TITLE: Ophthaproblem. Eales' disease.
AUTHOR(S): Cheung-J; Sharma-S
ADDRESS OF AUTHOR: Department of Ophthalmology, Queen's University, Kingston, Ont.
SOURCE (BIBLIOGRAPHIC CITATION): Can-Fam-Physician. 2000 Apr; 46(4): 805, 816
INTERNATIONAL STANDARD SERIAL NUMBER: 0008-350X
PUBLICATION YEAR: 2000
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: CANADA
MINOR MESH HEADINGS: Adult-; Diagnosis,-Differential; Prognosis-; Retinal-Diseases-therapy; Visual-Acuity
MAJOR MeSH HEADINGS: *Retinal-Diseases-diagnosis; *Retinal-Vessels
CHECKTAGS: Case-Report; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 20251407
UPDATE CODE: 200007
Record 2 of 23 in MEDLINE EXPRESS (R) 2000/01-2000/09
TITLE: Comparative evaluation of early vs. deferred vitrectomy in Eales' disease.
AUTHOR(S): Kumar-A; Tiwari-HK; Singh-RP; Verma-L; Prasad-N
ADDRESS OF AUTHOR: Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.
SOURCE (BIBLIOGRAPHIC CITATION): Acta-Ophthalmol-Scand. 2000 Feb; 78(1): 77-8
INTERNATIONAL STANDARD SERIAL NUMBER: 1395-3907
PUBLICATION YEAR: 2000
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: DENMARK
ABSTRACT: METHODS: 40 cases of vitreous haemorrhage secondary to Eales' disease were taken up for vitrectomy. Depending upon duration of vitreous haemorrhage patients were divided into two groups: Group I (20 eyes) - early vitrectomy group with duration between 3-6 months; Group II (20 eyes) - deferred vitrectomy group with duration of more than 6 months. All patients were followed up for a minimum period of 3 months following vitrectomy. RESULTS: Eyes in Group I showing a preoperative ultrasonic picture of complete posterior vitreous detachment, less mobility of organised vitreous haemorrhage and mid vitreous organisation on kinetic echography achieved a final visual acuity of 6/9 or better in 13 (65%) eyes as compared to 4 (20%) eyes in Group II (p<0.01). Poor visual outcome in the deferred group was secondary to cystoid macular oedema, macular scar, macular pucker formation and macular degeneration. CONCLUSION: Improved visual outcome in the early vitrectomy group was probably because the haemorrhagic blood and its toxic products had less time to damage the macula, a lesser incidence of macular traction and cystoid macular oedema.
MINOR MESH HEADINGS: Postoperative-Complications; Retinal-Diseases-complications; Retinal-Diseases-ultrasonography; Time-Factors; Treatment-Outcome; Visual-Acuity; Vitreous-Hemorrhage-etiology; Vitreous-Hemorrhage-ultrasonography
MAJOR MeSH HEADINGS: *Retinal-Diseases-surgery; *Vitrectomy-; *Vitreous-Hemorrhage-surgery
CHECKTAGS: Comparative-Study; Human
PUBLICATION TYPE: CLINICAL-TRIAL; JOURNAL-ARTICLE; RANDOMIZED-CONTROLLED-TRIAL
MEDLINE ACCESSION NUMBER: 20189329
UPDATE CODE: 200006
Record 3 of 23 in MEDLINE EXPRESS (R) 2000/01-2000/09
TITLE: Polymerase chain reaction for detection of Mycobacterium tuberculosis in epiretinal membrane in Eales' disease.
AUTHOR(S): Madhavan-HN; Therese-KL; Gunisha-P; Jayanthi-U; Biswas-J
ADDRESS OF AUTHOR: Vision Research Foundation, Sankara Nethralaya, Chennai, India. mdsaaa35@giasmd01-vsnl.net.in
SOURCE (BIBLIOGRAPHIC CITATION): Invest-Ophthalmol-Vis-Sci. 2000 Mar; 41(3): 822-5
INTERNATIONAL STANDARD SERIAL NUMBER: 0146-0404
PUBLICATION YEAR: 2000
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: Tuberculous etiology has been suggested in Eales' disease. Because epiretinal membrane (ERM) is formed on the inner surface of the retina in Eales' disease, it could be the most appropriate intraocular specimen for investigation. Therefore, a nested polymerase chain reaction (nPCR), which detects MPB64 gene of Mycobacterium tuberculosis on the archival specimens of ERM of well-documented Eales' and non-Eales' patients, was applied and the results compared. METHODS: nPCR technique was standardized, and the sensitivity and specificity of the primers were determined. nPCR technique was applied to tissue sections obtained from formalin-fixed and paraffin-embedded tissues of ERM from 23 patients with Eales' disease and 27 noninfective and non-Eales' disease patients as controls. RESULTS: nPCR technique was specific for M. tuberculosis genome and sensitive enough to detect 0.25 fg (corresponding to the presence of a single bacillus). Eleven (47.8%) ERM of 23 Eales' disease and 3 (11.1%) of 27 controls were positive for M. tuberculosis genome. The difference between the two groups was statistically significant (P = 0.001), indicating association of this bacterium with Eales' disease. CONCLUSIONS: The demonstration of the presence of M. tuberculosis DNA by nPCR technique in significant number of ERM of Eales' disease compared with the controls further emphasizes the probable role of this bacterium in the pathogenesis of this enigmatic clinical condition.
MINOR MESH HEADINGS: DNA-Primers-chemistry; Polymerase-Chain-Reaction-methods; Retinal-Hemorrhage-microbiology; Sensitivity-and-Specificity
MAJOR MeSH HEADINGS: *Bacterial-Proteins-genetics; *DNA,-Bacterial-analysis; *Epiretinal-Membrane-microbiology; *Mycobacterium-tuberculosis-genetics; *Phlebitis-microbiology; *Retinal-Vein; *Tuberculosis,-Ocular-microbiology
CHECKTAGS: Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: JOURNAL-ARTICLE
CAS REGISTRY NUMBER OR EC NUMBER: 0; 0; 0; 0
NAME OF SUBSTANCE: Bacterial-Proteins; DNA-Primers; DNA,-Bacterial; MPB64-protein
MEDLINE ACCESSION NUMBER: 20174841
UPDATE CODE: 200005
Record 4 of 23 in MEDLINE EXPRESS (R) 2000/01-2000/09
TITLE: Eales' disease: increased oxidation and peroxidation products of membrane constituents chiefly lipids and decreased antioxidant enzymes and reduced glutathione in vitreous.
AUTHOR(S): Sulochana-KN; Biswas-J; Ramakrishnan-S
ADDRESS OF AUTHOR: Sankara Nethralaya, Vision Research Foundation Biochemistry Research Department Chennai, India.
