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TI: Scrotal angiokeratoma in a young man [letter]
AU: Hisa-T; Taniguchi-S; Goto-Y; Teramae-H; Osato-K; Kakudo-K; Takigawa-M
SO: Acta-Derm-Venereol. 1996 May; 76(3): 248-9
ISSN: 0001-5555
PY: 1996
LA: ENGLISH
CP: NORWAY
MESH: Adult-
MESH: *Angiokeratoma-pathology; *Scrotum-; *Skin-Neoplasms-pathology
TG: Case-Report; Human; Male
PT: LETTER
AN: 96393543
UD: 9706
MEDLINE EXPRESS (R) 1/97-8/97 2 of 28
TI: Angiokeratomas: an update.
AU: Schiller-PI; Itin-PH
AD: Department of Dermatology, University Hospital, Basel, Switzerland.
SO: Dermatology. 1996; 193(4): 275-82
ISSN: 1018-8665
PY: 1996
LA: ENGLISH
CP: SWITZERLAND
AB: Angiokeratomas are vascular lesions which are defined histologically as one or more dilated blood vessel(s) lying directly subepidermal and showing an epidermal proliferative reaction. At the center of pathogenesis there is a capillary ectasia in the papillary dermis. The epidermal changes in all forms of angiokeratoma are secondary. The different entities causing vessel ectasia lead to the many clinical variants of angiokeratoma. Current classification distinguishes between widespread forms (angiokeratoma corporis diffusum), which is usually associated with an inborn error of metabolism, and localized forms, which include solitary angiokeratoma, Fordyce's angiokeratoma, angiokeratoma circumscriptum naeviforme and angiokeratoma of Mibelli.
MESH: Angiokeratoma-epidemiology; Angiokeratoma-pathology; Angiokeratoma-physiopathology; Diagnosis,-Differential; Prognosis-; Skin-Neoplasms-epidemiology; Skin-Neoplasms-pathology; Skin-Neoplasms-physiopathology
MESH: *Angiokeratoma-; *Skin-Neoplasms
TG: Human
PT: JOURNAL-ARTICLE; REVIEW; REVIEW,-TUTORIAL
AN: 97147093
UD: 9705
MEDLINE EXPRESS (R) 1/97-8/97 3 of 28
TI: Widespread angiokeratomas and tuberous sclerosis.
AU: Gil-Mateo-MP; Miquel-FJ; Velasco-AM; Pitarch-A; Fortea-JM; Aliaga-A
AD: Department of Dermatoogy, Hospital General Universitario, Valencia, Spain.
SO: Br-J-Dermatol. 1996 Aug; 135(2): 280-2
ISSN: 0007-0963
PY: 1996
LA: ENGLISH
CP: ENGLAND
AB: We report a 29-year-old woman who had prominent cutaneous markers of tuberous sclerosis, with subependymal nodules and renal cysts on computerized tomographic scan, who also showed multiple angiokeratomas widely distributed on the buttocks and posterior thighs. Enzymatic studies ruled out Fabry's disease and other lysosomal storage disorders. This is the first reported association of widespread angiokeratomas and tuberous sclerosis.
MESH: Adult-; Angiokeratoma-pathology; Skin-Neoplasms-pathology; Tuberous-Sclerosis-pathology
MESH: *Angiokeratoma-complications; *Skin-Neoplasms-complications; *Tuberous-Sclerosis-complications
TG: Case-Report; Female; Human
PT: JOURNAL-ARTICLE
AN: 97036026
UD: 9702
MEDLINE EXPRESS (R) 1992-1996 4 of 28
TI: Cutaneous and cerebral haemangiomas associated with eruptive angiokeratomas.
AU: Ostlere-L; Hart-Y; Misch-KJ
AD: Department of Dermatology, Kingston Hospital, Surrey, U.K.
SO: Br-J-Dermatol. 1996 Jul; 135(1): 98-101
ISSN: 0007-0963
PY: 1996
LA: ENGLISH
CP: ENGLAND
AB: We report a patient with multiple cutaneous and cerebral haemangiomas associated with angiokeratomas. As far as we are aware this patient is unique as the association of cutaneous and cerebral haemangiomas with angiokeratomas has not been previously described.
MESH: Brain-Neoplasms-radiography; Hemangioma-radiography; Middle-Age; Tomography,-X-Ray-Computed
MESH: *Angiokeratoma-pathology; *Brain-Neoplasms-pathology; *Hemangioma-pathology; *Neoplasms,-Second-Primary-pathology; *Skin-Neoplasms-pathology
TG: Case-Report; Human; Male
PT: JOURNAL-ARTICLE
AN: 96372553
UD: 9612
MEDLINE EXPRESS (R) 1992-1996 5 of 28
TI: Scrotal angiokeratoma in a young man [letter]
AU: Hisa-T; Taniguchi-S; Goto-Y; Teramae-H; Osato-K; Kakudo-K; Takigawa-M
SO: Acta-Derm-Venereol. 1996 Jan; 76(1): 75
ISSN: 0001-5555
PY: 1996
LA: ENGLISH
CP: NORWAY
MESH: Adult-; Angiokeratoma-complications; Hemorrhage-diagnosis; Hemorrhage-etiology; Skin-Neoplasms-complications
MESH: *Angiokeratoma-diagnosis; *Scrotum-pathology; *Skin-Neoplasms-diagnosis
TG: Case-Report; Human; Male
PT: LETTER
AN: 96282002
UD: 9611
MEDLINE EXPRESS (R) 1992-1996 6 of 28
TI: Laser treatment of recurrent vulvar angiokeratoma associated with Noonan syndrome.
