Postoperative-Complications; Postoperative-Period; Seizures-epidemiology; Seizures-etiology; Seizures-physiopathology; Treatment-Outcome
CHECKTAGS: Human
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: physiopathology; complications; surgery; epidemiology; etiology
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20077013
Record 5 of 30 in MEDLINE (R) 1999 Part B
TITLE: Dual pathology and its clinical relevance.
AUTHOR: Cendes,-F; Li,-L-M; Andermann,-F; Watson,-C; Fish,-D-R; Shorvon,-S-D; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology, FCM-University of Campinas-UNICAMP, Distrito de Barao Geraldo, Campinas, Brazil.
SOURCE: Adv-Neurol. 1999; 81153-64
INTERNATIONAL STANDARD SERIAL NUMBER: 0091-3952
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
MAJOR MESH DESCRIPTORS: *Epilepsies,-Partial-diagnosis; *Gliosis-diagnosis; *Hippocampus-pathology; *Magnetic-Resonance-Imaging; *Neurons-pathology
MINOR MESH DESCRIPTORS: Epilepsies,-Partial-surgery; Sclerosis-; Treatment-Outcome
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article; Review; Review,-Tutorial
SUBHEADINGS: diagnosis; surgery; pathology
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20077012
Record 6 of 30 in MEDLINE (R) 1999 Part B
TITLE: Migraine aura, seizures, and temporal lobe epilepsy.
AUTHOR: Hart,-Y-M; Andermann,-F
ADDRESS OF AUTHOR: Department of Neurology, Atkinson Morley's Hospital, London, United Kingdom.
SOURCE: Adv-Neurol. 1999; 81145-52
INTERNATIONAL STANDARD SERIAL NUMBER: 0091-3952
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
MAJOR MESH DESCRIPTORS: *Classic-Migraine-complications; *Epilepsy,-Temporal-Lobe-complications; *Seizures-complications
MINOR MESH DESCRIPTORS: Adult-; Child-; Epilepsy-etiology
CHECKTAGS: Case-Report; Female; Human; Male
PUBLICATION TYPE: Journal-Article; Review; Review,-Tutorial
SUBHEADINGS: complications; etiology
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20077011
Record 7 of 30 in MEDLINE (R) 1999 Part B
TITLE: Occipitotemporal relations: evidence for secondary epileptogenesis.
AUTHOR: Palmini,-A; Andermann,-F; Dubeau,-F; da-Costa,-J-C; Calcagnotto,-M-E; Gloor,-P; Olivier,-A; Paglioli,-E; Paglioli-Neto,-E
ADDRESS OF AUTHOR: Department of Internal Medicine, Hospital Sao Lucas da PUCRS, Porto Alegre, Brazil.
SOURCE: Adv-Neurol. 1999; 81115-29
INTERNATIONAL STANDARD SERIAL NUMBER: 0091-3952
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
MAJOR MESH DESCRIPTORS: *Epilepsy-physiopathology; *Occipital-Lobe-physiopathology; *Temporal-Lobe-physiopathology
MINOR MESH DESCRIPTORS: Electrodes,-Implanted; Electroencephalography-instrumentation; Electroencephalography-methods; Epilepsy-surgery
CHECKTAGS: Human
PUBLICATION TYPE: Journal-Article; Review; Review,-Tutorial
SUBHEADINGS: instrumentation; methods; physiopathology; surgery
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20077009
Record 8 of 30 in MEDLINE (R) 1999 Part B
TITLE: Presurgical motor and somatosensory cortex mapping with functional magnetic resonance imaging and positron emission tomography.
AUTHOR: Bittar,-R-G; Olivier,-A; Sadikot,-A-F; Andermann,-F; Pike,-G-B; Reutens,-D-C
ADDRESS OF AUTHOR: Montreal Neurological Institute and Hospital and Department of Neurology and Neurosurgery, McGill University, Quebec, Canada.
SOURCE: J-Neurosurg. 1999 Dec; 91(6): 915-21
INTERNATIONAL STANDARD SERIAL NUMBER: 0022-3085
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: OBJECT: Accurate identification of eloquent cortex is important to ensure that resective surgery in the region surrounding the central sulcus is performed with minimum risk of permanent neurological deficit. Functional localization has traditionally been accomplished using intraoperative cortical stimulation (ICS). However, this technique suffers from several disadvantages that make the development and validation of noninvasive methods desirable. Functional localization accomplished by activation studies in which positron emission tomography (PET) scanning and the tracer [15O]H2O have been used has been shown to correlate well with the results of ICS. Another noninvasive method for functional localization is functional magnetic resonance (fMR) imaging. We compared the locations of activation peaks obtained in individual patients using fMR and [15O]H2O PET imaging. METHODS: Twenty-six combined PET activation-fMR imaging studies were performed in 11 patients who were admitted for evaluation before undergoing surgery in the region surrounding the central sulcus. The PET scans were obtained using bolus injections of the cerebral blood flow tracer [15O]H2O (10 mCi). Multislice T2*-weighted gradient-echo echoplanar images were acquired using a 1.5-tesla MR imaging system. Activation maps were aligned with anatomical MR images and transformed into stereotactic space, after which the locations of activation peaks obtained using both modalities were compared. The average distance between activation peaks obtained using fMR imaging and those obtained using PET imaging was 7.9+/-4.8 mm (p>0.05), with 96% of the peaks being located on either the same or adjacent sulci and gyri. Overlapping of voxels activated by each modality occurred in 92% of the studies. Functional MR imaging failed to activate the primary sensorimotor cortex in one study and produced results that were ambiguous in the clinical setting in three cases. CONCLUSIONS: Overall, fMR imaging produced activation that correlated well with that obtained using PET scanning. Discrepancies between the sites of activation identified using these two techniques may reflect differences in their physiological bases.
MAJOR MESH DESCRIPTORS: *Brain-Diseases-surgery; *Brain-Mapping; *Brain-Neoplasms-surgery; *Magnetic-Resonance-Imaging; *Motor-Cortex-surgery; *Somatosensory-Cortex-surgery; *Tomography,-Emission-Computed
MINOR MESH DESCRIPTORS: Brain-Diseases-diagnosis; Brain-Diseases-physiopathology; Brain-Neoplasms-diagnosis; Brain-Neoplasms-physiopathology; Dominance,-Cerebral-physiology; Epilepsy-diagnosis; Epilepsy-physiopathology; Epilepsy-surgery; Motor-Cortex-physiopathology; Sensitivity-and-Specificity; Somatosensory-Cortex-physiopathology
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: diagnosis; physiopathology; surgery; physiology
SUBSET: Abridged-Index-Medicus; Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20049530
RECORD FEATURES: ABSTRACT (AB)
Record 9 of 30 in MEDLINE (R) 1999 Part B
TITLE: The Camera-Marugo-Cohen syndrome: report of two new patients.
AUTHOR: Lambert,-D-M; Watters,-G; Andermann,-F; Der-Kaloustian,-V-M
ADDRESS OF AUTHOR: F. Clarke Fraser Clinical Genetics Unit, Division of Medical Genetics, Department of Pediatrics, Montreal Children's Hospital, Quebec, Canada.
SOURCE: Am-J-Med-Genet. 1999 Sep 17; 86(3): 208-14
INTERNATIONAL STANDARD SERIAL NUMBER: 0148-7299
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: This report describes two unrelated patients with obesity, mental retardation, body asymmetry, and muscle weakness. Several obesity syndromes with common characteristics have been described. Findings in our patients, in addition to those of the previously reported cases, include body asymmetry, characteristic physiognomy, lordosis, and typical anomalies of hands and feet. These physical manifestations correspond to the Camera-Marugo-Cohen syndrome. Our patients represent the second and third cases of this condition. Copyright 1999 Wiley-Liss, Inc.
