Recent News & Events

10/26/2017

Congratulations to Chris Schlicksup, on being elected a Taylor Fellow.

8/25/2017

Zlotnick lab member, Chris Schlicksup, wins award for The Best Oral Presentation at the Phage/Virus Assembly Conference in Ellicott City, Maryland.

8/14/2017

Congratulations to Dr. Lye Siang Lee on earning her PhD.!!!

3/9/2017

Congratulations to Adam on his election to the American Academy of Microbiology.

2/16/2017

Assembly Biosciences (ASMB) announces successful completion of phase 1a clinical trials for ABI-H073 [Link].

1/29-2/4/2017

The fifth Gordon Conference on Physical Virology chaired by Brian Bothner, Mavis Agbandje, and Jeroen Cornelisen. Adam the chair of the first conference in this series.

1/11/2017

Congratulations Chenglei Li. Chenglei will begin a Post Doctoral position in the lab of Vinay Pathak at NCI-Frederick.

12/9/2016

Congratulations to Chris Schlicksup. Chris has been awarded a Quantitative Chemical Biology NRSA training grant.

07/21/2016

Developing drugs to eradicate the hepatitis B virus [Link].

07/18/2016

Check out Adam's interview at Bloom June-July 2016.

9/21-24/2016

Internetional HBV meeting in Seoul, Korea.

7/24-26/2016

FASEB Virus Structure & Assembly meeting at Steamboat Springs, Colorado.

3/26/2015

Congratulations to Dr. Selzer.

 

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We take viruses apart

We put them back together

We make them make mistakes

The Zlotnick lab dissects virus assembly using a broad array of biophysical and biochemical tools. We perturb “normal” assembly with mutants and small molecules. Results of perturbations are observed in vitro and in cells. Changes in structure are correlated with changes in assembly.

Assembly-directed small molecules can be antivirals. Our small molecules speed up assembly by orders of magnitude. How can this be antiviral? Imagine an assembly line, producing cars or viruses. It moves at a relatively slow rate and different pieces are added one at a time. If we accelerate the assembly line a little bit, say twofold, we get more cars but also more mistakes. If we accelerate the assembly line 100-fold, say from ¼ mile and hour to 25 miles an hour, we’ll be lucky to get a steering wheel.

 

These overlays show comparisons of Hepatitis B Virus capsids with bound drugs (purple) to a normal capsid without drug (green). Though the drugs, HAP1, HAP18, and AT130, each bind to different sites, their effects on capsid structure are distinctly different. (This figure was made by Bala Venkatakrishnan)

This Week In Virology (TWiV) comes to Indiana University! Click MicrobeTV.TWIV466 to watch the full episode.

Dr. Lye Siang Lee

About half of known virus families have icosahedral shells. Icosahedra have 5-fold, 3-fold, and 2-fold symmetry axes. In 1962, Caspar and Klug showed that you can make a larger icosahedron with the same sized subunit by mixing in quasi-6-folds with icosahedral fivefolds This graphic (from Christina Bourne) shows a T=3 icosahedron, where the quasi-6-fold is coincident with the icosahedral 3-folds.