AU: Meyer-WR; Dotters-DJ
AD: Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, USA.
SO: Obstet-Gynecol. 1996 May; 87(5 Pt 2): 863-5
ISSN: 0029-7844
PY: 1996
LA: ENGLISH
CP: UNITED-STATES
AB: BACKGROUND: Vulvar angiokeratoma is often confused with other, more common perineal lesions. Chronically elevated venous pressures may contribute to this rare disorder. Laser treatment may lend palliation for several years. CASE: A woman with the characteristic cardiac abnormalities of Noonan syndrome initially responded to Argon laser treatment of vulvar angiokeratoma. Excessive recurrent disease was treated satisfactorily with the Nd:YAG laser. CONCLUSION: Recurrent vulvar angiokeratoma in Noonan syndrome supports the premise that increased persistent central venous pressure may be involved in the disease process.
MESH: Adult-; Angiokeratoma-complications; Palliative-Care; Skin-Neoplasms-complications; Time-Factors; Vulvar-Neoplasms-complications
MESH: *Angiokeratoma-surgery; *Laser-Surgery; *Neoplasm-Recurrence,-Local-surgery; *Noonan-Syndrome-complications; *Skin-Neoplasms-surgery; *Vulvar-Neoplasms-surgery
TG: Case-Report; Female; Human
PT: JOURNAL-ARTICLE
AN: 96200648
UD: 9610
SB: AIM
MEDLINE EXPRESS (R) 1992-1996 7 of 28
TI: Of APACHEs and PALEFACEs [letter; comment]
CM: Comment on: Am J Dermatopathol 1994 Apr;16(2):130-3
AU: Puig-L
SO: Am-J-Dermatopathol. 1995 Apr; 17(2): 209-11
ISSN: 0193-1091
PY: 1995
LA: ENGLISH
CP: UNITED-STATES
MESH: Adolescence-; Diagnosis,-Differential; Endothelium,-Vascular-pathology; Lymphocytes-pathology; Lymphoma,-Small-Lymphocytic-pathology; Plasma-Cells-pathology; Thorax-
MESH: *Angiokeratoma-pathology; *Skin-Neoplasms-pathology
TG: Case-Report; Human; Male
PT: COMMENT; LETTER
AN: 96166795
UD: 9607
MEDLINE EXPRESS (R) 1992-1996 8 of 28
TI: [Angiokeratoma and fucosidosis. Immunohistochemical and ultrastructural study]
TO: Angiokeratomes et fucosidose. Etude immunohistochimique et ultrastructurale.
AU: Venencie-PY; Pauwels-C; Malherbe-V; Perie-G; Landrieu-P
AD: Unite de Dermatologie, Centre Hospitalier General, Saint-Germain en Laye.
SO: Ann-Dermatol-Venereol. 1995; 122(6-7): 432-5
ISSN: 0151-9638
PY: 1995
LA: FRENCH; NON-ENGLISH
CP: FRANCE
AB: INTRODUCTION. Angiokeratoma can lead to diagnoses other than Fabry's disease. We report a case of angiokeratoma in a child with fucosidosis. CASE REPORT. A 7-year-old child with psychomotor retardation presented angiokeratoma located on the penis. Uptake of type I Ulex Europaeus Agglutinin antilectin antiserum was intense in the endothelial structure. This antibody is specific for alpha-L-fucose residues which were thus found in large quantities in the vacuoles of the ultrastructure. The patient also had a major deficiency in leukocyte, serum and fibroblast alpha-fucosidase. COMMENTS. This is a typical case of fucosidosis, a rare hereditary disease with autosomal recessive transmission due to generalized deficiency in alpha-L-fucosidase. Diffuse angiokeratosis should suggest, other than Fabry's disease, fucosidase and other enzyme deficiencies including sialidase, GM1 gangliosidase as well as Kanzaki's disease.
MESH: Angiokeratoma-pathology; Angiokeratoma-ultrastructure; Child-; English-Abstract; Fucosidosis-pathology; Immunohistochemistry-; Skin-pathology; Skin-ultrastructure; Skin-Neoplasms-pathology; Skin-Neoplasms-ultrastructure
MESH: *Angiokeratoma-etiology; *Fucosidosis-complications; *Skin-Neoplasms-etiology
TG: Case-Report; Human; Male
PT: JOURNAL-ARTICLE
AN: 96099543
UD: 9603
SB: NURSING
MEDLINE EXPRESS (R) 1992-1996 9 of 28
TI: Argon laser treatment of cutaneous multiple angiokeratomas.
AU: Occella-C; Bleidl-D; Rampini-P; Schiazza-L; Rampini-E
AD: Department of Dermatology, Istituto Scientifico Giannina Gaslini, Genova, Italy.