MAJOR MESH DESCRIPTORS: *Abnormalities,-Multiple-genetics; *Mental-Retardation-genetics; *Obesity-genetics
MINOR MESH DESCRIPTORS: Adult-; Child-; Foot-Deformities,-Congenital-genetics; Hand-Deformities,-Congenital-genetics; Hormones-blood; Lordosis-genetics; Syndrome-
CHECKTAGS: Case-Report; Human; Male; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: genetics; blood
CAS REGISTRY NUMBER OR EC NUMBER: 0
NAME OF SUBSTANCE: Hormones
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99413854
RECORD FEATURES: ABSTRACT (AB)
Record 10 of 30 in MEDLINE (R) 1999 Part B
TITLE: Cortical dysplasias, genetics, and epileptogenesis.
AUTHOR: Guerrini,-R; Andermann,-E; Avoli,-M; Dobyns,-W-B
ADDRESS OF AUTHOR: Department of Child Neurology and Psychiatry, University of Pisa, Italy.
SOURCE: Adv-Neurol. 1999; 7995-121
INTERNATIONAL STANDARD SERIAL NUMBER: 0091-3952
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
MAJOR MESH DESCRIPTORS: *Cerebral-Cortex-abnormalities; *Epilepsy-etiology
MINOR MESH DESCRIPTORS: Abnormalities-genetics
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article; Review; Review,-Tutorial
SUBHEADINGS: genetics; abnormalities; etiology
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99444397
Record 11 of 30 in MEDLINE (R) 1999 Part B
TITLE: History of Joubert syndrome and a 30-year follow-up of the original proband.
AUTHOR: Andermann,-F; Andermann,-E; Ptito,-A; Fontaine,-S; Joubert,-M
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, McGill University, Montreal, QC. mida@musica.mcgill.ca
SOURCE: J-Child-Neurol. 1999 Sep; 14(9): 565-9
INTERNATIONAL STANDARD SERIAL NUMBER: 0883-0738
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: The 1960s were a period of great flowering in the recognition of neurologic disorders in children. The so-called ataxic cerebral palsies were an especially fertile field waiting for clarification. Congenital ataxia coupled with hyperpnea-apnea, abnormal eye movements, and retardation was identified as an autosomal-recessive syndrome eponimically associated with the senior author, Marie Joubert. The disorder, though rare, is increasingly recognized and a lay society dedicated to family support and research has been formed. In preparation for a recent symposium the original proband was re-examined 30 years later and the manifestations in adults clarified. Severe dysarthria was the most striking feature in this man, the hyperpnea-apnea had diminished, and the abnormal eye movements were less striking. Ataxia was still present but not severe. Poor judgment and borderline intelligence rounded out the clinical picture. Modern imaging has clarified, in part, the anatomic basis of this syndrome.
MAJOR MESH DESCRIPTORS: *Cerebellum-abnormalities; *Dysarthria-genetics; *Mental-Retardation-genetics; *Mental-Retardation-history
MINOR MESH DESCRIPTORS: Adult-; Cerebellar-Ataxia-genetics; Cerebellar-Ataxia-history; Cerebellum-pathology; Follow-Up-Studies; History-of-Medicine,-20th-Cent.; Infant-; Magnetic-Resonance-Imaging; Neuropsychological-Tests; Ocular-Motility-Disorders-genetics; Ocular-Motility-Disorders-history; Respiration-Disorders-genetics; Respiration-Disorders-history; Sleep-Disorders; Syndrome-
CHECKTAGS: Case-Report; Human; Male
PUBLICATION TYPE: Historical-Article; Journal-Article
SUBHEADINGS: genetics; history; abnormalities; pathology
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99417003
RECORD FEATURES: ABSTRACT (AB)
Record 12 of 30 in MEDLINE (R) 1999 Part B
TITLE: Familial agenesis of the cerebellar vermis: a syndrome of episodic hyperpnea, abnormal eye movements, ataxia, and retardation. 1969.
AUTHOR: Joubert,-M; Eisenring,-J-J; Robb,-J-P; Andermann,-F
SOURCE: J-Child-Neurol. 1999 Sep; 14(9): 554-64
INTERNATIONAL STANDARD SERIAL NUMBER: 0883-0738
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
MAJOR MESH DESCRIPTORS: *Cerebellar-Ataxia-history; *Cerebellum-abnormalities; *Mental-Retardation-history; *Ocular-Motility-Disorders-history; *Respiration-Disorders-history
MINOR MESH DESCRIPTORS: Cerebellar-Ataxia-genetics; Child,-Preschool; Genes,-Recessive; History-of-Medicine,-20th-Cent.; Infant-; Mental-Retardation-genetics; Ocular-Motility-Disorders-genetics; Pedigree-; Respiration-Disorders-genetics; Syndrome-
CHECKTAGS: Case-Report; Female; Human; Male
PUBLICATION TYPE: Classical-Article; Historical-Article; Journal-Article
SUBHEADINGS: genetics; history; abnormalities
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99417002
Record 13 of 30 in MEDLINE (R) 1999 Part B
TITLE: Detecting changes in nonisotropic images.
AUTHOR: Worsley,-K-J; Andermann,-M; Koulis,-T; MacDonald,-D; Evans,-A-C
ADDRESS OF AUTHOR: Department of Mathematics and Statistics, McGill University, Montreal, Quebec, Canada. worsley@math.mcgill.ca
SOURCE: Hum-Brain-Mapp. 1999; 8(2-3): 98-101
INTERNATIONAL STANDARD SERIAL NUMBER: 1065-9471
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: If the noise component of image data is nonisotropic, i.e., if it has nonconstant smoothness or effective point spread function, then theoretical results for the P value of local maxima and the size of suprathreshold clusters of a statistical parametric map (SPM) based on random field theory are not valid. This assumption is reasonable for PET or smoothed fMRI data, but not if these data are projected onto an unfolded, inflated, or flattened 2D cortical surface. Anatomical data such as structure masks, surface displacements, and deformation vectors are also highly nonisotropic. The solution offered here is to suppose that the image can be warped or flattened (in a statistical sense) into a space where the data are isotropic. The subsequent corrected P values do not depend on finding this warping; it is sufficient only to know that such a warping exists.
MAJOR MESH DESCRIPTORS: *Brain-anatomy-and-histology; *Image-Processing,-Computer-Assisted
MINOR MESH DESCRIPTORS: Magnetic-Resonance-Imaging; Tomography,-Emission-Computed
CHECKTAGS: Comparative-Study; Female; Human; Male
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99452230
RECORD FEATURES: ABSTRACT (AB)
Record 14 of 30 in MEDLINE (R) 1999 Part B
TITLE: Diagnosis of subtle focal dysplastic lesions: curvilinear reformatting from three-dimensional magnetic resonance imaging.
AUTHOR: Bastos,-A-C; Comeau,-R-M; Andermann,-F; Melanson,-D; Cendes,-F; Dubeau,-F; Fontaine,-S; Tampieri,-D; Olivier,-A
ADDRESS OF AUTHOR: Department of Neurology, Neurosurgery, McGill University, and the Montreal Neurological Institute and Hospital, Quebec, Canada.
