Richard DiMarchi Research Group

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Patents

DiMarchi, Richard D. Inhibiting undesired thiol reactions during cyanogen bromide cleavage of peptides. U.S. (1984), 4 pp. CODEN: US 4451396 A 19840529 CAN 101:68926 AN 1984:468926 CAPLUS

DiMarchi, Richard Dennis; Shaar, Carl Joseph. Growth hormone release factor analogs. Eur. Pat. Appl. (1985), 33 pp. CODEN: EPXXDW EP 138416 A2  19850424 CAN 104:34340 AN 1986:34340 CAPLUS

DiMarchi, Richard Dennis; Brooke, Gerald Stephen.  Synthetic vaccines for foot and mouth disease. Eur. Pat. Appl. (1986), 38 pp. CODEN: EPXXDW  EP  204480  A2  19861210  CAN 107:64833  AN 1987:464833 CAPLUS

DiMarchi, Richard D. Purifying proinsulin-like materials by chromatography on Amberlite XAD resins. U.S. (1986), 5 pp. CODEN: USXXAM  US  4616078  A  19861007  CAN 106:132388  AN 1987:132388 CAPLUS

DiMarchi, Richard Dennis. Inhibiting peptide carbamylation. Eur. Pat. Appl. (1986), 15 pp. CODEN: EPXXDW  EP  171276  A2  19860212  CAN 105:111514  AN 1986:511514 CAPLUS

DiMarchi, R. D. (1986).  Process for Inhibiting Peptide Carbamylation. U. S. Patent Number 4,605,513.

DiMarchi, R. D. and Shaar, C. J. (1986).  Growth Hormone Release Factor Analogs U. S. Patent Number 4,617,149.

DiMarchi, Richard Dennis; Brooke, Gerald Stephen.   Selective chemical removal of protein amino-terminal residues from biosynthetically-produced peptides.    Eur. Pat. Appl.  (1987), 27 pp.  CODEN:EPXXDW  EP  220958  A2  19870506  CAN 112:21293  AN 1990:21293    CAPLUS

DiMarchi, R. D. and Brooke, G. S. (1988).  Synthetic Vaccines for Foot and Mouth Disease.  U. S. Patent Number 4,732,971.

DiMarchi, Richard D.; Long, Harlan B.   Process for selective peptide bond cleavage at tryptophan residues using sulfoxides and trifluoroacetic acid.    U.S.  (1988), 6 pp. CODEN: USXXAM  US 4745178 A 19880517  CAN 110:58102  AN 1989:58102 CAPLUS

DiMarchi, R. D. and Brooke, G. S. (1988).  Selective Chemical Removal of a Protein Amino-Terminal Residue. U. S. Patent Number 4,782,139.

DiMarchi, R. D. and Long, H. B. (1989).  Process for Reducing Methionine Sulfoxide Residues in Peptides or Proteins. U. S. Patent Number 4,835,254.

Di Marchi, Richard Dennis; Long, Harlan Beall.   Reduction of methionine sulfoxide residues in   peptides and proteins. Ger. Offen. (1989), 6 pp. CODEN: GWXXBX  DE  3828287  A1  19890309 CAN 111:97728  AN 1989:497728    CAPLUS

Chance, Ronald Eugene; Dimarchi, Richard Dennis; Frank, Bruce Hill; Shields, James Edwin. Preparation of insulin with modified association and biological properties.Eur. Pat. Appl.  (1990), 67 pp. CODEN: EPXXDW  EP  383472  A2  19900822  CAN 114:179723  AN 1991:179723    CAPLUS

DiMarchi, R. D., Heiman, M. L., Shields, J. E., Smiley, D. L., Wickister, D. I. (1991). Superactive GRFAnalogs. U. S. Patent Number 4,904,001

Brooke, Gerald Stephen; Dimarchi, Richard Dennis; Heiman, Mark Louis; Hsiung, Hansen Maxwell; Smiley, David Lee; Smith, Dennis Paul. Growth hormone releasing factor analogs and their manufacture with recombinant Escherichia coli. Eur. Pat. Appl.  (1991),  39 pp.  CODEN: EPXXDW EP  454367  A2  19911030  CAN 116:188664  AN 1992:188664    CAPLUS

DiMarchi, Richard Dennis; Gesellchen, Paul David; Owens, Rebecca Anne.   Rapid synthesis and screening of peptide mimetics. Eur. Pat. Appl. (1992), 12 pp.  CODEN: EPXXDW  EP  519640  A1     19921223  CAN 119:139789  AN 1993:539789    CAPLUS

DiMarchi, Richard Dennis; Heiman, Mark Louis; Shields, James Edwin; Smiley, David Lee.   Superactive growth hormone-releasing factor (GRF) analogs. Eur. Pat. Appl.  (1992), 32 pp.  CODEN: EPXXDW  EP  511003  A1  19921028  CAN 118:184427  AN 1993:184427    CAPLUS