SO: Dermatol-Surg. 1995 Feb; 21(2): 170-2
ISSN: 1076-0512
PY: 1995
LA: ENGLISH
CP: UNITED-STATES
AB: BACKGROUND. Angiokeratomas are cutaneous vascular lesions with common clinical and histological features: dark red to black papules and ectasia of upper dermis vessels, respectively. Multiple angiokeratomas are difficult to treat because they are often too extensive for surgery and cautery, procedures frequently leading to hemorrhage and scarring. OBJECTIVE. Our report is designed to evaluate the efficacy of argon laser photocoagulation in the treatment of multiple angiokeratomas. METHODS. Two male patients affected by angiokeratoma circumscriptum and angiokeratoma of Fordyce, respectively, were treated using an argon laser under local anesthesia. The laser beam was used as a hemostyptic and to flatten vascular papules by photocoagulation. RESULTS. The cosmetic results of argon laser treatment were good. Posttreatment crusting lasted 2 weeks; 4 months later there was excellent healing without scarring. CONCLUSION. Angiokeratomas respond favorably to argon laser photocoagulation since vascular ectasias are localized in the papillary dermis. Thus, the argon laser offers significant advantages over traditional methods and produces no side effects.
MESH: Adult-; Angiokeratoma-pathology; Biopsy-; Buttocks-; Chronic-Disease; Remission-Induction; Scrotum-; Skin-pathology; Skin-Neoplasms-pathology
MESH: *Angiokeratoma-surgery; *Laser-Coagulation; *Skin-Neoplasms-surgery
TG: Case-Report; Human; Male
PT: JOURNAL-ARTICLE
AN: 95202320
UD: 9506
MEDLINE EXPRESS (R) 1992-1996 10 of 28
TI: On the discriminatory value of anti-HPCA-1 (CD-34) in the differential diagnosis of benign and malignant cutaneous vascular proliferations.
AU: Suster-S; Wong-TY
AD: Arkadi M. Rywlin Department of Pathology & Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140.
SO: Am-J-Dermatopathol. 1994 Aug; 16(4): 355-63
ISSN: 0193-1091
PY: 1994
LA: ENGLISH
CP: UNITED-STATES
AB: The staining pattern of monoclonal antibody anti-HPCA-1 (CD-34) was studied in 95 cases of benign and malignant cutaneous vascular proliferations and compared with other vascular endothelium-associated antigenic markers in paraffin-embedded tissues. The proliferating vessels in 22 cutaneous capillary hemangiomas, 8 lobular capillary hemangiomas, and 1 case of papillary intravascular endothelial hyperplasia stained strongly positively for anti-HPCA-1, and the intensity of the reaction was paralleled by that of factor VIII-related antigen (FVIII), Ulex europaeus lectin-1 (UEA), and vimentin (VIM). The vessels in 10 cases of granulation tissue, 6 cases of cavernous hemangioma, 6 cases of angiokeratoma, 5 cases of angiolymphoid hyperplasia with eosinophilia (epithelioid hemangioma), and 3 cases of bacillary angiomatosis showed a lack of reactivity with anti-HPCA-1 and staining of variable intensity with the other markers. Twenty cases of Kaposi's sarcoma (seven patch, five plaque, eight nodular stage) showed strong labeling with anti-HPCA-1 in small, well-formed vessels scattered among the spindle-cell proliferation, and four of these cases showed focal positivity of scattered spindle cells. Nine cases of cutaneous angiosarcoma, two cases of low-grade epithelioid angiosarcoma, and one case of spindle-cell hemangioendothelioma were negative for anti-HPCA-1 and showed variable reactivity for FVIII and UEA; all cases stained strongly positively for VIM. The results of this study indicate that although anti-HPCA-1 shows a high sensitivity for the staining of normal vascular endothelium, its specificity may be restricted to mature, well-formed vessels, therefore rendering its discriminatory value very limited for the identification of poorly differentiated vascular endothelial neoplasms.
MESH: von-Willebrand-Factor-analysis; Angiokeratoma-blood-supply; Angiokeratoma-diagnosis; Angiomatosis,-Bacillary-diagnosis; Angiomatosis,-Bacillary-pathology; Antibodies,-Monoclonal-diagnostic-use; Diagnosis,-Differential; Endothelium,-Vascular-pathology; Granulation-Tissue-blood-supply; Granuloma,-Pyogenic-diagnosis; Hemangioendothelioma,-Epithelioid-blood-supply; Hemangioendothelioma,-Epithelioid-diagnosis; Hemangioma-blood-supply; Hemangioma-diagnosis; Hemangioma,-Capillary-blood-supply; Hemangioma,-Capillary-diagnosis; Hemangioma,-Cavernous-blood-supply; Hemangioma,-Cavernous-diagnosis; Hemangiosarcoma-blood-supply; Hemangiosarcoma-diagnosis; Hyperplasia-; Lectins-analysis; Paraffin-Embedding; Sarcoma,-Kaposi's-blood-supply; Sarcoma,-Kaposi's-diagnosis; Skin-Diseases,-Vascular-pathology; Staining-; Vimentin-analysis
MESH: *Antigens,-CD-analysis; *Skin-Diseases,-Vascular-diagnosis; *Skin-Neoplasms-blood-supply; *Skin-Neoplasms-diagnosis; *Tumor-Markers,-Biological-analysis
TG: Comparative-Study; Human
PT: JOURNAL-ARTICLE
RN: 0; 0; 0; 0; 0; 0; 0; 0
NM: von-Willebrand-Factor; Antibodies,-Monoclonal; Antigens,-CD; Antigens,-CD34; Lectins; Tumor-Markers,-Biological; Ulex-europaeus-lectins; Vimentin
AN: 95068714
UD: 9502
MEDLINE EXPRESS (R) 1992-1996 11 of 28
TI: Rare palpebral tumours. Histopathological aspects.