SOURCE: Ann-Neurol. 1999 Jul; 46(1): 88-94
INTERNATIONAL STANDARD SERIAL NUMBER: 0364-5134
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: Focal cortical dysplasia is a frequent cause of medically intractable partial epilepsy. These lesions are being increasingly identified by high quality images provided by magnetic resonance imaging (MRI), resulting in improved seizure control of surgically treated patients. Small dysplastic lesions are often missed by conventional MRI methods. The identification of subtle structural abnormalities by rectilinear slices is often limited by the complex convolutional pattern of the brain. We developed a method of curvilinear reformatting of three-dimensional MRI data that improves the anatomical display of the gyral structure of the hemispheric convexities. It also reduces the asymmetric sampling of gray-white matter that may lead to false-positive results. We present 5 patients in whom conventional two-dimensional and three-dimensional MRI with multiplanar reformatting was initially considered normal. Subsequent studies using curvilinear reformatting identified lesions in all. Four patients underwent surgery with histological diagnosis of focal cortical dysplasia. Three patients are seizure-free and 1 had significant improvement in seizure control. These results indicate that an increase in the detection of subtle focal dysplastic lesions may be accomplished when one improves the anatomical display of the brain gyral structure by performing curvilinear reformatting.
MAJOR MESH DESCRIPTORS: *Brain-pathology; *Epilepsies,-Partial-pathology; *Image-Processing,-Computer-Assisted; *Magnetic-Resonance-Imaging-methods
MINOR MESH DESCRIPTORS: Adolescence-; Adult-
CHECKTAGS: Case-Report; Female; Human; Male
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: pathology; methods
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99328211
RECORD FEATURES: ABSTRACT (AB)
Record 15 of 30 in MEDLINE (R) 1999 Part B
TITLE: Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily.
AUTHOR: Andermann,-K; Wattler,-F; Wattler,-S; Heine,-G; Meyer,-M; Forssmann,-W-G; Nehls,-M
ADDRESS OF AUTHOR: Lower Saxony Institute for Peptide Research (IPF), Hannover, Germany.
SOURCE: Protein-Sci. 1999 Apr; 8(4): 810-9
INTERNATIONAL STANDARD SERIAL NUMBER: 0961-8368
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: Members of the Ly-6/uPAR protein family share one or several repeat units of the Ly-6/uPAR domain that is defined by a distinct disulfide bonding pattern between 8 or 10 cysteine residues. The Ly-6/uPAR protein family can be divided into two subfamilies. One comprises GPI-anchored glycoprotein receptors with 10 cysteine residues. The other subfamily includes the secreted single-domain snake and frog cytotoxins, and differs significantly in that its members generally possess only eight cysteines and no GPI-anchoring signal sequence. We report the purification and structural characterization of human SLURP-1 (secreted mammalian Ly-6/uPAR related protein 1) from blood and urine peptide libraries. SLURP-1 is encoded by the ARS (component B)-81/s locus, and appears to be the first mammalian member of the Ly-6/uPAR family lacking a GPI-anchoring signal sequence. A phylogenetic analysis based on the SLURP-1 primary protein structure revealed a closer relationship to the subfamily of cytotoxins. Since the SLURP-1 gene maps to the same chromosomal region as several members of the Ly-6/uPAR subfamily of glycoprotein receptors, it is suggested that both biologically distinct subfamilies might have co-evolved from local chromosomal duplication events.
MAJOR MESH DESCRIPTORS: *Antigens,-Ly-chemistry; *Phylogeny-; *Urinary-Plasminogen-Activator-chemistry
MINOR MESH DESCRIPTORS: Antigens,-Ly-blood; Antigens,-Ly-urine; Anura-; Cytotoxins-chemistry; Peptide-Library; Sequence-Analysis,-DNA; Sequence-Homology,-Amino-Acid; Snakes-; Spectrum-Analysis,-Mass; Time-Factors; Urinary-Plasminogen-Activator-blood; Urinary-Plasminogen-Activator-urine
CHECKTAGS: Animal; Human
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: blood; chemistry; urine
CAS REGISTRY NUMBER OR EC NUMBER: 0; 0; 0; 0; EC 3.4.21.73
NAME OF SUBSTANCE: Antigens,-Ly; Cytotoxins; Peptide-Library; SLURP-1-protein; Urinary-Plasminogen-Activator
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99226809
RECORD FEATURES: ABSTRACT (AB)
Record 16 of 30 in MEDLINE (R) 1999 Part B
TITLE: Clinical patterns of patients with temporal lobe epilepsy and pure amygdalar atrophy.
AUTHOR: Guerreiro,-C; Cendes,-F; Li,-L-M; Jones-Gotman,-M; Andermann,-F; Dubeau,-F; Piazzini,-A; Feindel,-W
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 1999 Apr; 40(4): 453-61
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: MRI volumetric measurements (MRIvol) have been proven reliable in determining mesial temporal atrophy in patients with TLE. We attempted to correlate the clinical features with different patterns of hippocampal formation (HF) and amygdala (AM) atrophy in patients with TLE without foreign tissue lesion. METHODS: We studied 65 patients with refractory TLE. They were divided into five groups according to MRIvol results: pure AM atrophy (n = 11, 10 unilateral and one bilateral), unilateral HF atrophy (n = 16), bilateral HF atrophy (n = 12), unilateral AM + HF atrophy (n = 13), and patients with normal volumes of AM and HF (n = 13). MRIvol of AM and HF were performed by using a protocol previously described by Watson et al. (Neurology 1992;42:1743-50). RESULTS: Patients with AM atrophy had later onset of seizures compared with those with unilateral HF atrophy (p < 0.01). History of febrile convulsions (p < 0.0001) and frequent secondarily generalized tonic-clonic seizures (GTCSs) were more often found in patients with HF atrophy compared with those with pure AM atrophy and those with normal volumes (p = 0.04). Prolonged postictal confusion was more often found with AM atrophy (p = 0.05). Memory impairment was more severe in patients with HF atrophy than in those with AM atrophy only or in those with normal volumes (p = 0.03). There were no significant differences among the five groups in the following parameters: age, duration of epilepsy, seizure frequency, and presence and type of aura. CONCLUSIONS: Prolonged postictal confusion appeared to be related to AM atrophy, in keeping with previous clinical observations. These patients also had a lower incidence of early febrile convulsions, older age at epilepsy onset, lower frequency of secondary GTCS, and lesser memory dysfunction compared with patients with hippocampal atrophy.
MAJOR MESH DESCRIPTORS: *Amygdala-pathology; *Epilepsy,-Temporal-Lobe-diagnosis; *Magnetic-Resonance-Imaging
MINOR MESH DESCRIPTORS: Adolescence-; Adult-; Age-of-Onset; Amygdala-surgery; Atrophy-; Biological-Markers; Comorbidity-; Confusion-diagnosis; Electroencephalography-statistics-and-numerical-data; Epilepsy,-Temporal-Lobe-epidemiology; Epilepsy,-Temporal-Lobe-pathology; Hippocampus-pathology; Hippocampus-surgery; Incidence-; Laterality-; Memory-Disorders-diagnosis; Memory-Disorders-epidemiology; Middle-Age; Neuropsychological-Tests; Seizures,-Febrile-diagnosis; Seizures,-Febrile-epidemiology; Treatment-Outcome
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: pathology; surgery; diagnosis; statistics-and-numerical-data; epidemiology
CAS REGISTRY NUMBER OR EC NUMBER: 0
NAME OF SUBSTANCE: Biological-Markers
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99236011
RECORD FEATURES: ABSTRACT (AB)
Record 17 of 30 in MEDLINE (R) 1999 Part B
TITLE: Psychosis after resection of ganglioglioma or DNET: evidence for an association.
AUTHOR: Andermann,-L-F; Savard,-G; Meencke,-H-J; McLachlan,-R; Moshe,-S; Andermann,-F
ADDRESS OF AUTHOR: Department of Psychiatry, University of Toronto, Ontario, Canada.