SOURCE (BIBLIOGRAPHIC CITATION): Curr-Eye-Res. 1999 Sep; 19(3): 254-9
INTERNATIONAL STANDARD SERIAL NUMBER: 0271-3683
PUBLICATION YEAR: 1999
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: ENGLAND
ABSTRACT: PURPOSE. To measure the levels of oxidation and peroxidation products of membrane constituents chiefly lipids produced by oxygen and lipid free radicals as thiobarbituric acid reacting substances (TBARS), reduced glutathione (GSH) and the antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GP) in vitreous samples from patients with Eales' disease and estimate GSH, SOD, GP in the erythrocytes of patients with Eales' disease with active perivasculitis and healed perivasculitis. METHODS. Vitreous samples on vitrectomy from 11 patients with Eales' disease and 11 patients with diabetic vitreous hemorrhage were used for comparison. For study on erythrocytes, 30 patients of Eales' disease at the active vasculitis stage (group-I), 33 of healed vasculitis stage (group-II) and 25 controls (group-III) were used. The male female ratio was kept the same among the patients and the controls. Oxidation and peroxidation products of membrane constituents chiefly lipids were estimated as TBARS, SOD by its activity to inhibit auto-oxidation of epinephrine, GP by estimating the reduction in the level of GSH and GSH by its colour reaction with 5,5'-dithio bis (2-nitro) benzoic acid (DTNB). RESULTS. TBARS were increased 6 fold in the vitreous of Eales' patients compared to the samples from those with diabetic vitreous hemorrhage while there was a reduction of 95.9% of SOD and 84.2% of GSH. Activity of SOD, GP and the levels of GSH in the erythrocytes were reduced (%) by 81.6, 65 and 56.5 respectively in group I and 22,46.4 and 29.2% respectively in group II. The values are statistically significant. CONCLUSIONS. Increased levels of TBARS and decreased levels of SOD and GSH in the vitreous could explain inflammation, retinal damage and neovascularization in patients with Eales' disease. Decrease of SOD, GP and GSH is found in erythrocytes both in the active perivasculitis stage and the healed perivasculitis stage. Treatment of Eales' disease with antioxidants vitamin E, C as also vitamin A may have a beneficial effect.
MINOR MESH HEADINGS: Adult-; Aged-; Diabetic-Retinopathy-metabolism; Erythrocytes-enzymology; Erythrocytes-metabolism; Glutathione-metabolism; Glutathione-Peroxidase-metabolism; Lipids-metabolism; Middle-Age; Oxidation-Reduction; Retinal-Diseases-enzymology; Retinal-Vessels-metabolism; Superoxide-Dismutase-metabolism; Thiobarbituric-Acid-Reactive-Substances-metabolism; Vasculitis-enzymology; Vitreous-Body-enzymology
MAJOR MeSH HEADINGS: *Antioxidants-metabolism; *Cell-Membrane-metabolism; *Retinal-Diseases-metabolism; *Vasculitis-metabolism; *Vitreous-Body-metabolism
CHECKTAGS: Comparative-Study; Female; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
CAS REGISTRY NUMBER OR EC NUMBER: EC 1.11.1.9; EC 1.15.1.1; 0; 0; 0; 70-18-8
NAME OF SUBSTANCE: Glutathione-Peroxidase; Superoxide-Dismutase; Antioxidants; Lipids; Thiobarbituric-Acid-Reactive-Substances; Glutathione
MEDLINE ACCESSION NUMBER: 99418968
UPDATE CODE: 200004
Record 5 of 23 in MEDLINE EXPRESS (R) 2000/01-2000/09
TITLE: Use of polymerase chain reaction in detection of Mycobacterium tuberculosis complex DNA from vitreous sample of Eales' disease [letter]
AUTHOR(S): Biswas-J; Therese-L; Madhavan-HN
SOURCE (BIBLIOGRAPHIC CITATION): Br-J-Ophthalmol. 1999 Aug; 83(8): 994
INTERNATIONAL STANDARD SERIAL NUMBER: 0007-1161
PUBLICATION YEAR: 1999
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: ENGLAND
MINOR MESH HEADINGS: Mycobacterium-tuberculosis-isolation-and-purification; Polymerase-Chain-Reaction-methods; Retinal-Hemorrhage-microbiology; Vitreous-Body-microbiology; Vitreous-Hemorrhage-microbiology
MAJOR MeSH HEADINGS: *DNA,-Bacterial-analysis; *Tuberculosis,-Ocular-diagnosis
CHECKTAGS: Human
PUBLICATION TYPE: LETTER
CAS REGISTRY NUMBER OR EC NUMBER: 0
NAME OF SUBSTANCE: DNA,-Bacterial
MEDLINE ACCESSION NUMBER: 20002109
UPDATE CODE: 200003
Record 6 of 23 in MEDLINE EXPRESS (R) 2000/01-2000/09
TITLE: [The significance of preoperative visual electrophysiology for vitrectomy]
AUTHOR(S): Wu-L; Wu-D; Luo-T
ADDRESS OF AUTHOR: Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou.
SOURCE (BIBLIOGRAPHIC CITATION): Chung-Hua-Yen-Ko-Tsa-Chih. 1997 Sep; 33(5): 344-6
INTERNATIONAL STANDARD SERIAL NUMBER: 0412-4081
PUBLICATION YEAR: 1997
LANGUAGE OF ARTICLE: CHINESE; NON-ENGLISH
COUNTRY OF PUBLICATION: CHINA
ABSTRACT: OBJECTIVE: To investigate the prognostic value of preoperative visual electrophysiology in patients with vitreoretinopathy (VRP) who underwent vitrectomy. METHODS: Electroretinogram (ERG) and visual evoked potential (VEP) were performed prior to vitrectomy in 82 patients with vitreous hemorrhage or opacity due to ocular trauma, retinal detachment or retinal vascular diseases (Eales' disease, diabetic retinopathy, etc.). A comparative analysis was made of the effectiveness and visual acuities 2 weeks postoperatively. RESULTS: Among the 82 eyes, the preoperative ERG was normal in 6 eyes, slightly or moderately reduced in 37 eyes and severely reduced or had no response in 39 eyes. Of these 39 eyes, no improvement or reduction in postoperative visual acuity was seen in 23 and 6 eyes respectively, a sharp contrast to the postoperative results of the 6 normal ERG eyes. The preoperative ERGs differed due to different causes. A further analysis regarding the VEP of the patients who had poor postoperative results was made. CONCLUSIONS: The data showed that the preoperative visual electrophysiology was significantly correlated with the effectiveness of the operation. It is helpful in prognostic assessment of the postoperative outcome and visual acuity changes in VRP patients treated mainly by vitrectomy.
