The following MEDLINE items were compiled by SilverPlatter and are presented with their generous cooperation and permission. (See SilverPlatter's Worldwide Library for bibliographic search information.)For a non-technical summary of Andermann's syndrome, try here!
Record 1 of 23 in MEDLINE (R) 2000
TITLE: Prognostic value of proton magnetic resonance spectroscopic imaging for surgical outcome in patients with intractable temporal lobe epilepsy and bilateral hippocampal atrophy.
AUTHOR: Li,-L-M; Cendes,-F; Antel,-S-B; Andermann,-F; Serles,-W; Dubeau,-F; Olivier,-A; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery and the Montreal Neurological Institute and Hospital, McGill University, Quebec, Canada.
SOURCE: Ann-Neurol. 2000 Feb; 47(2): 195-200
INTERNATIONAL STANDARD SERIAL NUMBER: 0364-5134
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: The objective of this study was to assess which features of temporal lobe proton magnetic resonance spectroscopic imaging (1H-MRSI) are associated with satisfactory surgical outcome in patients with intractable temporal lobe epilepsy and bilateral hippocampal atrophy. We studied 21 patients with intractable temporal lobe epilepsy and bilateral hippocampal atrophy defined by magnetic resonance imaging volumetric measurements who underwent surgical treatment. 1H-MRSI was used to determine the relative resonance intensity ratio of the neuronal marker N-acetylaspartate to creatine + phosphocreatine (NAA/Cr) for mid and posterior temporal lobe regions of the left and right hemisphere, as well as an asymmetry index. Values lower than 2 SDs below the normal mean were considered abnormal. We used Engel's classification to assess surgical outcome with respect to seizure control. Eleven patients (52%) were in class I-II and 10 (48%) were in class III-IV. All 21 were operated on the side of maximal electroencephalographic (EEG) lateralization. Concordant lateralization of decreases in NAA/Cr to the side of surgery and normal NAA/Cr values in the contralateral posterior-temporal region were significantly associated with good surgical outcome: 11 (69%) of 16 patients with 1H-MRSI abnormalities concordant with EEG lateralization and none of the 5 patients with nonconcordant 1H-MRSI had a good outcome (class I-II); 10 (77%) of 13 patients with normal NAA/Cr contralateral to the EEG lateralization versus 1 (12.5%) of 8 of those with NAA/Cr reduction contralateral to EEG lateralization were in class I-II. Regression correlation analysis showed significant linear correlation between the midtemporal NAA/Cr relative asymmetry ratio and surgical outcome; the greater the asymmetry, the better the outcome. We conclude that discriminant 1H-MRSI features associated with favorable surgical outcome in patients with temporal lobe epilepsy and bilateral hippocampal atrophy were (1) concordant 1H-MRSI lateralization, (2) a greater side-to-side asymmetry of NAA/Cr, and (3) an absence of contralateral posterior NAA/Cr reduction.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Epilepsy,-Temporal-Lobe-surgery; *Hippocampus-pathology; *Magnetic-Resonance-Spectroscopy
MINOR MESH DESCRIPTORS: Adolescence-; Adult-; Aspartic-Acid-analogs-and-derivatives; Aspartic-Acid-metabolism; Atrophy-; Brain-metabolism; Creatine-metabolism; Dominance,-Cerebral; Electroencephalography-; Epilepsy,-Temporal-Lobe-metabolism; Epilepsy,-Temporal-Lobe-pathology; Middle-Age; Phosphocreatine-metabolism; Prognosis-; Treatment-Outcome
CHECKTAGS: Female; Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: analogs-and-derivatives; metabolism; diagnosis; pathology; surgery
CAS REGISTRY NUMBER OR EC NUMBER: 56-84-8; 57-00-1; 67-07-2; 997-55-7
NAME OF SUBSTANCE: Aspartic-Acid; Creatine; Phosphocreatine; N-acetylaspartate
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20127256
RECORD FEATURES: ABSTRACT (AB)
Record 2 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 3 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 4 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 5 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 6 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 7 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 8 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 9 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 10 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 11 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 12 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 13 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 14 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 15 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 16 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 17 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 18 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 19 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 20 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 21 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 22 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)
Record 23 of 23 in MEDLINE (R) 2000
TITLE: Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data.
AUTHOR: Li,-L-M; Caramanos,-Z; Cendes,-F; Andermann,-F; Antel,-S-B; Dubeau,-F; Arnold,-D-L
ADDRESS OF AUTHOR: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
SOURCE: Epilepsia. 2000 Jul; 41(7): 832-42
INTERNATIONAL STANDARD SERIAL NUMBER: 0013-9580
PUBLICATION YEAR: 2000
LANGUAGE: English
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine whether or not pattern analysis of magnetic resonance volumetric (MRVol) and proton magnetic resonance spectroscopic imaging (1H-MRSI) data would enable (a) the accurate lateralization of temporal lobe epilepsy (TLE) and (b) the discrimination of TLE from extratemporal epilepsy (E-TLE). METHODS: For lateralization analysis, we used data from 150 nonforeign tissue lesional TLE patients [88 left-sided (L-TLE), 46 right-sided (R-TLE), and 16 bilateral (Bi-TLE)]. For the discrimination of TLE from E-TLE, we used data from 174 patients (145 with unilateral TLE, 14 with unilateral E-TLE, and 15 with widespread epileptogenic zones involving both the TL and extra-TL regions-multilobar epilepsy). A series of "leave-one-out" cross-validated linear discriminant analyses were performed using the MRVol and 1H-MRSI data sets to lateralize TLE and discriminate it from E-TLE. RESULTS: Lateralization: The leave-one-out linear discriminant analyses were able to correctly lateralize (with a posterior probability >0.50) 120 (90%) of the 134 L-TLE and R-TLE patients. Imposing higher posterior probability (>0.95) increased accuracy of lateralization to 98%, with only two discordant cases who underwent surgery on the side of electroencephalogram, and both had bad outcome. Discrimination: the leave-one-out linear discriminant analyses were able to correctly classify (with a posterior probability >0.50) 142 (89%) of the 159 TLE and E-TLE patients. Accuracy increased slightly as higher posterior probability cutoffs were imposed, with fewer patients being classified. CONCLUSIONS: Pattern analysis of 1H-MRSI and MRVol data can accurately lateralize TLE. Discriminating TLE from E-TLE was less accurate, probably due to the presence of temporal lobe damage in some patients with E-TLE reflecting dual pathology.
MAJOR MESH DESCRIPTORS: *Epilepsy,-Temporal-Lobe-diagnosis; *Laterality-; *Magnetic-Resonance-Imaging-statistics-and-numerical-data; *Magnetic-Resonance-Spectroscopy-diagnostic-use; *Temporal-Lobe-anatomy-and-histology
MINOR MESH DESCRIPTORS: Amygdala-anatomy-and-histology; Diagnosis,-Differential; Discriminant-Analysis; Electroencephalography-statistics-and-numerical-data; Epilepsy-diagnosis; Hippocampus-anatomy-and-histology; Magnetic-Resonance-Imaging-methods; Multivariate-Analysis
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: Journal-Article
SUBHEADINGS: anatomy-and-histology; statistics-and-numerical-data; diagnosis; methods; diagnostic-use
SUBSET: Index-Medicus
UPDATE CODE: 20001218
ACCESSION NUMBER: 20357675
RECORD FEATURES: ABSTRACT (AB)