SOURCE: Epilepsia. 1999 Jan; 40(1): 83-7
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: David Taylor and Murray Falconer suggested that some patients may develop a psychotic illness after resection of a ganglioglioma that led to intractable seizures. They implied that the mechanism of this association remained unclear. This concept is currently not universally accepted (M. Trimble, personal communication). METHODS: We studied six children or young adults from four centers who developed psychosis after resection of a ganglioglioma or dysembryoplastic neuroepithelioma (DNET). RESULTS: All patients were operated on because of intractable epilepsy. The lesions involved mainly the temporal lobe. Patients had good outcomes for seizure control. In none of the six was potentially psychogenic medication used nor were the psychotic symptoms postictal in nature. The psychosis was schizophreniform with paranoid features and prominent depressive symptoms. Although some behavioral abnormalities were described preoperatively, none had been psychotic before operation. This type of psychotic reaction was not encountered in the four centers in a comparable period after resection of other types of lesions. This complication is rare; it occurred in only one of 39 patients who had such a lesion resected. CONCLUSIONS: Psychotic illness may rarely occur after resection of a ganglioglioma or DNET for treatment of intractable epilepsy. This does not seem to occur after removal of other types of lesions. Because the patients had good outcomes for seizures, the mechanism may be related to "forced normalization." The original observations of Taylor and Falconer are confirmed by this study; the reasons for the selective occurrence, however, remain speculative.
MAJOR MESH DESCRIPTORS: *Brain-Neoplasms-surgery; *Epilepsy,-Temporal-Lobe-surgery; *Ganglioglioma-surgery; *Neuroectodermal-Tumors,-Primitive,-Peripheral-surgery; *Postoperative-Complications-etiology; *Psychotic-Disorders-etiology; *Temporal-Lobe-surgery
MINOR MESH DESCRIPTORS: Adolescence-; Adult-; Child-; Depressive-Disorder-etiology; Epilepsy,-Temporal-Lobe-etiology; Ganglioglioma-complications; Neuroectodermal-Tumors,-Primitive,-Peripheral-complications; Paranoid-Disorders-etiology; Treatment-Outcome
CHECKTAGS: Case-Report; Female; Human; Male
PUBLICATION TYPE: Journal-Article; Multicenter-Study
SUBHEADINGS: surgery; etiology; complications
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99122294
RECORD FEATURES: ABSTRACT (AB)
Record 18 of 30 in MEDLINE (R) 1999 Part B
TITLE: A systematic review of the literature exploring the role of primary care in genetic services.
AUTHOR: Emery,-J; Watson,-E; Rose,-P; Andermann,-A
ADDRESS OF AUTHOR: ICRF General Practice Research Group, Division of Public Health and Primary Care, Institute of Health Sciences, Headington, Oxford, UK.
SOURCE: Fam-Pract. 1999 Aug; 16(4): 426-45
INTERNATIONAL STANDARD SERIAL NUMBER: 0263-2136
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: ENGLAND
ABSTRACT: BACKGROUND: In response to growing demands on genetics departments and advances in genetic medicine, it has been proposed that primary care should provide a frontline service in clinical genetics. However, there are concerns that primary care may be unwilling or ill prepared to take on this new role. OBJECTIVES: This study aimed to review systematically the literature exploring the role of primary care in delivering genetic services, and define potential methods of supporting primary care in the provision of genetics services. METHODS: Seven electronic databases were searched. This was complemented by contacting experts in the field and handsearching reference lists. In total, 230 papers were identified, including traditional reviews, of which 96 were examined in detail. Fifty-one papers are included in this review. On account of the heterogeneity of papers identified, we conducted a qualitative synthesis of the results, focusing on five key questions. RESULTS: GPs accept that they have an increasing role to play in genetics, but lack confidence in their ability to do so because of limited knowledge of clinical genetics. Evidence from pilot studies of cystic fibrosis screening provides the strongest evidence for the feasibility of providing genetic services in primary care. CONCLUSIONS: Although genetic issues currently constitute a relatively small part of the overall workload in primary care, this will almost certainly change in the light of new genetic discoveries. Educational programmes and referral guidelines, computer decision support and genetic nurse specialist outreach clinics may provide useful methods of supporting GPs in the new field of primary care genetics.
MAJOR MESH DESCRIPTORS: *Family-Practice-organization-and-administration; *Genetics,-Medical-organization-and-administration; *Physician's-Role
MINOR MESH DESCRIPTORS: Attitude-of-Health-Personnel; Attitude-to-Health; Family-Practice-education; Genetics,-Medical-education; Health-Services-Research; Knowledge,-Attitudes,-Practice; Physician's-Practice-Patterns; Physicians,-Family-education; Physicians,-Family-psychology
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article; Review; Review,-Tutorial
SUBHEADINGS: education; organization-and-administration; psychology
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99421459
RECORD FEATURES: ABSTRACT (AB)
Record 19 of 30 in MEDLINE (R) 1999 Part A
TITLE: Preventing injuries in children. Elements of trial's design and analysis might have biased results.
AUTHOR: Waters,-E; Priest,-P; Foster,-C; Andermann,-A
SOURCE: BMJ. 1999 Aug 28; 319(7209): 574-5
INTERNATIONAL STANDARD SERIAL NUMBER: 0959-8138
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: ENGLAND
COMMENTS: Comment On: BMJ. 1999 Apr 10;318(7189):980-3
MAJOR MESH DESCRIPTORS: *Wounds-and-Injuries-prevention-and-control
MINOR MESH DESCRIPTORS: Bias-Epidemiology; Child-; Clinical-Trials; Data-Collection
CHECKTAGS: Human
PUBLICATION TYPE: Comment; Letter
SUBHEADINGS: prevention-and-control
SUBSET: Abridged-Index-Medicus; Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99393387
Record 20 of 30 in MEDLINE (R) 1999 Part A
TITLE: Intrauterine growth in the offspring of epileptic women: a prospective multicenter study.
AUTHOR: Battino,-D; Kaneko,-S; Andermann,-E; Avanzini,-G; Canevini,-M-P; Canger,-R; Croci,-D; Fumarola,-C; Guidolin,-L; Mamoli,-D; Molteni,-F; Pardi,-G; Vignoli,-A; Fukushima,-Y; Kan,-R; Takeda,-A; Nakane,-Y; Ogawa,-Y; Dansky,-L; Oguni,-M; Lopez-Ciendas,-I; Sherwin,-A; Andermann,-F; Seni,-M-H; Goto,-M; et-al.
ADDRESS OF AUTHOR: Carlo Besta Neurological Institute, Milan, Italy. dbattino.besta@interbusiness.it
SOURCE: Epilepsy-Res. 1999 Aug; 36(1): 53-60
INTERNATIONAL STANDARD SERIAL NUMBER: 0920-1211
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: NETHERLANDS
ABSTRACT: The aim of the present study was to evaluate the risk of intrauterine growth delay in the offspring of epileptic mothers and to quantify the risks of intrauterine exposure to antiepileptic drugs (AEDs). Data concerning 870 newborns, prospectively collected in Canada, Japan and Italy, using the same study design, were pooled and analyzed. The overall proportion of newborns whose body weight (7.8%) or head circumference (11.1%) at birth were below the 10th percentile was not increased. However, logistic regression analysis showed that the risk of small head circumference was significantly higher in Italian than in Japanese (RR 4.2; 95% CI: 2.2-8.0) or Canadian children (RR 2.6; 95% CI: 1.1-6.5), and in children exposed to polytherapy (RR 2.7; 95% CI: 1.2-6.3), phenobarbital (PB) (RR 3.6; 95% CI: 1.4-9.4) and primidone (PRM) (RR 4.5; 95% CI: 1.5-13.8). Country was also the only factor affecting low body weight, with Italian children having a higher risk than Japanese (RR 5.2; 95% CI: 2.6-10.4) or Canadian (RR 8.8; 95% CI: 2.0-38.1) children. Due to the small categories, the influence of AED doses and plasma concentrations was studied for each individual AED, without adjustment for the other potential confounding factors. A clear dose-dependent effect was found for PB and PRM in terms of both small head circumference and low body weight, and a concentration-dependent effect for PB in terms of small head circumferences. The size of the difference between the Italian and the other two populations, which is only partially explained by differences in therapeutic regimens, suggests that genetic, environmental and ethnic factors also need to be taken into account when considering possible explanations.