MINOR MESH HEADINGS: Electroretinography-; English-Abstract; Eye-Diseases-surgery; Visual-Acuity; Vitrectomy-; Vitreous-Hemorrhage-surgery
MAJOR MeSH HEADINGS: *Evoked-Potentials,-Visual; *Eye-Diseases-physiopathology; *Vitreous-Hemorrhage-physiopathology
CHECKTAGS: Comparative-Study; English-Abstract; Human; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 99381284
UPDATE CODE: 200002
Record 7 of 23 in MEDLINE EXPRESS (R) 1997-1999
TITLE: [Eales disease with neurologic manifestation: differential diagnosis of multiple sclerosis. Report of two cases]
ORIGINAL TITLE: Maladie de Eales avec manifestations neurologiques: un diagnostic differentiel de la sclerose en plaques. 2 observations.
AUTHOR(S): Rodier-G; Derouiche-F; Bronner-P; Cohen-E
ADDRESS OF AUTHOR: Service de Neurologie, Hopital E. Muller, Mulhouse.
SOURCE (BIBLIOGRAPHIC CITATION): Presse-Med. 1999 Oct 16; 28(31): 1692-4
INTERNATIONAL STANDARD SERIAL NUMBER: 0755-4982
PUBLICATION YEAR: 1999
LANGUAGE OF ARTICLE: FRENCH; NON-ENGLISH
COUNTRY OF PUBLICATION: FRANCE
ABSTRACT: BACKGROUND: Eales disease is a condition associating recurrent vitreous and retinal hemorrhage related to retinal periphlebitis. This ophthalmological disease is sometimes associated with central nervous system manifestations. CASE REPORT: Two patients with Eales disease of the retina developed a progressively worsening neurological deficit several years later. DISCUSSION: Evidence of multifocal anomalies of the white matter initially suggested a possible association of Earles disease with multiple sclerosis. Pathology findings enable formal differentiation of these two entities. Earles disease with neurological manifestations remains an uncommon condition and constitutes a differential diagnosis of multiple sclerosis.
MINOR MESH HEADINGS: Adult-; Age-Factors; Diagnosis,-Differential; English-Abstract; Eye-blood-supply; Middle-Age; Multiple-Sclerosis-complications; Phlebitis-; Retinal-Hemorrhage-complications; Sex-Ratio
MAJOR MeSH HEADINGS: *Multiple-Sclerosis-diagnosis; *Nervous-System-Diseases-etiology; *Retinal-Hemorrhage-etiology
CHECKTAGS: Case-Report; English-Abstract; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 20022258
UPDATE CODE: 200001
Record 8 of 23 in MEDLINE EXPRESS (R) 1997-1999
TITLE: Vitreoschisis in Eales' disease: pathogenic role and significance in surgery.
AUTHOR(S): Badrinath-SS; Gopal-L; Sharma-T; Parikh-S; Shanmugam-MP; Bhende-P; Biswas-J
ADDRESS OF AUTHOR: Vitreoretinal Service, Sankara Nethralaya, Chennai, India.
SOURCE (BIBLIOGRAPHIC CITATION): Retina. 1999; 19(1): 51-4
INTERNATIONAL STANDARD SERIAL NUMBER: 0275-004X
PUBLICATION YEAR: 1999
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To report the surgical anatomy of vitreoretinal adhesions as observed intraoperatively in patients undergoing vitreous surgery for complications of Eales' disease. METHODS: Eighteen consecutive male patients (18 eyes) undergoing vitrectomy for Eales' disease were studied prospectively. Intraoperative diagnosis was vitreous hemorrhage (VH) in nine cases, traction retinal detachment (TRD) in four, VH and TRD in three, and combined traction-rhegmatogenous retinal detachment in two. Epiretinal membranes (ERMs) obtained during surgery were studied using light microscopy and immunohistochemistry. RESULTS: An incomplete posterior vitreous detachment was observed in all eyes. Multifocal vitreoretinal adhesions were evident in 83.3% of eyes. The proliferation was fibrovascular in 10 eyes and fibrous in eight. A radial traction fold extending from optic disk to periphery was observed in three eyes. A double-layered membrane, probably the result of vitreoschisis, caused tangential traction. ERMs consisted principally of type II collagen and the cellular element was predominantly composed of lymphocytes, glial cells, and macrophage-like cells (probably hyalocytes). CONCLUSIONS: Fibrous and fibrovascular proliferations have multiple areas of adhesions to the posterior vitreous cortex. The presence of type II collagen in the ERM indicates a possible vitreous collagen component to the double-layered membranes (vitreoschisis). Recognition of the double-layered membranes aids in relief of traction during surgery by delamination.
MINOR MESH HEADINGS: Adhesions-; Adult-; Eye-Diseases-complications; Eye-Diseases-surgery; Fibrosis-; Middle-Age; Prospective-Studies; Retinal-Detachment-etiology; Retinal-Detachment-pathology; Retinal-Diseases-complications; Retinal-Diseases-surgery; Retinal-Vessels-surgery; Vasculitis-complications; Vasculitis-surgery; Vitreous-Hemorrhage-etiology; Vitreous-Hemorrhage-pathology
MAJOR MeSH HEADINGS: *Eye-Diseases-pathology; *Retinal-Diseases-pathology; *Retinal-Vessels-pathology; *Vasculitis-pathology; *Vitrectomy-; *Vitreous-Body-pathology
CHECKTAGS: Human; Male; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 99156118
UPDATE CODE: 199906
Record 9 of 23 in MEDLINE EXPRESS (R) 1997-1999
TITLE: Cellular immune response to retinal S-antigen and interphotoreceptor retinoid-binding protein fragments in Eales' disease patients.
AUTHOR(S): Saxena-S; Rajasingh-J; Biswas-S; Kumar-D; Shinohara-T; Singh-VK
ADDRESS OF AUTHOR: Department of Ophthalmology, King George's Medical College, Boston, Mass., USA.