AU: Halalau-F; Laky-D
AD: Victor Babes Institute, Bucharest, Romania.
SO: Rom-J-Morphol-Embryol. 1994 Jan-Jun; 40(1-2): 51-3
ISSN: 1220-0522
PY: 1994
LA: ENGLISH
CP: ROMANIA
MESH: Adult-; Angiokeratoma-pathology; Lymphoma,-B-Cell-pathology; Middle-Age; Neoplasm-Recurrence,-Local
MESH: *Eyelid-Neoplasms-pathology
TG: Case-Report; Human
PT: JOURNAL-ARTICLE
AN: 95367666
UD: 9511
MEDLINE EXPRESS (R) 1992-1996 12 of 28
TI: Angiokeratoma corporis diffusum in fucosidosis.
AU: George-S; Graham-Brown-RA
AD: Department of Dermatology, Leicester Royal Infirmary, UK.
SO: J-R-Soc-Med. 1994 Nov; 87(11): 707
ISSN: 0141-0768
PY: 1994
LA: ENGLISH
CP: ENGLAND
MESH: Angiokeratoma-pathology; Child-; Genitalia,-Female-pathology; Skin-Neoplasms-pathology
MESH: *Fabry's-Disease-etiology; *Fucosidosis-complications; *Skin-Neoplasms-etiology
TG: Case-Report; Female; Human
PT: JOURNAL-ARTICLE
AN: 95138992
UD: 9505
MEDLINE EXPRESS (R) 1992-1996 13 of 28
TI: Lack of association between varicocele and angiokeratoma of the scrotum (Fordyce).
AU: Orvieto-R; Alcalay-J; Leibovitz-I; Nehama-H
AD: Department of Obstetrics and Gynecology, Golda Medical Center, Hasharon Hospital, Petah Tiqva, Israel.
SO: Mil-Med. 1994 Jul; 159(7): 523-4
ISSN: 0026-4075
PY: 1994
LA: ENGLISH
CP: UNITED-STATES
AB: Angiokeratoma of the scrotum is thought to be associated with varicocele. Our study population consisted of young soldiers and adult reservists. The young population was screened during routine medical examination for the existence of varicocele or angiomas on the scrotum, while the adult reservists, who according to their medical records had varicocele, were randomly questioned for the existence of any kind of spots or lesions on their scrota. We found no association between varicocele and angiokeratoma of the scrotum. Since the prevalence of varicocele is high, it is possible that in the reported cases the association of varicocele and angiokeratoma of the scrotum was coincidental.
MESH: Adolescence-; Adult-; Middle-Age
MESH: *Angiokeratoma-complications; *Genital-Neoplasms,-Male-complications; *Military-Personnel; *Scrotum-; *Varicocele-complications
TG: Human; Male
PT: JOURNAL-ARTICLE
AN: 95115900
UD: 9504
MEDLINE EXPRESS (R) 1992-1996 14 of 28
TI: Multiple angiokeratomas with zosteriform distribution in two sisters.
AU: Eizaguirre-X; Landa-N; Raton-JA; Diaz-Perez-JL
AD: Department of Dermatology, Hospital de Cruces, Bilbao, Spain.
SO: Int-J-Dermatol. 1994 Sep; 33(9): 641-2
ISSN: 0011-9059
PY: 1994
LA: ENGLISH
CP: UNITED-STATES
MESH: Adult-; Age-of-Onset; Angiokeratoma-genetics; Angiokeratoma-physiopathology; Remission,-Spontaneous; Skin-Neoplasms-genetics; Skin-Neoplasms-physiopathology
MESH: *Angiokeratoma-classification; *Angiokeratoma-pathology; *Skin-Neoplasms-classification; *Skin-Neoplasms-pathology
TG: Case-Report; Female; Human
PT: JOURNAL-ARTICLE
AN: 95095457
UD: 9503
MEDLINE EXPRESS (R) 1992-1996 15 of 28
TI: Acral pseudolymphomatous angiokeratoma. A variant of the cutaneous pseudolymphomas [see comments]
CM: Comment in: Am J Dermatopathol 1995 Apr;17(2):209-11
AU: Kaddu-S; Cerroni-L; Pilatti-A; Soyer-HP; Kerl-H
AD: Department of Dermatology, University of Graz, Austria.