MAJOR MESH DESCRIPTORS: *Epilepsy-physiopathology; *Fetal-Development-physiology; *Pregnancy-Complications-physiopathology
MINOR MESH DESCRIPTORS: Anticonvulsants-therapeutic-use; Body-Weight; Canada-; Drug-Therapy,-Combination; Epilepsy-drug-therapy; Head-anatomy-and-histology; Infant,-Newborn; Italy-; Japan-; Prospective-Studies; Regression-Analysis; Risk-Factors
CHECKTAGS: Female; Human; Pregnancy
PUBLICATION TYPE: Journal-Article; Multicenter-Study
SUBHEADINGS: therapeutic-use; drug-therapy; physiopathology; physiology; anatomy-and-histology
CAS REGISTRY NUMBER OR EC NUMBER: 0
NAME OF SUBSTANCE: Anticonvulsants
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99391507
RECORD FEATURES: ABSTRACT (AB)
Record 21 of 30 in MEDLINE (R) 1999 Part A
TITLE: The zebrafish eya1 gene and its expression pattern during embryogenesis.
AUTHOR: Sahly,-I; Andermann,-P; Petit,-C
ADDRESS OF AUTHOR: Unite de Genetique des Deficits Sensoriels, CNRS URA 1968, Institute Pasteur, 25 rue du Dr. Roux, F-75724 Paris Cedex 15, France. cpetit@pasteur.fr
SOURCE: Dev-Genes-Evol. 1999 Jul; 209(7): 399-410
INTERNATIONAL STANDARD SERIAL NUMBER: 0949-944X
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: GERMANY
ABSTRACT: The eyes absent-like genes encode a group of putative transcriptional coactivators with a sole representative in Drosophila and several members in mammals. Haploinsufficiency of the human EYA1 gene results in branchio-oto-renal syndrome characterized by developmental anomalies of the branchial arches, the three compartments of the ear and the kidney. As a first step towards a functional analysis of this gene in lower vertebrates, we isolated its zebrafish homologue, eya1, and studied its expression pattern during embryogenesis. The eya1 cDNA predicts a protein with 84.7% identity with the human homologue. Transcripts are first detected at the tailbud stage in presumptive cranial placodal precursor cells. Thereafter, eya1 expression continues in anterior pituitary, olfactory, otic, and lateral line placodes. Aside from these placodal sites of expression, eya1 transcripts were observed in the somites, developing pectoral fins, and branchial arches. No expression was found in pronephros or Wolffian duct of the zebrafish renal system. Within the developing ear, eya1 expression becomes confined to the ventral part of the otic vesicle from where the acoustic ganglion precursor cells arise and the sensory patches differentiate. In the lateral line, eya1 is expressed in the placodes, ganglia, migrating primordia, and receptive organs at all developmental stages, including both the differentiating hair and supporting cells. Taken together, these results indicate a remarkable similarity in both the structure and expression pattern of eya1 between higher and lower vertebrates, suggesting that the function of this gene has been conserved throughout vertebrate evolution.
MAJOR MESH DESCRIPTORS: *Gene-Expression-Regulation,-Developmental; *Trans-Activators-genetics; *Zebrafish-genetics
MINOR MESH DESCRIPTORS: Amino-Acid-Sequence; Drosophila-genetics; Molecular-Sequence-Data; Organ-Specificity; Sequence-Alignment; Zebrafish-embryology
CHECKTAGS: Animal; Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: genetics; embryology
CAS REGISTRY NUMBER OR EC NUMBER: 0; 0
NAME OF SUBSTANCE: Eya1-protein,-vertebrate; Trans-Activators
SECONDARY SOURCE IDENTIFIER: GENBANK/AF118106
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99299580
RECORD FEATURES: ABSTRACT (AB)
Record 22 of 30 in MEDLINE (R) 1999 Part A
TITLE: Entorhinal cortex in temporal lobe epilepsy: a quantitative MRI study.
AUTHOR: Bernasconi,-N; Bernasconi,-A; Andermann,-F; Dubeau,-F; Feindel,-W; Reutens,-D-C
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, McGill University, and Montreal Neurological Institute and Hospital, Quebec, Canada.
SOURCE: Neurology. 1999 Jun 10; 52(9): 1870-6
INTERNATIONAL STANDARD SERIAL NUMBER: 0028-3878
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: BACKGROUND: The entorhinal cortex (EC) is a distinct anatomic and functional region of the anterior parahippocampal gyrus, which plays a role in seizure generation and propagation in temporal lobe epilepsy (TLE). In tissue resected from TLE patients, cell loss in the EC has been described. OBJECTIVES: To develop a standardized protocol for identifying the anatomic boundaries of the EC using high-resolution MRI and to examine morphologic changes of the EC in TLE. METHODS: We performed T1-weighted MRIs in 20 patients (7 males) with TLE (mean age 34 years) and 18 normal controls (mean age 26 years). Eleven patients had a left and 9 a right epileptic focus as defined by history, video-EEG, and surgical outcome. The volumes of the EC, the hippocampus, and the amygdala were measured using a standardized MRI protocol. Analysis of variance (ANOVA) was used to examine the effect of seizure focus lateralization and hemisphere on these volumes. An asymmetry ratio [A (%) = 100 x (R-L)/(R+L)/2] was also compared between groups using ANOVA. RESULTS: In normal controls the volume of the right EC was 1,247 +/- 127 mm3 (mean +/- standard deviation), and that of the left EC was 1,215 +/- 135 mm3 (p > 0.05). We found a bilateral reduction in the volume of the EC in TLE patients compared with controls (p < 0.05). Examination of the asymmetry ratios showed that the reduction in volume of the EC was greater ipsilateral to the epileptic focus (p < 0.05). The volumes of the hippocampus and the amygdala were smaller on the side of the focus in TLE patients compared with controls (p < 0.05). CONCLUSIONS: With a standardized protocol for the quantitative assessment of the EC, patients with unilateral TLE show bilateral reduction in the volume of the EC. However, this reduction is more severe ipsilateral to the epileptic focus.
MAJOR MESH DESCRIPTORS: *Entorhinal-Cortex-physiopathology; *Epilepsy,-Temporal-Lobe-physiopathology
MINOR MESH DESCRIPTORS: Adolescence-; Adult-; Entorhinal-Cortex-pathology; Epilepsy,-Temporal-Lobe-pathology; Magnetic-Resonance-Imaging; Middle-Age
CHECKTAGS: Female; Human; Male; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: pathology; physiopathology
SUBSET: Abridged-Index-Medicus; Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99297946
RECORD FEATURES: ABSTRACT (AB)
Record 23 of 30 in MEDLINE (R) 1999 Part A
TITLE: Surgical outcome in patients with epilepsy and dual pathology.
AUTHOR: Li,-L-M; Cendes,-F; Andermann,-F; Watson,-C; Fish,-D-R; Cook,-M-J; Dubeau,-F; Duncan,-J-S; Shorvon,-S-D; Berkovic,-S-F; Free,-S; Olivier,-A; Harkness,-W; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Quebec, Canada.