SOURCE (BIBLIOGRAPHIC CITATION): Pathobiology. 1999; 67(1): 39-44
INTERNATIONAL STANDARD SERIAL NUMBER: 1015-2008
PUBLICATION YEAR: 1999
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: SWITZERLAND
ABSTRACT: The role of retinal antigens in Eales' disease was studied in 24 patients and an equal number of healthy controls. Lymphocyte proliferative responses were tested in vitro against native S-antigen, its uveitopathogenic peptides (peptide M and peptide G), yeast histone H3 peptide and uveitopathogenic fragment of interphotoreceptor retinoid-binding protein (IRBP; R16) to establish their role in the pathogenesis of Eales' disease. Out of 24 Eales' disease patients, 6 showed significant proliferative response against S-antigen, its uveitogenic fragments or IRBP. None among the controls showed any response to any retinal antigen used in this study. There was no statistically significant difference in the response to purified protein derivative between patients and controls. These results suggest that retinal antigens may play a role in the etiopathogenesis of Eales' disease. An extraneous agent that could result in exposure of normally sequestered uveitopathogenic antigens of the immune system, leading to an exuberant immune response in the eye may initiate the disease.
MINOR MESH HEADINGS: Adolescence-; Adult-; Cell-Division; Eye-Proteins-immunology; Immunity,-Cellular; Leukocytes,-Mononuclear-immunology; Leukocytes,-Mononuclear-pathology; Peptide-Fragments-immunology; Receptors,-Laminin-immunology
MAJOR MeSH HEADINGS: *Arrestin-immunology; *Retinal-Diseases-immunology; *Retinol-Binding-Proteins-immunology
CHECKTAGS: Comparative-Study; Female; Human; Male; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: JOURNAL-ARTICLE
CAS REGISTRY NUMBER OR EC NUMBER: 0; 0; 0; 0; 0; 0; 0; 100179-05-3
NAME OF SUBSTANCE: peptide-M,-retinal-S-antigen; retinol-binding-glycoprotein; Arrestin; Eye-Proteins; Peptide-Fragments; Receptors,-Laminin; Retinol-Binding-Proteins; peptide-G
MEDLINE ACCESSION NUMBER: 99134182
UPDATE CODE: 199905
Record 10 of 23 in MEDLINE EXPRESS (R) 1997-1999
TITLE: Long term visual results of vitrectomy for Eales disease complications.
AUTHOR(S): Shanmugam-MP; Badrinath-SS; Gopal-L; Sharma-T
ADDRESS OF AUTHOR: Vision Research Foundation, Sankara Nethralaya, Madras, India.
SOURCE (BIBLIOGRAPHIC CITATION): Int-Ophthalmol. 1998; 22(1): 61-4
INTERNATIONAL STANDARD SERIAL NUMBER: 0165-5701
PUBLICATION YEAR: 1998
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: NETHERLANDS
ABSTRACT: BACKGROUND AND OBJECTIVES: Complications of Eales disease can cause visual loss. Long term visual prognosis following vitrectomy for Eales disease complications has been studied. PATIENTS AND METHODS: Retrospective analysis of 64 eyes of 57 patients who underwent vitrectomy for Eales disease complications with a minimum follow-up of 60 months. RESULTS: 62.4% eyes at 2 months and 71.8% at 60 months had 6/60 or better visual acuity. Visual acuities for individual cases were quite stable at the 60 month follow up with 50 eyes (78.5%) either maintaining or improving upon their 2 month post operative visual acuity. CONCLUSION: Visual acuity improves after vitrectomy in majority of patients with Eales disease complications and remains stable on long term follow-up.
MINOR MESH HEADINGS: Adolescence-; Adult-; Follow-Up-Studies; Middle-Age; Phlebitis-pathology; Retina-pathology; Retinal-Diseases-etiology; Retinal-Diseases-physiopathology; Retrospective-Studies; Treatment-Outcome; Vitreous-Body-pathology; Vitreous-Body-surgery; Vitreous-Hemorrhage-etiology; Vitreous-Hemorrhage-physiopathology
MAJOR MeSH HEADINGS: *Phlebitis-complications; *Retinal-Diseases-surgery; *Visual-Acuity; *Vitrectomy-; *Vitreous-Hemorrhage-surgery
CHECKTAGS: Comparative-Study; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 99188861
UPDATE CODE: 199907
Record 11 of 23 in MEDLINE EXPRESS (R) 1997-1999
TITLE: Peripheral retinal neovascularization (Eales disease) associated with the factor V Leiden mutation.
AUTHOR(S): Eller-AW; Bontempo-FA; Faruki-H; Hassett-AC
ADDRESS OF AUTHOR: Department of Ophthalmology, University of Pittsburgh School of Medicine, The Eye and Ear Institute, PA 15213, USA. aeller@vision.eei.upmc.edu
SOURCE (BIBLIOGRAPHIC CITATION): Am-J-Ophthalmol. 1998 Jul; 126(1): 146-9
INTERNATIONAL STANDARD SERIAL NUMBER: 0002-9394
PUBLICATION YEAR: 1998
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To illustrate a case of peripheral retinal neovascularization (Eales disease) in a patient who tested positive for the factor V Leiden mutation. METHODS: A 42-year-old woman had a 1-week history of blurred vision in her right eye. Her medical history was remarkable for a cerebrovascular accident. Ophthalmoscopy of the right eye disclosed a mild vitreous hemorrhage and a ridge of retinal neovascularization in the temporal periphery. The left fundus showed evidence of temporal retinal ischemia. A laboratory evaluation for hypercoagulability was positive for factor V Leiden mutation. RESULTS: Peripheral scatter laser photocoagulation was applied to the ischemic retina, and the neovascularization regressed. The patient began taking warfarin sodium to prevent further thrombotic events. CONCLUSION: A laboratory evaluation for coagulopathy, including the factor V Leiden mutation, should be added to the examination of patients with Eales disease, especially individuals with a history of a previous thrombotic event.
MINOR MESH HEADINGS: Adult-; Anticoagulants-administration-and-dosage; Fluorescein-Angiography; Fundus-Oculi; Ischemia-genetics; Ischemia-pathology; Laser-Coagulation; Retinal-Neovascularization-surgery; Retinal-Vessels-pathology; Vasculitis-genetics; Vitreous-Hemorrhage-genetics; Vitreous-Hemorrhage-pathology; Warfarin-administration-and-dosage
MAJOR MeSH HEADINGS: *Factor-V-genetics; *Mutation-; *Retinal-Neovascularization-genetics
CHECKTAGS: Case-Report; Female; Human
PUBLICATION TYPE: JOURNAL-ARTICLE
CAS REGISTRY NUMBER OR EC NUMBER: 0; 0; 81-81-2; 9001-24-5
NAME OF SUBSTANCE: factor-V-Leiden; Anticoagulants; Warfarin; Factor-V
MEDLINE ACCESSION NUMBER: 98346698
UPDATE CODE: 199810
SUBSET: AIM
Record 12 of 23 in MEDLINE EXPRESS (R) 1997-1999
TITLE: Retinal arteriovenous shunt at the arteriovenous crossing.
