LESCH-NYHAN SYNDROME,

Preliminary Remarks

Lesch-Nyhan syndrome [LNS], is comparatively rare condition in which afflicted persons are prone to severe self-mutilation (e.g. chewing off their lips and fingers). The syndrome (go here for general information) is a manifestation of a recessive, X-linked error of metabolism -- an enzyme deficiency of purine metabolism. In more recent years, LNS, has become the subject of both laboratory and clinical investigations. What follows are the hyperlinks to the results of searches of MEDLINE conducted at Indiana University, Bloomington, Indiana. The items were compiled by SilverPlatter and are presented with their generous cooperation and permission. (See SilverPlatter's Worldwide Library for bibliographic search information.)