SOURCE: Brain. 1999 May; 122 ( Pt 5)799-805
INTERNATIONAL STANDARD SERIAL NUMBER: 0006-8950
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: ENGLAND
ABSTRACT: High-resolution MRI can detect dual pathology (an extrahippocampal lesion plus hippocampal atrophy) in about 5-20% of patients with refractory partial epilepsy referred for surgical evaluation. We report the results of 41 surgical interventions in 38 adults (mean age 31 years, range 14-63 years) with dual pathology. Three patients had two operations. The mean postoperative follow-up was 37 months (range 12-180 months). The extrahippocampal lesions were cortical dysgenesis in 15, tumour in 10, contusion/infarct in eight and vascular malformation in five patients. The surgical approach aimed to remove what was considered to be the most epileptogenic lesion, and the 41 operations were classified into lesionectomy (removal of an extrahippocampal lesion); mesial temporal resection (removal of an atrophic hippocampus); and lesionectomy plus mesial temporal resection (removal of both the lesion and the atrophic hippocampus). Lesionectomy plus mesial temporal resection resulted in complete freedom from seizures in 11/15 (73%) patients, while only 2/10 (20%) patients who had mesial temporal resection alone and 2/16 (12.5%) who had a lesionectomy alone were seizure-free (P < 0.001). When classes I and II were considered together results improved to 86, 30 and 31%, respectively. Our findings indicate that in patients with dual pathology removal of both the lesion and the atrophic hippocampus is the best surgical approach and should be considered whenever possible.
MAJOR MESH DESCRIPTORS: *Epilepsy-surgery; *Hippocampus-pathology
MINOR MESH DESCRIPTORS: Adolescence-; Adult-; Analysis-of-Variance; Atrophy-; Electroencephalography-; Epilepsy-pathology; Epilepsy-physiopathology; Follow-Up-Studies; Hippocampus-physiopathology; Magnetic-Resonance-Imaging; Middle-Age; Treatment-Outcome
CHECKTAGS: Female; Human; Male; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article; Multicenter-Study
SUBHEADINGS: pathology; physiopathology; surgery
SUBSET: Abridged-Index-Medicus; Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99281797
RECORD FEATURES: ABSTRACT (AB)
Record 24 of 30 in MEDLINE (R) 1999 Part A
TITLE: Neuroimaging evidence of progressive neuronal loss and dysfunction in temporal lobe epilepsy.
AUTHOR: Tasch,-E; Cendes,-F; Li,-L-M; Dubeau,-F; Andermann,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Montreal Neurological Hospital and Institute and Department of Neurology and Neurosurgery, McGill University, Quebec, Canada.
SOURCE: Ann-Neurol. 1999 May; 45(5): 568-76
INTERNATIONAL STANDARD SERIAL NUMBER: 0364-5134
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: Whether temporal lobe epilepsy is the result of an isolated, early injury or whether there is ongoing neuronal dysfunction or loss due to seizures is often debated. We attempt to address this issue by using magnetic resonance techniques. Proton magnetic resonance spectroscopic imaging can detect and quantify focal neuronal dysfunction or loss based on reduced signals from the neuronal marker N-acetylaspartate (NAA), and magnetic resonance imaging (MRI)-based measurements of hippocampal volumes (MRIvol) can quantify the amount of atrophy in this structure. We performed magnetic resonance spectroscopic imaging and MRIvol in 82 consecutive patients with medically intractable temporal lobe epilepsy to determine whether there was a correlation between seizure frequency, or type or duration of epilepsy, with NAA to creatine (Cr) values or hippocampal volumes. Volumes and spectroscopic resonance intensities were categorized as to whether they were measured from the temporal lobe ipsilateral or contralateral to the predominant electroencephalographic focus. Ipsilateral and contralateral NAA/Cr was negatively correlated with duration of epilepsy. Hippocampal volumes were negatively correlated with duration ipsilaterally but not contralaterally. Frequency of complex partial seizures was not correlated with any of the magnetic resonance measures. However, patients with frequent generalized tonic-clonic seizures had lower NAA/Cr bilaterally and smaller hippocampal volumes ipsilaterally than patients with none or rare generalized tonic-clonic seizures. The results suggest that although an early, fixed injury may cause asymmetric temporal lobe damage, generalized seizures may also cause progressive neuronal dysfunction or loss.
COMMENTS: Comment In: Ann Neurol. 1999 May;45(5):553-6
Comment In: Ann Neurol. 1999 Nov;46(5):800
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-pathology; *Epilepsy,-Temporal-Lobe-physiopathology; *Neurons-pathology
MINOR MESH DESCRIPTORS: Adult-; Brain-pathology; Brain-physiopathology; Electroencephalography-; Magnetic-Resonance-Imaging
CHECKTAGS: Female; Human; Male
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: pathology; physiopathology
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99251596
RECORD FEATURES: ABSTRACT (AB)
Record 25 of 30 in MEDLINE (R) 1999 Part A
TITLE: Nonconvulsive status epilepticus of frontal origin.
AUTHOR: Thomas,-P; Zifkin,-B; Migneco,-O; Lebrun,-C; Darcourt,-J; Andermann,-F
ADDRESS OF AUTHOR: Service de Neurologie, Hopital Pasteur, Nice, France. piertho@calva.net
SOURCE: Neurology. 1999 Apr 12; 52(6): 1174-83
INTERNATIONAL STANDARD SERIAL NUMBER: 0028-3878
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: OBJECTIVES: To determine the electroclinical characteristics and causative factors of nonconvulsive status epilepticus (NCSE) of frontal origin. METHODS: The authors conducted a 5-year prospective study. RESULTS: Ten patients were studied (seven men, three women; mean age, 56.4 years). Six patients did not have previous epilepsy. The mean diagnostic delay was 48 hours (range, 3 to 96 hours). Two types of frontal NCSE were identified. In type 1 (n = 7), mood disturbances with affective disinhibition or affective indifference were associated with subtle impairment of cognitive functions without overt confusion. EEG showed a unilateral frontal ictal pattern and normal background activity. In type 2 (n = 3), impaired consciousness was associated with bilateral, asymmetric frontal EEG discharges occurring on an abnormal background. Ictal and postictal 99mTc hexamethyl propylene amine oxime (HMPAO) SPECT was performed in five patients and showed unilateral or bilateral frontal HMPAO uptake that aided localization, especially in type 2 NCSE of frontal origin. Etiologies included a focal frontal lesion in six patients (three of which were tumors), neurosyphilis, and nonketotic hyperglycemia. Eight patients did not respond to initial IV benzodiazepine (BZ), but IV phenytoin controlled six patients successfully. The immediate outcome was favorable in all patients. There was no long-term recurrence of SE in seven patients. CONCLUSIONS: NCSE of frontal origin is a heterogeneous syndrome. Some cases are best described as simple partial NCSE, others as complex partial SE, and there are forms that overlap with absence SE. Emergency EEG and neuropsychological assessment are diagnostic, and SPECT may be useful. Many patients may not respond to IV BZ.
MAJOR MESH DESCRIPTORS: *Frontal-Lobe-physiopathology; *Status-Epilepticus-physiopathology
MINOR MESH DESCRIPTORS: Adult-; Aged-; Electroencephalography-; Frontal-Lobe-radionuclide-imaging; Middle-Age; Status-Epilepticus-radionuclide-imaging; Tomography,-Emission-Computed,-Single-Photon
CHECKTAGS: Female; Human; Male; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: physiopathology; radionuclide-imaging
SUBSET: Abridged-Index-Medicus; Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99229552
RECORD FEATURES: ABSTRACT (AB)
Record 26 of 30 in MEDLINE (R) 1999 Part A
TITLE: Congenital malformations due to antiepileptic drugs.