AUTHOR(S): Tanaka-T; Muraoka-K; Tokui-K
ADDRESS OF AUTHOR: Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Japan.
SOURCE (BIBLIOGRAPHIC CITATION): Ophthalmology. 1998 Jul; 105(7): 1251-8
INTERNATIONAL STANDARD SERIAL NUMBER: 0161-6420
PUBLICATION YEAR: 1998
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: OBJECTIVE: The purpose of the study was to demonstrate that the arteriovenous shunt at the arteriovenous crossing could occur in major retinal vascular diseases other than Takayasu disease. DESIGN: Clinical review of consecutive case series. PARTICIPANTS: The authors studied 1885 eyes with retinal vascular diseases such as diabetic retinopathy, branch retinal vein occlusion, central retinal vein occlusion, central retinal artery occlusion, Leber's miliary aneurysms, Eales disease, Behcet disease, and systemic lupus erythematosus retinopathy. INTERVENTION: Fluorescein fundus angiography using a wide-field fundus camera (60 degrees) was performed. MAIN OUTCOME MEASURES: Dye transit from artery to vein through sequential angiography. RESULTS: The arteriovenous shunt at the arteriovenous crossing was found in 8 eyes with proliferative diabetic retinopathy, 27 eyes with branch retinal vein occlusion in the chronic stage, 2 eyes with central retinal vein occlusion, 2 eyes with central retinal artery occlusion, and 2 eyes with miliary aneurysms. The arteriovenous shunt was formed by a direct inflow from artery to vein, showing vasodilation and hyperpermeability, followed by obliteration peripheral to the shunts. The pattern of initial inflow was classified into axial flow and laminar flow, and the inflow became wider and more rapid in the advanced stage. CONCLUSIONS: These findings indicate that the arteriovenous shunt at the arteriovenous crossing is not a unique phenomenon in Takayasu disease but rather is a basic pattern of retinal vascular reaction pathologic states.
MINOR MESH HEADINGS: Adult-; Arteriovenous-Fistula-etiology; Fluorescein-Angiography; Fundus-Oculi; Middle-Age
MAJOR MeSH HEADINGS: *Arteriovenous-Anastomosis-pathology; *Arteriovenous-Fistula-pathology; *Retinal-Artery-pathology; *Retinal-Diseases-complications; *Retinal-Vein-pathology
CHECKTAGS: Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 98327732
UPDATE CODE: 199809
Record 13 of 23 in MEDLINE EXPRESS (R) 1997-1999
TITLE: Profiling of human leukocyte antigens in Eales' disease.
AUTHOR(S): Biswas-J; Mukesh-BN; Narain-S; Roy-S; Madhavan-HN
ADDRESS OF AUTHOR: Medical and Vision Research Foundation, Chennai, India.
SOURCE (BIBLIOGRAPHIC CITATION): Int-Ophthalmol. 1997-98; 21(5): 277-81
INTERNATIONAL STANDARD SERIAL NUMBER: 0165-5701
PUBLICATION YEAR: 1997
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: NETHERLANDS
ABSTRACT: Eales' disease is a primary retinal perivasculitis of an undetermined etiology seen predominantly in the Indian subcontinent and rarely in the West. Strong HLA association has been proven in retinal vasculitis of Behcet's disease. HLA association of Eales' disease is unknown and therefore the present study was undertaken to determine the same. The frequency of 30 HLA antigens (9 HLA-A antigens, 10 HLA-B antigens, 3 HLA-C antigens, 7 HLA-DR antigens and 1 HLA-DQ antigen) was studied by standard micro-lymphocytotoxicity test in 57 patients with Eales' disease and 50 age and sex-matched normal persons as controls. Both the patients and controls underwent complete ocular and clinical examinations and laboratory investigations. Inflammatory diseases similar to Eales' disease were ruled out in the patients before they were enrolled. Statistically significant higher phenotype frequencies of HLA B5 (B51), DR1 and DR4 were observed among patients with Eales' disease as compared to controls. The gene frequency of HLA B5 (B51) in our group of patients and controls was comparable with other earlier studies in the Indian population. The finding of significant association of Eales' patients with positive disequilibrium ( ) haplotypes A3-B44 and A11-B12 may be related to the development of this disease. The presence of the above HLA antigens may be indicative of predisposition to Eales' disease.
MINOR MESH HEADINGS: Adolescence-; Adult-; Cytotoxicity-Tests,-Immunologic; Gene-Frequency; HLA-Antigens-genetics; Phenotype-; Prospective-Studies; Retinal-Diseases-pathology; Retinal-Vessels-pathology; Vasculitis-pathology
MAJOR MeSH HEADINGS: *HLA-Antigens-immunology; *Retinal-Diseases-immunology; *Retinal-Vessels-immunology; *Vasculitis-immunology
CHECKTAGS: Female; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
CAS REGISTRY NUMBER OR EC NUMBER: 0
NAME OF SUBSTANCE: HLA-Antigens
MEDLINE ACCESSION NUMBER: 98427867
UPDATE CODE: 199901
Record 14 of 23 in MEDLINE EXPRESS (R) 1997-1999
TITLE: Evaluation of lymphocyte proliferation assay to purified protein derivative, enzyme linked immunosorbant assay, and tuberculin hypersensitivity in Eales' disease.
AUTHOR(S): Biswas-J; Narain-S; Roy-S; Madhavan-HN
ADDRESS OF AUTHOR: Medical and Vision Research Foundation, Chennai, India.
SOURCE (BIBLIOGRAPHIC CITATION): Indian-J-Ophthalmol. 1997 Jun; 45(2): 93-7
INTERNATIONAL STANDARD SERIAL NUMBER: 0301-4738
PUBLICATION YEAR: 1997
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: INDIA
ABSTRACT: The purpose of this study was to evaluate the immunological responses against mycobacterial antigens in Eales' disease. Fifty six patients with Eales' disease and fifty age-and-sex-matched healthy volunteers with normal fundus findings taken as controls, were subjected to Mantoux test, using 2 TU/0.1 ml of purified protein derivative (PPD), lymphocyte proliferation assay to PPD, and ELISA to detect IgM and IgG antibodies against mycobacterial A-60 antigen. The results of Mantoux test and lymphocytes proliferation assay did not differ significantly in the two groups suggesting a similar cellular immune response. The number of individuals with recent exposure/reexposure to tuberculosis (IgM+) was significantly higher among patients. However the number of people with past exposure (IgM-IgG+) was significantly higher among controls. Our study indicates that there are no statistically significant differences in the humoral and cellular immune responses to mycobacterial antigens between the patients with Eales' disease and controls, except for a significantly higher IgM positivity among the patients.