Belagaje, Rama M.; Dimarchi, Richard Dennis; Heath, William Francis, Jr.; Long, Harlan Beall. Proinsulin with an N-terminal A-chain and its manufacture and accurate processing in Escherichia coli. Eur. Pat. Appl.  (1992),     80 pp.  CODEN: EPXXDW  EP  518587  A2  19921216  CAN   118:118311  AN 1993:118311    CAPLUS

DiMarchi, Richard Dennis; Kit, Saul; Little, Sheila Parks; Gale, Charles; Kit, Malon.   Herpesvirus-based viral vector containing foot-and-mouth disease virus epitope and its use as a vaccine.  Eur. Pat. Appl. (1992), 72 pp.  CODEN: EPXXDW  EP  471457  A2  19920219  CAN 117:220059  AN 1992:620059             CAPLUS

Belagaje, R., M., DiMarchi, R. D., Heath, W. F. Jr., and Long, H. B. (1994). “A-C-B Proinsulin, Method of Manufacturing and Using Same, and Intermediates in Insulin Production.”  U. S. Patent   Number 5,304,473.

DiMarchi, R. D., Gesellchen, P. D., and Owens, R. A. (1995).  Rapid Synthesis and Screening of Peptide Mimetics. U. S. Patent Number 5,422,426.

DiMarchi, Richard Dennis; Fan, Li; Long, Harlan Beall.   IGF-1 superagonists.    Eur. Pat. Appl.  (1996), 15 pp. CODEN: EPXXDW  EP  742228  A1  19961113  CAN 126:55338  AN 1997:44641 CAPLUS

Chance, Ronald Eugene; DiMarchi, Richard Dennis; Hoffmann, James Arthur; Long, Harlan Beall; Miller, Anne Reifel.  Single chain insulin analogs with high biological activity for treatment of diabetes. Eur. Pat. Appl. (1996), 22 pp.  CODEN: EPXXDW  EP  741188  A2  19961106  CAN 126:14767  AN           1996:748391    CAPLUS

Basinski, Margret B.; DiMarchi, Richard D.; Flora, David B.; Heath, William F., Jr.; Hoffmann, James A.; Schoner, Brigitte E.; Shields, James E.; Smiley, David L.   Anti-obesity proteins.    U.S.  (1996), 12 pp., Cont.-in-part of U.S. Ser. No. 381, 247.  CODEN: USXXAM  US  5569744  A  19961029  CAN 126:2513 AN 1996:701935    CAPLUS

Basinski, Margret; DiMarchi, Richard D.; Flora, David B.; Heath, William F., Jr.; Hoffmann, James A.; Schoner, Brigitte E.; Shields, James E.; Smiley, David L.   Anti-obesity proteins.    U.S.  (1996), 12 pp.,   Cont.-in-part of U.S. Ser. No. 381,047, abandoned.  CODEN: USXXAM  US  5567803  A  19961022  CAN   126:22877  AN 1996:679505    CAPLUS

Basinski, Margret B.; DiMarchi, Richard D.; Heath, William F., Jr.; Schoner, Brigitte E. Anti-obesity proteins, their amino acid sequences, expression in Escherichia coli, and pharmaceutical uses.  U.S. (1996),13 pp., Cont.-in-part of U.S. Ser. No. 381,031, abandoned.  CODEN: USXXAM  US 5559208 A  19960924  CAN 125:309037  AN 1996:637440    CAPLUS

Basinski, Margaret B.; DiMarchi, Richard D.; Flora, David B.; Heath, William F., Jr.; Hoffmann, James A.; Schoner, Brigitte E.; Shields, James E.; Smiley, David L.   Anti-obesity proteins and their preparation for clinical use. PCT Int. Appl.  (1996), 30 pp.  CODEN: PIXXD2  WO  9623516  A1  19960808  CAN 125:244218  AN 1996:601768    CAPLUS

Basinski, Margaret B.; DiMarchi, Richard D.; Heath, William F., Jr.; Schoner, Brigitte E. Cloning and formulation of antiobesity proteins.    PCT Int. Appl.  (1996),  33 pp.  CODEN: PIXXD2  WO  9623513 A1  19960808  CAN 125:257215  AN 1996:596136    CAPLUS

Basinski, Margaret B.; DiMarchi, Richad D.; Heath, William F., Jr.; Schoner, Brigitte E.   Cloning and formulation of antiobesity proteins.    PCT Int. Appl.  (1996), 33 pp.  CODEN: PIXXD2  WO  9623519 A1  19960808  CAN 125:257212  AN 1996:596133    CAPLUS

Basinski, Margaret B.; DiMarchi, Richard D.; Heath, William F., Jr.; Schoner, Brigitte E.   Antiobesity   proteins.  PCT Int. Appl.  (1996), 33 pp.  CODEN: PIXXD2  WO  9623520  A1  19960808  CAN 125:257211  AN 1996:596132    CAPLUS