SO: Am-J-Dermatopathol. 1994 Apr; 16(2): 130-3
ISSN: 0193-1091
PY: 1994
LA: ENGLISH
CP: UNITED-STATES
AB: APACHE (acral pseudolymphomatous angiokeratoma of children) is a recently described benign cutaneous condition. Only a few cases have been documented to date. The disease has been previously reported in children between 2 and 13 years of age as unilateral eruptions of multiple angiomatous papules on acral sites of the hands and feet. We herein report two cases of APACHE, one occurring in a 16-year-old boy and the other in a 64-year-old woman. Unlike the previously reported cases, our female patient presented in adulthood with a single lesion on the back. Histopathologic and immunohistochemical investigations reveal characteristic features, allowing APACHE to be included among the group of cutaneous pseudolymphomas.
MESH: Adolescence-; Diagnosis,-Differential; Immunoenzyme-Techniques; Lymphoma,-Small-Lymphocytic-pathology; Middle-Age; Skin-pathology
MESH: *Angiokeratoma-pathology; *Skin-Neoplasms-pathology
TG: Case-Report; Female; Human; Male
PT: JOURNAL-ARTICLE
AN: 94303810
UD: 9410
MEDLINE EXPRESS (R) 1992-1996 16 of 28
TI: Angiokeratoma of Fordyce: a cause of scrotal bleeding.
AU: Taniguchi-S; Inoue-A; Hamada-T
AD: Department of Dermatology, Osaka City University Medical School, Japan.
SO: Br-J-Urol. 1994 May; 73(5): 589-90
ISSN: 0007-1331
PY: 1994
LA: ENGLISH
CP: ENGLAND
MESH: Angiokeratoma-pathology; Genital-Diseases,-Male-etiology; Middle-Age; Scrotum-pathology; Skin-Neoplasms-pathology
MESH: *Angiokeratoma-complications; *Hemorrhage-etiology; *Scrotum-; *Skin-Neoplasms-complications
TG: Case-Report; Human; Male
PT: JOURNAL-ARTICLE
AN: 94282555
UD: 9409
MEDLINE EXPRESS (R) 1992-1996 17 of 28
TI: Angiokeratomas in Fabry's disease and Fordyce's disease: successful treatment with copper vapour laser.
AU: Lapins-J; Emtestam-L; Marcusson-JA
AD: Department of Dermatology, University Hospital, Huddinge, Sweden.
SO: Acta-Derm-Venereol. 1993 Apr; 73(2): 133-5
ISSN: 0001-5555
PY: 1993
LA: ENGLISH
CP: SWEDEN
AB: Two patients with multiple angiokeratomas on genitalia and thighs, one with Fabry's disease and one with Fordyce's disease, were treated with copper vapour laser light of 578 nm wavelength. The result was desirable, with destruction and disappearance of the lesions and minimal scarring and posttreatment hyper- or hypopigmentation.
MESH: Adult-; Aged-; Aged,-80-and-over; Angiokeratoma-etiology; Buttocks-; Copper-; Genitalia,-Male; Skin-Neoplasms-etiology; Thigh-; Treatment-Outcome
MESH: *Angiokeratoma-surgery; *Fabry's-Disease-complications; *Fox-Fordyce-Disease-complications; *Laser-Surgery; *Skin-Neoplasms-surgery
TG: Case-Report; Human; Male
PT: JOURNAL-ARTICLE
RN: 7440-50-8
NM: Copper
AN: 93370068
UD: 9312
MEDLINE EXPRESS (R) 1992-1996 18 of 28
TI: Slides in dermatology: 1.
AU: Leslie-TA; Dowd-PM
AD: University College, London.
SO: Br-J-Hosp-Med. 1993 Oct 6-19; 50(7): 415-6
ISSN: 0007-1064
PY: 1993
LA: ENGLISH
CP: ENGLAND
MESH: Angiokeratoma-diagnosis; Angiokeratoma-pathology; Diagnosis,-Differential; Granuloma-Annulare-diagnosis; Granuloma-Annulare-pathology; Ischemia-diagnosis; Ischemia-pathology; Scleroderma,-Systemic-diagnosis; Scleroderma,-Systemic-pathology; Skin-blood-supply; Skin-pathology; Skin-Diseases-pathology; Skin-Neoplasms-diagnosis; Skin-Neoplasms-pathology
MESH: *Skin-Diseases-diagnosis
TG: Human
PT: JOURNAL-ARTICLE
AN: 94084512
UD: 9403
MEDLINE EXPRESS (R) 1992-1996 19 of 28
TI: [Surface microscopy of pigmented cutaneous tumors]
TO: Microscopie de surface des tumeurs cutanees pigmentees.
AU: Soyer-HP; Kerl-H
AD: Clinique Dermatologique et Venereologique, l'Universite de Graz, Autriche.
