Richard DiMarchi Research Group

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Publications

  1. Gurd, F. R. N., Garner, W. H., DiMarchi, R. D., and Wang, C. C. (1977). "Production of Semisynthetic Myoglobin by Stepwise and Fragment Condensation". Peptides V, (Goodman, M. and Meienhofer, J., Eds.), Halsted Press, New York, 480-483.
  2. DiMarchi, R. D., Garner, W. H., Wang, C. C., Hanania, G. I. H., and Gurd, F. R. N. (1978). "Characterization of the Reaction of Methyl Acetimidate with Sperm Whale Myoglobin". Biochemistry 17, 2822-2829.
  3. DiMarchi, R. D., Hemenway, J. H., Wang, C. C., and Gurd, F. R. N. (1978). "Complete Amino Acid Sequence of the Myoglobin from the Finback Whale". Biochemistry 17, 1968-1970.
  4. DiMarchi, R. D., Garner, W. H., Wang, C. C., and Gurd, F. R. N. (1978). "Semisynthetic Studies at the Amino-Terminal Region of Sperm Whale Myoglobin". In "Semisynthetic Peptides and Proteins", (Offord, R. E. and DiBello, C., Eds.). Academic Press, New York, 45-57.
  5. Wang, C. C., DiMarchi, R. D., and Gurd, F. R. N. (1978). "Replacement of the NH2-Terminal Tetradecapeptide Sequence of Sperm Whale Myoglobin". In "Semisynthetic Peptides and Proteins", (Offord, R. E., and DiBello, C., Eds.). Academic Press, New York, 56-69.
  6. DiMarchi, R. D., Neireiter, G. W., Garner, W. H., and Gurd, F. R. N. (1979). "Myoglobin Semisynthesis: Removal of the NH2-Terminal Valine of Sperm Whale Myoglobin and Its Subsequent Reintroduction". Biochemistry 18, 3101-3109.
  7. Neireiter, G. W., DiMarchi, R. D., and Gurd, F. R. N. (1980). "NH2-Terminal Myoglobin Semisynthesis". (Gross, E. and Meienhofer, J. Eds.), Peptides VI, 621 624.
  8. DiMarchi, R. D., Neireiter, G. W., Heath, W. F., and Gurd, F. R. N. (1980). "Structural Significance of the NH2-Terminal Residues of Sperm Whale Myoglobin". Biochemistry 19, 2454-2465.
  9. Tam, J. P., DiMarchi, R. D., and Merrifield, R. B. (1980). "Photolabile Multi-Detachable P-Alkoxybenzyl Alcohol Resin Supports for Peptide Fragment or Semisynthesis". Int. J. Pep. Prot. Res. 16, 412-425.
  10. Tam, J. P., DiMarchi, R. D., and Merrifield, R. B. (1981). "Design and Synthesis of a Multi-Detachable Benzhydrylamine-Resin for Solid Phase Peptide Synthesis". Tetrahedron Letter 22 (30), 2851-2854.
  11. DiMarchi, R. D., Tam, J. P., Kent, S. B. H., and Merrifield, R. B. (1982). "Weak Acid-Catalyzed Pyrrolidone Carboxylic Acid Formation From Glutamine During Solid Phase Peptide Synthesis". Int. J. Pep. Prot. Res. 19, 88-93.
  12. DiMarchi, R. D., Tam, J. P., and Merrifield, R. B. (1982). "Solid Phase Synthesis of the Protected (43-55) Tridecapeptide of the Heavy Chain of Myeloma Immunoglobulin M603, Employing Cyclohexyl Ester Protection for Glutamic Acid". Int. J. Pep. Prot. Res. 19, 270-279.
  13. Voss, C. , DiMarchi, R. D., Whitney, D. B., Tjoeng, F. S., Merrifield, R. B., and Tam, J. P. (1983). "Synthesis of the Protected Tridecapeptide (56-68) of the VH Domain of Mouse Myeloma Immunoglobulin M603 and Its Reattachment to Resin Supports". Int. J. Pep. Prot. Res. 22, 204-213.