Basinski, Margret B.; DiMarchi, Richard D.; Heath, William F., Jr.; Schoner, Brigitte E.   Antiobesity   proteins.  U.S.  (1996),  13 pp., Cont.-in-part of U.S. Ser. No. 381, 033, abandoned.  CODEN: USXXAM US  5554727  A  19960910  CAN 125:309021  AN 1996:590816    CAPLUS

Basinski, Margret B.; DiMarchi, Richard D.; Heath, William F., Jr.; Schoner, Brigitte E.   Anti-obesity proteins and pharmaceuticals containing them.    U.S.  (1996), 13 pp., Cont.-in-part of U.S. Ser. No. 381,661, abandoned.  CODEN: USXXAM  US  5552524  A  19960903  CAN 125:266029  AN 1996:577851             CAPLUS

Basinski, Margret B.; DiMarchi, Richard D.; Heath, William F., Jr.; Schoner, Brigitte E.   Anti-obesity proteins and pharmaceuticals containing them.    U.S.  (1996), 12 pp., Cont.-in-part of U.S. Ser. No. 381,458, abandoned.  CODEN: USXXAM  US  5552523  A  19960903  CAN 125:266028  AN 1996:577850             CAPLUS

Basinski, Margret B.; DiMarchi, Richard D.; Flora, David B.; Hale, John E.; Heath, William F., Jr.; Hoffmann, James A.; Schoner, Brigitte E. Synthetic anti-obesity proteins more stable than mouse or human proteins, sequences, recombinant production, and pharmaceutical uses.    Eur. Pat. Appl. (1996), 56 pp. CODEN: EPXXDW  EP  725079  A1  19960807  CAN 125:212702  AN 1996:567261 CAPLUS

Basinsky, Margret B.; DiMarchi, Richard D.; Heath, William F., Jr.; Schoner, Brigitte E.   Synthetic anti-obesity proteins more stable than mouse or human proteins, sequences, recombinant production, and pharmaceutical uses.  Eur. Pat. Appl.  (1996), 42 pp.  CODEN: EPXXDW  EP  725078  A1 19960807  CAN 125:212701  AN 1996:567260    CAPLUS

DiMarchi, Richard D.; Flora, David B.; Heath, William F., Jr.; Hoffmann, James A.; Shields, James E.; Smiley, David L. Anti-obesity proteins.  U.S.  (1996), 11 pp.  CODEN: USXXAM  US  5532336  A 19960702  CAN 125:140658  AN 1996:452794    CAPLUS

DiMarchi, Richard D.; Flora, David B.; Heath, William F., Jr.; Hoffmann, James A.; Shields, James E.; Smiley, David L. Synthesis and formulation of antiobesity proteins.    U.S.  (1996), 10 pp.  CODEN: USXXAM  US  5525705  A  19960611  CAN 125:77486  AN 1996:411078    CAPLUS

DiMarchi, Richard D.; Flora, David B.; Heath, William F., Jr.; Hoffmann, James A.; Shields, James E.; Smiley, David L.   Preparation of anti-obesity proteins.    U.S.  (1996), 10 pp.  CODEN: USXXAM  US 5521283  A  19960528  CAN 125:115163  AN 1996:380239    CAPLUS

Chen, Victor John; Dimarchi, Richard D.; Kriauciunas, Aidas V.; Smiley, David L.; Stucky, Russell D. Glucagon-like insulinotropic peptide analogs and their use in diabetes treatment. Eur. Pat. Appl.  (1996), 21 pp.  CODEN: EPXXDW  EP  708179  A2  19960424  CAN 124:307606  AN 1996:290631    CAPLUS

Chen, V. J., DiMarchi, R. D., Smiley, D. L., Stucky, R. D., and Kriauciunas, A. V. (1996).  “Glucagon-like Insulinotropic Peptide Analogs, Compositions, and Methods of Use.”  U. S. Patent Number 5,512,549.

Chance, R. E., DiMarchi, R. D., Frank, B. H. and Shields, J. E. (1996). “Insulin Analogs Modified at Position 29 of the B Chain.”  U. S. Patent Number 5,514,646.

DiMarchi, R. D., Flora, D. B., Heath, Jr., W. F., Hoffmann, J. A., Shields, J. E.,and Smiley, D. L. (1996). Anti-obesity Proteins.  U. S. Patent Number  5,521,283.

DiMarchi, R. D., Flora, D. B., Heath, Jr., W. F., Hoffmann, J. A., Shields, J. E.,and Smiley, D. L. (1996). Anti-obesity Proteins.  U. S. Patent Number  5,525,705.

DiMarchi, R. D., Flora, D. B., Heath, Jr., W. F., Hoffmann, J. A., Shields, J. E. and Smiley, D. L. (1996). Anti-obesity Proteins.  U. S. Patent Number 5,563,243.

