Indiana University Bloomington

Faming Zhang Research Group

Publications

Selected Publications

  1. Singh J, Ling L, Sawyer JS, Lee W, Zhang F, Yingling JM., (2005), Successful discovery of TbRI (ALK5) kinase inhibitors using HTS, target-hopping and virtual screening, Chemistry Today, 23 (3): 35-38.
  2. Hamdouchi C, Zhong B, Mendoza J, Zhang F et al. (2005), Structure-Based Design of a New Class of Highly Selective Aminoimidazo[1,2-a]pyridine-Based Inhibitors of Cyclin Dependent Kinases, bioorganic & Medicinal Chemistry Letters. 15 (7): 1943-1947.
  3. Jaramillo C, Zhang F. et al (2004), Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation, bioorganic & Medicinal Chemistry Letters. 14(24): 6095-6099.
  4. J. Singh, J. Yingling, Zhang F, et al (2004), Transforming the TGF-® pathway: Convergence of distinct lead generation strategies on a novel kinase pharmcophroe for TbRI, Current Opinion in Drug Discovery and Development 7(4): 10-20.
  5. Al-Awar RS, Ray JE, Zhang F. etal (2004). Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors. Bioorg Med Chem Lett. 14(15): 3925-3928.
  6. Sawyer JS, Beight DW, Zhang F, Yingling JM (2004). Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. Bioorg Med Chem Lett. 14(13): 3581-3584.
  7. Hadouchi C, Keyser H, Zhang F, Brooks H, et al (2004). The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo(1,2-a]pyridines. Molecular Cancer Therapeutics. 3(1):1-9
  8. Vincent J.-P, Johnson RB, Parsons S, Zhang F, Wang QM (2003). Identification of a C-terminal regulatory motif in hepatitis C virus RNA-dependent RNA polymerase: structural and biochemical analysis. J. Virology. 77: 9020-9028
  9. Sanchez-Martinez C, Shih C, Zhu G, Dempsey JA, Zhang F (2003) . Studies on Cyclin Dependent Kinase Inhibitors:Indolo[2,3-a]pyrrolo[3,4-c]carbazoles versus Bis-indolylmaleimides, Bioorganic & Medicinal Chemistry Letters 13:3841-3846.
  10. Vieth M, Brooks H, Hamdouchi C, McMillen W, Sawyer JS, Yingling J, and Zhang F(2003). Combining Medicinal Chemistry with Chemogenomic and Computer-Aided Structure-Based Design in Development of Novel Kinase Inhibitors, Cell. Mol. Biol. Lett 8 (2A):566-567
  11. Sawyer JS, Herron DK, Edward CR, Zhang F, and Yingling J (2003). Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-beta Type I Receptor Kinase Domain. Journal of Medicinal Chemistry 46 (19):3953-3956.
  12. Wang QM, Hockman M, Staschke K, Zhang F, Parsons S (2002). Oligomerization and Cooperative RNA Synthesis Activity of HCV RNA-Dependent RNA Polymerase, J. Virology. 76:3865-3872
  13. Jin L, Briggs S, Clawson D, Schevitz R, Smiley D, Tashjian A, Zhang F (2000). "Crystal Structure of Human Parathyroid Hormone 1-34 at 0.9 Resolution", J. Biol. Chem. 275:27238-27244.
  14. Zhang F, Basinski M, DiMarchi RD et al. (1997) "Crystal Structure of the Obese Protein Leptin-E100", Nature 387:206-209
  15. Zhang J, Zhang F, Ebert D, Cobb MH, and Goldsmith EJ(1995) "Activity of the MAP Kinase ERK2 is Controlled by a Flexible Surface Loop", Structure 3:299-307.
  16. Zhang F, Strand A, Robbins D, Cobb MH, and Goldsmith EJ (1994) "Crystal Structure of MAP kinase ERK2 at 2.3Â Resolution". Nature. 367: 704-711.
  17. Zhang F, Robbins D, Cobb MH and Goldsmith EJ (1993) " Crystallization and Preliminary X-ray Studies of Extracellular Signal-regulated Kinase-2/MAP kinase with an Incorporated His-tag". J. Mol.Biol. 233: 550-552.
  18. Lin Z, Li J , Zhang F and Tsou C-L (1993) "Structure of D-Glyceraldehyde-3-phosphate Dehydrogenase from Palinurus Versicolor Carrying the fluorescent NAD Derivatives at 2.7 Â Resolution" Arch. Biochem. Biophy. 302:161-166.
  19. Zhang F, Kobe B, Stewart CB, Rutter W and Goldsmith EJ (1991) " Structural Evolution of an Enzyme Specificity: The Structure of Rat Carboxypeptidase A2 at 1.9 Â Resolution". J. Biol. Chem. 266: 24606-24612.

Book Chapters

  1. Faming Zhang, John Beals, etal. (1997) "Obese Protein: Three-Dimensional Structure, Surface Properties, and Receptor-Binding Model". in Leptin: The Voice of Adipose Tissue, W.F. Blum/W.Kiess/W.Rascher Eds. Edition J & J, 25-31.
  2. Lei Jin, Armen Tashjian, and Faming Zhang (2003), " Toward an Understanding of Human Parathyroid Hormone (PTH) Structure and Function", in Parathyroid Hormone Molecular Biology, Tally Nareh/Justin Silver Eds. Landes Bioscience.
  3. Faming Zhang, figure and text (21-23) contributions to college textbook "Fundamentals of Biochemistry", 2/e by Voet and Pratt, John Wiley & Sons.
  4. Faming Zhang, figure and text contributions to: Growth Hormone Replacement Therapy in Adults with Hypopituitary Disease. V1.1.
  5. Faming Zhang, Yanyun Chen, Mark Heiman, and Richard DiMarchi (2005), "Leptin: Structure, Function and Biology". Vitamins and Hormones, 71:345-372.

Patents and Applications

  1. EP1007648, WO9828414, Anti-obesity proteins
  2. EP0973535, WO9827993, Protein crystals, their preparation and use
  3. EP0926158, WO9931137, Crystalline parathyroid hormone
  4. P13082, Aza-1,7 annulated carbazoles and Bisarylmaleimides as kinase inhibitors.
  5. P13782, Reversed indolocarbazoles as CDK4 inhibitors.
  6. NDA report 21-318. Forteo, Teriparatide injection: Chemistry, Manufacturing and Control