  14. DiMarchi, R. D., Brooke, G., Gale, C., Cracknell, V., Doel, T., and Mowat, N. (1986)."Protection of Cattle Against Foot-and-Mouth Disease by a Synthetic Peptide". Science 232, 639-641.
  15. Wagner, J. F., Anderson, D. B., Cain, T. D., DiMarchi, R. D., Monrey, D. H., McGuffey, R. K., and Wray, M. I. (1987). "Effect of Continuously Infused Human Pancreatic Growth Hormone-Releasing Factor on Plasma Growth Hormone Concentration in the Wether Lamb". J. Animal Science 221, 89 97.
  16. Johnson, B. G., DiMarchi, R. D., Smith, M. C., and Mendelsohn, L. G. (1987). "Stimulation of Aminoisobutyrate Transport and Protein Synthesis in Human Fibroblasts by the Insulin-Like Growth Factors: Measurement of the Biopotencies of Recombinant Human Peptides". J. of Cell Biol. 104, 109-114.
  17. Doel, T. R., Gale, C., Brooke, G., and DiMarchi, R. D. (1988). "Immunization against Foot-and- Mouth Disease with Synthetic Peptides Representing the C-Terminal Region of VP1". J. of Gen. Virol. 69, 2403- 2406.
  18. DiMarchi, R. D., Osborne, H. E., Roberts, E., and Slieker, L. (1988). "Chemical Synthesis of Human Epidermal Growth Factor and Human Type a Transforming Growth Factor". Peptides X, (Marshall, G., Ed.), 202-205.
  19. DiMarchi, R. D., Brooke, G., Gale, C., and Doel, T. (1988). "Structure-Function Relationship in Protection Against Foot-and-Mouth Disease (FMD) by a Synthetic Peptide". Peptide X, (Marshall, G., Ed.), 531-534.
  20. DiMarchi, R. D., Long, H., Epp, J., Schoner, B., and Belagaje, R. (1989). "Synthesis of Insulin-Like Growth Factor I through Recombinant DNA Techniques and Selective Chemical Cleavage at Tryptophan". J. of Cellular Biochemistry 86, 283-294.
  21. Thakkar, J. K., DiMarchi, R. D., MacDonald, K., and Caro, J. F. (1989). "Effect of Insulin and Insulin- Like Growth Factors I and II on Phosphatidylinositol in Human Liver Plasma Membranes". J. of Biol. Chem. 264, 7169-7175.
  22. Sinha, M. K., Buchanan, C., Leggett, N., Martin, L., Khazanie, P. G., DiMarchi, R. D., Pories, W. I., and Caro, J. F. (1989). "Mechanism of IGF-I Stimulated Glucose Transport in Human Fat Cells: Demonstration of Specific IGF-I Receptors Which Are Not Involved in Acute Metabolic Effects". Diabetes 38, 1217-1225.
  23. Schalch, D., Yang, H., Ney, D., and DiMarchi, R. D. (1989). "Infusion of Human Insulin-Like Growth Factor I Into Malnourished Rats Reduces Hepatic IGF-I mRNA Abundance". Biochem. Biophys. Res. Commun. 160, 795-800.
  24. Gale, C., Doel, T., Brooke, G., White, D., Mulcahy, G., and DiMarchi, R.D. (1989). "Protection Induced by Synthetic Peptides Corresponding to Three Serotypes in Foot-and-Mouth Disease Virus". Proceedings of Fifth International Symposium on the Immunobiology of Proteins and Peptides V, 161-167.
  25. Sinha, M. K., Buchanan, C., Martin, L., Atkinson, S., DiMarchi, R. D., and Caro, J. F. (1990). "Presence of Specific IGF-II Receptors and the Mechanism of IGF-II Stimulated Glucose Transport in Human Fat Cells". Am. J. Physiol. E534-E542.
  26. Doel, T. R., Gale, C., Amaral, C., Mulcahy, G., and DiMarchi, R. D. (1990). "Heterotypic Protection Induced by Synthetic Peptides Corresponding to Three Serotypes of Foot-and-Mouth Disease Virus". J. of Virology 64, (5) 2260-2264.