AUTHOR: Kaneko,-S; Battino,-D; Andermann,-E; Wada,-K; Kan,-R; Takeda,-A; Nakane,-Y; Ogawa,-Y; Avanzini,-G; Fumarola,-C; Granata,-T; Molteni,-F; Pardi,-G; Minotti,-L; Canger,-R; Dansky,-L; Oguni,-M; Lopes-Cendas,-I; Sherwin,-A; Andermann,-F; Seni,-M-H; Okada,-M; Teranishi,-T
ADDRESS OF AUTHOR: Department of Neuropsychiatry, Hirosaki University, Japan.
SOURCE: Epilepsy-Res. 1999 Feb; 33(2-3): 145-58
INTERNATIONAL STANDARD SERIAL NUMBER: 0920-1211
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: NETHERLANDS
ABSTRACT: To identify the major risk factors for the increased incidence of congenital malformations in offspring of mothers being treated for epilepsy with antiepileptic drugs (AEDs) during pregnancy and, to determine the relative teratogenic risk of AEDs, we prospectively analyzed 983 offspring born in Japan, Italy, and Canada. The incidence of congenital malformations in offspring without drug exposure was 3.1%, versus an incidence with drug exposure of 9.0%. The highest incidence in offspring exposed to a single AED occurred with primidone (PRM; 14.3%), which was followed by valproate (VPA; 11.1%), phenytoin (PHT; 9.1%), carbamazepine (CBZ; 5.7%), and phenobarbital (PB; 5.1%). The VPA dose and level positively correlated with the incidence of malformations. This study first determined a cut-off value of VPA dose and level at 1000 mg/day and 70 microg/ml, respectively, to avoid the occurrence of malformations. The incidence of malformations increases as the number of drugs increases, and as the total daily dose increases. Specific combinations of AEDs such as VPA + CBZ and PHT + PRM + PB produced a higher incidence of congenital malformations. The incidence of malformations was not associated with any background factors studied except for the presence of malformations in siblings. These results indicate that the increased incidence of congenital malformations was caused primarily by AEDs, suggesting that malformations can be prevented by improvements in drug regimen, and by avoiding polypharmacy and high levels of VPA (more than 70 microg/ml) in the treatment of epileptic women of childbearimg age.
MAJOR MESH DESCRIPTORS: *Abnormalities,-Drug-Induced-epidemiology; *Anticonvulsants-adverse-effects
MINOR MESH DESCRIPTORS: Abnormalities-epidemiology; Adult-; Anticonvulsants-therapeutic-use; Canada-; Dose-Response-Relationship,-Drug; Drug-Therapy,-Combination; Incidence-; Italy-; Japan-; Prospective-Studies
CHECKTAGS: Female; Human; Pregnancy; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: epidemiology; adverse-effects; therapeutic-use
CAS REGISTRY NUMBER OR EC NUMBER: 0
NAME OF SUBSTANCE: Anticonvulsants
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99192249
RECORD FEATURES: ABSTRACT (AB)
Record 27 of 30 in MEDLINE (R) 1999 Part A
TITLE: Characterization of mutations in the gene doublecortin in patients with double cortex syndrome.
AUTHOR: Gleeson,-J-G; Minnerath,-S-R; Fox,-J-W; Allen,-K-M; Luo,-R-F; Hong,-S-E; Berg,-M-J; Kuzniecky,-R; Reitnauer,-P-J; Borgatti,-R; Mira,-A-P; Guerrini,-R; Holmes,-G-L; Rooney,-C-M; Berkovic,-S; Scheffer,-I; Cooper,-E-C; Ricci,-S; Cusmai,-R; Crawford,-T-O; Leroy,-R; Andermann,-E; Wheless,-J-W; Dobyns,-W-B; Walsh,-C-A; et-al.
ADDRESS OF AUTHOR: Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
SOURCE: Ann-Neurol. 1999 Feb; 45(2): 146-53
INTERNATIONAL STANDARD SERIAL NUMBER: 0364-5134
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: Mutations in the X-linked gene doublecortin, which encodes a protein with no dear structural homologues, are found in pedigrees in which affected females show "double cortex" syndrome (DC; also known as subcortical band heterotopia or laminar heterotopia) and affected males show X-linked lissencephaly. Mutations in doublecortin also cause sporadic DC in females. To determine the incidence of doublecortin mutations in DC, we investigated a cohort of eight pedigrees and 47 sporadic patients with DC for mutations in the doublecortin open reading frame as assessed by single-stranded conformational polymorphism analysis. Mutations were identified in each of the eight DC pedigrees (100%), and in 18 of the 47 sporadic DC patients (38%). Identified mutations were of two types, protein truncation mutations and single amino acid substitution mutations. However, pedigrees with DC displayed almost exclusively single amino acid substitution mutations, suggesting that patients with these mutations may have less of a reproductive disadvantage versus those patients with protein truncation mutations. Single amino acid substitution mutations were tightly clustered in two regions of the open reading frame, suggesting that these two regions are critical for the function of the Doublecortin protein.
COMMENTS: Comment In: Ann Neurol. 1999 Feb;45(2):141-2
MAJOR MESH DESCRIPTORS: *Brain-Diseases-genetics; *Cerebral-Cortex-abnormalities; *X-Chromosome-genetics
MINOR MESH DESCRIPTORS: Brain-Diseases-pathology; Cerebral-Cortex-pathology; DNA-analysis; Magnetic-Resonance-Imaging; Pedigree-; Point-Mutation; Polymorphism,-Single-Stranded-Conformational; Syndrome-
CHECKTAGS: Female; Human; Male; Support,-Non-U.S.-Gov't; Support,-U.S.-Gov't,-P.H.S.
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: genetics; pathology; abnormalities; analysis
CAS REGISTRY NUMBER OR EC NUMBER: 9007-49-2
NAME OF SUBSTANCE: DNA
CONTRACT OR GRANT NUMBERS: 5K12NS0170104NSNINDS; MH10691MHNIMH; RO1NS35129NSNINDS
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99142721
RECORD FEATURES: ABSTRACT (AB)
Record 28 of 30 in MEDLINE (R) 1999 Part A
TITLE: Localization of somatosensory function by using positron emission tomography scanning: a comparison with intraoperative cortical stimulation.
AUTHOR: Bittar,-R-G; Olivier,-A; Sadikot,-A-F; Andermann,-F; Comeau,-R-M; Cyr,-M; Peters,-T-M; Reutens,-D-C
ADDRESS OF AUTHOR: Montreal Neurological Institute and Hospital and Department of Neurology and Neurosurgery, McGill University, Canada.
SOURCE: J-Neurosurg. 1999 Mar; 90(3): 478-83
INTERNATIONAL STANDARD SERIAL NUMBER: 0022-3085
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: OBJECT: To investigate the utility of [15O]H2O positron emission tomography (PET) activation studies in the presurgical mapping of primary somatosensory cortex, the authors compared the magnitude and location of activation foci obtained using PET scanning with the results of intraoperative cortical stimulation (ICS). METHODS: The authors used PET scanning and vibrotactile stimulation (of the face, hand, or foot) to localize the primary somatosensory cortex before surgical resection of mass lesions or epileptogenic foci affecting the central area in 20 patients. With the aid of image-guided surgical systems, the locations of significant activation foci on PET scanning were compared with those of positive ICS performed at craniotomy after the patient had received a local anesthetic agent. In addition, the relationship between the magnitude and statistical significance of blood flow changes and the presence of positive ICS was examined. In 22 (95.6%) of 23 statistically significant (p < 0.05) PET activation foci, spatially concordant sites on ICS were also observed. Intraoperative cortical stimulation was positive in 40% of the PET activation studies that did not result in statistically significant activation. In the patients showing these results, there was a clearly identifiable t-statistic peak that was spatially concordant with the site of positive ICS in the sensorimotor area. All PET activation foci with a t statistic greater than 4.75 were associated with spatially concordant sites of positive ICS. All PET activation foci with a t statistic less than 3.2 were associated with negative ICS. CONCLUSIONS: Positron emission tomography is an accurate method for mapping the primary somatosensory cortex before surgery. The need for ICS, which requires local anesthesia, may be eliminated when PET foci with high (> 4.75) or low (< 3.20) t-statistic peaks are elicited by vibrotactile stimulation.
