A literature search at Indiana University, Bloomington, IndianaRecord 1 of 3 in MEDLINE EXPRESS (R) 1996-1998
The following MEDLINE items were compiled by SilverPlatter and are presented with their generous co-operation and permission. (See SilverPlatter's Worldwide Library for bibliographic search information.)
TITLE: Acute zonal occult outer retinopathy and central nervous system inflammation.
AUTHOR(S): Jacobson-DM
ADDRESS OF AUTHOR: Department of Neurology, Marshfield Clinic, Wisconsin 54449, USA.
SOURCE (BIBLIOGRAPHIC CITATION): J-Neuroophthalmol. 1996 Sep; 16(3): 172-7
LANGUAGE OF ARTICLE: ENGLISH
ABSTRACT: This case report describes a patient who developed the characteristic features of acute zonal occult outer retinopathy (AZOOR), but whose case was unusual because of macular involvement, recurrences, and association with an inflammatory CNS disorder. The patient was followed for > 7 years; clinical examinations, electroretinography, electro-oculography, cerebrospinal fluid evaluations, and magnetic resonance imaging (MRI) were used to document the recurrent AZOOR and CNS disorder. The patient first presented with entoptic symptoms and a scotoma referable to dysfunction of her peripapillary and peripheral right retina. At that time, she also had asymptomatic involvement of her peripheral left retina, cerebrospinal fluid pleocytosis, and multiple brain MRI signal abnormalities. During the next several years, she developed recurrences of AZOOR, which first affected her right macula and later involved her peripheral left retina. Visual electrophysiological studies confirmed impairment of outer retinal function. The patient developed her first neurological symptom, acute relapsing-remitting cervical myelitis, > 6 years after her visual presentation. Her clinical course, laboratory studies, and neurodiagnostic evaluations were consistent with CNS inflammation, but they were not typical of multiple sclerosis. Since AZOOR is a newly recognized disorder, its full clinical spectrum may not yet be established and could include CNS involvement.
Record 2 of 3 in MEDLINE EXPRESS (R) 1996-1998
TITLE: Acute zonal occult outer retinopathy.
AUTHOR(S): Lee-AG; Prager-TC
ADDRESS OF AUTHOR: Department of Ophthalmology, Neurology, Baylor College of Medicine, Houston, Texas, USA.
SOURCE (BIBLIOGRAPHIC CITATION): Acta-Ophthalmol-Scand. 1996 Feb; 74(1): 93-5
LANGUAGE OF ARTICLE: ENGLISH
ABSTRACT: Retinal photoreceptor dysfunction is an uncommon and often unrecognized cause of acute visual loss. Acute zonal occult outer retinopathy (AZOOR) has been reported to cause cone and rod dysfunction. Patients with AZOOR may present with normal visual acuity, normal fluorescein angiography, and a normal fundus examination despite severe loss of visual field. A healthy young white female presented with acute, unilateral loss of visual field and an afferent pupillary defect, but normal visual acuity, color vision, fundus examination, and fluorescein angiogram. A pattern visual evoked potential was normal, but an electroretinogram showed a unilateral peripheral photoreceptor dysfunction consistent with the diagnosis of AZOOR. Ophthalmologists should be aware of the diagnosis of AZOOR and should consider an ERG in the evaluation of any patient with unexplained visual field loss even in the presence of normal visual acuity, color vision, fluorescein angiography, or retinal examination.
Record 3 of 3 in MEDLINE EXPRESS (R) 1996-1998
TITLE: Analysis of phosducin as a candidate gene for retinopathies.
AUTHOR(S): Ara-Iwata-F; Jacobson-SG; Gass-JD; Hotta-Y; Fujiki-K; Hayakawa-M; Inana-G
ADDRESS OF AUTHOR: Bascom Palmer Eye Institute, University of Miami School of Medicine, FL 33136, USA.
SOURCE (BIBLIOGRAPHIC CITATION): Ophthalmic-Genet. 1996 Mar; 17(1): 3-14
LANGUAGE OF ARTICLE: ENGLISH
ABSTRACT: Phosducin, a retina-expressed gene mapped to chromosome 1q25-32.1, was analyzed as a candidate gene for retinopathies. The phosducin gene was cloned and characterized, and PCR primers were designed. Eighty-three patients with various retinopathies and 45 control subjects (24 American, 21 Japanese) were analyzed for mutations in the phosducin gene by PCR, denaturing gradient gel electrophoresis (DGGE), and sequencing. A heterozygous sequence variant changing a glycine to arginine at codon 178 was found in one Usher syndrome type II (USH2) patient, while the other USH2 patients did not show any coding sequence variant. A heterozygous sequence variant changing an asparagine to lysine at codon 174 was found in a patient with a severe retinal degeneration in the category of diseases known as acute zonal occult outer retinopathy (AZOOR). Three non-coding sequence variants were found. Two of these were always present together and found in 20.8% of American and 2.4% of Japanese control subjects, reflecting a difference in population pools. In conclusion, the phosducin gene did not show mutations consistent with it being the causative gene for USH2, but its possible pathogenicity in AZOOR or other retinopathies remains an open question which may be answered by further analysis.
ADDENDUM (from a supplemental search):
Record 10 of 15 in MEDLINE EXPRESS (R) 1996-1998
TITLE: Multifocal electroretinogram indicates visual field loss in acute zonal occult outer retinopathy.