  27. Mulcahy, G., Gale, C., Robertson, P., Lyisan, S., DiMarchi, R. D., and Doel, T. R. (1990). "Isotype Responses of Infected, Virus-Vaccinated and Peptide-Vaccinated Cattle to FMDV". Vaccine 8, 249-256.
  28. Heiman, M. L., Surface, P. L., Mowrey, D. H., and DiMarchi, R. D. (1990). "Sexual Dimorphic Porcine Pituitary Response to Growth Hormone-Releasing Hormone". Domestic Animal Endocrinology 7, (2) 273-276.
  29. Flynn, J. N., Harkiss, G. D., Doel, T. R., and DiMarchi, R. D. (1990). "Analysis of Immune Responses in Sheep to Synthetic Peptides of FMDV Using Ovine Polyclonal and Monoclonal Antibodies". Immunology 69, 1-7.
  30. Dohm, G. L., Elton, C. W., Raju, M. S., Mooney, N. D., DiMarchi, R. D., Pories, W. I, Flickinger, E. G., Atkinson, S. M., and Caro, J. F. (1990). "IGF-I Stimulated Glucose Transport in Human Skeletal Muscle: IGF-I Resistance in Obesity and NIDDM". Diabetes, 39, (9) 1028-1032.
  31. Mulcahy, G., Pullen, L. A., Gale, C., DiMarchi, R. D., and Doel, T.R. (1990). "A Mouse Protection Test as a Predictor of the Protective Capacity of Synthetic FMDV Vaccines". Vaccine 9, 19-24.
  32. DiMarchi, R. D., Long, H. B., Kroeff, E. P., and Chance, R. E. (1990). "Utilization of Analytical Reversed-Phase HPLC in Biosynthetic Insulin Production". In "HPLC in Biotechnology", (Hancock, W. S., Ed.). Wiley and Sons, Inc., New York, 181-189.
  33. DiMarchi, R. D., Long, H. B., Epp, J., Schoner, B., and Belagaje, R. (1990). "Biosynthesis and Characterization of Insulin-Like Growth Factor I (IGF-I)". Peptides XI, (Rivier, J. Ed.), 57-59.
  34. DiMarchi, R. D., Brooke, G. S., Johnson, M., Long, H. B., and Mayer, J. P. (1990). "Chromatography Viewed As An Integral Part of Successful SPPS". Peptides XI, (Rivier, J., Ed.), 78-80.
  35. DiMarchi, R. D., Mulcahy, G., DoAmaral, C. M. C. F., Brooke, G., Gale, C., and Doel, T. (1990). "Heterotypic Protection Induced by Synthetic Peptides Corresponding to Three Serotypes of Foot-and-Mouth Disease Virus". Peptides XI, (Rivier, J., Ed.), 275-277.
  36. Mayer, J. D., Brooke, G. S., and DiMarchi, R. D. (1990). "Chemical Synthesis of the A-Chain of Human Insulin". Peptides XI, (Rivier, J., Ed.), 398-400.
  37. Collen, T., DiMarchi, R. D., and Doel, T. R. (1991). "A T-Cell Epitope in VP1 of Foot-and-Mouth Disease Virus is Immunodominant for Vaccinated Cattle". J. of Immunology 146, 749-755.
  38. Rossetti, L., Frontoni, S., DeFronzo, R., DiMarchi, R. D., and Giaccari, A. (1991). "Metabolic Effects of Insulin-Like Growth Factor-l in Diabetic Rats". Diabetes 40, 444-448.
  39. Steward, M. W., Stanley, C. M., DiMarchi, R. D., Mulchay, G. and Doel, T. R. (1991). "High-Affinity Antibody Induced by Immunization with a Synthetic Peptide is Associated with Protection of Cattle Against Foot-and-Mouth Disease". J. of Immunology 72, 99-103.
  40. Burguera, B., Frank, B. H., DiMarchi, R. D., Long, S., and Caro J. (1991). "The Interaction of Proinsulin with the Insulin-Like Growth Factor-l Receptor in Human Liver, Muscle, and Adipose Tissue". J. Clinical Endocrinology 72, 1238-1241.