DiMarchi, R. D., Flora, D. B., Heath, Jr., W. F., Hoffmann, J. A., Shields, J. E. and Smiley, D. L. (1996). Anti-obesity Proteins.  U. S. Patent Number 5,563,244.

DiMarchi, R. D., Flora, D. B., Heath, Jr., W. F., Hoffmann, J. A., Shields, J. E. and Smiley, D. L. (1996). Anti-obesity Proteins.  U. S. Patent  Number 5,563,245.

DiMarchi, R. D., Flora, D. B., Heath Jr., W. F., Hoffmann, J. A., Shields, J. E. and Smiley, D. L. (1996).  Anti-obesity Proteins.  U. S. Patent Number 5,567,678.

DiMarchi, R. D., Flora, D. B., Heath, Jr., W. F., Hoffmann, J. A., Shields, J. E. and Smiley, D. L. (1996). Anti-obesity Proteins.  U. S. Patent Number 5,569,743.

DiMarchi, R. D., Flora, D. B., Heath, Jr., W. F., Hoffmann, J. A., Shields, J. E. and Smiley, D. L. (1996). Anti-obesity Proteins.  U. S. Patent Number 5,574,133.

DiMarchi, R. D., Flora, D. B., Heath, Jr., W. F., Hoffmann, J. A., Shields, J. E.and Smiley, D. L. (1996).  Anti-obesity Proteins.  U. S. Patent Number 5,580,954.

DiMarchi, R. D., Fan, L., Long, H. B. (1997).  “IGF-I  Superagonists.” U.S. Patent Number 5,622,932.Basinski, Margret B.; Dimarchi, Richard D.; Flora, David B.; Heath, William F., Jr.; Hoffmann, James A.; Schoner, Brigitte E.; Shields, James E.; Smiley, David L.  Anti-obesity proteins. U.S. (1997), 11 pp., Cont.-in-part of U.S. Ser. No. 381,451, abandoned.  CODEN: USXXAM  US  5691309 A  19971125  CAN 128:30714  AN 1997:772196    CAPLUS

Borts, Tracy L.; Broderick, Carol L.; Dimarchi, Richard D.; Grinnell, Brian W.; Miller, Anne R. Glucagon-like peptide 1-based protein heterologous expression in transformed mammal cell line, gene therapy of diabetes, and transformed cell line implants. PCT Int. Appl.  (1997), 30 pp. CODEN: PIXXD2  WO  9729180  A1  19970814  CAN 127:201022  AN 1997:542509    CAPLUS

Broderick, Carol L.; Dimarchi, Richard D.; Heiman, Mark L.; Stramm, Lawrence E.   Method of treating insulin resistance with GH releasing agents.    PCT Int. Appl.  (1997),  28 pp. CODEN: PIXXD2  WO9709060  A1  19970313  CAN 126:288562  AN 1997:317749    CAPLUS

Basinski, Margret B.; Dimarchi, Richard D.; Flora, David B.; Heath, William F., Jr.; Hoffmann, James A.; Schoner, Brigitte E.; Shields, James E.; Smiley, David L.   Antiobesity proteins.    U.S.  (1997), 12 pp., Cont.-in-part of U.S. Ser. No. 383,648, abandoned.  CODEN: USXXAM  US  5605886  A  19970225 CAN 126:216641  AN 1997:196177    CAPLUS

Basinski, Margret B.; Dimarchi, Richard D.; Flora, David B.; Heath, William F., Jr.; Hoffmann, James A.; Schoner, Brigitte E.; Shields, James E.; Smiley, David L.  Cloning and formulation of anti-obesity proteins.    U.S.  (1997),     12 pp., Cont.-in-part of U.S. Ser. No. 381,266, abandoned.  CODEN:  USXXAM  US  5594104  A  19970114  CAN 126:162223  AN 1997:97732    CAPLUS

Basinski, M. B., DiMarchi, R. D., Flora, D. B., Heath, Jr., W. F., Hoffmann, J. A., Schoner, B. E., Shields, J. E., and Smiley, D. L. (1997).  Anti-obesity Proteins.   U. S. Patent Number 5,691,309.

Chance, R. E., DiMarchi, R. D., Frank, B. H., and Shields, J. E.  (1997). Process for Preparing Insulin Analogs. U. S. Patent Number 5,700,662,

DiMarchi, Richard D.; Efendic, Suad.   Use of glucagon-like peptide-1 analogs and derivatives administered peripherally in regulation of obesity. PCT Int. Appl.  (1998), 42 pp. CODEN: PIXXD2  WO  9819698  A1  19980514  CAN 129:8575  AN 1998:323152    CAPLUS

Beals, John M.; Dimarchi, Richard D. Chimpanzee leptin derivatives that do not aggregate for use as parenteral anti-obesity agents. PCT Int. Appl.  (1998), 55 pp.  CODEN: PIXXD2  WO  9816545 A1  19980423  CAN 128:326468  AN 1998:251188    CAPLUS