MINOR MESH HEADINGS: Adolescence-; Adult-; Antibodies,-Bacterial-analysis; Antigens,-Bacterial-immunology; Enzyme-Linked-Immunosorbent-Assay; IgG-analysis; IgM-analysis; Mycobacterium-tuberculosis-immunology; Mycobacterium-tuberculosis-isolation-and-purification; Retinal-Diseases-microbiology; Tuberculin-Test; Tuberculosis,-Ocular-microbiology; Vasculitis-microbiology
MAJOR MeSH HEADINGS: *Hypersensitivity,-Delayed-immunology; *Lymphocyte-Transformation-immunology; *Retinal-Diseases-immunology; *Tuberculin-immunology; *Tuberculosis,-Ocular-immunology; *Vasculitis-immunology
CHECKTAGS: Comparative-Study; Female; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
CAS REGISTRY NUMBER OR EC NUMBER: 0; 0; 0; 0; 0; 0
NAME OF SUBSTANCE: mycobacterial-A60-antigen; Antibodies,-Bacterial; Antigens,-Bacterial; IgG; IgM; Tuberculin
MEDLINE ACCESSION NUMBER: 98135367
UPDATE CODE: 199805
Record 15 of 23 in MEDLINE EXPRESS (R) 1997-1999
TITLE: Eales' disease: accumulation of reactive oxygen intermediates and lipid peroxides and decrease of antioxidants causing inflammation, neovascularization and retinal damage.
AUTHOR(S): Bhooma-V; Sulochana-KN; Biswas-J; Ramakrishnan-S
ADDRESS OF AUTHOR: Biochemistry Research Department, Vision Research Foundation, Madras, India.
SOURCE (BIBLIOGRAPHIC CITATION): Curr-Eye-Res. 1997 Feb; 16(2): 91-5
INTERNATIONAL STANDARD SERIAL NUMBER: 0271-3683
PUBLICATION YEAR: 1997
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: ENGLAND
ABSTRACT: PURPOSE: To measure the blood levels of oxygen and lipid-free radicals as lipid peroxidation products and of vitamins E, C and A, in order to explain intraocular inflammation, retinal neovascularization and detachment in Eales' disease. METHODS: Levels of the lipid peroxidation products produced by oxygen and lipid free radicals (estimated as thiobarbituric acid reactive substances-TBARS), vitamin E with ferric chloride, vitamin C with 2,6-dichlorophenol-indophenol and vitamin A with antimony trichloride were all evaluated in three groups of subjects between 20 and 40 years of age. Twenty three were patients with Eales' disease in the active perivasculitis stage (Group I), 19 were patients with Eales' disease in the healed-perivasculitis stage (Group II), and 46 were healthy volunteers (Group III), used as normal controls. Patients in each group were subdivided into two age groups, 20-30 and 31-40 years, each group containing both sexes. RESULTS: The results showed a 4.6- and 5.6-fold increase in the levels of TBARS in erythrocytes of patients with Eales' disease in the active perivasculitis stage (Group I) and a 2-fold increase in patients with Eales' disease in the healed perivasculitis stage (Group II), when compared to levels in the controls (Group III). On the other hand, there was a decrease of 75 and 76.2% in the levels of vitamin E in serum, 34 and 40.9% of vitamin C in plasma and 72.8 and 67% of vitamin A in serum in patients with Eales' disease in the active perivasculitis stage (Group I), as compared to the controls (Group III). Also decreases of 56 and 43.5% of vitamin E in serum, 26.8 and 12.5% of vitamin C in plasma and 50.5 and 49.4% of vitamin A in serum were found in patients with Eales' disease in the healed perivasculitis stage (Group II) as compared to the healthy controls (Group III). The two values of variations between the patients and the normal control group given above for TBARS, vitamins E,C and A are for the two age groups, 20-30 and 31-40 respectively. The differences were statistically significant (P < 0.01 to 0.001). CONCLUSIONS: Lowered levels of antioxidant vitamins E and C and consequent accumulation of oxygen and lipid free radicals, or vice versa, could explain the inflammation, neovascularization and retinal pathology in patients with Eales' disease. Also, vitamin A deficiency could aggravate retinal illness.
MINOR MESH HEADINGS: Adult-; Ascorbic-Acid-metabolism; Neovascularization,-Pathologic-etiology; Retinitis-etiology; Vitamin-A-metabolism; Vitamin-E-metabolism
MAJOR MeSH HEADINGS: *Antioxidants-metabolism; *Lipid-Peroxides-metabolism; *Reactive-Oxygen-Species-metabolism; *Retinal-Diseases-etiology; *Retinal-Diseases-metabolism; *Vasculitis-metabolism
CHECKTAGS: Female; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
CAS REGISTRY NUMBER OR EC NUMBER: 0; 0; 0; 11103-57-4; 1406-18-4; 50-81-7
NAME OF SUBSTANCE: Antioxidants; Lipid-Peroxides; Reactive-Oxygen-Species; Vitamin-A; Vitamin-E; Ascorbic-Acid
MEDLINE ACCESSION NUMBER: 97221892
UPDATE CODE: 199707
Record 16 of 23 in MEDLINE EXPRESS (R) 1994-1996
TITLE: [Dragged disk syndrome. Review of etiologies. Apropos of a case]
ORIGINAL TITLE: Syndrome d'attraction papillaire. Revue des etiologies. A propos d'un cas.
AUTHOR(S): Barreau-E; Cohen-SY; Coscas-G
ADDRESS OF AUTHOR: Clinique Ophtalmologique Universitaire, Creteil.
SOURCE (BIBLIOGRAPHIC CITATION): J-Fr-Ophtalmol. 1996; 19(1): 58-63
INTERNATIONAL STANDARD SERIAL NUMBER: 0181-5512
PUBLICATION YEAR: 1996
LANGUAGE OF ARTICLE: FRENCH; NON-ENGLISH
COUNTRY OF PUBLICATION: FRANCE
ABSTRACT: A young woman presented with an elevated, retinal yellow-white lesion in mid-periphery of one eye, associated with a dragged disc. Different aetiologies were discussed including retinopathy of prematurity, familial exudative vitreoretinopathy, congenital retinal folds, incontinentia pigmenti, Eales' disease, toxocariasis, combined hamartoma of the retina and the pigment epithelium.