  41. Broderick, C. L., Brooke, G. S., DiMarchi, R. D., and Gold, G. (1991). "Human and Rat Amylin have no Effects on Insulin Secretion in Isolated Rat Pancreatic Islets." Biochem. Biophys. Res. Commun. 177, 932-938.
  42. Kit, M., Kit, S., Little, S., DiMarchi, R. D., and Gale, C. (1991). "Infectious Bovine Rhinotracheitis Virus Vector which Expresses Foot and Mouth Disease Virus Epitopes on Surface of Virus Particles and Virus-Infected Cells." Vaccine 1991, 327-331.
  43. Bodkin, N. L., Sportsman, R., DiMarchi, R. D., and Hansen, B. C. (1991). "IGF-l in Noninsulin-Dependent Diabetic Monkeys: Basal Plasma Concentrations and Metabolic Effects of Exogenously Administered Biosynthetic Hormone." Metabolism 40, 1131-1137.
  44. Burguera, B., Brown, G. L., Mustafa, J. S., Frank, B. H., DiMarchi, R. D., and Caro, J. F. (1991). "The Interaction of Proinsulin with Insulin-Like Growth Factors-l and ll Receptors in Smooth Muscle Membranes from Bovine Coronary Arteries". J. Clinical Endocrinology, 72, 1238-41.
  45. Kit, M., Kit, S., Little, S., DiMarchi, R. D., Gale, C. (1991). "Bovine Herpesvirus-1 (Infectious Bovine Rhinotracheitis Virus) - Based Viral Vector Which Expresses Foot and Mouth Disease Epitopes." Vaccine 9, 564-572.
  46. Kit, S., Kit, M., DiMarchi, R. D., Little, S. P., and Gale, C. (1991). "Modified- Live Infectious Bovine Rhinotracheitis Virus Vaccine Expressing Monomer and Dimer of Foot-and-Mouth Disease Capsid Protein Epitopes on Surface of Hybrid Virus Particles." Archives of Virology 120, 1-17.
  47. Owens, R. A., Gesellchen, P. D., Houchins, B. J., DiMarchi, R. D. (1991). "The Rapid Identification of HIV Protease Inhibitors Through the Synthesis and Screening of Defined Peptide Mixtures." Biochem. Biophys. Res. Comm., 181, 402-408.
  48. Kit, S., Kit, M., DiMarchi, R. D., Little, S. P., and Gale, C. (1991). "Modified- Live Infectious Bovine Rhinotracheitis Virus (IBRV) Vaccine Expressing Foot-and-Mouth Disease Virus (FMDV) Capsid Protein Epitopes on Surface of Hybrid Virus Particles." Immunobiology of Proteins and Peptides VI, 211-220.
  49. Mulcahy, G. Reid, E., DiMarchi, R. D., Gale, C., and Doel, T. (1991). "Maturation of Functional Antibody Affinity In Animals Immunized with Synthetic FMDV Peptides." Research in Veterinary Science, 52, 133-140.
  50. Glass, E. J., Oliver, R. A., Collen, T., Doel, T. R., DiMarchi, R. D., and Spooner, R. L. (1991). "MHC Class II Restricted Recognition of FMDV Peptides by Bovine T Cells." Immunology, 74, 594-599.
  51. DiMarchi, R. D., Mayer, J. P., Fan, L., Brems, D. N., Frank, B. H., Green, L. K., Hoffmann, J. A., Howey, D. C., Long, H. B., Shaw, W. N., Shields, J. E., Slieker, L. J., Su, K. S., Sundell, K., and Chance, R. E. (1992). "Synthesis of a Fast-Acting Insulin Based on Structural Homology with Insulin-Like Growth Factor I." Peptides XII, (Smith, J. Ed.), 26-28 (1992).
