A literature search at Indiana University, Bloomington, IndianaRecord 1 of 6 in MEDLINE EXPRESS (R) 1996
The following MEDLINE items were compiled by SilverPlatter and are presented with their generous co-operation and permission. (See SilverPlatter's Worldwide Library for bibliographic search information.)
TITLE: Acute zonal occult outer retinopathy and central nervous system inflammation. AUTHOR(S): Jacobson-DM
ADDRESS OF AUTHOR: Department of Neurology, Marshfield Clinic, Wisconsin 54449, USA. SOURCE (BIBLIOGRAPHIC CITATION): J-Neuroophthalmol. 1996 Sep; 16(3): 172-7 INTERNATIONAL STANDARD SERIAL NUMBER: 1070-8022 PUBLICATION YEAR: 1996
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: This case report describes a patient who developed the characteristic features of acute zonal occult outer retinopathy (AZOOR), but whose case was unusual because of macular involvement, recurrences, and association with an inflammatory CNS disorder. The patient was followed for > 7 years; clinical examinations, electroretinography, electro-oculography, cerebrospinal fluid evaluations, and magnetic resonance imaging (MRI) were used to document the recurrent AZOOR and CNS disorder. The patient first presented with entoptic symptoms and a scotoma referable to dysfunction of her peripapillary and peripheral right retina. At that time, she also had asymptomatic involvement of her peripheral left retina, cerebrospinal fluid pleocytosis, and multiple brain MRI signal abnormalities. During the next several years, she developed recurrences of AZOOR, which first affected her right macula and later involved her peripheral left retina. Visual electrophysiological studies confi rmed impairment of outer retinal function. The patient developed her first neurological symptom, acute relapsing-remitting cervical myelitis, > 6 years after her visual presentation. Her clinical course, laboratory studies, and neurodiagnostic evaluations were consistent with CNS inflammation, but they were not typical of multiple sclerosis. Since AZOOR is a newly recognized disorder, its full clinical spectrum may not yet be established and could include CNS involvement. MINOR MESH HEADINGS: Adult-; Central-Nervous-System-Diseases-diagnosis; Central-Nervous-System-Diseases-physiopathology; Electroretinography-; Fluorescein-Angiography; Follow-Up-Studies; Fundus-Oculi; Inflammation-complications; Inflammation-diagnosis; Inflammation-physiopathology; Magnetic-Resonance-Imaging; Retinal-Diseases-diagnosis; Retinal-Diseases-physiopathology; Scotoma-diagnosis; Scotoma-physiopathology; Visual-Acuity; Visual-Fields MAJOR MeSH HEADINGS: *Central-Nervous-System-Diseases-complications; *Retinal-Diseases-complications; *Scotoma-complications CHECKTAGS: Case-Report; Female; Human
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 97018392
UPDATE CODE: 9703
Record 2 of 6 in MEDLINE EXPRESS (R) 1996
TITLE: Acute zonal occult outer retinopathy. AUTHOR(S): Lee-AG; Prager-TC
ADDRESS OF AUTHOR: Department of Ophthalmology, Neurology, Baylor College of Medicine, Houston, Texas, USA. SOURCE (BIBLIOGRAPHIC CITATION): Acta-Ophthalmol-Scand. 1996 Feb; 74(1): 93-5 INTERNATIONAL STANDARD SERIAL NUMBER: 1395-3907 PUBLICATION YEAR: 1996
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: DENMARK
ABSTRACT: Retinal photoreceptor dysfunction is an uncommon and often unrecognized cause of acute visual loss. Acute zonal occult outer retinopathy (AZOOR) has been reported to cause cone and rod dysfunction. Patients with AZOOR may present with normal visual acuity, normal fluorescein angiography, and a normal fundus examination despite severe loss of visual field. A healthy young white female presented with acute, unilateral loss of visual field and an afferent pupillary defect, but normal visual acuity, color vision, fundus examination, and fluorescein angiogram. A pattern visual evoked potential was normal, but an electroretinogram showed a unilateral peripheral photoreceptor dysfunction consistent with the diagnosis of AZOOR. Ophthalmologists should be aware of the diagnosis of AZOOR and should consider an ERG in the evaluation of any patient with unexplained visual field loss even in the presence of normal visual acuity, color vision, fluorescein angiography, or retinal examination.