DiMarchi, Richard D.; Hermeling, Ronald N.; Hoffmann, James A. Preparation of anti-obesity proteins.  U.S. (1998), 17 pp. CODEN: USXXAM  US  5719266  A  19980217  CAN 128:201061  AN 1998:146588    CAPLUS

DiMarchi, R. D., Hermeling, R. N. and Hoffmann, J. A.  (1998). Anti-Obesity Proteins.  U. S. Patent   Number 5,719,266

Basinski, M. B., DiMarchi, R. D., Flora, D. B., Heath, Jr., W. F., Hoffmann, J. A.,Schoner, B. E., Shields, J. E., and Smiley, D. L.  (1998).  Anti-Obesity Proteins. U. S. Patent Number 5,851.995.

DiMarchi, R.D., Harrison R.G., and Wolff, R.K Pulmonary Delivery of Insulin Analogs.  U. S. Patent Application  Docket  P-11794. (Jan 1998)

Broderick, C. L., DiMarchi, R. D., Heiman, M. L., and Stramm, L. E. (1999). Method of Treating Insulin Resistance.  U. S. Patent Number 5,939,387.

DiMarchi, Richard Dennis; Harrison, Roger Garrick; Wolff, Ronald Keith.   Inhalation method for administering monomeric insulin analogs.  PCT Int. Appl.  (1999), 39 pp.  CODEN: PIXXD2  WO           9934816  A1  19990715  CAN 131:106786  AN 1999:451201    CAPLUS

DiMarchi, Richard Dennis; Harrison, Roger Garrick; Wolff, Ronald Keith. Inhalation method for administering AspB28-human insulin.  PCT Int. Appl.  (1999), 41 pp.CODEN: PIXXD2  WO  9934815  A1  19990715  CAN 131:106785  AN 1999:451200    CAPLUS 

DiMarchi, R.D., DeFelippis, M. R., Frank, B. H., Hines, P.A., and Lents, M. P. Cartridge Assembly for Medicament Suspensions. U. S. Patent Application  Docket  P-12012. (April 1999)
        
DiMarchi, R.D., Harrison R.G., and Wolff, R.K Pulmonary Delivery of Insulin Analogs. U. S. Patent Application  Docket  P-12733. (Jan 1999)

Chance, R. E., DiMarchi, R. D., and Flora, D. B. (2001).  Insulin Analogs.  U. S. Patent Number 6,191,102

DiMarchi, R.D., Trautmann, M. E., and DeFelippis, M. R. Biphasic Mixtures of GLP-1 and Insulin. U.S. Patent Application  Docket  P-14815. (Oct 2001)

DiMarchi, R.D., DeFelippis, M. R., Kohn, W.D., Micanovic R., Zhang, L., Beals, J.M., and Myers, S.R.  Insulin Derivative Having Protracted Time Action. U. S. Patent Application  Docket  P-15012. (Dec 2001)

DiMarchi, R.D., Glaesner W., and Millican R. L.  Amidated Glucagon-Like Peptide 1. U. S. Patent Application  Docket  P-15402. (Nov 2001)

DiMarchi, R.D., Smiley, D.E., and Zhang, L. Modified Glucagon-Like Peptide-1 Analogs. U. S. Patent Application  Docket  P-15642. (June 2002)

Millican, Rohn Lee, Jr.; Glaesner, Wolfgang; Dimarchi, Richard Dennis.   Amidated glucagon-like peptide-1.    PCT Int. Appl.  (2002),  50 pp.  CODEN: PIXXD2  WO  2002048192  A2  20020620  CAN 137:52331  AN 2002:466049    CAPLUS

DiMarchi, R.D., and DeFelippis, M. R. GLP-1 and Basal Insulin Mixtures. U. S. Patent Application Docket  P-14314A. (May 2002)

DiMarchi, R.D., and DeFelippis, M. R. GLP-1 and Basal Insulin Mixtures. U. S. Patent Application Docket  P-14314B. (June 2002)

DiMarchi, R.D., DeFelippis, M. R., and Ng, K. Pre-Mixed Formulation of GLP-1 and Basal Insulin. U. S. Patent Application  Docket  P-14314. (August 2002)

DiMarchi, R.D. and Efendic, S. (2003). Use of GLP-1 Analogs and Derivatives Administered Peripherally in Regulation of Obesity. U.S. Patent 6,583,111 B1

DiMarchi, R.D., Glaesner, W., Millican, R.L., Vick, A.M., and Zhang, L.  Pegylated GLP-1. U. S. Patent Application  Docket  P-16020. (Mar 2003)

DiMarchi, Richard Dennis; Smiley, David Lee; Zhang, Lianshan.   Preparation of modified glucagon-  like peptide-1 analogs. PCT Int. Appl.  (2003), 124 pp.  CODEN: PIXXD2  WO  2003103572  A2 20031218  CAN 140:42466  AN 2003:991273    CAPLUS