SO: Ann-Dermatol-Venereol. 1993; 120(1): 15-20
ISSN: 0151-9638
PY: 1993
LA: FRENCH; NON-ENGLISH
CP: FRANCE
AB: BACKGROUND: Clinical guidelines for the diagnosis of pigmented lesions of the skin are not always reliable. Especially the differential diagnosis between benign dysplastic nevi (Clark's nevi) and early melanomas, as well as between melanocytic and nonmelanocytic skin tumors (seborrheic keratoses, pigmented basal cell carcinomas and angiokeratomas) is often difficult. OBJECTIVE: Surface microscopy, which is performed today under various synonyms (dermoscopy, dermatoscopy, epiluminescence microscopy, incident light microscopy, skin microscopy), has been shown to provide additional features and subtle clues for the assessment of pigmented skin lesions. METHODS: The pigmented lesions are covered in vivo with a drop of immersion oil and a glass slide, and observed in incident light by using a stereomicroscope (magnification 6- to 40-fold) or a hand-held instrument called dermatoscope (magnification 10-fold). The immersion oil renders the stratum corneum translucent and allows a better observation of distinctive alterations of the dermoepidermal junction and the papillary dermis. RESULTS: The various criteria of surface microscopy (e.g. pigment network, black dots or irregular extensions) that cannot be discerned by the naked eye are summarized and discussed in detail. The diagnostic significance but also the limitations of this technique are emphasized. CONCLUSION: Surface microscopy opens up a new dimension of clinical morphology for the diagnosis of pigmented skin tumors and facilitates a more reliable assessment of the lesions.
MESH: Angiokeratoma-pathology; Carcinoma,-Basal-Cell-pathology; Diagnosis,-Differential; English-Abstract; Keratosis,-Seborrheic-pathology; Pigmentation-Disorders-pathology
MESH: *Melanoma-pathology; *Microscopy-methods; *Nevus,-Pigmented-pathology; *Skin-Neoplasms-pathology
TG: Human
PT: JOURNAL-ARTICLE
AN: 93332353
UD: 9310
SB: NURSING
MEDLINE EXPRESS (R) 1992-1996 20 of 28
TI: Angiokeratoma corporis circumscriptum naeviforme with transepidermal elimination.
AU: Miwa-N; Kobayashi-T; Kanzaki-T; Tsuji-T
AD: Department of Dermatology, Nagoya City University Medical School, Japan.
SO: J-Dermatol. 1993 Apr; 20(4): 247-51
ISSN: 0385-2407
PY: 1993
LA: ENGLISH
CP: JAPAN
AB: A 5-year-old Japanese boy visited our clinic for treatment of a dark bluish papulonodular lesion on his right thigh. The histopathology of the lesion indicated angiokeratoma corporis circumscriptum naeviforme. Topical antibiotics were prescribed for occasional bleeding from the site. Frequent bleeding started in April of 1992, when erythema and itching were observed around the angiokeratoma. Histopathology of the lesion showed heavy lymphoid cell infiltration around dilated capillaries and irregular acanthosis engulfing dilated capillaries. Interestingly, there were confined masses of red blood cells in the epidermal layer as well as both in and on the horny layer. This is a feature of transepidermal elimination. This transepidermal elimination appeared to be triggered or enhanced by the concomitant contact dermatitis due to topical antibiotics. To the best of our knowledge, this is the first report of angiokeratoma in which the angiokeratoma itself reduced in size through transepidermal elimination, possibly caused by contact dermatitis.
MESH: Angiokeratoma-blood-supply; Capillaries-pathology; Child,-Preschool; Epidermis-pathology; Erythrocytes-pathology; Neomycin-adverse-effects; Povidone-Iodine-adverse-effects; Skin-Neoplasms-blood-supply
MESH: *Angiokeratoma-pathology; *Dermatitis,-Contact-pathology; *Skin-Neoplasms-pathology
TG: Case-Report; Human; Male
PT: JOURNAL-ARTICLE
RN: 1404-04-2; 25655-41-8
NM: Neomycin; Povidone-Iodine
AN: 93301263
UD: 9309
MEDLINE EXPRESS (R) 1992-1996 21 of 28
TI: Ramon syndrome with diabetes mellitus and vascular skin lesions in two sibs.
AU: Pridmore-C; Baraitser-M; Leonard-J
AD: Department of Clinical Genetics, Institute of Child Health, London, UK.
SO: Clin-Dysmorphol. 1992 Jan; 1(1): 29-35
ISSN: 0962-8827
PY: 1992
LA: ENGLISH
CP: ENGLAND
AB: Two sibs are reported with Ramon syndrome with the previously undescribed associations of insulin dependent diabetes mellitus and vascular skin lesions.
MESH: Adolescence-; Angiokeratoma-genetics; Child-; Diabetes-Mellitus,-Insulin-Dependent-genetics; Facial-Bones-abnormalities; Facial-Bones-radiography; Mental-Retardation-genetics; Skin-Diseases,-Vascular-genetics; Syndrome-; Telangiectasis-genetics
MESH: *Diabetes-Mellitus,-Insulin-Dependent; *Skin-Diseases,-Vascular
TG: Case-Report; Female; Human; Male
PT: JOURNAL-ARTICLE; REVIEW; REVIEW-OF-REPORTED-CASES
AN: 94115528
UD: 9404
MEDLINE EXPRESS (R) 1992-1996 22 of 28
TI: Angiokeratoma of the clitoris: a subtype of angiokeratoma vulvae.
AU: Yamazaki-M; Hiruma-M; Irie-H; Ishibashi-A
AD: Department of Dermatology, National Defense Medical College, Saitama, Japan.