MINOR MESH HEADINGS: Acute-Disease; Adult-; Electroretinography-; Evoked-Potentials,-Visual; Photoreceptors-physiopathology; Pupillary-Functions,-Abnormal-diagnosis; Pupillary-Functions,-Abnormal-etiology; Pupillary-Functions,-Abnormal-physiopathology; Retinal-Diseases-complications; Retinal-Diseases-physiopathology; Scotoma-diagnosis; Scotoma-etiology; Scotoma-physiopathology; Vision-Disorders-diagnosis; Vision-Disorders-etiology; Vision-Disorders-physiopathology; Visual-Acuity; Visual-Fields MAJOR MeSH HEADINGS: *Photoreceptors-pathology; *Retinal-Diseases-diagnosis CHECKTAGS: Case-Report; Female; Human
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 96254320
UPDATE CODE: 9610
Record 3 of 6 in MEDLINE EXPRESS (R) 1996
TITLE: Analysis of phosducin as a candidate gene for retinopathies. AUTHOR(S): Ara-Iwata-F; Jacobson-SG; Gass-JD; Hotta-Y; Fujiki-K; Hayakawa-M; Inana-G ADDRESS OF AUTHOR: Bascom Palmer Eye Institute, University of Miami School of Medicine, FL 33136, USA. SOURCE (BIBLIOGRAPHIC CITATION): Ophthalmic-Genet. 1996 Mar; 17(1): 3-14 INTERNATIONAL STANDARD SERIAL NUMBER: 0167-6784 PUBLICATION YEAR: 1996
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: NETHERLANDS
ABSTRACT: Phosducin, a retina-expressed gene mapped to chromosome 1q25-32.1, was analyzed as a candidate gene for retinopathies. The phosducin gene was cloned and characterized, and PCR primers were designed. Eighty-three patients with various retinopathies and 45 control subjects (24 American, 21 Japanese) were analyzed for mutations in the phosducin gene by PCR, denaturing gradient gel electrophoresis (DGGE), and sequencing. A heterozygous sequence variant changing a glycine to arginine at codon 178 was found in one Usher syndrome type II (USH2) patient, while the other USH2 patients did not show any coding sequence variant. A heterozygous sequence variant changing an asparagine to lysine at codon 174 was found in a patient with a severe retinal degeneration in the category of diseases known as acute zonal occult outer retinopathy (AZOOR). Three non-coding sequence variants were found. Two of these were always present together and found in 20.8% of American and 2.4% of Japa nese control subjects, reflecting a difference in population pools. In conclusion, the phosducin gene did not show mutations consistent with it being the causative gene for USH2, but its possible pathogenicity in AZOOR or other retinopathies remains an open question which may be answered by further analysis. MINOR MESH HEADINGS: Base-Sequence; Chromosome-Mapping; Chromosomes,-Human,-Pair-1; Cloning,-Molecular; DNA-Primers; Molecular-Sequence-Data; Mutation-; Polymorphism-Genetics MAJOR MeSH HEADINGS: *Eye-Proteins-genetics; *Phosphoproteins-genetics; *Retinal-Diseases-genetics CHECKTAGS: Human; Support,-Non-U.S.-Gov't; Support,-U.S.-Gov't,-P.H.S. PUBLICATION TYPE: JOURNAL-ARTICLE
CONTRACT OR GRANT NUMBERS: EY05627EYNEI
CAS REGISTRY NUMBER OR EC NUMBER: 0; 0; 0; 0 NAME OF SUBSTANCE: phosducin; DNA-Primers; Eye-Proteins; Phosphoproteins MEDLINE ACCESSION NUMBER: 96303763
UPDATE CODE: 9612
Record 4 of 6 in MEDLINE EXPRESS (R) 1991 - 1995
TITLE: Pattern of retinal dysfunction in acute zonal occult outer retinopathy. AUTHOR(S): Jacobson-SG; Morales-DS; Sun-XK; Feuer-WJ; Cideciyan-AV; Gass-JD; Milam-AH ADDRESS OF AUTHOR: Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, USA. SOURCE (BIBLIOGRAPHIC CITATION): Ophthalmology. 1995 Aug; 102(8): 1187-98 INTERNATIONAL STANDARD SERIAL NUMBER: 0161-6420 PUBLICATION YEAR: 1995
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To elucidate the pathophysiology of the diseases recently grouped under the name of acute zonal occult outer retinopathy (AZOOR). METHODS: Twenty-four patients with the diagnosis of multiple evanescent white dot syndrome, acute idiopathic blind-spot enlargement syndrome, acute macular neuroretinopathy, multifocal choroiditis, or pseudo-presumed ocular histoplasmosis syndrome, or a combination of these diagnoses, were evaluated on one or more visits with full-field electroretinograms (ERGs) and kinetic and static perimetry. Sera and IgG fractions were tested using immunofluorescence on cryostat sections of fixed and unfixed human and rat retina. RESULTS: Patients with AZOOR as a group showed abnormal results for all eight ERGs and two visual field parameters measured. Interocular asymmetry was a prominent feature of the patients' test results. Logistic regression indicated that interocular differences in ERG parameters significantly increased the efficacy of identifying patients with AZOOR beyond that of the parameter values alone. Visual field area correlated well with ERG a-wave amplitude. Serial visual function tests in a subset of patients showed that there could be short-term partial recovery or progressive loss of function. Autoantibodies to a specific retinal cell type were not detected. CONCLUSIONS: All patients with AZOOR showed a pattern of visual dysfunction that was photoreceptor in origin, patchy in its distribution across the retina, and asymmetric in the two eyes. There was considerable variability in the severity and the natural history of retinal dysfunction in the patients studied. The full-field ERG was found to be a valuable adjunct in diagnosing AZOOR, especially when the expected interocular variation in measured parameters was known for control subjects. No evidence was obtained for autoantibodies to any retinal cell type in the patients with AZOOR who were tested. MINOR MESH HEADINGS: Acute-Disease; Adolescence-; Adult-; Age-of-Onset; Aged-; Autoantibodies-analysis; Electroretinography-; Fluorescent-Antibody-Technique; IgG-analysis; Middle-Age; Rats-; Retina-immunology; Retina-pathology; Retinal-Diseases-diagnosis; Retinal-Diseases-immunology; Vision-Disorders-diagnosis; Vision-Disorders-immunology; Visual-Acuity; Visual-Fields MAJOR MeSH HEADINGS: *Retina-physiopathology; *Retinal-Diseases-physiopathology; *Vision-Disorders-physiopathology CHECKTAGS: Animal; Female; Human; Male; Support,-Non-U.S.-Gov't; Support,-U.S.-Gov't,-P.H.S. PUBLICATION TYPE: JOURNAL-ARTICLE
CONTRACT OR GRANT NUMBERS: EY05627EYNEI; EY01311EYNEI; EY01730EYNEI CAS REGISTRY NUMBER OR EC NUMBER: 0; 0
NAME OF SUBSTANCE: Autoantibodies; IgG
MEDLINE ACCESSION NUMBER: 97252206
UPDATE CODE: 9707
Record 5 of 6 in MEDLINE EXPRESS (R) 1991 - 1995
TITLE: MEWDS, MFC, PIC, AMN, AIBSE, and AZOOR: one disease or many? [editorial] AUTHOR(S): Jampol-LM; Wiredu-A
SOURCE (BIBLIOGRAPHIC CITATION): Retina. 1995; 15(5): 373-8 INTERNATIONAL STANDARD SERIAL NUMBER: 0275-004X PUBLICATION YEAR: 1995
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: UNITED-STATES
MINOR MESH HEADINGS: Adult-; Choroid-pathology; Choroid-physiopathology; Choroid-Diseases-etiology; Choroid-Diseases-physiopathology; Diagnosis,-Differential; Fundus-Oculi; Retina-pathology; Retina-physiopathology; Retinal-Diseases-etiology; Retinal-Diseases-physiopathology MAJOR MeSH HEADINGS: *Choroid-Diseases-diagnosis; *Retinal-Diseases-diagnosis CHECKTAGS: Female; Human; Male; Support,-Non-U.S.-Gov't PUBLICATION TYPE: EDITORIAL; REVIEW; REVIEW,-TUTORIAL MEDLINE ACCESSION NUMBER: 96156600
UPDATE CODE: 9606
Record 6 of 6 in MEDLINE EXPRESS (R) 1991 - 1995
TITLE: Acute zonal occult outer retinopathy (AZOOR) associated with multifocal choroidopathy. AUTHOR(S): Holz-FG; Kim-RY; Schwartz-SD; Harper-CA; Wroblewski-J; Arden-GB; Bird-AC ADDRESS OF AUTHOR: Department of Clinical Ophthalmology, Moorfields Eye Hospital, London, UK. SOURCE (BIBLIOGRAPHIC CITATION): Eye. 1994; 8 ( Pt 1): 77-83 INTERNATIONAL STANDARD SERIAL NUMBER: 0950-222X PUBLICATION YEAR: 1994
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: ENGLAND
ABSTRACT: Acute zonal occult outer retinopathy (AZOOR) may be precipitated by various retinal disorders and is characterised by rapid loss of visual field which cannot be explained by the ophthalmoscopic changes consequent upon the initiating disease. The electroretinogram is abnormal, indicating that the field loss is due to retinal dysfunction. The phenomenon was first recognised in the multiple evanescent white dot syndrome (MEWDS) as the enlarged blind spot syndrome. It was subsequently described with multifocal inner choroidopathy and acute macular neuropathy (AMN). We have identified 7 patients who presented with widespread visual loss associated with multifocal inner choroidopathy in whom functional loss was documented with electroretinography and automated visual field testing. All patients were young, myopic, and otherwise healthy women. Initial photopsia was noted by 4 patients. Fundus findings included scattered small partially pigmented yellowish lesions resemblin g those in multifocal inner choroidopathy or pseudo presumed ocular histoplasmosis syndrome, disc swelling, vitritis, and secondary choroidal neovascularisation. Two patients had bilateral involvement. All patients had an enlargement of the blind spot, and widespread visual field loss which was not explained by fundus changes. All had an abnormal electroretinogram suggesting widespread retinal disease. In AZOOR retinal dysfunction occurs without corresponding visible retinal lesions. This disorder appears to be precipitated by several conditions, although the causal relationship between the initiating event and the widespread functional loss is unknown. MINOR MESH HEADINGS: Acute-Disease; Adolescence-; Adult-; Blindness-etiology; Electroretinography-; Fluorescein-Angiography; Fundus-Oculi; Myopia-complications; Optic-Disk-pathology; Retina-pathology; Visual-Acuity; Visual-Fields MAJOR MeSH HEADINGS: *Choroid-Diseases-complications; *Retinal-Diseases-complications CHECKTAGS: Case-Report; Female; Human; Support,-Non-U.S.-Gov't PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 94283695
UPDATE CODE: 9409