COMMENTS: Comment In: J Neurosurg. 1999 Jul;91(1):166-7
MAJOR MESH DESCRIPTORS: *Epilepsy-physiopathology; *Epilepsy-surgery; *Somatosensory-Cortex-physiopathology; *Tomography,-Emission-Computed
MINOR MESH DESCRIPTORS: Craniotomy-; Epilepsy-diagnosis; Intraoperative-Period; Magnetic-Resonance-Imaging; Physical-Stimulation; Postoperative-Period; Somatosensory-Cortex-pathology; Somatosensory-Cortex-radionuclide-imaging; Touch-physiology; Vibration-
CHECKTAGS: Comparative-Study; Female; Human; Male; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Clinical-Trial; Journal-Article
SUBHEADINGS: diagnosis; physiopathology; surgery; pathology; radionuclide-imaging; physiology
SUBSET: Abridged-Index-Medicus; Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99165239
RECORD FEATURES: ABSTRACT (AB)
Record 29 of 30 in MEDLINE (R) 1999 Part A
TITLE: Periventricular leukomalacia and epilepsy: incidence and seizure pattern.
AUTHOR: Gurses,-C; Gross,-D-W; Andermann,-F; Bastos,-A; Dubeau,-F; Calay,-M; Eraksoy,-M; Bezci,-S; Andermann,-E; Melanson,-D
ADDRESS OF AUTHOR: Montreal Neurological Institute and Hospital, McGill University, Quebec, Canada.
SOURCE: Neurology. 1999 Jan 15; 52(2): 341-5
INTERNATIONAL STANDARD SERIAL NUMBER: 0028-3878
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: OBJECTIVE: To study the incidence and pattern of epilepsy in patients with periventricular leukomalacia (PVLM) in two specialty clinic settings. BACKGROUND: Motor and cognitive deficit as well as epilepsy are common in patients with PVLM. With modern imaging techniques, PVLM is now easily recognized. METHODS: Epileptic seizures and syndromes as well as motor and cognitive deficits were correlated with MRI findings. Two patient populations were studied: Group A-children with cerebral palsy and PVLM presenting to a center for children with motor disability (n = 19); and Group B-epileptic patients with PVLM presenting to a tertiary epilepsy center (n = 12). A single patient with PVLM and epilepsy who underwent extensive investigations, including intracranial EEG telemetry, is reported. RESULTS: In Group A, 47% of patients had epilepsy (9/19). PVLM was found in 1.27% of patients investigated for epilepsy at a tertiary epilepsy center (12/942). The majority of patients in both groups had multiple seizure types, with complex partial seizures being most common. Of patients with seizures (Groups A and B), 85.7% had intractable epilepsy (18/21). Intracranial EEG in the illustrative case demonstrated a multifocal epileptic process with occipitotemporal predominance. CONCLUSIONS: PVLM was an uncommon underlying cause in patients presenting with epilepsy (Group A); however, patients presenting with motor disability and PVLM (Group B) had a high incidence of seizures. PVLM in epileptic patients is associated with multiple seizure types and medically refractory disease.
MAJOR MESH DESCRIPTORS: *Epilepsy-epidemiology; *Infant,-Premature,-Diseases-epidemiology; *Leukomalacia,-Periventricular-complications
MINOR MESH DESCRIPTORS: Cognition-Disorders-etiology; Disabled-Persons; Electroencephalography-; Epilepsy-etiology; Gestational-Age; Incidence-; Infant,-Newborn; Psychomotor-Performance-physiology; Quebec-epidemiology; Risk-Factors; Turkey-epidemiology
CHECKTAGS: Female; Human; Male; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: etiology; epidemiology; complications; physiology
SUBSET: Abridged-Index-Medicus; Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99129734
RECORD FEATURES: ABSTRACT (AB)
Record 30 of 30 in MEDLINE (R) 1999 Part A
TITLE: Interictal spikes increase cerebral glucose metabolism and blood flow: a PET study.
AUTHOR: Bittar,-R-G; Andermann,-F; Olivier,-A; Dubeau,-F; Dumoulin,-S-O; Pike,-G-B; Reutens,-D-C
ADDRESS OF AUTHOR: Montreal Neurological Institute and Hospital, and Department of Neurology and Neurosurgery, McGill University, Quebec, Canada.
SOURCE: Epilepsia. 1999 Feb; 40(2): 170-8
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 1999
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: In patients with reflex epilepsy, it is sometimes possible to evoke interictal spikes predictably, thus providing an uncommon but important experimental paradigm for examining the physiological changes produced by epileptiform discharges. METHODS: To examine the changes in regional cerebral blood flow (rCBF) and glucose consumption (rCMRglc) produced by interictal spikes, we performed positron emission tomography (PET) scans with the blood-flow tracer [15O]H20 and with [18F]fluorodeoxyglucose in a patient with fixation-off epilepsy. The scans were performed in states of high and low spike frequency produced by eye closure and opening, respectively. RESULTS: The rCBF study revealed a focal increase in blood flow associated with the state of increased interictal spiking. The focus was in the posterior portion of the left superior parietal lobule (Talairach coordinates: x: -36, y: -71, z: 39; t = 4.5; p<0.05) and corresponded to the site of maximal ictal EEG abnormality recorded with implanted electrodes. In a volume of interest of 10-mm diameter centered on the t statistic peak in the rCBF study, the mean rCMRglc was 39.1 micromol/100 g/min with eyes open and 44.1 micromol/100 g/min (13% increase) with eyes closed. An identical activation paradigm was used in six normal subjects studied with functional magnetic resonance imaging. In the normal subjects, no significant activation was observed in the parieto-occipital region, indicating that the changes observed in the patient were due to interictal spiking rather than to task performance alone. CONCLUSIONS: Interictal spiking produces focal increases in cerebral blood flow and glucose metabolism.
MAJOR MESH DESCRIPTORS: *Brain-blood-supply; *Brain-metabolism; *Electroencephalography-statistics-and-numerical-data; *Epilepsy-diagnosis; *Glucose-metabolism; *Tomography,-Emission-Computed
MINOR MESH DESCRIPTORS: Adult-; Brain-radionuclide-imaging; Epilepsy-metabolism; Epilepsy-radionuclide-imaging; Fludeoxyglucose-F-18-diagnostic-use; Magnetic-Resonance-Imaging; Oxygen-Radioisotopes-diagnostic-use; Regional-Blood-Flow; Water-diagnostic-use
CHECKTAGS: Case-Report; Human; Male; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: blood-supply; metabolism; radionuclide-imaging; statistics-and-numerical-data; diagnosis; diagnostic-use
CAS REGISTRY NUMBER OR EC NUMBER: 0; 50-99-7; 63503-12-8; 7732-18-5
NAME OF SUBSTANCE: Oxygen-Radioisotopes; Glucose; Fludeoxyglucose-F-18; Water
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 99135734
RECORD FEATURES: ABSTRACT (AB)