AUTHOR(S): Arai-M; Nao-i-N; Sawada-A; Hayashida-T
ADDRESS OF AUTHOR: Department of Ophthalmology, Miyazaki Medical College, Japan. mikkia@post.miyazaki-med.ac.jp
SOURCE (BIBLIOGRAPHIC CITATION): Am-J-Ophthalmol. 1998 Sep; 126(3): 466-9
INTERNATIONAL STANDARD SERIAL NUMBER: 0002-9394
PUBLICATION YEAR: 1998
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To report alterations of electrophysiologic tests, including the multifocal electroretinogram, in a case of acute zonal occult outer retinopathy. METHOD: We recorded photopic, scotopic, and single-flash electroretinograms and a multifocal electroretinogram in a 47-year-old woman with acute zonal occult outer retinopathy in the right eye. RESULTS: Her visual acuity was 20/20 in the right eye throughout the follow-up period. The electroretinograms indicated retinal impairment of the right eye, predominantly in the cones. The multifocal electroretinogram showed reduced responses corresponding to the visual field defect of the static perimetry. CONCLUSIONS: In acute zonal occult outer retinopathy, impairment of the retinal area results in a visual field defect. The multifocal electroretinogram can be useful in determining the location of the defect.
MINOR MESH HEADINGS: Acute-Disease; Dark-Adaptation; Middle-Age; Photic-Stimulation; Retinal-Diseases-complications; Vision-Disorders-etiology; Visual-Acuity
MAJOR MeSH HEADINGS: *Electroretinography-methods; *Retinal-Diseases-diagnosis; *Vision-Disorders-diagnosis; *Visual-Fields
CHECKTAGS: Case-Report; Female; Human
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 1998415638
UPDATE CODE: 199811
SUBSET: AIM
Record 11 of 15 in MEDLINE EXPRESS (R) 1996-1998
TITLE: Scanning laser ophthalmoscopic findings in a patient with acute zonal occult outer retinopathy.
AUTHOR(S): Nishio-M; Suzuki-T; Chikuda-M; Sato-Y
ADDRESS OF AUTHOR: Department of Ophthalmology, Dokkyo University School of Medicine, Koshigaya Hospital, Saitama, Japan. masay@msi.biglobe.ne.jp
SOURCE (BIBLIOGRAPHIC CITATION): Am-J-Ophthalmol. 1998 May; 125(5): 712-5
INTERNATIONAL STANDARD SERIAL NUMBER: 0002-9394
PUBLICATION YEAR: 1998
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To examine a 33-year-old woman who had an enlarged scotoma in her right eye and who was diagnosed with acute zonal occult outer retinopathy. METHODS: We performed a full ophthalmologic examination and scanning laser ophthalmoscopy. RESULT: With a 514-nm wavelength laser, scanning laser ophthalmoscopy demonstrated abnormal lesions bilaterally. No abnormalities were detected with a 630-nm wavelength laser. CONCLUSION: Scanning laser ophthalmoscopy can demonstrate retinal damage caused by acute zonal occult outer retinopathy, which is useful in differential diagnosis.
MINOR MESH HEADINGS: Acute-Disease; Adult-; Fluorescein-Angiography; Fundus-Oculi; Retinal-Diseases-complications; Scotoma-etiology; Scotoma-pathology
MAJOR MeSH HEADINGS: *Lasers-diagnostic-use; *Ophthalmoscopy-methods; *Retina-pathology; *Retinal-Diseases-diagnosis
CHECKTAGS: Case-Report; Female; Human
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 1998287244
UPDATE CODE: 199808
SUBSET: AIM
Record 12 of 15 in MEDLINE EXPRESS (R) 1996-1998
TITLE: Progressive zonal outer retinitis.
AUTHOR(S): Abe-T; Sakamoto-T; Hamano-K; Takagi-T; Sakuragi-S
ADDRESS OF AUTHOR: Department of Ophthalmology, Akita University School of Medicine, Japan.
SOURCE (BIBLIOGRAPHIC CITATION): Jpn-J-Ophthalmol. 1996; 40(3): 412-8
INTERNATIONAL STANDARD SERIAL NUMBER: 0021-5155
PUBLICATION YEAR: 1996
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: JAPAN
ABSTRACT: A 27-year-old woman with uniocular progressive zonal outer retinitis was examined. The retinitis area was curvilinear and gray, with zonal opacification. It enlarged centrifugally and concentrically, with narrowing of the zonal opacification. Results of perimetry and electroretinography showed that the outer retina was primarily affected. Damage was more severe in the photoreceptor cones than in the rods. Peripheral retinal phlebitis was seen on fluorescein angiography. Intraretinal pigment migration with retinal pigment epithelial atrophy occurred in the macula as sequelae.
MINOR MESH HEADINGS: Adult-; Disease-Progression; Electroretinography-; Fluorescein-Angiography; Fundus-Oculi; Perimetry-; Retina-physiopathology; Retinitis-etiology; Retinitis-pathology; Visual-Fields
MAJOR MeSH HEADINGS: *Retinitis-physiopathology
CHECKTAGS: Case-Report; Female; Human
PUBLICATION TYPE: JOURNAL-ARTICLE; REVIEW; REVIEW-OF-REPORTED-CASES
MEDLINE ACCESSION NUMBER: 1997142207
UPDATE CODE: 199706