  52. Heath, W. F., Belagaje, R. M., Brooke, G. S., Chance, R. E., Hoffmann, J. A., Long, H. B., Reams, S. G., Roundtree, C., Shaw, W. N., Slieker, L. J., Sundell, K. L., and DiMarchi, R. D. (1992). "(A-C-B) Human Proinsulin, A Novel Insulin Agonist and Intermediate in the Synthesis of Biosynthetic Human Insulin." Journal of Biological Chemistry, 267, 419-425
  53. Long, H. B., Belagaje, R. M., Brooke, G. S., Chance, R. E., DiMarchi, R. D., Hoffmann, J. A., Reams, S. G., Roundtree, C., Shaw, W. N., Slieker, L. J., Sundell, K. L. and Heath, W. F. (1992). "A-C-B Human Proinsulin, A Novel Agonist and Intermediate in the Synthesis of Human Insulin." Peptides XII, (Smith, J. Ed.), 93-94 (1992).
  54. Smiley, D., Heiman, M., Tinsley, F., Wagner, J., and DiMarchi, R. D. (1992). "Chemical Potentiation of Growth Hormone Releasing Factor Analogs."Peptides XII, (Smith, J. Ed.), 91-92 (1992).
  55. Long, H. B., Baker, J. E., Belagaje, R. M., DiMarchi, R. D., Frank, B. H., Green, L.K., Hoffmann, J. A., Muth, W. L., Pekar, A. H., Reams, S. G., Shaw, W. N., Shields, J. E., Slieker, L. J., Su, K.S.E., Sundell, K., and Chance, R. E. (1992). "Human Insulin Analogs with Rapid Onset and Short Duration of Action." Peptides XII, (Smith, J. Ed.), 88-90 (1992).
  56. Flynn, J. N., Harkiss, G. D., Moore, D., and DiMarchi, R. D. (1992). "T and B-Cell Responses to Synthetic Peptide Analogs of Foot-and-Mouth Disease Virus in Sheep". Immunology, 131, 26-31.
  57. Brems, D. N., Alter, L. H., Beckage, M. J., Chance, R. E., DiMarchi, R. D., Green, L. K., Long, H. B., Pekar, A. H., Shields, J. E., and Frank, B. E. (1992). "Altering the Association Properties of Insulin by Amino Acid Replacement." Protein Engineering, 5, 527-533.
  58. Doel, T. R., Doel, C. M. F. A., Staple, R. F., DiMarchi, R. D. (1992). "Cross Reactive and Serotype Specific Antibodies Against Foot-and-Mouth Disease Virus Generated by Different Regions of the same Synthetic Peptide. J. Virology, 66, 2187-94.
  59. Brems, D. N., Brown ,P. L., Bryant, C., Chance, R. E., DiMarchi, R. D., Green, L. K., Howey, D. C., Long, H. B., Miller, A.A., Millican, R., Pekar, A. H., Shields, J. E., and Frank, B. E. (1993). "Altering the Self-Association and Stability of Insulin by Amino Acid Replacement." In "Protein Folding and Recovery", 254-69.
  60. Slieker, L. J., Brooke, G. S., Chance, R. E., DiMarchi, R. D., Fan, L., Hoffmann, J. A., Howey, D. C., Long, H., Mayer, J., Shaw, W. N., Shields, J. E., and Sundell, K. L. (1993). "Insulin and IGF-I Analogs: Novel Approaches to Improved Insulin." Peptides:Biology and Chemistry Proceedings of the Chinese 1992 Peptide Symposium, (Du Y., Tam J.P., Zhang, Y. Ed.), 7-10.
  61. Slieker, L. J., Brooke, G. S., Chance, R. E., Fan, L., Hoffmann, J. A., Howey, D. C., Long, H. B., Mayer, J., Shields, J. E., Sundell, K. L., and DiMarchi, R. D. (1993). "Insulin and IGF-I Analogs: Novel Approaches to Improved Insulin Pharmacokinetics." Proceedings of the Fourth Intl. Symposium on Insulin, IGFs and Their Receptors, (LeRoith, D., Raizada, M. K. Ed.), 25-32.
  62. DiMarchi, R. D., Chance, R. E., Long, H. E., Shields, J. E., Slieker, L. J. (1994). "Preparation of an Insulin with Improved Pharmacokinetics Relative to Human Insulin through Consideration of Structural Homology with Insulin-Like Growth Factor I." Symposium Session II: Hormone Receptor Physiology and Novel Therapeutic Approaches, Horm. Res., 41 (Suppl. 2), 93-96.