DiMarchi, R.D. Insulin Analog Having Protracted Time Action. U. S. Patent Application  Docket  P-16270. (April 2003)

DiMarchi, R.D. Insulin Analog Having Protracted Time Action. U. S. Patent Application  Docket  P-16270A. (May 2003)

Beals, John Michael; Defelippis, Michael Rosario; DiMarchi, Richard Dennis; Kohn, Wayne David; Micanovic, Radmila; Myers, Sharon Ruth; Ng, Kingman; Zhang, Lianshan. Synthesis, properties, and therapeutic uses of insulin derivatives having protracted time action.  PCT Int. Appl.  (2003), 87 pp.  CODEN: PIXXD2  WO  2003053339  A2  20030703  CAN 139:79536  AN 2003:511080    CAPLUS

Defelippis, Michael Rosario; DiMarchi, Richard Dennis; Trautmann, Michael Ernst; Ng, Kingman.  Biphasic mixtures of GLP-1 and insulin.  PCT Int. Appl.  (2003), 62 pp. CODEN: PIXXD2  WO 2003035099  A1  20030501  CAN 138:374155  AN 2003:334931    CAPLUS

Defelippis, Michael Rosario; DiMarchi, Richard Dennis; Ng, Kingman.   Premixes of GLP-1 and basal  insulin.    PCT Int. Appl.  (2003), 75 pp.  CODEN: PIXXD2  WO  2003020201  A2  20030313  CAN 138:243271  AN 2003:202411    CAPLUS

DiMarchi, Richard Dennis; Kohn, Wayne David; Zhang, Lianshan. Methods for the synthesis of insulin analogs having protracted time action and therapeutic uses thereof.  PCT Int. Appl. (2004), 35 pp.  CODEN: PIXXD2  WO  2004096854  A2  20041111  CAN 141:389285  AN 2004:965289 CAPLUS

DiMarchi, Richard Dennis; Glaesner, Wolfgang; Millican, Rohn Lee, Jr.; Vick, Andrew Mark; Zhang, Lianshan. Polyethylene glycol linked glucagon-like peptide-1 (GLP-1) compounds.    PCT Int. Appl.  (2004), 77 pp. CODEN: PIXXD2  WO  2004093823  A2  20041104  CAN 141:400875  AN 2004:927026  CAPLUS

DiMarchi, R.D. Insulin Analog Having Protracted Time Action. U. S. Patent Application  Docket  P-16270M. (May 2004)

Cho, H.S, Daniel, T.D., DiMarchi, R.D., Hays A., Wilson, T., Sim, B. and Litzinger, D. Modified Human Four Helical Bundle Polypeptides and Their Uses. U. S. Patent Application  Docket    PCT/US05/03537 (Jan 2005)

Cho, Ho Sung; Daniel, Thomas O.; DiMarchi, Richard D.; Hays, Anna-Maria; Wilson, Troy E.; Sim, Bee-cheng; Litzinger, David C. Modified human growth hormone polypeptides with improved pharmaceutical properties.  U.S. Pat. Appl. Publ.  (2005), 119 pp.  CODEN: USXXCO  US 2005170404  A1  20050804  CAN 143:179642  AN 2005:6982

Sim, Bee-Cheng; Litzinger, David C.; Cho, Ho Sung; Daniel, Thomas O.; DiMarchi, Richard D.; Hays, Anna-Maria; Wilson, Troy E.   Modified human growth hormone polypeptides with improved pharmaceutical properties.  PCT Int. Appl.  (2006), 337 pp. CODEN: PIXXD2  WO  2006/069220  A2 20060629  CAN 145:89716  AN 2006:633792    CAPLUS

DiMarchi, Richard D.; Smiley, David L. Glucagon analogs exhibiting physiological solubility and stability for treating hypoglycemia and weight gain.  PCT Int. Appl. (2007),  2007/056362 65pp.

Day, Jonathan; Patterson, James; Chabenne, Joseph; DiMarchi, Maria; Smiley, David; Dimarchi, Richard D.. Preparation of modified glucagons as therapeutic glucagon/GLP-1 receptor co-agonists with improved solubility and stability.    PCT Int. Appl.  (2008),

DiMarchi, Richard D.; DiMarchi, Maria; Chabenne, Joseph. C-terminal substitution analogs of glucagon with improved solubility at physiological pH. PCT Int. Appl.  2008/086086  56pp.

 Sheffer, Joseph; Norman, Thea; Dimarchi, Richard D.; Putnam, Anna-Maria A. Hays; Feng, Tian; Chu, Stephanie; Krawitz, Denise; Cho, Ho Sung.   Modified human plasma polypeptide or Fc scaffolds as carriers for modulating half-life and/or immunogenicity of therapeutic molecules in circulation or serum. PCT Int. Appl.  (2008),  240pp. 

