DiMarchi Research
Professor DiMarchi is most readily recognized for discovery and development of rDNA-derived Humalog¨ (LisPro-human insulin). This designer insulin represents the first demonstration that structurally altered rDNA-derived biosynthetic proteins can improve pharmacological performance without increasing the risk of an abnormal immunological response. As scientist and administrator Dr. DiMarchi participated in the commercial development of Humulin¨, Humatrope¨, Xigris¨, and Forteo¨. The goal of his current research and commercial endeavors is to develop proteins with enhanced therapeutic properties through biochemical optimization with non-natural amino acids, an approach he has termed chemical-biotechnology. He was recently awarded the 2005 AAPS Achievement Award in Biotechnology and the 2006 ACS Award for Chemical Research Management.
Articles
Giving Biotechnology A Chemical PushWatching Peptide Drugs Grow Up
Powerpoint Slides
Beili B24 25 InsulinBin Poster1(alkylation)
Bin Presentation(sulfonic)3
Levy APS
Lilly Arg - Insulins
Smiley NMeHisInsulin APS
Vasily's Glucagon Co-Agonist APS