  63. Burguera, B., Elton, C. W., Tapscott, E. B., Pories, W. J., DiMarchi, R., Sakano, K.-i., and Dohm, G. L. (1994). "Stimulation of Glucose Uptake by Insulin-like Growth Factor II in Human Muscle is not Mediated by the Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor." Biochem. J., 300, 781-785.
  64. DiMarchi, R.D. and Trautmann, M. (1996). "Insulin Lispro: Molekularstruktur und Biologische Wirkungen." Diabetes und Stoffwechsel, 5, 113-116.
  65. Zhao, M., Fan, L., Long, H. B., Pekar, A. H., Slieker, L. J., Chance, R. E. and DiMarchi, R. D. (1996). "Sequential Replacement of the C-terminal Residues of the Human Insulin B Chain with Alanine." Peptides: Chemistry, Structure and Biology, Proceedings of the XIV American Peptide Symposium, (Kaumaya, P. T. P. and Hodges, R. S., Eds.), 643-644.
  66. Zhao, M. and DiMarchi, R. D. (1996). "Amino-methylene, _(CH2NH) Substitution of Amide Bonds in the C-terminal Portion of the Insulin B Chain." Peptides: Chemistry, Structure and Biology, Proceedings of the XIV American Peptide Symposium, (Kaumaya, P. T. P. and Hodges, R. S., Eds.), 641-642.
  67. Smiley, D. L., DiMarchi, R. D., Surface, P. L., Harris, G. C. and Heiman, M. L. (1996). "p-Methylhippuric Acid is a Novel N-terminal Tyr Replacement for Growth Hormone-releasing Hormone (GHRH)". Peptides: Chemistry, Structure and Biology, Proceedings of the XIV American Peptide Symposium, (Kaumaya, P. T. P. and Hodges, R. S., Eds.),631-632 .
  68. Anderson, Jr., J. H., Chance, R. E., Slieker, L. J., Vignati, L. and DiMarchi, R. D. (1996). "Design of an Optimal Mealtime Insulin (Lys-Pro) and its Assessment in Phase III Clinical Studies." Peptides: Chemistry, Structure and Biology, Proceedings of the XIV American Peptide Symposium, (Kaumaya, P. T. P. and Hodges, R. S., Eds.), 617-619.
  69. Anderson, Jr., J. H., Wilke, T. S., DiMarchi, R. D., and Chance, R. E. (1966). "Insulin Analogues: Designer Insulins with Improved Characteristics for Better Patient Care." Diabetes News, XVII, 5-7.
  70. Radziuk, J. M., Davies, J. C., Pye, S. W., Shields, J. E., DiMarchi, R. D. and Chance, R. E. (1997). "Bioavailability and Bioeffectiveness of Subcutaneous Human Insulin and Two of Its Analogs: LysB28ProB29-Human Insulin and AspB10LysB28Pro29-Human Insulin Assessed in a Conscious Pig Model." Diabetes, 46, 548-556.
  71. Anderson, Jr., J. H., Brunelle, R. L., Koivisto, V. A., PfŸtzner, A., Trautmann, M. E., Vignati, L., DiMarchi, R. D., and the Multicenter Insulin Lis Pro Study Group (1997). "Reduction of Postprandial Hyperglycemia and Frequency of Hypoglycemia in IDDM Patients on Insulin-Analog Treatment." Diabetes, 46, 265-270.
  72. Anderson, Jr., J. H., Brunelle, R. L., Koivisto, V. A., Trautmann, M. E., Vignati, L., DiMarchi, R. D. and the Multicenter Insulin Lispro Study Group (1997). "Improved Mealtime Treatment of Diabetes Mellitus Using an Insulin Analogue." Clinical Therapeutics, 19, 62-72.
  73. Anderson, Jr., J. H., Brunelle, R. L., Keohane, P., Koivisto, V. A., Trautmann, M. E., Vignati, L., and DiMarchi, R.D. (1997). "Mealtime Treatment with Insulin Analog Improves Postprandial Hyperglycemia and Hypoglycemia in Patients with Non-Insulin-Dependent Diabetes Mellitus." Archives of Internal Medicine, 157, 1249-1255.