Day, Jonathan; Patterson, James; Chabenne, Joseph; DiMarchi, Maria; Smiley, David; Dimarchi, Richard D. Preparation of modified glucagons as therapeutic glucagon/GLP-1 receptor co-agonists with improved solubility and stability.    PCT Int. Appl.  2008/101017,

DiMarchi, Richard D.; DiMarchi, Maria; Chabenne, Joseph. C-terminal substitution analogs of glucagon with improved solubility at physiological pH.    PCT Int. Appl.  (2008),  56pp.

Sheffer, Joseph; Norman, Thea; Dimarchi, Richard D.; Putnam, Anna-Maria A. Hays; Feng, Tian; Chu, Stephanie; Krawitz, Denise; Cho, Ho Sung.   Modified human plasma polypeptide or Fc scaffolds as carriers for modulating half-life and/or immunogenicity of therapeutic molecules in circulation or serum.    PCT Int. Appl.  (2008), 240pp.

Richard DiMarchi, and Ma Tao, GIP-Based Peptides, U.S. Patent Application No. 61/073,274, filed 17 June 2008.

Richard DiMarchi, Ma Tao, GIP-Based Peptides, U.S. Patent Application No. 61/078,171, filed 3 July 2008.

Richard DiMarchi, Ma Tao, GIP-Based Mixed Agonists, U.S. Patent Application No. 61/090,448, filed 20 August 2008.

Richard DiMarchi, Ma Tao, GIP-Based Mixed Agonists, U.S. Patent Application No. 61/151,349, filed 10 February 2009.

Richard DiMarchi, Ma Tao, GIP-Based Mixed Agonists for Treatment of Metabolic Disorders and Obesity, International Patent Application No. PCT/US2009/47447, filed 16 June 2009

Richard DiMarchi, David Smiley, Maria DiMarchi, Joseph Chabenne, Jonathan Day, James Patterson, Brian Ward, Ma Tao, GIP Receptor-Active [analog] Compounds,U.S. Patent Application No. 61/187,578, file 16 June 2009.

DiMarchi, Richard; Yang, Bin.  Preparation of peptides as glucagon antagonists.  PCT Int. Appl. (2009), 127 pp.  CODEN: PIXXD2  WO 2009058662 A2 20090507  CAN 150:515462  AN 2009:553416  CAPLUS

DiMarchi, Richard D.; Yang, Bin; Ouyang, Chenguang.  Preparation of peptides exhibiting glucagon antagonist and GLP-1 agonist activity.  PCT Int. Appl. (2009), 171 pp.  CODEN: PIXXD2 WO 2009058734 A1 20090507  CAN 150:515461  AN 2009:552639  CAPLUS

DiMarchi, Richard D.; De, Arnab.  Dipeptide ester-based bioactive peptide prodrugs with improved biological half-lives.  PCT Int. Appl. 2009/099763 309pp.

DiMarchi, Richard D; Smiley, David L; DiMarchi, Maria; Chabenne, Joseph; Day, Jonathan.  Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers.  PCT Int. Appl. 2009/155257, 165 pp.

DiMarchi, Richard D; Smiley, David L; DiMarchi, Maria; Chabenne, Joseph; Day, Jonathan; Patterson, James; Ward, Brian C.  Glucagon/GLP-1 receptor co-agonists.  PCT Int. Appl. 2009/155258 241 pp.

DiMarchi, Richard D.; Smiley, David L.   Glucagon analogs exhibiting physiological solubility and stability. US Patent (2009),  137456 A1

DiMarchi, Richard D.; Tao, Ma.  Glucagon peptides with GIP and GLP-1 agonist effects for treatment of metabolic disorders and obesity.  PCT Int. Appl. 2010/011439, 213 pp.

DiMarchi, Richard D.; Kou, Binbin. Amide Based Glucagon Superfamily Peptide Prodrugs.  PCT Int. Appl. 2010/071807, 311 pp.

DiMarchi, Richard D.; Han, Jie. Insulin Analogs.  PCT Int. Appl. 2010/080606, 45 pp.

DiMarchi, Richard D.; Cheng, Shujiang; Kou, Binbin; Han, Jie. YL Based Insulin-Like Growth Factors Exhibiting High Activity at the Insulin Receptor.  PCT Int. Appl. 2010/080607, 181 pp.

DiMarchi, Richard D.; Cheng, Shujiang; Kou, Binbin Amide Based Insulin Prodrugs.  PCT Int. Appl. 2010/080609, 169 pp.

DiMarchi, Richard Dipeptide-Linked Medicinal Agents.  PCT Int. Appl. 2010/080605, 98 pp.