MINOR MESH HEADINGS: Adult-; Diagnosis,-Differential; English-Abstract; Eye-Infections,-Parasitic-diagnosis; Infant,-Newborn; Retinal-Diseases-genetics; Toxocariasis-diagnosis
MAJOR MeSH HEADINGS: *Optic-Disk-abnormalities; *Retinal-Diseases-diagnosis
CHECKTAGS: Case-Report; English-Abstract; Female; Human
PUBLICATION TYPE: JOURNAL-ARTICLE; REVIEW; REVIEW,-TUTORIAL
MEDLINE ACCESSION NUMBER: 96343261
UPDATE CODE: 199612
Record 17 of 23 in MEDLINE EXPRESS (R) 1994-1996
TITLE: Stroke--a rare presentation of Eales' disease. A case report.
AUTHOR(S): Misra-UK; Jha-S; Kalita-J; Sharma-K
ADDRESS OF AUTHOR: Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
SOURCE (BIBLIOGRAPHIC CITATION): Angiology. 1996 Jan; 47(1): 73-6
INTERNATIONAL STANDARD SERIAL NUMBER: 0003-3197
PUBLICATION YEAR: 1996
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: Eales' disease is common in India and the Middle East, but its neurologic manifestations are rare. The authors report a young man with recurrent vitreous hemorrhage and acute amnestic confusional state who subsequently developed myelopathy. Eales' disease should be considered in the differential diagnosis of stroke in a young patient.
MINOR MESH HEADINGS: Adult-; Cerebrovascular-Disorders-diagnosis; Diagnosis,-Differential; India-epidemiology; Phlebitis-diagnosis; Phlebitis-epidemiology; Recurrence-; Retinal-Diseases-complications; Retinal-Diseases-diagnosis; Retinal-Diseases-epidemiology; Vitreous-Hemorrhage-diagnosis; Vitreous-Hemorrhage-epidemiology
MAJOR MeSH HEADINGS: *Cerebrovascular-Disorders-etiology; *Phlebitis-complications; *Retinal-Vein; *Vitreous-Hemorrhage-complications
CHECKTAGS: Case-Report; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 96133183
UPDATE CODE: 199604
Record 18 of 23 in MEDLINE EXPRESS (R) 1994-1996
TITLE: Ocular morbidity in patients with active systemic tuberculosis.
AUTHOR(S): Biswas-J; Badrinath-SS
ADDRESS OF AUTHOR: Vision Research Foundation, Madras, India.
SOURCE (BIBLIOGRAPHIC CITATION): Int-Ophthalmol. 1995-96; 19(5): 293-8
INTERNATIONAL STANDARD SERIAL NUMBER: 0165-5701
PUBLICATION YEAR: 1995
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: NETHERLANDS
ABSTRACT: The ocular morbidity pattern in 2010 eyes of 1005 patients with active pulmonary and extrapulmonary tuberculosis was studied prospectively. A complete clinical (ocular and systemic) examination, radiologic evaluation, Mantoux test and sputum analysis for acid-fast bacilli were carried out in all patients. The ocular morbidity in patients in this study with active tuberculosis was 1.39%. The most common ocular finding was bilateral healed focal choroiditis (50%). No case of Eales' disease was found in this series. There was no statistically significant correlation between the ocular lesions and Mantoux positivity.
MINOR MESH HEADINGS: Adult-; Fundus-Oculi; India-epidemiology; Morbidity-; Prospective-Studies; Sputum-microbiology; Tuberculin-Test; Tuberculosis-epidemiology
MAJOR MeSH HEADINGS: *Eye-Diseases-epidemiology; *Tuberculosis,-Ocular-epidemiology; *Tuberculosis,-Pulmonary-epidemiology
CHECKTAGS: Female; Human; Male; Support,-Non-U.S.-Gov't
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 97018197
UPDATE CODE: 199702
Record 19 of 23 in MEDLINE EXPRESS (R) 1994-1996
TITLE: Bilateral bullous exudative retinal detachment complicating idiopathic central serous chorioretinopathy during systemic corticosteroid therapy.
AUTHOR(S): Gass-JD; Little-H
ADDRESS OF AUTHOR: Bascom Palmer Eye Institute, University of Miami School of Medicine, Department of Ophthalmology, FL 33101, USA.
SOURCE (BIBLIOGRAPHIC CITATION): Ophthalmology. 1995 May; 102(5): 737-47
INTERNATIONAL STANDARD SERIAL NUMBER: 0161-6420
PUBLICATION YEAR: 1995
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: UNITED-STATES
ABSTRACT: PURPOSE: To present evidence that systemic corticosteroid therapy may cause bilateral bullous serofibrinous exudative retinal detachment in some patients with idiopathic central serous chorioretinopathy. BACKGROUND: Idiopathic central serous chorioretinopathy usually causes mild, transient loss of central vision, usually in otherwise healthy men with a type A personality. A few patients have permanent visual loss because of chronic and recurrent retinal detachment. The clinical findings in these patients may lead to incorrect diagnoses and use of corticosteroid therapy. METHODS: The clinical and photographic records of three patients in whom bilateral bullous serofibrinous exudative retinal detachment associated with idiopathic central serous chorioretinopathy developed after treatment with systemic corticosteroids were reviewed. RESULTS: Systemic corticosteroid treatment was instituted (1) as a prophylaxis to prevent exacerbation of the disease while undergoing surgery in the fellow eye, and (2) as the result of misdiagnoses of multifocal choroiditis and retinal vasculitis (Eales disease). Two of the patients had a history of chronic recurrent retinal detachments before institution of corticosteroid treatment. In one of these patients, bilateral chronic inferior retinal detachment developed, causing peripheral retinal vascular nonperfusion, retinal neovascularization, and vitreous hemorrhage. All three patients had severe permanent visual loss in one or both eyes. CONCLUSION: The findings in these patients provide further evidence that systemic corticosteroid treatment may cause severe exacerbation of retinal detachment and lasting visual loss in some patients with idiopathic central serous retinopathy. Recognition of the atypical presentations of this disorder is important to avoid incorrect diagnoses and treatment.