  74. Slieker, L. J., Brooke, G. S., DiMarchi, R. D., Flora, D. B., Green, L. K., Hoffmann, J. A., Long, H. B., Fan, L., Shields, J. E., Sundell, K. L., Surface, P. L., and Chance, R. E. (1997). "Modifications in the B10 and B26-30 Regions of the B Chain of Human Insulin Alter Affinity for the Human IGF-1 Receptor More than for the Insulin Receptor." Diabetologia, 40 (Suppl 2), S54-S61.
  75. Radziuk, J. M., Davies, J. C., Pye, W. S ., Shields, J. E., DiMarchi, R. D., and Chance, R. E. (1997). "Bioavailability and Bioeffectiveness of Subcutaneous Human Insulin and Two of its Analogs Ð LysB28ProB29- Human Insulin and AspB10 LysB28 ProB29-Human Insulin Ð Assessed in a Conscious Pig Model." Diabetes, 46, 548-556.
  76. Ido, Y., Vindigni, A., Chang, K., Stramm, L., Chance, R. E., Heath, W. F., DiMarchi, R. D., Di Cera, E., and Williamson, J. R. (1997). "Prevention of Vascular and Neural Dysfunction in Diabetic Rats by C-peptide." Science, 277, 563-566.
  77. Davidson, J. A., Garber, A. J., DiMarchi, R. D., and Santiago, J. V. (1997) "New Advances in Insulin Treatment of Diabetes: Overcoming Barriers." Endocrine Practice, 3, 372-384.
  78. Zhang, F., Basinski, M. B., Beals, J. M., Briggs, S. L., Churgay, L. M., Clawson, D. K., DiMarchi, R. D., Furman, T. C., Hale, J. E., Hsiung, H. M., Schoner, B. E., Smith, Dennis P., Zhang, X. Y., Wery, J.-P., and Schevitz, R. W. (1997). "Crystal Structure of the Obese Protein Leptin-E100." Nature, 387, 206-209.
  79. Chance, R. E., Frank, B. H., Radziuk, J. M., and DiMarchi, R. D. (1998). "Discovery and Development of Insulin Lispro." Drugs of Today 34, 1-9.
  80. Radziuk, J., Pye, S., Bradley, B., Braaten, J., Vignati, L., Roach, P., Bowsher, R., DiMarchi, R., and Chance, R. (1998). "Basal Activity Profiles of NPH and [NÕ-palmitoyl Lys (B29)] Human Insulins in Subjects with NIDDM." Diabetologia, 41, 116-120.
  81. Huster, W., Shah, A., Kaiser, G., Dere, W., and DiMarchi, R. (1999). "Statistical and Operational Issues Arising in an Interim Analysis when the Study will Continue." Drug Information Journal, 33, 869-875.
  82. Bolli, G. B., DiMarchi, R. D., Park, G. D., Pramming, S. and Koivisto, V. A. (1999). "Insulin Analogues and their Potential in the Management of Diabetes Mellitus." Diabetologia, 42, 1151-1167.
  83. Zhang, F., Chen Y., Heiman, M., and DiMarchi, R.D. (2005). "Leptin: Structure, Function and Biology" In "Vitamins and Hormones" Vol 70 (2005), Elsevier Inc., in press.
  84. Mayer, J.P., DiMarchi, R. D. and Yan, L. Z. (2005). "Discovery of a beta-MSH Derived MC-4 Receptor Agonist and Its Evaluation as an Anti-Obesity Agent" J. Med. Chem., in press.
  85. Quan, B., Smiley, D.L., Gelfanov, M.L. and DiMarchi, R.D. (2005). "Site Specific Introduction of Unnatural Amino Acids at Sites Critical to Insulin Receptor Recognition & Biological Activity" Peptides: Chemistry, Structure and Biology, Proceedings of the XIX American Peptide Symposium, in press.