DiMarchi, Richard D.; DiMarchi, Maria; Chabenne, Joseph Glucagon Analogs Exhibiting Enhanced Solubility in Physiological pH Buffers.    US Patent Appl. (2010),  190699 A1

Day, Jonathan; Patterson, James; Chabenne, Joseph; DiMarchi, Maria; Smiley, David; DiMarchi, Richard D. Glucagon/GLP-1 Receptor Co-Agonists.   US Patent Appl. (2010), 190701 A1

Bianchi, E.; Carrington, P.E.; Eiermann, G.J.; Ingallinella, P.; Marsh, D.J.; Metzer, J.M.; Pessi, A.; Pocai, A.; Sinha Roy, R.; Santoprete, A.; Cipito, E.; DiMarchi, R.; Ward, B. Oxyntomodulin Analogs.  PCT Int. Appl. 2010/096052 123 pp.

Carrington, P.E.; Eiermann, Marsh, D.J.; Metzer, J.M.; Pocai, A.; Sinha Roy, R.; Bianchi, E.; Ingallinella, P.; Pessi, A.; Santoprete, A.; Cipito, E.; DiMarchi, R.; Ward, B. Oxyntomodulin Analogs.  PCT Int. Appl. 2010/096142 125 pp.

Richard DiMarchi, David Smiley, Maria DiMarchi, Joseph Chabenne, Jonathan Day, James Patterson, Brian Ward, Ma Tao, GIP Receptor-Active Glucagon Compounds.  PCT Int. Appl. 2010/148089 A1 262 pp.

DiMarchi, Richard D.; De, Arnab.  Ester-Based Insulin Prodrugs.  US Patent Appl. (2010), 0331246 A1.

DiMarchi, Richard D.; De, Arnab.  Ester-Based Peptide Prodrugs.  US Patent Appl. (2011), 0065633 A1.

DiMarchi, Richard D.; Yang, Bin; Ouyang, Chenguang.  Compounds Exhibiting Glucagon Antagonist and GLP-1 Agonist Activity.  US Patent Appl. (2011),  0098217 A1.

DiMarchi, R. Glucagon/GLP-1 Receptor Co-Agonists.  PCT Int. Appl. 2011/075393 A2 129 pp.

Richard DiMarchi, Ma Tao, GIP-Based Mixed Agonists For Treatment of Metabolic Diseases and Obesity, U.S. Patent Appl.  (2011), 166062 A1

Richard DiMarchi, David Smiley, Maria DiMarchi, Joseph Chabenne, Jonathan Day, Glucagon Analogs Exhibiting Enhanced Solubility in Physiological pH Buffers.    US Patent Appl. (2011),  190200 A1

Richard DiMarchi, Ma Tao, Glucagon Antagonist/GIP Agonist Conjugates and Compositions For Treatment of Metabolic Diseases and Obesity, PCT Int. Appl. 2011/094337 A2 275 pp.

DiMarchi, Richard Dipeptide-Linked Medicinal Agents.  US Patent Appl. (2011),  0237493 A1

DiMarchi, Richard D.; Cheng, Shujiang; Kou, Binbin; Han, Jie. YL Based Insulin-Like Growth Factors Exhibiting High Activity at the Insulin Receptor.  US Patent Appl. (2011),  0245164

DiMarchi, Richard D.; Han, Jie.  Insulin Analogs.  US Patent. Appl. (2011) 0257091

DiMarchi, Richard D.; Cheng, Shujiang; Kou, Binbin Amide Based Insulin Prodrugs.  US Patent. Appl. (2011) 257076

Richard DiMarchi; Lianshan Zhang Glucagon Superfamily Peptides Exhibiting G Protein-Coupled Receptor Activity, PCT Int. Appl. 2011/143208 A1 327 pp.

Richard DiMarchi; Bin Yang; Brian Finan Glucagon Superfamily Peptides Nuclear Hormone Receptor Activity, PCT Int. Appl. 2011/143209 A1 416 pp.

DiMarchi, Richard D.; Kou, Binbin.  Amide Based Glucagon Superfamily Peptide Prodrugs.  US Patent. Appl. (2011) 0288003 A1

Richard DiMarchi; Jie Han; Piotr Mroz. Novel Stable Insulin Analogs, PCT Int. Appl. 2011/159882 A2 261 pp.

Richard DiMarchi; Julia Azriel; Zach Kaur; Jonathan Meyers; Todd Parody; Yan Zhao. Single Chain Insulin Analogs Exhibiting High Activity at the Insulin Receptor, PCT Int. Appl. 2011/159895 A2 257 pp.

DiMarchi, Richard Dipeptide-Linked Medicinal Agents.  PCT Int. Appl. 2011/162968 A1 183 pp.

DiMarchi, Richard D.; Cheng, Shujiang; Kou, Binbin; Han, Jie. YL Based Insulin-Like Growth Factors Exhibiting High Activity at the Insulin Receptor.  PCT Int. Appl. 2011/163460 A1 310 pp.

Richard DiMarchi, Maria DiMarchi, Joseph Chabenne, Glucagon Analogs Exhibiting Enhanced Solubility and Stability in Physiological pH Buffers PCT Int. Appl. 2011/163473 A1 164 pp.