SO: J-Dermatol. 1992 Sep; 19(9): 553-5
ISSN: 0385-2407
PY: 1992
LA: ENGLISH
CP: JAPAN
AB: A 24-year-old married woman had an angiokeratoma of the vulva measuring 3 x 3 x 4 mm localized at the clitoris. The nodule was noticed when she was pregnant with her first child. This tumor grew with occasional tenderness and bleeding during pregnancy, but its size did not change after delivery. The growth of this tumor might be attributable to an increase in venous pressure or serum progesterone levels; therefore this disorder might be classified as a subtype of angiokeratoma of the vulva. This is the first case of angiokeratoma localized at the clitoris.
MESH: Adult-; Angiokeratoma-surgery; Clitoris-surgery; Pregnancy-; Pregnancy-Complications,-Neoplastic-pathology; Vulvar-Neoplasms-surgery
MESH: *Angiokeratoma-pathology; *Clitoris-pathology; *Vulvar-Neoplasms-pathology
TG: Case-Report; Female; Human
PT: JOURNAL-ARTICLE
AN: 93123614
UD: 9304
MEDLINE EXPRESS (R) 1992-1996 23 of 28
TI: Angiokeratoma of the clitoris.
AU: McNeely-TB
AD: Department of Pathology, Vancouver (British Columbia) General Hospital, Canada.
SO: Arch-Pathol-Lab-Med. 1992 Aug; 116(8): 880-1
ISSN: 0003-9985
PY: 1992
LA: ENGLISH
CP: UNITED-STATES
AB: A 25-year-old woman, multigravida, presented with a dark ulcerated tumor of the clitoris. Histologic examination demonstrated an angiokeratoma, a benign telangiectatic vascular tumor. To our knowledge, this is the first report of angiokeratoma of the clitoris and only the fifth describing vascular tumor of this organ. The clinical differential diagnosis of angiokeratoma and of clitoral tumors includes malignant neoplasms such as melanoma. Biopsy with histologic examination is, therefore, recommended to ensure appropriate treatment of these unusual tumors.
MESH: Adult-; Angiokeratoma-diagnosis; Biopsy-; Diagnosis,-Differential; Melanoma-diagnosis; Melanoma-pathology; Vulvar-Neoplasms-diagnosis
MESH: *Angiokeratoma-pathology; *Clitoris-; *Vulvar-Neoplasms-pathology
TG: Case-Report; Female; Human
PT: JOURNAL-ARTICLE
AN: 92359692
UD: 9211
SB: AIM
MEDLINE EXPRESS (R) 1992-1996 24 of 28
TI: Scrotal angiokeratoma (Fordyce): histopathological and ultrastructural findings.
AU: Gioglio-L; Porta-C; Moroni-M; Nastasi-G; Gangarossa-I
AD: Institute of Human Anatomy, University of Pavia, Italy.
SO: Histol-Histopathol. 1992 Jan; 7(1): 47-55
ISSN: 0213-3911
PY: 1992
LA: ENGLISH
CP: SPAIN
AB: Bioptic findings related to four cases of scrotal angiokeratoma-Fordyce, were studied under light and electron microscopy. A particular heterogeneity of the structural and ultrastructural patterns typical of this lesion was thus observed. Light microscopy study pointed out, in particular, different degrees of dilation of papillary vessels, whereas ultrastructural study highlighted marked alterations of endothelial cells with structural and quantitative modifications of cytoplasmic organelles.
MESH: Angiokeratoma-ultrastructure; Endothelium,-Vascular-ultrastructure; Scrotum-ultrastructure; Skin-Neoplasms-ultrastructure
MESH: *Angiokeratoma-pathology; *Endothelium,-Vascular-pathology; *Scrotum-pathology; *Skin-Neoplasms-pathology
TG: Human; Male
PT: JOURNAL-ARTICLE
AN: 92248279
UD: 9208
MEDLINE EXPRESS (R) 1992-1996 25 of 28
TI: Acquired benign and "borderline" vascular lesions.
AU: Hunt-SJ; Santa-Cruz-DJ
AD: Division of Dermatology, University of California, San Diego Medical Center.
SO: Dermatol-Clin. 1992 Jan; 10(1): 97-115
ISSN: 0733-8635
PY: 1992
LA: ENGLISH
CP: UNITED-STATES
AB: In recent years, the classification of vascular lesions has been expanded and modified with the addition of several newly described entities, the redefinition of others, the recognition of lesions of borderline biologic behavior, and the need to avoid misdiagnosis with early Kaposi's sarcoma. This review clarifies the nomenclature, updates information on previously known lesions, and summarizes data on several recently discovered, lesser-known entities such as glomeruloid hemangioma, microvenular hemangioma, and multinucleate cell angiohistiocytoma. Clinicopathologic features and differential diagnosis are emphasized.