  86. Smiley, D.L., Boaquan, M., Gelfanov, V.M., and DiMarchi, R.D. (2005). "Exploration and Elaboration of Reported Insulin Superagonism through Site-Selective Replacement at TyrB26 Peptides" Chemistry, Structure and Biology, Proceedings of the XIX American Peptide Symposium, in press.
  87. Yang, B. and DiMarchi, R.D. (2005). "A Novel Approach to Resin-based Cysteine Alkylation" Peptides: Chemistry, Structure and Biology, Proceedings of the XIX American Peptide Symposium, in press.
  88. DiMarchi, R.D., Han, J., Hoffman, A., Gelfanov, V.M., Kohn, W., Micanovic, R., and Mayer J.P. (2005). "Synthesis and Biological Assessment of Insulin-Like Analogs with Differential Activity at the Insulin and IGF-1 Receptors" Peptides: Chemistry, Structure and Biology, Proceedings of the XIX American Peptide Symposium, in press.
  89. Kohn, W.D., Micanovic, R., Myers, S.L., Vick, A.M., Kahl, S., Zhang, L., Strifler, B., Li, S., Shang, S., Beals, J., Mayer, J.P. and DiMarchi, R.D. (2005). "pI-shifted Basal Insulin Analogs With High Selectivity for Insulin vs IGF- 1 Receptor" Peptides: Chemistry, Structure and Biology, Proceedings of the XIX American Peptide Symposium, in press.
  90. Gelfanov, V.M., Smiley, D.L, Whittaker, W. and DiMarchi, R.D. (2005). "Discovery and Structural Optimization of High Affinity Co-Agonists at the Glucagon and GLP-1 Receptors" Peptides: Chemistry, Structure and Biology, Proceedings of the XIX American Peptide Symposium, in press.
  91. Yang, B., Gelfanov, V.M. and DiMarchi, R.D. (2005). "Synthesis and Biological Assessment of Sulfonic Acid-Based Glucagon Antagonists" Peptides: Chemistry, Structure and Biology, Proceedings of the XIX American Peptide Symposium, in press.
  92. Levy, J.J., Gelfanov, V.M. and DiMarchi, R.D. (2005). "Optimization of the C-terminal Sequence in Glucagon to Maximize Receptor Affinity" Peptides: Chemistry, Structure and Biology, Proceedings of the XIX American Peptide Symposium, in press.
  93. Mayer, J.P., Hsiung, H.H., Flora, D.B., Edwards, P., Smith, D.P., Zhang, X-Y., Gadski, R.A., Heiman, M.L., Emmerson, P.J., Husain, S., OÕBrien, T.P., Kahl, S., Smiley, D., Zhang, L., DiMarchi, R.D. and Yan, L-Y (2005). Discovery and Optimization of beta-MSH Derived Melanocortin-4 Selective Agonists, Chemistry, Structure and Biology, Proceedings of the XIX American Peptide Symposium, in press.
  94. Yan, L-Y, Flora, D.B., Edwards, P., Smiley, D.L., Emmerson, Hansen, H.H., Gadski, R., Hertel, J., Heiman, M.L., P.J., Husain, S., OÕBrien, T.P., Kahl, S., Zhang, L., DiMarchi, R.D. and Mayer, J.P. (2005). "Disulfide as a Constraint to Build Super Potent and Selective Melanocortin-4 Receptor (MCR4) Agonists" Chemistry, Structure and Biology, Proceedings of the XIX American Peptide Symposium, in press.
  95. Yan, L-Y, Flora, D.B., Edwards, P., Smiley, D.L., Emmerson, Hansen, H.H., Gadski, R., Hertel, J., Heiman, M.L., P.J., Husain, S., OÕBrien, T.P., Kahl, S., Zhang, L., DiMarchi, R.D. and Mayer, J.P. (2005). "Potent and Selective MC-4 Receptor Agonists Based on a Novel Disulfide Scaffold" Chemistry, Biorganic & Medicinal Chemistry Letters, in press.
  96. Mayer, J.P. and DiMarchi, R.D. (2005) "Drugging the Undruggable" Chemistry & Biology 12, 1-2.