MINOR MESH HEADINGS: Adrenal-Cortex-Hormones-therapeutic-use; Adult-; Choroid-pathology; Choroid-Diseases-complications; Choroid-Diseases-pathology; Exudates-and-Transudates; Fluorescein-Angiography; Fundus-Oculi; Middle-Age; Retina-pathology; Retinal-Detachment-pathology; Retinal-Diseases-complications; Retinal-Diseases-pathology; Stress,-Psychological-complications; Type-A-Personality; Vision-Disorders-etiology; Visual-Acuity
MAJOR MeSH HEADINGS: *Adrenal-Cortex-Hormones-adverse-effects; *Choroid-Diseases-drug-therapy; *Retinal-Detachment-chemically-induced; *Retinal-Diseases-drug-therapy
CHECKTAGS: Case-Report; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
CAS REGISTRY NUMBER OR EC NUMBER: 0
NAME OF SUBSTANCE: Adrenal-Cortex-Hormones
MEDLINE ACCESSION NUMBER: 95296059
UPDATE CODE: 199509
Record 20 of 23 in MEDLINE EXPRESS (R) 1994-1996
TITLE: Affective psychosis in Eales' disease and response to sodium valproate [letter]
AUTHOR(S): Nizamie-SH; Chatterjee-S
SOURCE (BIBLIOGRAPHIC CITATION): Gen-Hosp-Psychiatry. 1994 Sep; 16(5): 364-6
INTERNATIONAL STANDARD SERIAL NUMBER: 0163-8343
PUBLICATION YEAR: 1994
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: UNITED-STATES
MINOR MESH HEADINGS: Adult-; Affective-Disorders,-Psychotic-psychology; Combined-Modality-Therapy; Delirium,-Dementia,-Amnestic,-Cognitive-Disorders-psychology; Electroconvulsive-Therapy; India-; Neurologic-Examination-drug-effects; Retinal-Diseases-psychology; Valproic-Acid-adverse-effects
MAJOR MeSH HEADINGS: *Affective-Disorders,-Psychotic-drug-therapy; *Delirium,-Dementia,-Amnestic,-Cognitive-Disorders-drug-therapy; *Retinal-Diseases-drug-therapy; *Valproic-Acid-therapeutic-use
CHECKTAGS: Case-Report; Human; Male
PUBLICATION TYPE: LETTER
CAS REGISTRY NUMBER OR EC NUMBER: 99-66-1
NAME OF SUBSTANCE: Valproic-Acid
MEDLINE ACCESSION NUMBER: 95087873
UPDATE CODE: 199503
Record 21 of 23 in MEDLINE EXPRESS (R) 1994-1996
TITLE: [Eales' disease involving central nervous system white matter]
ORIGINAL TITLE: Enfermedad de Eales con afectacion de la sustancia blanca del sistema nervioso central.
AUTHOR(S): Antiguedad-A; Zarranz-JJ
ADDRESS OF AUTHOR: Servicio y Catedra de Neurologia, Hospital de Cruces, Universidad del Pais Vasco, Vizcaya.
SOURCE (BIBLIOGRAPHIC CITATION): Neurologia. 1994 Aug-Sep; 9(7): 307-10
INTERNATIONAL STANDARD SERIAL NUMBER: 0213-4853
PUBLICATION YEAR: 1994
LANGUAGE OF ARTICLE: SPANISH; NON-ENGLISH
COUNTRY OF PUBLICATION: SPAIN
ABSTRACT: Eales' disease (ED) is a rare condition characterized by repeated retinal and vitreous hemorrhages. The only extraocular involvement described occasionally in the literature is neurological. Histologically, vasculitis in ED is usually restricted to the eye, but occasionally involves the central nervous system, where demyelinizing lesions may also occur. We present a 34-year-old male with ED and subclinical central nervous system involvement. Craneal magnetic resonance images (MR) suggested demyelinization; brainstem auditory and somatosensory evoked potentials were abnormal. There was moderate pleocytosis in CSF and intratecal production of immunoglobulins with oligoclonal bands. Follow-up over a period of 2.5 years showed no clinical, MR or CSF changes in spite of continued opthamological impairment. Little is known about factors that affect the development or not of demyelinizing lesions in ED patients with neurological involvement demonstrated by intratecal production of immunoglobulins. Identification of such factors may contribute to our understanding of other diseases, such as multiple sclerosis.
MINOR MESH HEADINGS: Adult-; Demyelinating-Diseases-diagnosis; Demyelinating-Diseases-physiopathology; English-Abstract; Evoked-Potentials,-Auditory,-Brain-Stem; Evoked-Potentials,-Somatosensory; Nervous-System-Diseases-physiopathology; Retinal-Diseases-physiopathology; Retinal-Hemorrhage-diagnosis; Retinal-Hemorrhage-physiopathology; Vasculitis-physiopathology; Vitreous-Hemorrhage-diagnosis; Vitreous-Hemorrhage-physiopathology
MAJOR MeSH HEADINGS: *Nervous-System-Diseases-diagnosis; *Retinal-Diseases-diagnosis; *Vasculitis-diagnosis
CHECKTAGS: Case-Report; English-Abstract; Human; Male
PUBLICATION TYPE: JOURNAL-ARTICLE
MEDLINE ACCESSION NUMBER: 95033319
UPDATE CODE: 199502
Record 22 of 23 in MEDLINE EXPRESS (R) 1994-1996
TITLE: Eales' disease.
AUTHOR(S): Das-T; Biswas-J; Kumar-A; Nagpal-PN; Namperumalsamy-P; Patnaik-B; Tewari-HK
ADDRESS OF AUTHOR: L.V. Prasad Eye Institute, Hyderabad, India.
SOURCE (BIBLIOGRAPHIC CITATION): Indian-J-Ophthalmol. 1994 Mar; 42(1): 3-18
INTERNATIONAL STANDARD SERIAL NUMBER: 0301-4738
PUBLICATION YEAR: 1994
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: INDIA
MINOR MESH HEADINGS: Retinal-Neovascularization-etiology; Retinal-Neovascularization-pathology; Retinal-Neovascularization-therapy; Retinal-Vessels-pathology; Vasculitis-etiology; Vasculitis-pathology; Vasculitis-therapy
MAJOR MeSH HEADINGS: *Retinal-Neovascularization; *Retinal-Vessels; *Vasculitis-
CHECKTAGS: Human
PUBLICATION TYPE: JOURNAL-ARTICLE; REVIEW; REVIEW,-ACADEMIC
MEDLINE ACCESSION NUMBER: 95012545
UPDATE CODE: 199501
Record 23 of 23 in MEDLINE EXPRESS (R) 1994-1996
TITLE: Collaborative Eales' Disease Study [editorial]
AUTHOR(S): Das-T
SOURCE (BIBLIOGRAPHIC CITATION): Indian-J-Ophthalmol. 1994 Mar; 42(1): 1
INTERNATIONAL STANDARD SERIAL NUMBER: 0301-4738
PUBLICATION YEAR: 1994
LANGUAGE OF ARTICLE: ENGLISH
COUNTRY OF PUBLICATION: INDIA
MINOR MESH HEADINGS: Recurrence-; Research-Design; Retinal-Neovascularization-complications; Vitreous-Hemorrhage-etiology
MAJOR MeSH HEADINGS: *Retinal-Neovascularization
CHECKTAGS: Human
PUBLICATION TYPE: EDITORIAL
MEDLINE ACCESSION NUMBER: 95012541
UPDATE CODE: 199501