NIH has posted a request for applications for the 2010 NIH Director’s Transformative Research Projects Program. The program has been created under the auspices of the NIH Roadmap for Medical Research "to enhance submission and support of exceptionally innovative, high risk, original and/or unconventional research that has the potential to have a profound impact in clinical, basic, and or behavioral/social science arenas."

The awards provide up to $25 million total costs per year for a single project. The deadline for submitting applications is Friday, Jan. 22, with letters of intent due by Tuesday, Dec. 22.

See: grants.nih.gov/grants/guide/rfa-files/RFA-RM-09-022.html