MESH: Angiokeratoma-pathology; Angiolymphoid-Hyperplasia-with-Eosinophilia-pathology; Hemangioendothelioma-pathology; Hemangioma-pathology; Telangiectasis-pathology
MESH: *Neoplasms,-Vascular-Tissue-pathology; *Skin-Neoplasms-pathology
TG: Human
PT: JOURNAL-ARTICLE; REVIEW; REVIEW,-ACADEMIC
AN: 92110984
UD: 9204
MEDLINE EXPRESS (R) 1991 26 of 28
TI: Transepidermal elimination of thrombi in three cases of thrombotic angiokeratoma: an incidental histopathologic finding of angiokeratoma.
AU: Bang-DS; Choi-YS; Song-MS
AD: Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
SO: J-Dermatol. 1991 Oct; 18(10): 605-9
ISSN: 0385-2407
PY: 1991
LA: ENGLISH
CP: JAPAN
AB: Transepidermal elimination (TEE) is a well known phenomenon by which foreign or altered constituents are removed from the dermis. A thrombosis in the dilated dermal blood vessels of angiokeratoma is not unusual, hence the term thrombotic angiokeratoma. We recently reviewed the histopathologic findings of previously diagnosed cases of angiokeratoma and found that multiple histologic sections of surgical biopsy materials disclosed changes indicating TEE of thrombi in three cases. Special stains searching for an altered substance in those thrombi failed. In this report of three cases, we suggest that this phenomenon could be an incidental and long missed histopathologic finding of angiokeratoma which might explain the fate of these thrombi.
MESH: Adult-; Infant-; Leg-Dermatoses-pathology
MESH: *Angiokeratoma-pathology; *Epidermis-pathology; *Thrombosis-pathology
TG: Case-Report; Female; Human; Male
PT: JOURNAL-ARTICLE
AN: 92166085
UD: 9206
MEDLINE EXPRESS (R) 1991 27 of 28
TI: Two Japanese cases with aspartylglycosaminuria: clinical and morphological features.
AU: Yoshida-K; Ikeda-S; Yanagisawa-N; Yamauchi-T; Tsuji-S; Hirabayashi-Y
AD: Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan.
SO: Clin-Genet. 1991 Oct; 40(4): 318-25
ISSN: 0009-9163
PY: 1991
LA: ENGLISH
CP: DENMARK
AB: Two members of a consanguineous Japanese family with a clinical picture of aspartylglycosaminuria (AGU) are described. Both patients exhibited mental retardation, coarse facial features, angiokeratoma and myoclonic seizures. Biochemical studies showed elevated excretion of urinary sialyloligosaccharides and decreased activity of aspartylglycosaminidase in lymphoblasts. Morphologic studies of skin biopsy specimens showed many clear vacuoles mainly in the vascular endothelial cells and secretory cells of the sweat glands. Osmiophilic lamellar cytoplasmic inclusions were also noted in the ganglion cells in rectal biopsy. The ethnic distribution of AGU may be more widespread than previously suspected and appears not to be restricted to Finnish populations. Ours are the first Japanese patients diagnosed as AGU. We conclude that AGU should also be included in the differential diagnosis of mentally retarded patients in Asian countries.
MESH: Acetylglucosamine-urine; Adult-; Angiokeratoma-genetics; Carbohydrate-Sequence; Epilepsy,-Myoclonic-genetics; Japan-epidemiology; Mental-Retardation-genetics; Molecular-Sequence-Data; Oligosaccharides-urine; Rectum-pathology; Rectum-ultrastructure; Skin-Neoplasms-genetics
MESH: *Acetylglucosamine-analogs-and-derivatives; *Aspartylglucosylaminase-deficiency
TG: Case-Report; Female; Human
PT: JOURNAL-ARTICLE
RN: EC 3.5.1.26; 0; 0; 2776-93-4; 7512-17-6
NM: Aspartylglucosylaminase; sialooligosaccharides; Oligosaccharides; N-acetylglucosaminylasparagine; Acetylglucosamine
AN: 92097321
UD: 9204
MEDLINE EXPRESS (R) 1991 28 of 28
TI: Acral pseudolymphomatous angiokeratoma of children (APACHE): a case report and immunohistological study.
AU: Hara-M; Matsunaga-J; Tagami-H
AD: Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
SO: Br-J-Dermatol. 1991 Apr; 124(4): 387-8
ISSN: 0007-0963
PY: 1991
LA: ENGLISH
CP: ENGLAND
AB: Acral pseudolymphomatous angiokeratoma of children (APACHE) is a new clinical entity that is characterized by angiomatous papules on the extremities. We report a case APACHE in a 14-year-old Japanese girl with asymptomatic red and violaceous papules and nodules on the ring finger of the left hand. Histological and immunohistochemical studies of our patient indicated that APACHE is a pseudolymphoma rather than an angiokeratoma.
MESH: Adolescence-; Angiokeratoma-immunology; Antigens,-Differentiation,-T-Lymphocyte-analysis; Fingers-pathology; Lichen-Planus-pathology; Lymphoma-immunology; Lymphoma-pathology; Skin-pathology; Skin-Neoplasms-immunology
MESH: *Angiokeratoma-pathology; *Skin-Neoplasms-pathology
TG: Case-Report; Female; Human
PT: JOURNAL-ARTICLE
RN: 0
NM: Antigens,-Differentiation,-T-Lymphocyte
AN: 91222965
UD: 9108